Conserved Protein Domain Family
Cas1_AcylT

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pfam07779: Cas1_AcylT 
10 TM Acyl Transferase domain found in Cas1p
Cas1p protein of Cryptococcus neoformans is required for the synthesis of O-acetylated glucuronoxylomannans, a consitutent of the capsule, and is critical for its virulence. The multi TM domain of the Cas1p was unified with the 10 TM Sugar Acyltransferase superfamily. This superfamily is comprised of members from the OatA, MdoC, OpgC, NolL and GumG families in addition to the Cas1p family. The Cas1p protein has a N terminal PC-Esterase domain with the opposing Acyl esterase activity.
Statistics
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PSSM-Id: 311634
View PSSM: pfam07779
Aligned: 21 rows
Threshold Bit Score: 500.268
Threshold Setting Gi: 596649834
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74604759    313 SDTCCIHYkQPRTMGQVLLLGVi-------CAILPIIYLGQRYTRSDyyprfvryvSWPVPSIQD--------------- 370
gi 198430770   292 DGTCCRKP-DPLTIVQIIM-AVlg----fiFILLAVGIRIQRIGKPT---------PTNEDEVAKnkdsi---------- 346
gi 675888464   256 DGSCCTSP-ENPTTVQIAMAAFfatslaaaVLIATCRRLNGRSNKNN---------KNNNKTNNNnnnqs---------- 315
gi 754348346   466 DVTCCAPY-PALTGLQYVFFAV--------VLFALVCWLGGSYAARH---------HTGGAVASGaesafgatararhml 527
gi 629655651   213 DKTCCNVQ-PPINLEQQVLIFVa-------TLTILYAFYSASKRKML---------NQPATTLLAv-------------- 261
gi 527303253   328 DRTCCRRY-PWPSALHSLVLAVa-------VFWGPACVLLARRVAPP---------TSGQPYIGD--------------- 375
gi 557022910   301 DASCCLPK-PSFTVIQKLTACFfg----isIIGFLIFSYLFRNNHKK---------SKPCTDVES--------------- 351
gi 931574282   230 DGSCCQPR-PPVTLIQKLAACFft----lsIIGYLIFYIIHRNAHRK---------NKPCTDLES--------------- 280
gi 847140131   228 DGSCCQPT-PSLTIIQKLAACFfi----faMIAFVSVTIVQRNKHRR---------NKQCDDIES--------------- 278
gi 1110924762  336 DGSCCQTL-RAPNLLQKLSALFfl----gsAVVFVVFHILGNNRHRR---------HVP-PDVES--------------- 385
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74604759    371 -----E----------------TLLTACVVIAASLAYSFFCDRTQFFGKSSKQFEASEFWVLILLFLVATGYS------- 422
gi 198430770   347 -hniiA----------------ELTYAAAKMSLILFYFYICDRTDVFMKSNKHYTNTRFFLPLLYIVFLGIFG------- 402
gi 675888464   316 knmdcP----------------TLISCIAKLGLILLYFFICDRTTFFMKENKYYTHVNFFLPFTYLMILGLFF------- 372
gi 754348346   528 sspnlL----------------SVAMPVAQLGLVLVFAFLCDRTHIFPKERKIYTHFDLIASIGVMFVAGWCT------- 584
gi 629655651   262 ---------------------nGITAAVGIIAMAVVYCFVADRTLIFDKVQKVSSQRTFLQMITIVMLGGVLTvrkpgdt 320
gi 527303253   376 -----Qe------------------MPAVVMSVAAALIYLADRTDFWLKEQKQFSPWVFTFLSLLSLAAGLST------- 425
gi 557022910   352 -----Geekpttat-papanteILLQSLCKLGLIMAYFYLCDRANLFMKEHKFYTNSTFFVPLIFILMLGVFC------- 418
gi 931574282   281 -----Geekkniin-tpvssleILLQSFCKLGLIMAYFYMCDRANLFMKENKFYTHSSFFIPIIYILVLGVFY------- 347
gi 847140131   279 -----GeekkpatatpaassleILLFSLSKLGLIMAYFYFCDRANLFMKENKFYTHSSFFIPIIYILVLGVFY------- 346
gi 1110924762  386 -----Leekkpata-avppgpkAPFQALCRMGVIMGYFYLCDRADVFMKEQKFYTHSTFFIPLIYIFVLGVFY------- 452
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74604759    423 --------FEPqNDN-S-FLNRHQTEEWKGWMQIIILIYHITGASKILPIYKFVRVLVAAYLFMTGFGHATFFIKRGDFS 492
