Conserved Protein Domain Family
Nop53

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pfam07767: Nop53 
Nop53 (60S ribosomal biogenesis)
This nucleolar family of proteins are involved in 60S ribosomal biogenesis. They are specifically involved in the processing beyond the 27S stage of 25S rRNA maturation. This family contains sequences that bear similarity to the glioma tumor suppressor candidate region gene 2 protein (p60). This protein has been found to interact with herpes simplex type 1 regulatory proteins.
Statistics
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PSSM-Id: 311626
View PSSM: pfam07767
Aligned: 137 rows
Threshold Bit Score: 166.299
Threshold Setting Gi: 303270943
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74668966   17 KGKKAWRKNVDVTEVQEGLRLLKde-eiKGGVLAEKPSEELFVIDKKGSAE---------------I-RNAY-----FKQ 74
gi 321475047  29 HKKKAWRV-TEIEDVERYLESKRld-erLGAPFEERPSDSLFVVDTKAIAdqpakse---ptrkrkL------------K 91
gi 170047680  33 KNKASWRKNVDISDVEGFLEEQReheriAGN-VADRSDAELFVEEKKPQKG-----------------GQRSrrelrKQQ 94
gi 242020710  11 KNKRSWRKNVDITDVENFLEDQRle-erLGVKFSDTKNEELFEIDVKGQDDsnelsdiktnkcprvLlSKPNnsssyRLR 89
gi 642913995  12 KSKLAWRKHVNINDVEEFLEDQRle-erLGPSLASLNNEELFQVDTKPSEpeslsi-----------------knrkkLK 73
gi 328793336  14 KTKKAWRKYTDTKDIEKFLENSQle-erLGS-FAIHKDSELFSISIAPEIfskq--------krreL-----------LK 72
gi 746832219  19 KTKRSWRKYIDIKDVDTFLDNNRle-erLGTPFSKRIDTQLFSIDKTADVtenvis----kraarlA-----------LK 82
gi 307207709  13 KTKKSWRKHIDTKDVDAFLEDIRle-erMGPPLSKQANSELFTIDRTAGKtktvvss---kraarlA-----------LK 77
gi 156551285  14 KTKKSWRKHVDTKDVDSFLDNERle-erLGTPFAQRKDEELFAVDRTRDESalqessglskkqrreL-----------LK 81
gi 241653566  15 NRKKTWVKHSDIKDIEGFLEDQRld-erLGGAVSTKPDEELFYVDKSPAApkp----------kraVqSKR-------ER 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74668966   75 H-KPLKADEILAQRSAI----PAVD-TRKRL-NskvtdgviepksKKHKSDw-vTRK--EWLRLKQVAKEANPT------ 138
gi 321475047  92 EiGPLKCYAILTPNSAV----QDPLkSRNRVrL------------PEERGDpllRKVmeERRARGKIATHFLQSmkhhqe 155
gi 170047680  95 FeGKPKFCAALENTSKV----ADPVlKRNVItN------------K---------------EKLLAIGKRKSKAeavsvg 143
gi 242020710  90 EtELPKCYEILEKRSAAkikkPAEAtKKQRVeE------------EEE--------KepVKKf----------------- 132
gi 642913995  74 LqKPLRCFSILEPHTKV----PDPIkKRNRVrS------------KEERKNeliKKKeaENRAKGILKHRELQAlrdka- 136
