4DXR


Conserved Protein Domain Family
Sad1_UNC

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pfam07738: Sad1_UNC 
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Sad1 / UNC-like C-terminal
The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.
Statistics
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PSSM-Id: 336792
View PSSM: pfam07738
Aligned: 25 rows
Threshold Bit Score: 116.648
Threshold Setting Gi: 313104227
Created: 26-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4DXR_A         66 LWYHSQSPRVILQPD---VHPGNCWAFQGPQGFAVVRLSARIRPTAVTLEHVPKalspnstISSAPKDFAIFGFDEDLQQ 142
gi 74869267   613 HNSESKHTEAVLTQStdeYMLSTC----ESRIWFVVELCEAIQAQKVDVANYEL-------FSSSPKNFTVAVSKRFPTR 681
gi 74959927   144 NPEAENAKAVVNEKDvddYMRNPCQSAKEK--FIVIELCEAIQIKKIAIGNFEL-------FASRPKTIQVFISERYPPL 214
gi 74883899   628 HSRGIINIKSIQQYDydsYMLTPC----DSDIWWIYSFSDFIHIEKIGLVSLEH-------YASNFKVIEILGSDTYPAT 696
gi 158564054  321 ANPEAKSTSAILIENmdlYMLNPC----STKIWFVIELCEPIQVKQFDIANYEL-------FSSTPKDFLVSISDRYPTN 389
gi 74614117   245 tSPGAKNAKAILVENkdsYMLLECHA-KS--KFVIVQLSDDILVDTVVLANFEF-------FSSMIRQFKVSVSDRYPVK 314
gi 75157487   244 FNKEAKGASNILDKDkdkYLRNPC-SAEGK--FVIIELSEETLVDTIAIANFEH-------YSSNLKEFEMLSSLNYPTD 313
gi 74676556   203 SNPEAIGATSTLIESkdkYLLNPC---SAPQQFIVIELCEDILVEEIEIANYEF-------FSSTFKRFRVSVSDRIPMV 272
gi 74582219   207 TNPEAVGSSSILTENkdkYMLNKC-SAENK--FVVIELCEDIYVDTVQIANFEF-------FSSIFRDFKVSVSGKYPKY 276
gi 2462835    236 sNKEAKGAASILSRDndkYLRNPC-STEGK--FVVVELSEETLVNTIKIANFEH-------YSSNLKEFELQGTLVYPTD 305
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
4DXR_A        143 E--GTLLGKFTYDQDGEPIQTFHFQAP--TMA-----TYQVVELRILTNW--GHPEYTCIYRFRVHGEP 200
gi 74869267   682 D--WSNVGRFA-AEDKRTIQTFELHPH--L-------FGKFVRVDITSHY--ANEHFCPLSLFRVFGTS 736
gi 74959927   215 An-WISVGPFHLQDHHKNLQTFDVPNT--Nv------YAKYVRINLEDHY--GKEHYCIVSVVNVMGST 272
gi 74883899   697 K--WKKLGKIS-TNFTKSFELFNIYDHckNYDed-ncWVKYLKFIVLSHHniEKNYYCTLTHLQIFASS 761
gi 158564054  390 K--WIKLGTFH-GRDERNVQSFPLDEQm--YAkyvkmFIKYIKVELLSHF--GSEHFCPLSLIRVFGTS 451
gi 74614117   315 LdkWVELGTFE-ARNSRDIQAFSVEHP--Q-I-----YTKYIRIEFLSHY--GNEYYCPVSLLRVHGTr 372
gi 75157487   314 S--WETLGRFTV-ANAKIAQNFTFPEP--K-------WARYLKLNLLSHY--GSEFYCTLSMLEVYGMD 368
gi 74676556   273 KneWTILGEFE-ARNSRELQKFQIHNP--Q-I-----WASYLKIEILSHY--EDEFYCPISLIKVYGKS 330
gi 74582219   277 EssWMELGTFT-ALNLRTLQSFHIENP--L-I-----WAKYLKIEFLTHY--GSEFYCPVSLLRVYGKT 334
gi 2462835    306 T--WVHMGNFT-ASNVKHEQNFTLLEP--K-------WVRYLKLNFISHY--GSEFYCTLSLIEVYGVd 360
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