Conserved Protein Domain Family
Sad1_UNC

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pfam07738: Sad1_UNC 
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Sad1 / UNC-like C-terminal
The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.
Statistics
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PSSM-Id: 311603
View PSSM: pfam07738
Aligned: 25 rows
Threshold Bit Score: 117.015
Threshold Setting Gi: 313104227
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5ED8_A        132 LWYHSQSPRVILQPD---VHPGNCWAFQGPQGFAVVRLSARIRPTAVTLEHVPKALspnstISSAPKDFAIFGFDEDLQQ 208
gi 32700069   675 LWYFSQSPRVVIQPD---IYPGNCWAFKGSQGYLVVRLSMMIHPAAFTLEHIPKTLsptgnISSAPKDFAVYGLENEYQE 751
gi 162416243  219 FLNHEMPPDIILQPD---VYPGKCWAFPGSQGHTLIKLATKIIPTAVTMEHISEKVspsgnISSAPKEFSVYGITKKCEG 295
gi 27805719   293 FWNYARPPSVILEPD---VFPGNCWAFEGEQGQVVIRLPGHVQLSDITLQHPPPTVahtggASSAPRDFAVFGLQADDDE 369
gi 27805720   231 LWNYAQPPDVILEPN---VTPGNCWAFEGDRGQVTIQLAQKVYLSNLTLQHIPKTIslsgsLDTAPKDFVIYGMEGSPKE 307
gi 75170173   313 RRAHTNAVKMLSPSF---GEPGQCFPLKGSEGYVQIRLRGPIIPEAFTLEHVAKSVay--dRSSAPKDCRVSGSLQGPES 387
gi 75204744   310 rrVHSKAVKMLTPSF---GEPGQCFPLKGSNGYVLVRLRAPIIPEAVTLEHVSKAVay--dRSSAPKDCRVSGWLGDIDM 384
gi 29428181   971 IYYFHYSPRVVIQRNsksLFPGECWCFKESRGYIAVELSHFIDVSSISYEHIGSEVapegnRSSAPKGVLVWAYKQIDDL 1050
gi 1351036    353 LVVRGHEPSIALTPN---NAVAMCWSFQGSEGQLGISLSRPVYVTNVTIEHVQHKIah--dLSSAPKDFELWVQGMSSKM 427
gi 74621059   141 GFRKHKDPATVFDEN---VGVGECLTFKGSSCRFSVDFDKEVEICKLGIYHPVTRD-----TSSAVQEFEVFSQGPDG-- 210
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
5ED8_A        209 E-----GTLLGTFAYDQDGEPIQTFYFQASKMA---TYQVVELRILTNWGHPEYTCIYRFRVHGEP 266
gi 32700069   752 E-----GQLLGQFTYDQDGESLQMFQALKRPDDt--AFQIVELRIFSNWGHPEYTCLYRFRVHGEP 810
gi 162416243  296 E-----EIFLGQFIYNKTGTTVQTFELQHAVSE---YLLCVKLNIFSNWGHPKYTCLYRFRVHGTP 353
gi 27805719   370 T-----EVFLGKFIFEVQKSEIQTFHLQNDPPS---AFPKVKIQILSNWGHPRFTCLYRVRAHGVR 427
gi 27805720   308 ------EVFLGAFQF-QPENIIQMFPLQNQPAR---AFSAVKVKISSNWGNPGFTCLYRVRVHGSV 363
gi 75170173   388 SaetenMQLLTEFTYDLDRSNAQTFNILESSSSg--LIDTVRLDFTSNHGSDSHTCIYRFRVHGRA 451
gi 75204744   385 Ete--tMPLLTEFSYDLDRSNAQTFDIADSAHSg--LVNTVRLDFNSNHGSSSHTCIYRFRVHGRe 446
gi 29428181  1051 Ns----RVLIGDYTYDLDGPPLQFFLAKHKPDF---PVKFVELEVTSNYGAP-FTCLYRLRVHGKV 1108
gi 1351036    428 ------FVLLGKARYSLTEDSIQTFSFESSNYIvaePIQNVILKIKSNWGNPNYTCLYQVRVHGTV 487
gi 74621059   211 ------HLLVGEFKYDPDVCGFQTFEFEGR------TVKSVEFVVKSNGGNKKFTCIYKLYLFGNK 264
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