Conserved Protein Domain Family
Plug

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pfam07715: Plug 
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TonB-dependent Receptor Plug Domain
The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.
Statistics
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PSSM-Id: 311584
View PSSM: pfam07715
Aligned: 635 rows
Threshold Bit Score: 36.8671
Threshold Setting Gi: 81740726
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FEP_A        21 QNLQAP-GVST--ITADEIRKNPvARDVSKIIRT-XPGVNLtgnsTSGQRGNNRQI------DIRGXGP----------- 79
gi 81740726  132 DKASYLgSAAT--VYTDQVSSLM-GTTILPSLQGrLPGLDI----VRTRGARKSQIessssgTIFNFNSptlgkeaysdn 204
gi 81442806  211 AEKALSyNVQQ--IKSEDITGIK-DANFINSLNGkIAGVSIn--kSGSGVGGATRV------VMRGAKSie--------- 270
gi 81445045  206 EQKALSyNVQK--VNNDALTSVK-DANFVNSLNGkVAGVNIq--rSASGVGGSTRV------TMRGNKSis--------- 265
gi 81314068  202 aEKALSySVQQ--VKSDAINDVK-DANFVNGLTGkVAGVSIn--rSSSGIGGATRV------VMRGAKSiv--------- 261
gi 81442593  201 EAKSLSyNVQQ--VSNAEITRIA-DANFVNNLNGkVAGVTIn--sSSAGVGGSSRV------VMRGTKSln--------- 260
gi 75494161   85 EADATGeAASQgyVTRGQLENRP-LLRPRELLET-VPGLIVt---QHSGDGKANQY------FLRGFNLdhgtdla---- 149
gi 81735094   91 GPEGPPgMASAltVSGEELNARP-FTRPGEVLEA-VPGLIVt---QHSGEGKANQY------FVRGYNLdh--------- 150
gi 81768491   46 AAAATGeAASQgyVPRAQLENRP-LLRPGELLET-VPGLIVt---QHSGDGKANQY------FLRGFNLdh--------- 105
gi 81535663   36 DLGRATsASEGr-IAYADFASRP-LLRPGELIEA-VPGLAAt---QHSGAGKANQY------FLRGFNLdh--------- 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1FEP_A        80 ---------ENTLILIDGKPVSSrnsvr----qgwrgERDTRG-----DTS-WVP---PEXIERIEVLR-GPAAA-RYGN 135
gi 81740726  205 tefnvlsrhNAPVVVVDGV----------------------QR-----ELY-SID---PDAIESVSIQKdALSSM-FLGM 252
gi 81442806  271 -------gdNNALYVVDGIPLFNtnmgntd-sgimgeGKAGTE-----GIA-DFN---PEDIESISILS-GPSAAaLYGS 332
gi 81445045  266 -------gdNNVLYVVDGVPIGNqadr------tgdgTGFGSGrtsgeGIA-NFN---PDDIESVSVLT-GPSAAaLYGA 327
gi 81314068  262 -------gnNNVLYVVDGMPIGNpskgei---nndysTPGGGE-----GIS-DFN---PEDIESLSILT-GPAAAaLYGS 321
gi 81442593  261 -------gnNNALYVVDGIPMSDmsaastqptdsyegAGQSGD-----PIS-GLN---PEDIESISVLS-GPSAAaLYGS 323
gi 75494161  150 --ttvasmpVNMRTHVHGQG---------------------YT-----DLNf-VI---PELVSGIAYKK-GTYFA-EEGD 195
gi 81735094  151 --------gTDLAIYVDDVPVNM--------------RTHAHG-----QGYaDLNwliPETISAMDVRK-GPYFA-DESD 201
gi 81768491  106 --------gTDLATTVAGMPVNM--------------RTHAHG-----QGYtDLNfliPELVSGIAYKK-GTYFA-EEGD 156
gi 81535663   95 --------gTDLAASLDGVPLNLps----------hgHGQGYL-----DLN-VLT---PEFVHDISFKK-GPYSA-ENGD 145

                 ....*.
1FEP_A       136 GAAGGV 141
gi 81740726  253 RSSRGA 258
gi 81442806  333 SAANGV 338
gi 81445045  328 SAANGV 333
gi 81314068  322 SAANGV 327
gi 81442593  324 AAANGV 329
gi 75494161  196 FSAAGA 201
gi 81735094  202 FASVGS 207
gi 81768491  157 FSAAGA 162
gi 81535663  146 FATAGA 151
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