Conserved Protein Domain Family
MFMR

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pfam07777: MFMR 
G-box binding protein MFMR
This region is found to the N-terminus of the pfam00170 transcription factor domain. It is between 150 and 200 amino acids in length. The N-terminal half is rather rich in proline residues and has been termed the PRD (proline rich domain), whereas the C-terminal half is more polar and has been called the MFMR (multifunctional mosaic region). It has been suggested that this family is composed of three sub-families called A, B and C, classified according to motif composition. It has been suggested that some of these motifs may be involved in mediating protein-protein interactions. The MFMR region contains a nuclear localization signal in bZIP opaque and GBF-2. The MFMR also contains a transregulatory activity in TAF-1. The MFMR in CPRF-2 contains cytoplasmic retention signals.
Statistics
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PSSM-Id: 311632
View PSSM: pfam07777
Aligned: 44 rows
Threshold Bit Score: 92.793
Threshold Setting Gi: 695030726
Created: 23-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75297815    1 MGSSEMEKS-GKEkePKTTPPSTsssapatvvsqepssAVSAGVAvTQDWS-GFQAY--SPM-PPHGY----VASSPQ-- 69
gi 695056349   1 MASNEAATP-PKS--NKASSPVQs--------------RETPANPpYADWA-TMQAYygHGM-IPPTYl-----SGHV-- 54
gi 125527133   1 MGNDEAVVT-QKM--GKAPSPPK---------------DHPALSP-YLDWS-NMQAYygPGI-LPPTFfspgIAAGHT-- 57
gi 721643101   1 MGHDEAVVI-QNS--GKAPSPPK---------------DQPALYP-CLDWS-TMQAYygPGI-MPPTYfcpgLVPGHA-- 57
gi 685352085   1 MGSNEEGKT-TQS--DKPAQVQAppp----------ppEQSNVHVyHHDWA-AMQAYygPRVaITPQYyn---snGHApp 63
gi 297810049   1 MGSNEEGKP-TNS--DKPSQAAAp--------------EQSNVHVyHHDWA-AMQAYygPRV-GIPQYynsnVAPGHA-- 59
gi 359474054   1 MGKSEAEMS-SKS--DKISSSAE---------------EQTNIHLlNPDWA-SIQAYygSGVpLLAPHfnsaVPGSHF-- 59
gi 586723605   1 MGNNDTGTTtSKS--DKASSPVQ---------------EQSG--PtYPDWAtAFQAYygPGVsLPPPYfgstIPSGHT-- 59
gi 162459829   1 MAQDEAVAT-QKT--GNTTSPSK---------------DYPTPSP-YPDWS-TMQAYygPGV-LPPTYftpaIAPGH--- 56
gi 514779502   1 MGHDEAVVT-QNS--VKAPSPPK---------------DQPAMYP-CLDWS-TMQAYygPGV-FPPTFfspgIASGHV-- 57
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 75297815   70 PHPYMWG-VQHMMPP-YGTPphpYVTMYPPGGMYAHPSLP 107
gi 695056349  55 PHPYMWG-PQPLIPP-FGSP---YTAIYPLGGVYSHASVP 89
gi 125527133  58 PPPFIWG-PQPLVPSaFGKP---YAAIYPPGGAFSHPFMP 93
gi 721643101  58 PPPYMWS-PQPLLPS--ASAk-pYTAVHPHGGGFSHPFMP 93
gi 685352085  64 PPPYIWGsPSPMMAP-YGTP---YPPFCPPGGVYAHPALq 99
gi 297810049  60 PPPYMWAsPSPMMAP-YGAP---YPPFCPPGGVYAHPGVQ 95
gi 359474054  60 PYPYVWApSQPLIPP-YGVP---YTAIYSHEGVHAHPAVP 95
gi 586723605  60 PHPYMWG-PQPLMPP-YGTPa--YAAIYSHGGVYAHPAVP 95
gi 162459829  57 PPPYMWG-PQPIMPPpFGTP---YAAVYPHGGAYPHPLVP 92
gi 514779502  58 PPPYMWG-PQNMPPAsFGKP---YGAIYPHAGGFLHPFMP 93
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