Conserved Protein Domain Family
EMC1_C
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pfam07774: EMC1_C 
ER membrane protein complex subunit 1, C-terminal
This is the C-terminal domain of ER membrane protein complex subunit 1. ER membrane protein complex subunit 1 is a component of the ER membrane protein complex (EMC, composed of EMC1, EMC2, EMC3, EMC4, EMC5 and EMC6). In Saccharomyces cerevisiae, the EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).
Links
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Statistics
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PSSM-Id: 462261
Aligned: 150 rows
Threshold Bit Score: 108.782
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_014171554  791 FENTFMCTFFADyrvddsaniaaTIKGYHLTVSDLYESLEP--NERGWGAAAaavrhss----------ssnetaaWFSs 858 
Q57ZY7        598 VEHAVLYHFMDV-----------EKMRHSLGVWEMFETEVG--------------------------------------- 627  Trypanosoma b...
CAM71841      594 VEHAIVYYYLDA-----------KKMRYCFGVWELFEDENS--------------------------------------- 623 
Q5CTP8        734 FQNIILITSFHS-----------NYKVPVILILELFQFIKD--ETSTGINMLdkfiflvssk-----knvkeskiySEK- 794  Cryptosporidi...
A0E6E8        116 DDHKVFVTYQNQ-----------AKMIFEIWTVEIYHMKRS--VHLQKCQSIiislkiqqiniimkqntilfsnskYIDf 182  Paramecium te...
A0CJK9        666 DEHQVFVTYYNK-----------AQMMFEIWTVEIYHAKIE--VSFIKMLENyyftktp----------iitnyykADF- 721  Paramecium te...
Q245W3        775 DENGVFVSYYNP-----------VYSIFQIWTVELFSKKME--NNFVSMLQNyyfsesgak-------yedfnylnENM- 833  Tetrahymena t...
6_pfamImport    1 SENWIAYSYWSE-----------KGRRTELGIIELYEGHGEq-ARKEFFdsklg-------------------------- 42  
CCD72387      737 SENWIAYSYWSD-----------KGRRTELGIIELYEGTEEqhTQKEVFdskia-------------------------- 779 
XP_001742198  289 AENWVLYSFRDR-----------KHKRTEIAVTELYDSMGK--------VAE------------------------QGFs 325 

XP_014171554  859 slepveaeegaaavattlePAV--VSQTWVV--GARLRA---------------------------------LAVSQTRQ 901 
Q57ZY7        628 --------------------PVlfKDTGATP--PQVISSffsrhkrvfssratwppvvvgsvlgmhgggvakMSVTTSFG 685  Trypanosoma b...
CAM71841      624 --------------------PVvfKTAGATI--PQIIASffvntkrefssratrppivvvstlgsfggpladMGVTTSYN 681 
Q5CTP8        795 --------------------HVhvQETTFLYnyELPIDY---------------------------------SLLSKTSE 821  Cryptosporidi...
A0E6E8        183 ------------------------LQQVYGF--PLGIKY---------------------------------LGITRTRK 203  Paramecium te...
A0CJK9        722 --------------------EAffLQQVYGY--PLGIKY---------------------------------LGMSRTQK 746  Paramecium te...
Q245W3        834 --------------------DIiaLEQKYGY--SLGIKK---------------------------------MAVVTTKL 858  Tetrahymena t...
6_pfamImport   43 ---------------nkhqPAV--LMQSYIY--AQGVEA---------------------------------MTISETEK 70  
CCD72387      780 ---------------eklpPVV--AQQSYIY--AQGVDA---------------------------------MSVSETEQ 807 
XP_001742198  326 sfk-------------rqePLV--LRQSYAF--PGFINR---------------------------------LAVTNTAL 355 