gi 328793336  73 LkEP-RCFNILKPHTAV----PDPItKRNRVrT------------KDERKNalvLKKeaIRKSQNILTLKEKLRlknkm- 134
gi 746832219  83 NkEP-RCFASLKSHTCV----PDPIsKRNRVrT------------KEERMNsilRQRevERQVKGVLKLKEKEAlknri- 144
gi 307207709  78 EkEA-KCFASLKPHTQV----PDPIsKRNRVrT------------KEERMNsilRQReaERKLKGILKLKEKEAlknra- 139
gi 156551285  82 NtEP-KCFAILKPHTAV----PDPIvKRNRVrT------------PEERKSiirKQKeaERKLKGQLKLKERVAiknrl- 143
gi 241653566  77 RnRKLTCYLNLEPSSKV-----APPtKPRRVrD------------PEERK-----PAavRRVQQQRLAKRHEQAvtqrl- 133
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74668966  139 ------QTAe-ESEL------YDPWADSEDPtp-----vEDP-----------QFDYLeKPKPKVAPPTIKQPpisLAAN 189
gi 321475047 156 nvealaNKKkpERLRtt--fdFDIWGE--AGdylmigdkKVSaldlsdplktyTMEKI-GKRIYGRPKSMFSK---TTGL 227
gi 170047680 144 vrkkkvVKDkv--------vtKDLWADEDSG----------------------------KKPIRARPNAVSN-------- 179
gi 242020710 133 --------------------sYDIW-S--DDgknnkikkENEwiqie--tlrhNLQNI-GEHKKVIPKTIQSK---TSKL 183
gi 642913995 137 --tnenKKQaiPK-Rgd--fnQNIWDQ--EDnl----neKNEwfsns--ttkhNLVGT-GKSRKTVKTPKRPK---SSVL 199
gi 328793336 135 --iaakKKLnkPK-Rde--fnINIWKE--KNtk----diNIDwmssd--tirhTLTHF-GIKKKRIPSSLHKK---PSNI 197
gi 746832219 145 --lakiASInrSK-Ske--ikEDIWNS--INvli--petITEwmssn--sirhTLKHL-GIKKRKLP-LLCKK---PSVL 208
gi 307207709 140 --lakaAFKkrPK-Rge--fkTDLWDV--TKnvl--petVTEwms----------------------------------- 175
gi 156551285 144 --lakeKRAnqPK-Rge--fkVDVWKK--EPive--aelKSEwltnd--tvrhTLANT-GKKRKRVPESLHKK---PSVL 208
gi 241653566 134 --rsvaRKAkqANGHsdftglRDIWAD--EE--------KKAdsgldpeletyIAEYT-KERRPNIPAHRYQK---PSLL 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74668966  190 GkpipSVRKPDAGISYNPSFEDWDRLLqekgheAVEAEKKRLEEERKEQERQRLi--AEAqnddgEV----KSDdesawe 263
gi 321475047 228 K----QVEVPHPGTSYNPTFQDHQALLk----eAYDVEAKEIKQEVKTRRRLGPml-kKIpiqrkEEqwwsEMTqglgee 298
gi 170047680 180 ------VELPPAGASYNPSIDDYNELKq----aVVESEKKHIKRAQHLDRVVTAkfgKKLtpeqrEKqlfeEMSeglfek 249
gi 242020710 184 P----AIDIPHPGLSYNPSLKDHKEILs----kAAEKEYALIKEKKHLNRVTKEmf-sSIpreemEKnwieEMCvgltvs 254
gi 642913995 200 P----PVEPPHPGMSYNPSYEDHQDLLk----tIVEKETKIIKEEEHLNRVTRDmf-sKVsekqkNSmwmeEMSqglpqa 270
gi 328793336 198 P----AVEAPHPGTSYNPSFEDHQKLLl----eVAQKEMELIKEEEHLNRVTTKmf-kKVslkekEDnlikEMSeglkle 268
gi 746832219 209 P----AVETPHPGTSYNPSYNDHQELLh----nIVQKELELMKQDEHLNRVTTQmf-kKIslqkrDEnmmkEMLeglpkn 279
