3I4U


Conserved Protein Domain Family
OB_NTP_bind

?
pfam07717: OB_NTP_bind 
Click on image for an interactive view with Cn3D
Oligonucleotide/oligosaccharide-binding (OB)-fold
This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself. The structure Structure 3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Statistics
?
PSSM-Id: 336780
View PSSM: pfam07717
Aligned: 59 rows
Threshold Bit Score: 47.6616
Threshold Setting Gi: 74644973
Created: 23-Mar-2017
Updated: 23-May-2017
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3I4U_A        169 VQKAICSGFFRNAA-----------------KKDP----------QE-G------YRTL--ID------------QQVVY 200
gi 980952826  919 LRAVIAVGLYPMLG-----------------RMCP----------LSkNrtrsviETIA----------------GAKVR 955
gi 980952138  895 LRAVLAVGLYPMVG-----------------RLCP----------AFgNnrrtivETAS----------------GAKVR 931
gi 74582920  1158 LSTLIAAALSPNVVkcvypdkkfvasfsgslEMEQ----------EArLtk---fYDQN----------------NQRLF 1208
gi 47116751   800 LKLVLGRGLYPQLA-----------------VPDAf--------nSGrKdsdqifHTQA----------------KQGTV 838
gi 75027634   786 LKLLLGSGFYPQLA-----------------ISDEf--------nYCkGggqqffHTRL----------------KPFVL 824
gi 74964743  1023 IQAVIAAGCYPFIG------------------VSA----------SEsNlkkvqtFN------------------DKPAF 1056
gi 75013540  1315 IRAIICSGLFPNIA------------------RQR----------KKrE------FKTL----------------SENTF 1344
gi 74644973  1205 LRAILTGAFYPHIArvqlpdvkylstssgavEKDPeakmikywirSEeYqdkleeYKTKisQEtqkvdledlplpATRAF 1284
gi 336269729 1230 LRALTASAFSPQIAriqfpdkkfaasmtgavELDP----------EAkT------IKFF--SQe-----------NGRVF 1280
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3I4U_A        201 IHPSSALFNR------Q-----PE-----------------------WVVYHE--LVLTTK-EYMREVTTIDPR-WLVEF 242
gi 980952826  956 VPSLSNNVDM------SstkfdEA-----------------------LIVFDE--ITRGDWgVVIRSCTVLPTI-PVLLF 1003
gi 980952138  932 VHSLSNNFNL------SskkydES-----------------------LLVFDE--ITRGDGgMHIRNCTVARDL-PLLLI 979
gi 74582920  1209 IHPSSTMFVN------SpnasrCT-----------------------FVAYEQ--KVETTK-PFLRNCTPINTY-GMILL 1255
gi 47116751   839 LHPTCVFANSpevlhtQgqeasGQegsqdgrd--------qmsckhqLLAFVS--LLETNK-PYLVNCVRIPALqSLLLF 907
gi 75027634   825 QHPNSQFAKHfellklTesdllPKpdfytpkl--------plskrhqLLCYQS--LLETAK-PYLINCIRLPAAqTLLLF 893
gi 74964743  1057 LHPSSMVKKQivkmgkSeksprVE-----------------------YVAFQEmcQMPSDRsLSMKTVTVIPSM-TALLF 1112
gi 75013540  1345 LHPSSIVYNLf-----QelnpkEN-----------------------WVIFEE--KFKTKL-TFIKTITRIPEI-SLLLF 1392
gi 74644973  1285 IHPSSVLFST------NsvnleDAkllsevdgpisrqskiptvvkypFVLFTT--SQVTNK-LYLRDLTPTTTL-SLLLF 1354
gi 336269729 1281 IHPSSTLFDS------QgftgnAS-----------------------FMSYFT--KIATSK-IFIRDLTPFNAY-TLLLF 1327

                  ...
3I4U_A        243 APA 245
gi 980952826 1004 SRE 1006
gi 980952138  980 STe 982
gi 74582920  1256 GAN 1258
gi 47116751   908 SRS 910
gi 75027634   894 SFA 896
gi 74964743  1113 TGP 1115
gi 75013540  1393 GST 1395
gi 74644973  1355 GGA 1357
gi 336269729 1328 SGA 1330
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap