Conserved Protein Domain Family
Toxin_12

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pfam07740: Toxin_12 
Ion channel inhibitory toxin
This is a family of potent toxins that function as ion-channel inhibitors for several different ions. Omega-Grammotoxin SIA is a VSCC antagonist that inhibits neuronal N- and P-type VSCC responses. Huwentoxin-IV, from the Chinese bird spider, is a highly potent neurotoxin that specifically inhibits the neuronal tetrodotoxin-sensitive voltage-gated sodium channel in rat dorsal root ganglion neurons. Hainantoxin-4, from the venom of spider Selenocosmia hainana, adopts an inhibitor cystine knot structural motif like huwentoin-IV, and is a potent antagonist that acts at site 1 on tetrodotoxin-sensitive (TTX-S) sodium channels. Study of the molecular nature of toxin-receptor interactions has helped elucidate the functioning of many ion-channels.
Statistics
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PSSM-Id: 336793
View PSSM: pfam07740
Aligned: 31 rows
Threshold Bit Score: 26.0897
Threshold Setting Gi: 17433179
Created: 26-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 50401386   2 ACAPRGQLCFSDKLCCIGLRCKSRvanMwpTF--CLV 36
gi 74838365  46 DCKGLFRQCKKSSECCKGSSCESDltgL------CIF 76
gi 46577143   1 ECRYLFGGCSSTSDCCKHLSCRSD---W--KY--CAW 30
gi 7388332    1 ECRYLFGGCKTTSDCCKHLGCKFR---D--KY--CAW 30
gi 7388334    1 TCRYLFGGCKTTADCCKHLACRSD---G--KY--CAW 30
gi 7388243    6 GCRYMFGGCSVNDDCCPRLGCHSL---F--SY--CAW 35
gi 46577142   1 DCTRMFGACRRDSDCCPHLGCKPT---S--KY--CAW 30
gi 363548492 50 DCVRFWGKCSQTSDCCPHLACKSK---WprNI--CVW 81
gi 46577144   1 ECRYFWGECNDEMVCCEHLVCKEK---WpiTYkiCVW 34
gi 25091452   1 ECRYWLGGCSAGQTCCKHLVCSRR---H--GW--CVW 30
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