gi 307207709 176 ---tdtVEAPHPGTSYNPSYTDHQKLLn----dIAQKELELMKEEAHLDRVTTKmf-kKVplnkrDEnlmkEMSeglpik 247
gi 156551285 209 P----AVNAPHPGTSYNPSFKDHQELLa----qVAAEEVKLMKEEEHLNRVTNKmf-rKVtakqkDAdnltEMSeglplp 279
gi 241653566 198 P----AVQPPHPGASYNPAPDAHQELLh----eAFLIEQKRLKEEQHIDRVLTKml-pTRetmptEEdmiaEMSqglydd 268
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74668966  264 gfes-----------------eyekpewlnKKRpARKTKAERNRIKRRKEAERKARWEAKMKQKEEQLEQAKAIAEQVQQ 326
gi 321475047 299 eepa----------------ngaevevpcvRPT-KPKTRRQKIRAKALKWQDMRRKKLKEAKKRLLEFDRLRSIRREIRK 361
gi 170047680 250 pskkssskke-----aeedtedykainapvQN--KKKTRAQQNKKFREVAKRNAAVALKEELKKLADINRLPEMNSKLAK 322
gi 242020710 255 ksdsddd-----------dgqeykalnppvR-N-KKKTLQKKRKKREALLLKEKLKNQKIEKKKISDLHKLTKFNESILK 321
gi 642913995 271 stqqsdn----------esdgeyksinpptK-N-RKKTQQQRRKLREQKKLELLKQIAKKEKKKISDIHRIKLLKNQIEK 338
gi 328793336 269 dnqdfned--------enndpivksinppvK-N-KKKTRVQRRKQKEQKNLVHKKQQEKVEKKKISDIYKLRVLDRQLAA 338
gi 746832219 280 qttssfksiee--dheeenssitiannkskK-N-IKKTLVQKRKQREQKQAINERTLMKLEKKKISDIYKLKTLQKQIEA 355
gi 307207709 248 kqttenskptkegdveeedssvaianskpvK-N-IKKTLVQKRKQREQKQAANERTLAKIEKRKVSDIYKLKMLKKQIES 325
gi 156551285 280 nqkqdddsd-------edndpnvrsinppaL-N-VKKTLVQRRKQKEQRKLQQQRLKQKIEKKKVADIYHLNHLGKQISK 350
gi 241653566 269 pssdeaegde----vagddgarsgqanppvRAE-DRKTKQKRRRELEQKRIQSAAKVRKTERVLANQVYRIPTIKAELRR 343
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74668966  327 RQLERSR-ESGDD--SseegddaaLRRKPLGKARVPEKPLEVVLPDELQDSLRLLKPEGNLLDDRFRTL 392
gi 321475047 362 SEELTVKrMETRKkeKea----kmFKPAMLGKHKYEPPQIEVNLSEEIVGTLRGLKTEGHVLIDRYKSL 426
gi 170047680 323 TEKNIEVkRGRRAvrDee----kkQLPGRVAYMQYEAPEPDFVEPTQLTDKLRTVAPNKSLVVDRFKSL 387
gi 242020710 322 KEQKIKEkMEKKKekQkk----kpFTTRVLSQIKYQDADIDFQLPEELSGNLRNINSIGSILHDRFKSL 386
gi 642913995 339 REKTTQIlREKRKkvQel----kkTEPKRLSAIKFEECDLEFNMGPDIAGNLRNMKKEGNLLTDRFKSL 403
gi 328793336 339 KEKKEKVlHEKRLkkKil----ktVGTKTLSKVKFEPLELDFKLGSELTGNLRNSEPTGNLLKDRFKSL 403
gi 746832219 356 KERKQESlRQKRTkkRes----esLMPKTLSKTKFEPIDPDFQLAEELTGNLRNFKPSNNLLKERYKSL 420
gi 307207709 326 KEKKEDFlRQKRMkkHer----esTTPKILSKTKFEPLDPVFQLSEELSGNLRNCNPSKNLLKDRFKSL 390
gi 156551285 351 KEQKLGLlKEKREkiKak----keLEPKVLSRHKFEPLEQEFLMGDEIAGNLRNTTPAGNLLKDRYKSL 415
gi 241653566 344 EAEISEErQKRRQerEdd----klYQANRLSKFKFEEPDMELKLPEELTESLRQLKPECNVLEDRYKSL 408
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