Conserved Protein Domain Family
FCD

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pfam07729: FCD 
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FCD domain
This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392. This domain is found in Escherichia coli NanR and DgoR that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).
Statistics
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PSSM-Id: 311596
View PSSM: pfam07729
Aligned: 210 rows
Threshold Bit Score: 35.4127
Threshold Setting Gi: 123726909
Created: 23-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4P9F_A        78 EINRIRYELELXAVALAVENL-TP-QDLAELQELLEKLQQAQE-----KGDXEq----IINVNRLFRLAIYHRSNXPILC 146
gi 123058214  89 DIYSLREILESTAALEAVRLA-TP-SDLNAIEVAMRDTETAAL-----SNSRSr----MMESDAAFHTALCRAGKNDRIT 157
gi 81777011   90 ATYQFRSIVERAAVRVFAEQG-DE-AVMNALEIRHSRLLRRVErdglgKEQLEe----MDALEGELHGAVIAALRNPLID 163
gi 123590197  80 EVFFLRLELEPLAARSAVRLP-PA-QVDAMEERVRLLMASDPA-----VNDL------QRQTDYEFHHLLGREFGNQAVA 146
gi 500664445  96 DLYEMRLIFEPETAYYAAKRA-TD-KELERILYYGRLEEEMIL-----NNED------RTEVERSFHKSIAKATHNEFMN 162
gi 590120774  36 EIFEMRLALESTAAFLAARSGvTP-GLCEAAGKMRELIDRDVA-------DIMl----EQRIGWVFHQELFAAARNVRIS 103
gi 501038740  83 EAFQFRLFIEKESIAIFCQSA-SDeLLRSLRAEHEDTLNRAMS-----EGETPeleerAQNIDWSLHDTIVGSLDNEIIW 156
gi 490285633  86 EHYEIRAVLESEAVAKASRPG-TD---ISRIAQVHYAAEKALA-----DNNSAe----YSDLNQAFHMEIWSAAGNEKMK 152
gi 500132776 181 ELYELRAALEPVALRGAVRQT-PR-ETLQALCERCSASRRRPW-----TADM------IDRIESDLHESLLLATTNDRLA 247
gi 501062114 188 ELFEMRAILEPAALRLAAPRL-PP-ATLAALRGNLADAMAAPE-----AVDGAr----LSALEEELHISLLGHCGNATLM 256
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
4P9F_A       147 EXIEQLWVRXG-Pg-LHYLYEAiNPAELREHIENYHLLLAALKA-KDKEGCRHCLAE 200
gi 123058214 158 ETFKRLATELR----LVHLMMSpNPEQLRAAALDHAAILRALRS-RNAQHVVDALRS 209
gi 81777011  164 STYRRMHNYLR-L--LRLDRKI-TTPIMVRTLKEHLDILEACGT-RNADAAEAKLQA 215
gi 123590197 147 QTVATLHRRTC-I--FDHTQ---VPERFLRGCEEHLEILEAVRS-GNADAVEAGLRA 196
gi 500664445 163 KLMPILYKAID-NgvILSDE---NKSILQNTLNDHRMIMEFLEA-RDAEGAKTAMKI 214
gi 590120774 104 SAYGLLRAQTL-A--LNELPRG-DAETVRRGTIEHLHIFQAIEA-NNGELARQHMWN 155
gi 501038740 157 RAYQTNTIKMR-L--INQERFR-ITGRVIPVMQEHLAVLAAIET-RDPQTAMDAIAV 208
gi 490285633 153 MLLCNMWNGLS-M--GHKVT---EEEYAVISIREHKAILQALEQ-HNEALARQRMHE 202
gi 500132776 248 ESLRHIQLPLVeTerFLRSL---GLPIDPRIVDEHRIIYELLLLhDAVDAAAAALTN 301
gi 501062114 257 DALSTYQTLLV-AltFLYDAAA-RAPGVEPFLIEHMDVAERLAA-GQAEAAVEALKS 310
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