Conserved Protein Domain Family
TAT_ubiq

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pfam07706: TAT_ubiq 
Aminotransferase ubiquitination site
This segment contains a probable site of ubiquitination that ensures rapid degradation of tyrosine aminotransferase in rats. The half life of the enzyme in vivo is about 2-4 hours. In addition, unpublished information identifies at least 2 phosphorylation sites including CAPK at Ser29 and, at the other end of the protein, a casein kinase II site at S*QEECDK. This region of TAT is probably primarily related to regulatory events. Most other transaminases are much more stable and are not phosphorylated.
Statistics
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PSSM-Id: 311577
View PSSM: pfam07706
Aligned: 24 rows
Threshold Bit Score: 32.7452
Threshold Setting Gi: 348503754
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114714        1 MDSYVIQTDVDDSLSSVLDVHVNIGGRNSV------------------------------QGRKKGRKAR 40
gi 1002575714    1 MDSCLIQVNSNTSLSSVLDVHVNLNGKSPS------------------------------LPKGKGRKPh 40
gi 327285454     1 MDSYLIQVTGKSAFPSVMDVQLGRAGRGPC------------------------------CVAGKGKGHR 40
gi 1040221840    1 MDPYMIQTNGNNhipsvldvhvnFGGRSSV------------------------------PGKMKGRRTR 40
gi 348503754     7 TKSYMVQMNGNG-----------VCGKTTVngktlnengvnrngvhgngvhhvnikgalyPTKSKSRRQR 65
gi 1003947049    1 MDSYLIQVNGQGdhvplldihlkTNGNSMS------------------------------LGKMKGRKPR 40
gi 542173601     1 MDSYLIQVNGHGdhapvldvhlkNTGNTIS------------------------------PGKVKGRKPR 40
gi 410907123     3 NKAYLVQMNGNG-----------VHGKNPVnsktpngtgvtgsg-----lhrlsgngslyptKVKSRRLR 56
gi 47221906      3 NQAYVVQMNGNA-----------VHGKGPAkcptpngtrvtgn-----gmhrvgangslyPAKGKSRRLG 56
gi 126304845     1 MDSYVIQMNGNGdlssvldvhvnINGRNTV------------------------------SGKMKGRKAR 40
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