4P9F,3C7J


Conserved Protein Domain Family
FCD

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pfam07729: FCD 
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FCD domain
This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392. This domain is found in Escherichia coli NanR and DgoR that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).
Statistics
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PSSM-Id: 336786
View PSSM: pfam07729
Aligned: 209 rows
Threshold Bit Score: 35.4126
Threshold Setting Gi: 123726909
Created: 26-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4P9F_A        78 EINRIRYELELXAVALAVENLTP---QDLAELQELlEKLQQAQE---KGDXEqIINVNRLFRLAIYHRSNXPILCEXIEQ 151
gi 81790321  145 ELAEVRALIEVPVWLRLARTVPA---EHWAELRPLaEGTVRAAS---SGCPAtYAEADRAFHRAALALAGNEQLVRIAGD 218
gi 81713173   87 nhFDVRVMLESGALATLARQGLT----DTAPLVALaDEVAQAVK---DQDVGqYIESDRSFHEALVSRAGNPLLTRMIMH 159
gi 123057399  85 QLRDFRILNEGWAARRLARSREP---AAIARMRESiEAMEANPPrgqDRDYVgISRADENFHNAMLEAAGNEILSQAVKG 161
gi 81734224   89 ALCTFRIALEPKAAELAFRHDRD---GAVATMSEAiAAMEPAVS---ARDNIaYGRADAAFHEALFTHCGNRYLVESYQL 162
gi 500104251  89 QLFELRNVLERHAIESALPLA-----DLDRDLEPVrAALEQMDA---SSDVLsLDDAHRAFHAAVVGLAKNRQLDIALEP 160
gi 500045999  84 DLFVVRKLIELTAV-DAAGTAGA---AALAELRRAvDEFGQAIR---TGAAVdRNRADMFVHITLVGLLNSPRLSRIHGE 156
gi 500013246  82 DIYLARAYLESEVLR---RLART---RDVPEAALQaNRDIAAVQ---TGAPLdVVEPDMRFHTSLIDAVGNERISRMYRS 152
gi 500047660  85 DMYLAREAIERAAAA---KILRG---DHVAAGDALlEIVEQMTK---ARTPAeNSEVDIRFHIRLVELSDSPRLSRMHQT 155
gi 501362437 100 DMYRSREVLELDAAKRWCRAGEVdsgYRFHRLTEAlGRLEQASR---GTDSGlIVKSDLDFHAAIIGLLDSPRVDRFFAA 176
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
4P9F_A       152 LWVRXGPg-LHYLYEAi------------NPAELREHIEN--YHLLLAALKAKDKEGCRHCLAE 200
gi 81790321  219 VHRRAQWppAGSPSVR-------------GRADLVADAHQ--HTALLDALIAGDLDVVRALVGD 267
gi 81713173  160 LRADMRL--YGINSEE-------------GRVRQRASVEE--HYEMIDLAVKQQPDAIVALITR 206
gi 123057399 162 LHPHLH---HARLFSR-------------IPHDIAPMLDE--HRAIYDAIIRGDEDGAQAAVEV 207
gi 81734224  163 VSGRVA---ALRTNLTs-----------pIDVRTRTSFDE--HRKLLDLFARGEFAAFEALMTT 210
gi 500104251 161 ILLKLQL--PMARNMReearqhagpgrrhRPGAADEGIGR--HKAILSALETNDPAAVVTAIRD 220
gi 500045999 157 LMSELQLalVSQYRDS-------------TILPGTELTNR--HEEFLRMLLDGDTVGAREQLER 205
gi 500013246 153 LVGEVR---LCMVRIQ-------------SLHLLDTALIQaeHQKILELIEAGQGDAAAELLDE 200
gi 500047660 156 FITETQM--CIHALDE-------------SYSVSDFRSEE--HRAIAAAIKAGDRELTDELLIA 202
gi 501362437 177 IEAEMLY--ALAILEAse---------geYKTDAAKAFGE--HKAMYEALRDRDEQRSTQLISE 227
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