3ZFX,4K33,2QOH,3BYS,3KUL,3SXR,4ANS,2WD1,3PXK,4OT5,5AMN,3ZBF,1LUF,5TO8,3MIY,3ZZW,2OO8,3PLS,3QUP,5D7V,1BYG,1U46,1U59,4E4L,5TQ5,4GVJ,4RIY,4PX6,4HVD,4FVP,4L00


Conserved Protein Domain Family
Pkinase_Tyr

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pfam07714: Pkinase_Tyr 
Click on image for an interactive view with Cn3D
Protein tyrosine kinase
Statistics
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PSSM-Id: 336778
View PSSM: pfam07714
Aligned: 153 rows
Threshold Bit Score: 211.202
Threshold Setting Gi: 73920239
Created: 25-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZFX_A         21 VKIEEVIGAGEFGEVYKGRLK----------LP------GKREIYVAIKTLkaGYSEKq-RRDFLSEASIMGQF-DHPNI 82
gi 73920239    16 FEIYEEIAQGVNAKVFRAKEL-------------------DNDRIVALKIQ--HYDEEh-QVSIEEEYRTLRDYcDHPNL 73
gi 215274013  583 LVQGEHLGRGTRTHIYSGTLMdykd---degTS------EEKKIKVILKVLdpSHRDI--SLAFFEAASMMRQV-SHKHI 650
gi 21263757   580 IVQGEHLGRGTRTNIYAGILKpksdd-eddlGG------YSQEVKVVLKVL--GSGHRdiSLAFFETASMMRQI-SHKHT 649
gi 12643404   545 LIFNESLGQGTFTKIFKGVRRev------gdYG------QLHETEVLLKVL--DKAHRnySESFFEAASMMSKL-SHKHL 609
gi 2499671    517 LEWHENLGHGSFTKIFHGHRRev-------vDG------ETHDTEVLLKVM--DSRHQncMESFLEAASLMSQV-SYPHL 580
gi 34761802   368 lQTTEGLGQGTFTQVFRGIRRev------gdYG------EVHKMEVVMKILdkSHRNY--TESFFESASMMSQL-SHKHL 432
gi 47222167   586 iEQEEHLGRGTRTNIYSGTLRvkseededagYS------SFQEVKVVLKLLsyGHRDI--SLAFFETASMMRQV-SHKHI 656
4FVP_A         10 LIFNESLGQGTFTKIFKGVRRev------gdYG------QLHETEVLLKVLd-KAHRNy-SESFFEAASMMSKL-SHKHL 74
4L00_A         27 LVQGEHLGRGTRTHIYSGTLMd---------YKddegtsEEKKIKVILKVLdpSHRDIs-L-AFFEAASMMRQV-SHKHI 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZFX_A         83 IRLEGVVT-Ksr-----pVMIITEFMENG---ALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNIL 153
gi 73920239    74 PEFYGVYK-LskpngpdeIWFVMEYCAGGtavDMVNKLLKLDRRMREEHIAYIIRETCRAAIELNRNHVLHRDIRGDNIL 152
gi 215274013  651 VYLYGVCV-Rdv-----eNIMVEEFVEGG---PLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL 721
gi 21263757   650 ALLYGVCVrHqe------nIMVEEFVQYG---PLDLFMRRQTTPLSTAWKFQVAKQLASALSYLEDKKMVHGYVCSKNIL 720
gi 12643404   610 VLNYGVCVcGde------nILVQEFVKFG---SLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNIL 680
gi 2499671    581 VLLHGVCM-Agd------sIMVQEFVYLG---AIDTYLRKRGHLVPASWKLQVTKQLAYALNYLEDKGLPHGNVSARKVL 650
gi 34761802   433 LLNYGICV-Cad-----eHIMVQEYVRFG---SLDTYLKRNRNTINITWKLEVAKQLAWALHHLEEKSLTHGNVCARNVL 503
