Conserved Protein Domain Family
7TM-7TMR_HD

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pfam07698: 7TM-7TMR_HD 
7TM receptor with intracellular HD hydrolase
These bacterial 7TM receptor proteins have an intracellular pfam01966. This entry corresponds to the 7 helix transmembrane domain. These proteins also contain an N-terminal extracellular domain.
Statistics
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PSSM-Id: 311570
View PSSM: pfam07698
Aligned: 71 rows
Threshold Bit Score: 52.5571
Threshold Setting Gi: 147848446
Created: 19-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123516584 330 LSVFLGIFLTIILLSLVLYYWRIRNwpKKYARSNvdllflsTTAFFQILLVKTgifmsdaINrafpylsmETCFFAIPFA 409
gi 123557200 391 WPGLIGFGGIVTMGLAVFWLMQRRWq-PNLRVGD-------RLLLLVLALSVPlg---ysTP-----------LHVSTLP 448
gi 123056594 403 WRSLVVFVCIVSASVAIVVIVGKKFq-SCLRRRD-------HILLLLLSLSAPll---vaLR----------IPWTSSLP 461
gi 1723098   376 WQGLLRTAGLVGGALIIFCGVSRRIh-RPLRRRD-------HILLCLLSVSTPvl---flLD----------PVYNN-LP 433
gi 81771293  415 WLALLKLGGLVTGGICIFALVETRSk-CPLRQRD-------RLLVLLLTLSTPgv---laMG----------VPYTT-WS 472
gi 123502935 386 IWGLVGVAGVMGMGLAVFVPLQQRLr-PGLRRRD-------RVLILMVSLTAPll---aaLF----------KLEFSSLP 444
gi 81708754  342 WPELGLLAVIQIVAFSTFLGIDKRLgrACLCKRD-------YLLTLVVALGTAiigviigNS--------WGWGGFLPFI 406
gi 585123923 440 WLKLTTLAGIVTGAIGIFVVVGRQRs-CKLRQRD-------YLLVLLLTLSIPgv---laFG----------VPYTT-WS 497
gi 497228881 386 WVGLGISAVIVMGTVTIFCVVSHKVh-RPMRRRD-------HILLCMLSLSTPll---aiFN----------LGYTN-LP 443
gi 147848446 247 LGIWLIRFTESLAACGILLLVMRREr-PCLEAPH-------GLLALGLLLISQackvwfgAA----------VSPLAVIV 308
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123516584 410 AGAMLVAVLTNRNMALILNIFISFLISFL-F----EYDIKMSLFCFLGSIAASYHVVRCRQRSAFLKAGLYLGFFNI-AV 483
gi 123557200 449 AVGLLAGSFYGARLGSTLVVLLTAIAPLG-LnlvpVVDLNSLMASSVAGLVGAVRVGSLRSREEVALLGLGVGMAEG-VT 526
gi 123056594 462 AIGLLVGNFYGSTMGVTLVGLISVVLPIGmD-----VDKIDWFASAVGGIVGSLVVEKMRSREEQALLGVGVGLTQG-MV 535
gi 1723098   434 AISLLTSSFYGPTLAITQVVLVGGLSAFAmE----SIVWEYLLGSAAAALLAGMIASKLRSRDELALLGVGVGATQG-IV 508
gi 81771293  473 AVGLLLGSFYGRELSMTVIGLLLFILPMS-M----EISTIGLVAGAAGGILGSYIAHRLRSREELALLGGAIALTQG-GV 546
gi 123502935 445 AVGLLLGSFYGAGLGLVVVVGQALFLPLV-S----PVNLLTLVPLLSSSVVASALAGRSRSREELALLGGGAAAVQM-LA 518
gi 81708754  407 AAGLLLGNFYGSLRGSVALLALAVPFWYGlA-----LPPAIFWPVLAGGLVAAVQVGRLRSREEMAFLGVLAAAVQG-GV 480
gi 585123923 498 AVGLLLGSFYAPALGATVVGLLLLILPTT-V----EISIISLLAGGAAGILGSSMAQRLRSREELALLGVAIAVTQG-GM 571
gi 497228881 444 AVGLLTSSFYGPTLAITQVVLLSGLSTFAaT----TINWSYVLAGTAGGLLAASVAWKLRSRDELACLGGVVGLVQG-SL 518
gi 147848446 309 PPTLLLAQGLGTSSALAWMAVASLLWPTPvT----GLGEGRLLIAAATATVAALQAGRLRSRAQLLQLAVLLPLGALvLE 384
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 123516584 484 IACISL--IMNEIF----S-FDLFSKLAMGMAGGLLSG---VIVAGMTPLFETIFKYTT 532
gi 123557200 527 FLLCSL--INPPAGlffaSwISLLTTVGIHALRGMAWS---VVALGISPYLERIFDLVT 580
gi 123056594 536 YLLTNLi-VRANPGl---LwYAIIGPVGWQVLTGLIWG---IVALGLSPYLEHLFDLIT 587
gi 1723098   509 YLFTYLi-VNASAVt--iIwYTALPSAIVYGLLGLAWS---AMAIGVSPYLERLFDVVT 561
gi 81771293  547 YLLMKV--LIGAAFg--sSwYLILQEAGLFTLSGLAWS---VVALGLSPYLEKLFDLVT 598
gi 123502935 519 YGAVSL--ATTGGI----D----LLAMALAGGTSLGWS---IVALGASPYLERLFDLAT 564
gi 81708754  481 YALLNL--VFPAGY----DwRELLIHTGEMFGGGLVCS---IVALGASPYLERLFDVVT 530
gi 585123923 572 YLLMKL--FIGAAFg--gGwYVVLQGAGLFALSGLAWS---IVALGLSPYLEKVFDLVT 623
gi 497228881 519 YFIGYLi-VAPVAGt---IwSIVLPEAIIYGLSGIAWS---VMALGISPYLERLFDLVT 570
gi 147848446 385 LLLLNRssGSLVDQ----DwSRLLPNSGDLTSEALLLGllmMLTILVIPLLESSFGLLT 439
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