gi 198430770   403 --------IDS-TKQ-PvFLNRDQTDEWKGWMQLVILIYHVTGASVNVPIYMHVRLLVAMYLFMTGYGHFSYFWNKGDFG 472
gi 675888464   373 --------TES-TKQ-VqVLNRCQTDEWKGWMQIVILIYHLTGASKVLSIYMHIRVMVSAYLFLSAYGHFVYFFNKNDFS 442
gi 754348346   585 --------LTH-VKTaPtFLSRDQTDEWKGWMQIVFLIYHFLGGSSVLPLYMLVRVFVASYLFLTGFGHFTFFYTKKQFG 655
gi 629655651   321 saetsakpTRA-TLG-QkFLSRDQTDEWKGWMQFVILIYHYTGMSNVLWVYQIIRLLVASYLFMTGYGHTIYFLKTNNFS 398
gi 527303253   426 --------MRQaDKD-LgFLNREQTDEWKGWMQIAILIYHYTGASKISGIYNVIRVLVAAYLFMTGYGHTTFYIKKADFG 496
gi 557022910   419 --------NEN-AKE-SkLLNRDQTDEWKGWMQLVILLYHISGASSFLPVYMHVRVLVAAYLFQTGYGHFSYFWIKDDLG 488
gi 931574282   348 --------NEN-TKE-TkVLNREQTDEWKGWMQLVILIYHISGASTFLPVYMHIRVLVAAYLFQTGYGHFSYFWIKGDFG 417
gi 847140131   347 --------NEN-TKE-AkLLNREQTDEWKGWMQLVILIYHISGASSFLPVYMHVRVLVAAYLFQTGYGHFSYFWLKGDFG 416
gi 1110924762  453 --------SDN-SKE-AkLLNREQTDEWKGWMQLVILIYHISGASAFIPVYMHVRVLVAAYLFQTGYGHFSFFWLKGDFG 522
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74604759    493 LKRATSVLFRMNFLSILLAYVMDTDYLFYYFAPLVSFWFCVVWITFRVL--PSWNSIDtsv------------------g 552
gi 198430770   473 VHRVFGVMFRLNFLTVMLCLTMDRSYQFYYFVPMCSFWFLVLYLFMALW--PRAYMVAtnkettlsdgetkevtftspif 550
gi 675888464   443 FHRLCTVLVRFNLLVVLLCLSMNRPYQFYYFVPLVTFWFIVIFIVMALP--PRSSSSmsis----------------sff 504
gi 754348346   656 ITRIIQVLTRLNVLTIGLCMVMDKPYQFYYFVPLSSFWFLVVYAIMAFPsiPAVQKRFpg-------------------l 716
gi 629655651   399 LQRIVSVLVRLNLLSCLLAYVMRTDYNFYYFPALSSFWFLVVYLTIRVHhqPNVVPRV---------------------- 456
gi 527303253   497 FSRIAQVMIRLNFLTLLLAYTMNTDYISYYFAPLVSWWFLIIYGTMV----PGSQYNDrt-------------------a 553
gi 557022910   489 LYRLCQILFRLNFLVVVLCLVMDRPYQFYYFVPLVTFWFVVIYVVFALW--PPIVNRTasgsc-------------fwnl 553
gi 931574282   418 IHRVCQVLFRLNFLVVVLCIVMDRPYQFYYFVPLVTVWFMVIYVTLALW--PQIIQKKangnc-------------fwhf 482
gi 847140131   417 IYRISQVLFRLNFLVVVLCVVMDRPYQFYYFVPLVTFWFMFIYATMAVW--PQILQKTanans-------------lwnc 481
gi 1110924762  523 LYRVCQVLFRLNFLVLVLCVVMDRPYQFYYFVPLVTFWFVVIYTTMAIW--PQILQKTanssg-------------vwhf 587
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74604759    553 pVLAKISASAVILNILVRFQL------------PFQIVFAV--LKYLF-N-IQWNLREWRFRLILDIYIVYIGMFAAVAT 616
gi 198430770   551 vMCAKLSLLLFTIVLVFLSQE------------LFESMFSWwpVIRLF-ElPPGMVREWWFRCHLDRFAMLHGAVFAFGY 617
gi 675888464   505 wIFLKIVGLAVVVTLLYSSEV------------FFDQLFLStsLKPLFvT-SDESIHDWRFRWNLDRYSSIYGLLFALAL 571
gi 754348346   717 dAPARILALFTICSIVWLPFSgnykstsaddfpIFQFLFDWwpIKELF-S-VSDSLYEWRFRSGLDCFIVAHGMLIAYAY 794
gi 629655651   457 -LVLKVFVSVIVVQLLLHTPG------------VLEFVFEL--LQKTC-K-VNVDVHELRFRLSLDAYVVYIGMFTAILH 519
gi 527303253   554 fVLVKILLSMTLVTWFMSEHW------------ILEAIFDF--LSRTC-G-IHWSAREWAFRVNLDLWIVYFGMLAALAV 617
gi 557022910   554 sLLLRLGLLLTCICILAYFQS------------TFEAVFATwpVSKLF-E-LQGSVHEWWFRWKLDRFAVFHGMMFAFLY 619
gi 931574282   483 gLLLKLGFLLLFICFLAYSQG------------AFEKIFSLwpLSKCF-E-LKGNVYEWWFRWRLDRYVVFHGMLFAFIY 548
gi 847140131   482 gLIIKLTFALLCIIFLSYSQG------------AFENVFSLwpLSKLF-E-LNGNVYEWWFRWKLDRFAVIYGMAFAFIY 547
