Conserved Protein Domain Family
Toxin_12

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pfam07740: Toxin_12 
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Ion channel inhibitory toxin
This is a family of potent toxins that function as ion-channel inhibitors for several different ions. Omega-Grammotoxin SIA is a VSCC antagonist that inhibits neuronal N- and P-type VSCC responses. Huwentoxin-IV, from the Chinese bird spider, is a highly potent neurotoxin that specifically inhibits the neuronal tetrodotoxin-sensitive voltage-gated sodium channel in rat dorsal root ganglion neurons. Hainantoxin-4, from the venom of spider Selenocosmia hainana, adopts an inhibitor cystine knot structural motif like huwentoin-IV, and is a potent antagonist that acts at site 1 on tetrodotoxin-sensitive (TTX-S) sodium channels. Study of the molecular nature of toxin-receptor interactions has helped elucidate the functioning of many ion-channels.
Statistics
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PSSM-Id: 311605
View PSSM: pfam07740
Aligned: 31 rows
Threshold Bit Score: 26.4716
Threshold Setting Gi: 17433179
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30
                ....*....|....*....|....*....|....*.
1MB6_A        1 ECLEIFKACNPSNDqCCksSKLVCSRK---TRWCKY 33
gi 306755717 30 ACGQFWWKCGEGKPpCC--ANFACKIG---LYLCIW 60
1QK6_A        1 ACKGVFDACTPGKNeCC--PNRVCSDK---HKWCKW 31
gi 310946975 49 GCKGFGDSCTPGKNeCC--PNYACSSK---HKWCKV 79
2MXO_A        2 ECKGFWKSCVPGKNeCC--SGYACSSR---DKWCKV 32
gi 48428590   2 DCGGLFSGCDSNAD-CC--EGYVCR------LWCKY 28
gi 17433179   1 ECGTLFSGCSTHAD-CC--EGFICK------LWCRY 27
gi 48428588   2 DCGWLFHSCESNAD-CC--ENWACATTgrfRYLCKY 34
gi 17433177   1 DCGTIWHYCGTDQSeCC--EGWKCS-----RQLCKY 29
gi 42559581   2 DCLGMFSSCDPKNDkCC--PNRVCRSR---DQWCKY 32
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