Conserved Protein Domain Family
Glyco_hydro_53

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pfam07745: Glyco_hydro_53 
Glycosyl hydrolase family 53
This domain belongs to family 53 of the glycosyl hydrolase classification. These enzymes are enzymes are endo-1,4- beta-galactanases (EC:3.2.1.89). The structure of this domain is known and has a TIM barrel fold.
Statistics
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PSSM-Id: 311610
View PSSM: pfam07745
Aligned: 12 rows
Threshold Bit Score: 381.753
Threshold Setting Gi: 81747655
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81754546   53 IGGMDVSSMLS-----------------------------------------LEESGVT--FKNANGEVEDLFTLLKE-S 88
gi 81786809  222 MKGVDISSIIA-----------------------------------------LEQSGVT--FYDDHGNVQDIFQTLQE-A 257
gi 6226797    54 IKGADVSSVIA-----------------------------------------LENSGVT--FYNTNGKRQDIFTTLKQ-A 89
gi 81747655   41 IKGVDISSYVNvtsnflneqnikkddkssysykeyetenitinntqqtiqdyIDNNLYSyiDDNGNRKYQNFFKILKDqG 120
gi 81553467   30 IFGMDVSMLYE-----------------------------------------IEQLGGK---YFENGVEKDCLEILKN-H 64
gi 1346096    28 YVGADLSYVNE-----------------------------------------MESCGAT---YRDQGKKVDPFQLFAD-K 62
gi 81795393   31 YLGADLSYVNE-----------------------------------------MEECGVQ---YRENGVVKDPFELFHT-H 65
gi 81721038  184 IKGSDISSLAK-----------------------------------------SEAFGGV--YKTGSGTTGDALTILKS-A 219
gi 81792672   30 AKGADVSWINQ-----------------------------------------QAAANPPqvFQDASGKTTDFIKLFKD-V 67
gi 81529734   35 ANGADIGWLNQ-----------------------------------------LENNGVK--WQDTNGQRKDALQILKN-H 70
gi 74622866   20 YRGADISSLLI-----------------------------------------EEDAGIS--YKNLNGETQALEDILVN-N 55
gi 367020646  22 YRGVDWSSVVV-----------------------------------------EERAGVS--YKNTNGNAQPLENILAA-N 57
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81754546   89 GVNYVRLRVWNDPFTadgq------gygGGNVNADRALTMAKRATAAGLKVL-VDFHYSDFWADPSKQQVPKAWKSF-EG 160
gi 81786809  258 GVNYIRIRIWNDPYDtnen------gygGGNNDLEKAIEIGKRATKNGMRVL-ANFHYSDFWADPAKQKPPKAWETL-SF 329
gi 6226797    90 GVNYVRVRIWNHPYDsngn------gygGGNNDVQKAIEIGKRATANGMKVL-ADFHYSDFWADPAKQKVPKAWANL-SF 161
gi 81747655  121 DVNSIRLRLWNDPYDenkks---ymgelEGVNDLDTDIYIMKQAIKEGINHFnLDFHYSDFWADPGHQINPKAWDGL-DT 196
gi 81553467   65 GINWIRLRVWNDPRDengn------plgGGNCDYLKMTEIAKRAKNLGMKVL-LDFHYSDWWADPGKQNKPKEWEYL-HG 136
gi 1346096    63 GADLVRVRLWHNATW-------------TKYSDLKDVSKTLKRAKNAGMKTL-LDFHYSDTWTDPEKQFIPKAWAHItDT 128
gi 81795393   66 GANLVRVRLWNDARW-------------TKYSDLSDVKKTIRRARAQGMQVL-LDLHYSDDWADGEKQLIPKAWASItDT 131
gi 81721038  220 GMNYARLKVWVNPAD--------------GYNNKTRVLAMAKRVKAQGMKLL-VDFHYSDTWADPGAQSKPAAWAGH-SY 283