gi 1110924762  588 gVLAKLLGLLIFICFFAFSQG------------IFERVFSVwpISKLF-E-LNGSIHEWWFRWKLDRFAVIHGMVFAFIY 653
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74604759    617 LRYKQGNFPLK-----------------------NLvTN------------RLVLGVVALITFIVYIAVAASFGIKQNYN 661
gi 198430770   618 IILKRLSIVDDsrqg----------------cllST-KV------------SLIAVTASILCTLFYSVWALQCSDKQSCN 668
gi 675888464   572 VMAKRFKLIDDsvsd----------------lvaSR-KV------------NMLSMALSICGLVGYAVFTSLCNSKEQCN 622
gi 754348346   795 QIAKSHGVIHDnqpavrpgttppppgpllsgllfNT-AT------------SAILSIVSIGIFCWYIMFTRSCTDKAYCN 861
gi 629655651   520 LQITggl-------------------------pcST-TClatqikkiptaaHVSAICASGVIVPTYLVLIQKFPDKYAYN 573
gi 527303253   618 IKIREHRLTDHp---------------------qWPlAV------------KGAIGASC-VVLLWFFAFELYQPDKFAYN 663
gi 557022910   620 LTLQKWQVFSEgnge----------------plfSH-MV------------SYCLLFVSVVSFLSYSIWAANCKIKAECN 670
gi 931574282   549 LALQKRQILSEgkge----------------plfSN-KI------------SNFLLFISVVSFLTYSIWASSCKNKAECN 599
gi 847140131   548 LWLQKHQVLFEgkge----------------alfST-KV------------SSVLLFFSVVSFFTYSIWASSCKNKSECN 598
gi 1110924762  654 LVLQKRQVLSEgkge----------------alfSA-KI------------SNFLLFLSVVSFITYSIWASSCKTKTECN 704
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74604759    662 QAHPYISWMPIVAFVILRNITVRFRSHYSTWMSFIGTCSLETFTLQFHFFLAADTKGRLYILnTPtssgVlgmlqK---- 737
gi 198430770   669 EVHSFASLIPISAFILIRNIPGYLRAGYSSFFAWFGKISLELFIGQYHIWLAADTKGILVITsPQ----W-----P---- 735
gi 675888464   623 NNNNK----KILSYICLRNMMGCARRKFSAFFAWFGKMSLELFIAQYHIWLAADTHGILVLI-PS----Y-----P---- 684
gi 754348346   862 YIHTFSSPFLVAAFAFLRNLTGRSRAVYSRFFAYIGQLSLELFLLQFHIWLAADTKGILVLI-PGtsgfW-----R---- 931
gi 629655651   574 WWHPMISPMPIAAFAILRNATQPLRDFHSGLFAWLGRFSLETFILQYHIWLAADTKGLLSLG-LS----S-----Rdavv 643
gi 527303253   664 AWHPYMSFLPVGAFVVLRNANVVLRSASSRAFAWIGACSLETFIIQYHFWLAGDTKGVLLII-PGt--rW-----R---- 731
gi 557022910   671 EWHPYISVIQILAFVLIRNIPGYARSVYSTFFAWFGKISLELFICQYHIWLAADTRGILVLI-PG----N-----P---- 736
gi 931574282   600 ELHPSVSVVQILAFILIRNIPGYARSVYSSFFAWFGKISLELFICQYHIWLAADTRGILVLI-PG----N-----P---- 665
gi 847140131   599 EMHPSISVVQILSFVLIRNIPGYARSVYSSFFAWFGKISLELFICQYHIWLAADTKGILVLI-PG----N-----P---- 664
gi 1110924762  705 EMHPYISVVQILAFILIRNIPGYARSIYSSFFAWFGKISLELFICQYHIWLAADTKGILVLI-PG----N-----P---- 770
                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|.
gi 74604759    738 ----------YLNFGLVTVIFIIVSHAVAEQSNALTKLFVGNQDQQLPEHV 778
gi 198430770   736 ----------MLNLLVSTFVFVCVAHEISALTGTFAKYLVGPAKTADTKTV 776
gi 675888464   685 ----------VMNLIVTSFVFVCVAHEIKLLTSLLTPVLVPRSRLKLARNV 725
gi 754348346   932 ----------LLNAAFTTGLFVAVSEVASDSSALIVSLLAPGDNTRAVISR 972
gi 629655651   644 gtewidklglLCDFTLVTAFFLWVSWAVSHATNVVTSFIVNGQQPTKAPNL 694
gi 527303253   732 ----------PVNLVLTTIVFIYVSHRVAQATGEITNWMCGTVKAQSLPTv 772
gi 557022910   737 ----------VLNIIISTFIFVCIAHEISKITNDLVQIAIPKDDTALLKRL 777
gi 931574282   666 ----------MLNIIVSTFIFVCVAHEISQITNDLAQIIIPKDNSSLLKRL 706
gi 847140131   665 ----------MLNIIISTFIFVCVAHEISLITNDLAQIVVPKESSALTKRL 705
gi 1110924762  771 ----------SLNILVSTFIFVCVAHEISLITNDLAQVVIPKDSMALLKRL 811
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