Conserved Protein Domain Family
DUF1619

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pfam07773: DUF1619 
Protein of unknown function (DUF1619)
This is a family of sequences derived from hypothetical eukaryotic proteins. The region in question is approximately 330 residues long and has a cysteine rich amino-terminus.
Statistics
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PSSM-Id: 311629
View PSSM: pfam07773
Aligned: 69 rows
Threshold Bit Score: 143.765
Threshold Setting Gi: 122100068
Created: 20-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91208023  171 CPCDLTAKACDIQCCCDQDCQPEVREL-FAqSCFSGVFGg------------------HVsppshHHCAVST-------- 223
gi 122067818 262 CKCDLKINICDVNCCCDIDCSESVLRT-FA-------------------------------------CDEEEldieeyh- 302
gi 255080780  75 CLCDLTEGTCDANCCCDPDCDSNEKAQ-FT-ECATCVYDganaamngkvclpegrsppSL-----EYCLPSStvsrvnll 147
gi 170052804   9 yyenrRINICDVNCCCDIDCSDQILRT-FS-------------------------------------CSEERldvaeyh- 49
gi 968053587 149 CSCDLRQDLCEVNCCCDRDCSQESLQV-FS-------------------------------------CLPEQhtrledfq 190
gi 195434649 129 CSCDLREGICDLNCCCDRDCPSEILVV-FN--CL--GLEa------------------PA-----EL----Qtrledfq- 175
gi 158294196 254 CRCDLTINVCDINCCCDIDCSAAILRT-FD-------------------------------------CDQELlhtdeyh- 294
gi 195030586 271 CACDLHSDVCELNCCCDRDCPPEALLV-FS--CAQPAT-------------------------------EEQlrrrledf 316
gi 194760153 116 CSCDVQAGRCNLNCCCDHDCNSEVRKV-FS--CLSSTTSp------------------EV-----QAKLEDFqynh---- 165
gi 290992759  67 CVCDVTLNQCDVNCCCDPDCAYSIVENsFS-KCLVPYTKk------------------DFn----YLCVQKTlvtfsnln 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91208023  224 ----------THQTPDWFpl--lCVQSPpSTSPf----L-GHFYHGatSPRHS-P-GFeAHLHFDLr-dFA--------- 274
gi 122067818 303 ---hqeglqsCEVQGGLF-----CLVGErRDTT-----R-GTVSKKfrNLNHAaS-NYeIATKRKWi-dIFpvdtn---- 362
gi 255080780 148 s-ssslgvveQRKADMSFlsqqlCIKDDnSASL-----G-KYFLDP--GFATD-D-ILkSSVTLQSe-rFWnpvpa---- 211
gi 170052804  50 ---hreglqsCEVQGGLF-----CLVGEhRPPEegedgG-GVFYDPnlKe---------SSSKYKWs-eIFpvgdv---- 106
gi 968053587 191 ---ynhglptCQISDGWL-----CVFRShTK--------------PakKQTPS-Q-IFdSKDYNRWp-eQLdafeta--- 242
gi 195434649 176 ---ythglptCQLHDGWL-----CVFRSn---------------TKpvKMQPI-FrDFdSSKYRKWp-dLLeayetd--- 227
gi 158294196 295 ---hgeglqsCRVQGGLF-----CLV-EpVYEE-----GdESFYNAa---------kLpAATRYKWk-eVFpldsst--- 347
gi 195030586 317 --qynhglstCQLNDGWL-----CVFRSnSK--------------PpkIKAQS-N-NFdAEQYKKWp-eLLvayesql-- 370
gi 194760153 166 ------glpsCQINDGWL-----CVFRSnL---------------KptNVPAL-SlNLnADSQKKWpdlEAydgnpi--- 215
gi 290992759 124 nlkistkevvQDAGTPLF-----CVYFEaASVD-------GLYYAVvsDLDAT-------SIKKVFe-kYEalttyrtsy 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91208023  275 ----------------DASYKQGD----PIMTT---------EGYFTIPQVSLAGQCLQDAPVAF--------------- 310
gi 122067818 363 -----------skdkiASSYRVND----IIKFYnet---sehVEPFNLPRSLTNSECQILQPIRF--------------- 409
gi 255080780 212 -----------aasetQPKYRHND----TIGVVkaasepllpGNKFVLPGATFSGVCGWTNVIGYnmpl---------pa 267
gi 170052804 107 -----------pkrgpVSTYRVND----RIKLYnet---sekIETLTLPFSLTNSECQLAQPVRY--------------- 153
gi 968053587 243 ----------lpappmTSHYKFGQ----ALQLWqpe---sksLANWELPMAYESASCQLKQTLLY--------------- 290
gi 195434649 228 -----------nvpstQSHYKLGQ----ALQLWhpe---skeSSVFMLPTSYETAHCHIRQAIRH--------------- 274
gi 158294196 348 -----------eeavrPNHYHVDD----VIYFYnet---selVQPFAIPYSLTGSTCQLEHPVRF--------------- 394
gi 195030586 371 ----------platqfTAHYKYGE----ALQLWqpd---sktVSYFELPIGYESASCQLKRTLLH--------------- 418
gi 194760153 216 -----------etrssSLYYKFGE----PLQLWqpe---sneLTTLELPISYESSQCKLKQAVRH--------------- 262
gi 290992759 184 tqkyiydvaavktntrVTIFQDGDkipyTISAPssntsqvttVSYFTLHRSSNSDVCEKT-FVKFmrnngkenkcswips 262