gi 81792672   68 GGNAIRLRVWVNPQG--------------GWNDGRDTLDKAKRAAAQGMRIM-IDFHYSDSWADPGKQTKPAAWASH-SV 131
gi 81529734   71 GINSVRLRVFVNPPSnfvwtkndgskclLGYGDTKGVVYMAQRAKNLGMKVM-IDFHYSDHFADPAYQDKPAAWIND-NF 148
gi 74622866   56 GVNSIRQRVWVDPSD--------------GSYDLDYNLKLAKRVQAAGMSIY-LDLHLSDTWADPSDQTTPTGWSTT-DI 119
gi 367020646  58 GVNTVRQRVWVNPAD--------------GNYNLDYNIAIAKRAKAAGLGVY-IDFHYSDTWADPAHQTMPAGWPS--DI 120
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81754546  161 DADKTAdtVYDYTKQTLTTF-KQAGVDVGMVQVGNETTAKIAG------------ISGWDGMSKVFSAGSKAIRE----- 222
gi 81786809  330 EDKKQA--LYEFTKESVKTM-LDEGIDIGMVQVGNETTNAFVG------------ETNWEKMSELFNEGSRAVRE----- 389
gi 6226797   162 EAKKAK--LYEYTKQSLQKM-IKEGVDIGMVQVGNETTGGFAG------------ETDWTKMCQLFNEGSRAVRE----- 221
gi 81747655  197 EGIKKA--IKDFTYNSLVKIyQETGVLPAQVQIGNEITKGFVWgnddskfesdylKPDVS--IKYLRSAIEAVNEaqeyi 272
gi 81553467  137 ELLERA--VYSYTKLVLNHM-RRNGALPDMVQVGNEVNNGFLWpdgki---sgegAGGFDGFTRLLKAAIKAVRE----- 205
gi 1346096   129 KELAKA--LYDYTTDTLASL-DQQQLLPNLVQVGNETNIEILQaedt----lvhgIPNWQRNATLLNSGVNAVRDys--- 198
gi 81795393  132 DELART--LYGFTYDTLSAL-DRAGLMPELVQVGNESNSDLMDsipw----dkkrPIDWQRNAKLFNAGIKAVRDis--- 201
gi 81721038  284 SQLKTD--VYNHTYDVLSAL-KSQGTTADMVQIGNEINGGMLWse--------gsTDNWPQLAGLLNSGYSATKA----- 347
gi 81792672  132 AQLNTD--VYNHTQGILKYL-KDNGITVTWVQVGNEINSGMLWdq--------gkTPNFANLGQFINSGYNATKA----- 195
gi 81529734  149 NQLQKD--VYSHTSYVMTAL-KNAGITPDWVQVGNETNSGMLWpd--------gnYRNFNKWAALINQGYSAIKY----- 212
gi 74622866  120 DTLTWQ--LYNYTLDVCNTF-AENDIDIEIVSIGNEISSGLLWpl--------gkTSNYDNIAKLLHSGAWGVKDs---- 184
gi 367020646 121 DNLSWK--LYNYTLDAANKL-QNAGIQPTIVSIGNEIRAGLLWpt--------grTENWANIARLLHSAAWGIKDs---- 185
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81754546  223 -----VLPEAKVVIHFTNPEKAGTYATYAKQLSNH--N----VDYDVFASSYYP---FWHG--TT-----ENLTSVLKNV 281
gi 81786809  390 -----VDETILVALHFTNPETPGRYETIAQRLYEY--N----VDYDVFASSYYP---FWHG--TL-----NNLTTVLSHV 448
gi 6226797   222 -----TNSNILVALHFTNPETAGRYSFIAETLSKN--K----VDYDVFASSYYP---FWHG--TL-----QNLTSVLKAV 280
gi 81747655  273 nktynKNTNIKIAVHLESLSSQTSKKAISTFLNDQfiD----ENLDIVGVTYYP---FWSL--NL-----EKFRQDFSSF 338
gi 81553467  206 -----VDPDIKIVIHLAEGGNNSLFRWFFDEITRR--N----VDFDVIGVSYYP---YWHG--TL-----EDLKNNLYDI 264
gi 1346096   199 ---kkTGKPIQVVLHIAQPENA---LWWFKQAKEN--Gv---IDYDVIGLSYYP---QWSEy-SL-----PQLPDAIAEL 258
gi 81795393  202 ---arSTIKPRVMLHIAQPENV---EPWFAAAAKA--Gv---TDFDLIGISYYR---KWSSq-SM-----AELGKTIKRL 261
gi 81721038  348 -----VSSSTVVALHLAKGGDLAGTRAWFDKAVAG--G----VNFDAIGLSYYG---YWHG--SL-----YDFQTTLDDA 406
gi 81792672  196 -----VYPNAKVIVHLANGYDNANFRWFFDNLRSA--G----GKWDVIGMSHYPpvgSWQD--YN-----ARLDTNLRDM 257
gi 81529734  213 -----VSPTSKVIIHLSSGANNSLYRSVFDGLTKA--G----AKFDVIGMSYYP---YWDK--VNytqniNNLSYNLNDM 276
