Conserved Protein Domain Family
HNOBA

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pfam07701: HNOBA 
Heme NO binding associated
The HNOBA domain is found associated with the HNOB domain and pfam00211 in soluble cyclases and signalling proteins. The HNOB domain is predicted to function as a heme-dependent sensor for gaseous ligands, and transduce diverse downstream signals, in both bacteria and animals.
Statistics
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PSSM-Id: 311573
View PSSM: pfam07701
Aligned: 64 rows
Threshold Bit Score: 159.264
Threshold Setting Gi: 156382244
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75288400  231 FTLSPNDFYQLFPFHLLLDRSCRVVQAGAVLERLFpeLRGRSGVPLGDVFQMRAPS-MTISFDSLHAAHADtVLLRA--- 306
gi 52782815  221 ILVGLRDFKNIFPYHVCFNKQMIIEHIGIYLLREYg-LENKKTLKVSDLMQLVQPSdIQLTYKNVLSYLNTlFIFQLkhh 299
gi 52782812  224 LKVSLQDFSRALPYHFVLDESCRLVQCGDELYNHIpnELLQPGTPILRIFEINRPQ-IPLDFENICNFINAvFVLQVkts 302
gi 308508829 224 LQMSLDDFSKALPYHFVIDESCKLVQCGSELHNHIpnELLQPGTPILRIFEINRPQ-IPLDFENICNFINAvFVLQVkts 302
gi 393910787 127 LQVNKADFISLQPYHFIADNNCNLIQCGKGFYQHIsmESLTPGTPLECIFDIIWPQ-ISFNFNAIYNLINAiFILQLrrg 205
gi 341884672 217 IRLTHMDFVSTFPYHMVVDQDCKIVQVGRELYNHIpkDLLAVGTPLMRIFEVTRPQ-IPLDFDSICNFINAvFVLQVktt 295
gi 167533895 205 VSMDSAAIDRLFPWHFAFDEELKIVSIGSQLRRHL--NANPIGSKLADIMAIQRPLeAKYRYDDFQQRSGNpYQLALhrd 282
gi 167523324 187 LNLSPDTLDALFPWHLSFNRDFKVTSIGSNLAKRF--AKSCVGDSLDAIARVVRPYtIKFEFDKKSEWDGSqMVFAVvrd 264
gi 514681518 204 LSADTGLFDELFPWHVQIDRKMRVVSMGSSLQTRFq-DQKLDSLTFHDVFKLTQPNvPQKTFTTFMQFDHDaFVAIArde 282
gi 514699907 202 cdatTTEFDELFPWHLQVDSDLRVISMGSSLALRFneEELKKQKRLMDVVTVTRPNhVLNDFEHLKQFDRTaVMLMVrde 281
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75288400  307 -------------------------------------------------------------RATGLDLKGQVLPVrvlas 325
gi 52782815  300 skrne------------------------------------------------vqegsseaFQQPLVLKGEMMPI----- 326
gi 52782812  303 plrkkhmnamtkeer-----------------------------eqeveameeevesneltQGCHLKLKGQMMML----- 348
gi 308508829 303 plkkklmdamsqeel----------------------------kqevealeeeedksneltQGHHLKLKGQMMLL----- 349
gi 393910787 206 inneep-----------------------------------------------nsvrtttyQKKKLKLKGQMMIL----- 233
gi 341884672 296 pmefqrnankrnaqnn---------------------------dalensnddsmnavvtlsQSQHLKLKGQMMLM----- 343
gi 167533895 283 aqadiqiashyaatddnsdacsvaaselsnvgcpfsggrrrsdesaissidrmqalrnmpqRI--IQLHGEFVAL----- 355
gi 167523324 265 daardepvsmkcpvtgr-------------------------tyeltgaaaeryrrvgvanLKGHLFLKGEVRYE----- 314
gi 514681518 283 qyhmkkeqkhmaklraraaehgw-------------dddddallqrtvscssvegesfisvATDYLYIKGEMIYI----- 344
gi 514699907 282 wysqikeqkldekkkaqlmragssl---------fnvdahantpagsamsaaflndqfisaTADFLYLQGEFRYN----- 347
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75288400  326 pepvtatqcaehvrtehgghqrqlaehvgqrdgrpeqDGEQGFLFLGSPWLAGLAGMRQHGICISDIARHDSTRDFVLLA 405
gi 52782815  327 -------------------------------------NDGNSIIFICSPHVTTVRDILNLKLYISDMPMHDATRDLVMLN 369
gi 52782812  349 -------------------------------------STKKHIIYLCSPYVTSINELMQFGMRLTAMPLHDATRDLILLN 391
gi 308508829 350 -------------------------------------SSKKHIIYLCSPYVTSINELMQYGMRLTAMPLHDATRDLILLN 392
gi 393910787 234 -------------------------------------EQRNWLLYIGSPDISTISELFEYGMRLEAMPLHDFTRDVILLN 276
gi 341884672 344 -------------------------------------SSGGHIMYLCSPYVTSIPELLQYGLRLTAMPLHDATRDLILLN 386
gi 167533895 356 -------------------------------------QEGQ-LFFAGAPLLRDVKQLDAQGITMSDLPVHSHASEILYAS 397
gi 167523324 315 -------------------------------------QEMDVMVFVGTPHLSNLEELKTYDIDLVELPVHSNARDMVFAQ 357
gi 514681518 345 -------------------------------------SKTDTILFAGVPQFSKPEEMYLRGLSLADIPIHSNGREILFST 387
gi 514699907 348 -------------------------------------PRDNTLLFVGVPSAQTPEELYKCGLGLPDIPIHSNGREMLFNN 390
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 75288400  406 EQRHAETQLKERLETLTLELKDANSRlgemagwLDEERRRSDGLLYQMLPPEVAS-C 461
gi 52782815  370 QSRICQMELNKKLEETMKKMKKMTEE-------LEVKKSQTDRLLFEFVPPVIAEaL 419
gi 52782812  392 QQRLSDVEVNLQLEANNEQLETMTHE-------LEVERQKTDSILKDMLPRKIAKqL 441
gi 308508829 393 QQRLTDVEVNLQLEANNEQLETMTRE-------LEQERLKTDSILKDMLPKRIAQqL 442
gi 393910787 277 QQRLSNIEQNMQLQANNTQMEEQARN-------MKCERVKTETLLYQLLPTFVVTqL 326
gi 341884672 387 QQRLSDVEMNLQLEANNEQLENMAKD-------LEVEKGKTDALLREMLPPSVAQqL 436
gi 167533895 398 MFQAMSAKRANKADKELLMLNNNRDE-------VRRQQEITANLLHSILPPRIADaL 447
gi 167523324 358 QHSSATIGMAKELEVLTRELEVEREN-------VNREKMRIHELLYSILPPTIADsL 407
gi 514681518 388 AHQAATVSIAAELEQTTSDLSRAQQE-------VTHEKHRVQELLHSILPKQVAQcL 437
gi 514699907 391 VHQSATVGVAAQLEQVTQDLEKAKRE-------LGLEKKKVHELLSSILPQTVIQ-Y 439
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