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91208023  311 -LRNFDSVCTMDLEvhqgRD-E--------------IVLENMkirt--------------tggpV------TP------- 347
gi 122067818 410 -LQDQTTECL--------RT-SldelesftttlmeqQSHLRYlrlpkaei------------------------------ 449
gi 255080780 268 sAASEDATCLVPIDd--tLSkScttll----nakylVNDLKLaktpgss---------atpteaP------TI------- 319
gi 170052804 154 -LRDQSTECLRSLEdlelfn----------lalleqQAFVRYlrs-----------------pkA------EImehclde 199
gi 968053587 291 -LQPMESSCl--------LA-DatqlqmnlwsllnlTNSHQLlsrpre----------leeqqvH------GL------- 337
gi 195434649 275 -LQPTENNCl--------MN-DinqlqenlalilniTSNYQVlgk------------------------prDI------- 313
gi 158294196 395 -LRDRTNLCRRq-----tVD-Elsefnr--aflrhaTSSARFfqtpkkstvmehycvedgdclnA------TV------- 452
gi 195030586 419 -LQPMHSSCLMSd-----AS-Qlqlnlw--tllnltNSHQLLskp-----------------reLddqdlqGI------- 465
gi 194760153 263 -LQSVSSHCP--------MK-DanqlqeslwdimnfTSTSQLlgkprdp--------eetehdgI------TI------- 311
gi 290992759 263 tLEDFRTKCLGDFSvssfVS-Nyfsygaa----------------------------pdsysqyI------KV------- 300
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91208023  348 ----TVTYEEAIDlDKFITSPDTVlsv------------gsAPRN------------------------------VNVEE 381
gi 122067818 450 ----------------------------------mehcmdqDCFNssiqfcsfaglncrttnssesnddgsgepwYCPRI 495
gi 255080780 320 ----SSMKYRSRIgGKLTDLTGTVpaatftdg-sggsgaadTCNF------------------------------AVVEA 364
gi 170052804 200 dcfnSSVRFCDLSgQNCQKTNQSSvndpe-------gsyswYC----------------------------------PEV 238
gi 968053587 338 ----NITICQQLLlQPKIQCLEHNetqs---------------------------------------------ellVDRI 368
gi 195434649 314 ----EETEVE--GiNMQICQLWQSvnlt----------rklACFDqandt---------------------qldmIVDKI 356
gi 158294196 453 ----SICYHNSPHgWNCTQSSNVTtstssveelvleefpdsIC----------------------------------LEL 494
gi 195030586 466 ----NIQVCQQLLlKPKELCLEANetev---------------------------------------------dilVDSI 496
gi 194760153 312 ----QV---CQRDvGGKTVCEKQGnetql-------dalpeA-------------------------------------L 340
gi 290992759 301 ----ELLEMISVSsSGAETVLSTIpttt---------yasqTCTN------------------------------AVIGA 337
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91208023  382 HYVFRWQNN-SISGLDITV-I-RA-EIS-AQ------------------QRg--MMTQRFTVKFlshhsg-----gekef 431
gi 122067818 496 NFEFQHNYT-HLEGLNIKL-L-CG-RAE-LF------------------DMkgdKIWTRLSVKFtrknee----kfsrsv 548
gi 255080780 365 HYVITHDGSgSISSFAVDL-V-FA-DVM-TStrwsavynangaladpgnPS---SVRVKYTVSWklsae------tvvpr 431
gi 170052804 239 KIRFVHNYT-HLTAMETRL-L-CG-SID-LE------------------QD---TIWQRISVEFkrkdee----kfsrkv 288
gi 968053587 369 ELQLLHNYT-NILEAKLLL-R-EA-SVE-DD------------------KT---MLWLTYALVYqsveel-----ntkps 417
gi 195434649 357 ELEFLHNYT-NILGVKLLL-R-EApTRQ-TE------------------SE---ELWLHYKVSFksvnet-----askpi 406
gi 158294196 495 EITFIHNYT-NLFNVQLKL-L-CE-RSA-DEdd--------------lwME---SVWQRITPKLtr------------tv 540
gi 195030586 497 ELQLLHNYT-HILAAKLLL-R-EA-NQQ-DE------------------NE---EIWLTYQLSFesinai-----kakps 545
gi 194760153 341 ELQFIHNFT-NILEAKLII-GpSA-SWTeDE------------------NE---PVWLTYEVTFisvnep-----iakpt 391
gi 290992759 338 KYYFVFTSSgSISKAYVTLrV-KT-LVN-PS-----------------------FVELKSQVNYingtisdfrqgvikpk 391
                        490
                 ....*....|.
gi 91208023  432 SGNPGYQLGKP 442
gi 122067818 549 SGNLGYLKGKP 559
gi 255080780 432 SGAPGYVVGAP 442
gi 170052804 289 SGNLGYLVGKP 299
gi 968053587 418 SGALGYELGAP 428
gi 195434649 407 SGPLGYLTGKP 417
gi 158294196 541 SGNIGYLTGKP 551
gi 195030586 546 SGPLGYVQGAP 556
gi 194760153 392 SGPLGYLPSSP 402
gi 290992759 392 SGNPGYI---R 399
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