gi 74622866  185 ----nQATTPKIMIHLDNGWDWEEQEYFYKTVLAT--GsllsTDFDLMGVSYYP---FYNSeaTL-----SALQTSLTNM 250
gi 367020646 186 ----sLSPKPKIMIHLDNGWDWGTQNWWYTNVLKQ--GtlelSDFDMMGVSFYP---FYSSsaTL-----SALKSSLDNM 251
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81754546  282 ASTYKKDVMVAETSWAYTLDDGDDDSNTVPSkvtaDNLKKYDISPQGQADEIRAVAEAVNNIGdndgdgeNDGLGVFYWE 361
gi 81786809  449 ADTYDKLVMVAETSYTYTREDGDGHANTAPSs---GQTLNYPITVQGQGTAVRDVIEAVVNVG-------KSGMGVFYWE 518
gi 6226797   281 ANTYGKKVMVAETSYTYTAEDGDGHGNTAPKs---GQTLPYPISVQGQATAVRDVMEAVANTG-------KAGLGVFYWE 350
gi 81747655  339 WTKLGKEIIFEEYSTPYTSDNTGYTGDLDYKt----nSNSIPTTSSGQVVMLNAFLNLISQLTp------DKETGFYYWE 408
gi 81553467  265 ATRYNKDVLVVETAYAWTLEDGDGYPNIFNGee-mELTGGYKATVQGQATFLRDLIEVVNSVPn------GHGLGIFYWE 337
gi 1346096   259 QNTYHKPVMIVETAYPWTLHNFDQAGNVLGEk---aVQPEFPASPRGQLTYLLTLTQLVKS---------AGGMGVIYWE 326
gi 81795393  262 RGRFDADVVVVETAYPWTLASGDTSHNLLGEd---sLIAGYPATPQGQARYMVDLTQLVID---------TGGAGVVYWE 329
gi 81721038  407 ASRYGKPVFLAETAYPFRLDSDDSLTNQIDTt--gELVSGYAATTAGQSAWLRDVMNIVEAVPn------GRGLGVFYWE 478
gi 81792672  258 ISRYGSDVIVAEVGMDWQ-------------------------QAATTRAMLGNLITRSNAIg-------SRMLGIFYWE 305
gi 81529734  277 ASRYHKQVMICEIG-------------------------GLENDSTNTYNMIKQVISKVKAVPg------SNGLGVFYWE 325
gi 74622866  251 QSNYDKSVVVVETNWPVS--------CPDPEysfpSDLSSIPFSAAGQEEFLEKLAEVVEGV--------TDGLGIYYWE 314
gi 367020646 252 AKTWNKEIAVVETNWPIS--------CPNPRysfpSDVKNIPFSPEGQTTFITNVANIVSSV--------SRGVGLFYWE 315
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 81754546  362 PAWVPVGtggkdnaelvdtwnkygggwateaageydpnDAGLYWGGSGVDNQ-ALFD--FDGKALASLPTF 429
gi 81786809  519 PAWIPVGppesieqnkqlwerd-gsgwatsyaaaydpeDAGEWYGGSAVDNQ-ALFD--FQGHPLPSLHVF 585
gi 6226797   351 PAWIPVGpktqieknkvlwety-gsgwassyaaeydpeDAGKWYGGSAVDNQ-ALFD--FNGHPLPSLQVF 417
gi 81747655  409 PGWLYKGkqtwasqsg--------------inyitnsdKSLDWKYGYNWSNQ-GLFD--RNGIMLPSLKVL 462
gi 81553467  338 GDWIPVRg------------------------------AGWKTGEGNPWDNQ-AMFD--FSGNALPSLNVF 375
gi 1346096   327 PAWVSTR-------------------------------CRTLWGKGSHWENA-SFFDatRKNNALPAFLFF 365
gi 81795393  330 PAWTSSS-------------------------------CKTRWGTGSSWENA-SFFDfqHNNEVLPAIDFM 368
gi 81721038  479 ATWTAVTgngwd---------------------------padaaSGNGWENQ-ALFG--YDDKALPAMTLF 519
gi 81792672  306 PNAYP-------------------------------------GWQGYTMGAV----D--NNGRLTEALQAF 333
gi 81529734  326 PEANSSV-----------------------------------LPDAYPLGSTsKVSN--NVLRFTNAINAF 359
gi 74622866  315 PAWVDNA-------------------------------A-----LGSSCADN-LMVDi-DTDEVLESVTVF 347
gi 367020646 316 PAWIHNA-------------------------------N-----LGSSCADN-TMFS--QSGQALSSLSVF 347
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