XP_014171554  902 GITVRQVLaYLPGTHGVLG-LPRvgAFLDARRPVgrdPTPAE------LE-EG---LTRYAPAFEVDPRLVVSHERDVVG 970 
Q57ZY7        686 AIARKSLL-FVFTSGRVAS-VGLnrLLAGGQVSL------GD------GAgQLthvIIP--------STAIVTHRYRAAR 743  Trypanosoma b...
CAM71841      682 AIARKSLV-LAYATGRVVV-VELrhLLAGNQMPL-----PGA------KDrQMshlLLP--------SFLFASHKYRVAF 740 
Q5CTP8        822 SLASKIIL-FGSEKSNVFEcIPE--RLFSTLRPN--------------KSkKK---NLIHNSNLPF-YQSILSE-----R 875  Cryptosporidi...
A0E6E8        204 SLTKKNLL-IITTFSQMYQ-LDR--NLVSARRREn-sDLDHPf------------------vQLTYRLFNMNSLF-IF-K 258  Paramecium te...
A0CJK9        747 SLTKKNLL-IITTSGQLHS-LDR--NLVSTRRREk---aDQPile-ysLQsAE---LPPYQYQLPINFLNMLSYHQTF-D 814  Paramecium te...
Q245W3        859 SLTKRNLM-IITPNNQIHS-LDR--DILSTRRAVk-lPKDNQlqnafsFEsTT---LPPYNYMVPIDRLSIISYHANLND 930  Tetrahymena t...
6_pfamImport   71 GLSMRSIL-LAHPSGNIHE-VSR--RLLDATRPMe--LTPAM------RE-EM---IIGYVPEIAVSSEEMINYNLTVHR 134 
CCD72387      808 GLTTRSIL-VAHPSGNIHE-VSR--RLLDANRPMe--LTQAM------RE-EM---MIGYMPEIAVATEEMINYNQTVHR 871 
XP_001742198  356 GVTQRNAL-VGLASGGVLS-LPR--PMFSARRPA---EKGAG------AA-LG---LPDYHPLISVSTRSILNYNHTVEN 418 

XP_014171554  971 IR--------AIVAAPT---------HVESTSVVLAFGrVDVFGTR-VAPSLTFDLLDKSFGKASMLATVAALAVGVAVL 1032
Q57ZY7        744 PT--------LIATRPT---------NLESSCHVLVSG-MDLFYVR-TSSGKEFDLLNSDFNKTLLIALTCSFGVLSLVA 804  Trypanosoma b...
CAM71841      741 PR--------KITTEPT---------LLESSCHVVVSG-LDLFYVR-SSSGKPFDLLNSDFNKPLLITLVCGFAALSVMA 801 
Q5CTP8        876 IKfstkfnskKIFSFPHe--------TYESKSKLLSVG-FNSLEVFeIYPNTSFDLLPYDFNYYNIINTVFLILTITAIS 946  Cryptosporidi...
A0E6E8        259 VC--------QLTIKHSiskgfqqnlQIQNPMPFLSF----MVLTI-ITPYKSYDMVQKNFNYDAVILTTVLITLTIQVS 325  Paramecium te...
A0CJK9        815 IE--------KFSIEST---------NLESSALLLVYG-SDIFFTR-IAPDKTYDMLLDNFNYNALIVTTVLIVVATKVL 875  Paramecium te...
Q245W3        931 IK--------EIYFSGS---------NLESTILFVAYG-NDVFMSS-IAPDRTYDMINEDFNYILVTLSIIICFVGVFIA 991  Tetrahymena t...
6_pfamImport  135 VR--------GIKASPS---------GLESTSLVLAYG-TDLFFTR-LVPSGTFDILKDDFDHIFISMVLSGLVFGSYIT 195 
CCD72387      872 VR--------GIKTSPS---------GLESTSLVLAYG-TDLFFTR-LVPSGTFDILKDDFDHVLISLVLTGLVVGSYVS 932 
XP_001742198  419 LR--------TIVTAPT---------GLESTCIVVAFG-ADIFLTQ-HSPSKQYDRLNSDFDFVSLTLVLTALVALTFVL 479 

XP_014171554 1033 RPMVTKKQIDMRW 1045
Q57ZY7        805 RYFAMRKGVRQLW 817  Trypanosoma brucei
CAM71841      802 RYFVNRKALNSAW 814 
Q5CTP8        947 IYFSKRNQLK-KW 958  Cryptosporidium parvum
A0E6E8        326 QKLIKSSKQVKQF 338  Paramecium tetraurelia
A0CJK9        876 SKLVKSSKQVKQF 888  Paramecium tetraurelia
Q245W3        992 KKYASQSNLH-RL 1003 Tetrahymena thermophila SB210
6_pfamImport  196 KRLARSNALSAQW 208 
CCD72387      933 KRLARSNALASQW 945 
XP_001742198  480 SNLAGRKRLAALW 492
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