gi 47222167   657 VLLYGVCV-Hhq-----eNIMVEEFVQLG---PLDVFMRRQQNPLSIPWKFQVAKQLASALSYLEDKKLVHGFVCAKNIL 727
4FVP_A         75 VLNYGVCV-Cgd-----eNILVQEFVKFG---SLDTYLKKNKNCINILWKLEVAKQLAAAMHFLEENTLIHGNVCAKNIL 145
4L00_A         95 VYLYGVCV-Rdv-----eNIMVEEFVEGG---PLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3ZFX_A        154 V--------NS--------NL-VCKVSDFGLSRYLQDdtsDPTYTSSLGGKIPVRWTAPEAIAYRK-----FTSASDVWS 211
gi 73920239   153 L--------TK--------NG-RVKLCDFGLSRQV-----DSTLGKRGTCIGSPCWMAPEVVSAMEsrepdITVRADVWA 210
gi 215274013  722 L--------ARegid-secGP-FIKLSDPGIPITV---------LSRQECIERIPWIAPECVEDSKn----LSVAADKWS 778
gi 21263757   721 V--------ARdgl--dgeGGpFIKLSDPGIPITV---------LSREECVDRIPWIAPECVKDTAn----LTIAADKWS 777
gi 12643404   681 L--------IReedr-ktgNPpFIKLSDPGISITV---------LPKDILQERIPWVPPECIENPKn----LNLATDKWS 738
gi 2499671    651 L--------ARegv---dgNPpFIKLSDPGVSPTV---------LSLEMLTDRIPWVAPECLQEAGt----LNLEADKWG 706
gi 34761802   504 V--------TReedrktgtPP-FIKLSDPGISITV---------QPREILLERIPWVPPECVKDSRn----LSLAADKWS 561
gi 47222167   728 L--------ARdgmgtdegGP-FIKLSDPGIPITV-------LTRE--ECVHRIPWIAPECVKNVSa----LSVAADKWG 785
4FVP_A        146 LireedrktGN--------PP-FIKLSDPGISITVLP---KD------ILQERIPWVPPECIENPKn----LNLATDKWS 203
4L00_A        166 L--------ARegid-secGP-FIKLSDPGIPITV---------LSRQECIERIPWIAPECVEDSKn----LSVAADKWS 222
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
3ZFX_A        212 YGIVMWEVMSFGERPywdmSNQDVINAI-EQDYR--LPPPMDCPAALHQLMLDCWQKDRNSRPRFAEI--VNTL 280
gi 73920239   211 LGITTIELAD-GKPPfadmHPTRAMFQI-IRNPPptLMRPTNWSQQINDFISESLEKNAENRPMMVEMveHPFL 282
gi 215274013  779 FGTTLWEICYNGEIPlkdkTLIEKERFY-ESRCR--PVTPS--CKELADLMTRCMNYDPNQRPFFRAI--MRDI 845
gi 21263757   778 FGTTLWEICYNGEIPlkdkKLSE-KERFyAAQCQ--LATPD--CDELAKLMTHCMTYDPRQRLFFRAI--VRDI 844
gi 12643404   739 FGTTLWEICSGGDKPlsalDSQR-KLQFyEDRHQ--LPAPK--WAELANLINNCMDYEPDFRPSFRAI--IRDL 805
gi 2499671    707 FGATTWEVFSGAPMHitslEPAK-KLKFyEDRGQ--LPALK--WTELEGLIAQCMAYDPGRRPSFRAI--LRDL 773
gi 34761802   562 FGTTLWEIYCGGEQPlaayDTAKKLLFY-EDKHQ--LPAPK--WTELASVINSCMDYEPLHRPSFRAL--IRDL 628
gi 47222167   786 FGTTLWEICYDGEVPlkekKLTEKERFY-ETECQ--LATPD--CTELAELMTHCMNYDPKKRPFFRAI--VRDi 852
4FVP_A        204 FGTTLWEICSGGDKPlsalDSQRKLQFY-EDRHQ--LPAPKAA--ELANLINNCMDYEPDHRPSFRAI--IRDL 270
4L00_A        223 FGTTLWEICYNGEIPlkdkTLIEKERFY-ESRCR--PVTP--SCKELADLMTRCMNYDPNQRPFFRAI--MRDI 289
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