Conserved Protein Domain Family
HNOB

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pfam07700: HNOB 
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Haem-NO-binding
The HNOB (Haem NO Binding) domain, is a predominantly alpha-helical domain and binds heme via a covalent linkage to histidine. It is a haem protein sensor (SONO) that displays femtomolar affinity for nitrous oxide, NO. It is predicted to function as a haem-dependent sensor for gaseous ligands and to transduce diverse downstream signals in both bacteria and animals.
Statistics
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PSSM-Id: 311572
View PSSM: pfam07700
Aligned: 175 rows
Threshold Bit Score: 104.105
Threshold Setting Gi: 495731427
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1U55_B          2 KGTIVGTWIKTLRDLYGNDVVDESLKSVGwepDRVITPLEDIDDDEVRRIFAKVSEKTGKNVNEIWREVGRQNIKTFS-E 80
4U9B_A          2 KGIIFNVLEDMVVAQCGMSVWNELLEKHAp-kDRVYVSAKSYAESELFSIVQDVAQRLNMPIQDVVKAFGQFLFNGLA-S 79
gi 123089948    2 KGAVLIALNDMVEEVFSMAVWDQVLAKVKpdsEGIYISAESYDDAEVVGLVVALSELTGVPVNELVRSFGTYLFHQLN-S 80
gi 123090013    2 KGAVFVTLKTMIEESHGPTAWAALVDKVApecEGVYDANENYPDADAIAYIGAVAELLNSSASAVTEIFGRYLFDALN-S 80
gi 81377766     2 KGIVFTSLNDMIIEQFGIETWDQLVSSLDlpsGGSYTAGGTYSDTEFQQLIKAIAKRTNQHASVFLEAFGEYMFPILS-S 80
gi 515610788    2 qGIIYTVLSDLVIEKFGALFWDQMLEDLKpssQGIYTAGEQYSDDELLAMVAYLSEKKNIPADDLVRLYGQYLFSRLYnS 81
gi 1032681078   2 HGIILQTLQSFVVDTYGEDAWLAIQDEADi-eEKVYVPVTVYPDGDVYEIARTAGELTDQSPRTILTQYGRWVVPALLeT 80
gi 941258122    2 HGVILAHLRHFVTDRYGPSVWDDVNHRAGl-tDCLHVPIQLYPDSHLEDLVAALQSVTGLHRDDLLEEFGAWVIPPLI-N 79
gi 503644736    2 HGIVLKGLKDFVTEEYGADVWTDLHEAAGf-rTRLYVPVTEYPDEIVLELVDAATDLTGLEEPTLLAAFGRFLVPHLL-S 79
gi 495731427    2 HGIVHKTLKEYVVERTDDGTWDTIVEQSGf-ePKLYLPVSHYDDREIDAILETLSTMATQDRRAIERDFGTTLAPKLL-S 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1U55_B         81 ---WFPSYF-A--Gr-RLVNFLMMMDE-VHlQL---TKM-IKGATPPRLIAKPvAKDAIEMEYVSKR--KMYDYFLGLIE 146
4U9B_A         80 ---RHTDVV-D--KfdDFTSLVMGIHDvIHlEV---NKL-YHEPSLPHINGQLlPNNQIALRYSSPR--RLCFCAEGLLF 147
gi 123089948   81 ---KFPIFC-D--LhtNIFDLLSSIHGvIHkEV---DKL-YSNASLPTINCTKlSDSHLQMRYYSPR--KLCVLAEGLII 148
gi 123090013   81 ---MSPQYA-A--AspTLFGFLQSIEPlIHrEIrnsNK----SSSLPVIVVKVtDEQHLLMRYNSPR--KLCFLAEGLIR 148
gi 81377766    81 ---KCAIFL-K--KdmTLKEFLKSIDGtIHvEV---EKL-YPDETLPTISYEEpAANQLVMVYRSHR--RLCHFAMGLIQ 148
gi 515610788   82 lpeNYPN------Kn-NLLEFLISVDQvIHkEV---KRL-YPDAYLPQFQCKSeGDR-LTMYYTSKRk--LCAAAEGLII 147
gi 1032681078  81 ----YDLHI-DddWe-GL-ELIANIQQ-FHtSL---RTRdMTTLTTPRIRSERlDEDRVRITYDSDRk--LCDVARGAIR 147
gi 941258122   80 ---MYRAMIpRe---wDAVAFLLNVEErIHqRV---IRLkNPEATPPRIDVRElEPRVLQVEYRSHRd--LSLLALGCVH 148
gi 503644736   80 ---TYGVHV-DreWt-GL-ELIANVETyIHeAL---RAKqSGEFTPPELRTRRvDDRRVALAYESDR--GLCALARGLLE 148
gi 495731427   80 ---TFSAHI-Krd--wDLPELLAGLED-VYdDI---EAAtEDTA-LPELSCTSeAD-HAIVSYDTHRdqQYCGLAHGILE 147
                         170
                  ....*....|....
1U55_B        147 GSSKFFKEEISVEE 160
4U9B_A        148 GAAQHFQQKIQISH 161
gi 123089948  149 GAAEHYKADVSVSQ 162
gi 123090013  149 GAAKHYGETVELSH 162
gi 81377766   149 GAAQHFKKKITIKQ 162
gi 515610788  148 GASEQFGEEVEIEQ 161
gi 1032681078 148 GVADRFDEDLVAEE 161
gi 941258122  149 GVAAFYGEKVEIle 162
gi 503644736  149 GIADYYDEPLHIEQ 162
gi 495731427  148 GVVAAFGADAAVTE 161
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