Conserved Protein Domain Family
RabGGT_insert

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pfam07711: RabGGT_insert 
Rab geranylgeranyl transferase alpha-subunit, insert domain
Rab geranylgeranyl transferase (RabGGT) catalyzes the addition of two geranylgeranyl groups to the C-terminal cysteine residues of Rab proteins, which is crucial for membrane association and function of these proteins in intracellular vesicular trafficking. This domain is inserted between pfam01239 repeats. This domain adopts an Ig-like fold and is thought to be involved in protein-protein interactions and might be involved in the recognition and binding of REP.
Statistics
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PSSM-Id: 311580
View PSSM: pfam07711
Aligned: 10 rows
Threshold Bit Score: 153.351
Threshold Setting Gi: 260824986
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742332   243 IRCVMVSLDEPCVSVTFSHPVEV---QEDLILFLNN-RPIFVSWRTAGRKEKRSLFWVCDLPKECINDPCCQY-NFQVLW 317
gi 260824986  243 IRCLHVCRPLNRLVATFSKHLKAs--AATLNVVKDG-EVITGRWHTPRGTDTFEQVLIFEFPEHSLTPDRDQHiHVTLDT 319
gi 597742768  266 ISCVYVSREGERVAVAFSKPVNAl--TEGLMLVLDGqQQQRVEWRSAHPRFRHSPVWLCELPPGSVSDINNEH-NLTVHW 342
gi 115496183  260 ISCVYASREGERVSVAFSKPVHAg--SVGLMLVLDG-QPQQVQWRNAHPRLRHSPVCLRDLPAGSISDTSNEH-NLTIHW 335
gi 734604647  285 ISCVYVSRDEERVAVAFSRPVNAq--SVGLLLVLDG-QPQRVEWRSVHPRFKHSPVWICDLPPGTISDITNEH-NLTVHW 360
gi 664752395  245 LRCLHVSRDEACLTVSFSRPLLVgs--gTLLLMVDE-SPLAVEWRTPDGRNRPSHVWLCDLPAASLNDQLPQH-TFRVIW 320
gi 821454058  245 IRCLHVSRNEACLTVCFSRPIIVgpgIETVMLLVDE-SPLPVEWRTPDGKKRPNHVWLCDLPADSFNDQDSQH-SFFLMW 322
gi 620950496   17 VLCLHVSRDDACLTVGFSRPLAVgpgAERLLLLVDE-SPLAVEWRTPDGRNGPGNVWLCDLPAAslNDQWPQH-TFRLLW 94
gi 1033374783 127 IRCVYVNREDTSLAVAFSHPVAIapaSHDLIIFGDE-SPLVVRWRTPDGRNRPGFMWLCDLPASALNDHWPQH-TFRILW 204
gi 765116765  171 ISCVYVSREDERVAVAFSRPINAr--CVGLLLVLDG-QPLRVEWRSVHPRFRHSPVLICDLPPGTINDVTNEH-NLTVHW 246
                          90
                  ....*....|....*....
gi 55742332   318 KDGEAKKECILYPGRRESW 336
gi 260824986  320 EAGLVGRECVLGAGHPEVF 338
gi 597742768  343 MEKHTHRDCALYTGRPESW 361
gi 115496183  336 TDKHTHRDCALYTGCAESW 354
gi 734604647  361 TEKHTHRDCALYTGRTESW 379
gi 664752395  321 TAGDAQKECVLFKGRQETW 339
gi 821454058  323 --GDVQKECVLYKGRKESW 339
gi 620950496   95 RGGDAQKECVLFKGRREGW 113
gi 1033374783 205 SEGQSQKECVLFKGHRDCW 223
gi 765116765  247 TGNHTHRDCALYTGRVESW 265
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