Conserved Protein Domain Family
Cas1_AcylT

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pfam07779: Cas1_AcylT 
10 TM Acyl Transferase domain found in Cas1p
Cas1p protein of Cryptococcus neoformans is required for the synthesis of O-acetylated glucuronoxylomannans, a consitutent of the capsule, and is critical for its virulence. The multi TM domain of the Cas1p was unified with the 10 TM Sugar Acyltransferase superfamily. This superfamily is comprised of members from the OatA, MdoC, OpgC, NolL and GumG families in addition to the Cas1p family. The Cas1p protein has a N terminal PC-Esterase domain with the opposing Acyl esterase activity.
Statistics
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PSSM-Id: 311634
View PSSM: pfam07779
Aligned: 21 rows
Threshold Bit Score: 500.268
Threshold Setting Gi: 596649834
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74604759   313 SDTCCIHYkQPRTMGQVLLLGVi-------CAILPIIYLGQRYTRSDyyprfvryvSWPVPSIQD--------------- 370
gi 198430770  292 DGTCCRKP-DPLTIVQIIM-AVlg----fiFILLAVGIRIQRIGKPT---------PTNEDEVAKnkdsi---------- 346
gi 675888464  256 DGSCCTSP-ENPTTVQIAMAAFfatslaaaVLIATCRRLNGRSNKNN---------KNNNKTNNNnnnqs---------- 315
gi 754348346  466 DVTCCAPY-PALTGLQYVFFAV--------VLFALVCWLGGSYAARH---------HTGGAVASGaesafgatararhml 527
gi 629655651  213 DKTCCNVQ-PPINLEQQVLIFVa-------TLTILYAFYSASKRKML---------NQPATTLLAv-------------- 261
gi 527303253  328 DRTCCRRY-PWPSALHSLVLAVa-------VFWGPACVLLARRVAPP---------TSGQPYIGD--------------- 375
gi 557022910  301 DASCCLPK-PSFTVIQKLTACFfg----isIIGFLIFSYLFRNNHKK---------SKPCTDVES--------------- 351
gi 931574282  230 DGSCCQPR-PPVTLIQKLAACFft----lsIIGYLIFYIIHRNAHRK---------NKPCTDLES--------------- 280
gi 847140131  228 DGSCCQPT-PSLTIIQKLAACFfi----faMIAFVSVTIVQRNKHRR---------NKQCDDIES--------------- 278
gi 908530417  336 DGSCCQTL-RAPNLLQKLSALFfl----gsAVVFVVFHILGNNRHRR---------HVP-PDVES--------------- 385
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74604759   371 -----E----------------TLLTACVVIAASLAYSFFCDRTQFFGKSSKQFEASEFWVLILLFLVATGYS------- 422
gi 198430770  347 -hniiA----------------ELTYAAAKMSLILFYFYICDRTDVFMKSNKHYTNTRFFLPLLYIVFLGIFG------- 402
gi 675888464  316 knmdcP----------------TLISCIAKLGLILLYFFICDRTTFFMKENKYYTHVNFFLPFTYLMILGLFF------- 372
gi 754348346  528 sspnlL----------------SVAMPVAQLGLVLVFAFLCDRTHIFPKERKIYTHFDLIASIGVMFVAGWCT------- 584
gi 629655651  262 ---------------------nGITAAVGIIAMAVVYCFVADRTLIFDKVQKVSSQRTFLQMITIVMLGGVLTvrkpgdt 320
gi 527303253  376 -----Qe------------------MPAVVMSVAAALIYLADRTDFWLKEQKQFSPWVFTFLSLLSLAAGLST------- 425
gi 557022910  352 -----Geekpttat-papanteILLQSLCKLGLIMAYFYLCDRANLFMKEHKFYTNSTFFVPLIFILMLGVFC------- 418
gi 931574282  281 -----Geekkniin-tpvssleILLQSFCKLGLIMAYFYMCDRANLFMKENKFYTHSSFFIPIIYILVLGVFY------- 347
gi 847140131  279 -----GeekkpatatpaassleILLFSLSKLGLIMAYFYFCDRANLFMKENKFYTHSSFFIPIIYILVLGVFY------- 346
gi 908530417  386 -----Leekkpata-avppgpkAPFQALCRMGVIMGYFYLCDRADVFMKEQKFYTHSTFFIPLIYIFVLGVFY------- 452
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74604759   423 --------FEPqNDN-S-FLNRHQTEEWKGWMQIIILIYHITGASKILPIYKFVRVLVAAYLFMTGFGHATFFIKRGDFS 492
gi 198430770  403 --------IDS-TKQ-PvFLNRDQTDEWKGWMQLVILIYHVTGASVNVPIYMHVRLLVAMYLFMTGYGHFSYFWNKGDFG 472
gi 675888464  373 --------TES-TKQ-VqVLNRCQTDEWKGWMQIVILIYHLTGASKVLSIYMHIRVMVSAYLFLSAYGHFVYFFNKNDFS 442
gi 754348346  585 --------LTH-VKTaPtFLSRDQTDEWKGWMQIVFLIYHFLGGSSVLPLYMLVRVFVASYLFLTGFGHFTFFYTKKQFG 655
gi 629655651  321 saetsakpTRA-TLG-QkFLSRDQTDEWKGWMQFVILIYHYTGMSNVLWVYQIIRLLVASYLFMTGYGHTIYFLKTNNFS 398
gi 527303253  426 --------MRQaDKD-LgFLNREQTDEWKGWMQIAILIYHYTGASKISGIYNVIRVLVAAYLFMTGYGHTTFYIKKADFG 496
gi 557022910  419 --------NEN-AKE-SkLLNRDQTDEWKGWMQLVILLYHISGASSFLPVYMHVRVLVAAYLFQTGYGHFSYFWIKDDLG 488
gi 931574282  348 --------NEN-TKE-TkVLNREQTDEWKGWMQLVILIYHISGASTFLPVYMHIRVLVAAYLFQTGYGHFSYFWIKGDFG 417
gi 847140131  347 --------NEN-TKE-AkLLNREQTDEWKGWMQLVILIYHISGASSFLPVYMHVRVLVAAYLFQTGYGHFSYFWLKGDFG 416
gi 908530417  453 --------SDN-SKE-AkLLNREQTDEWKGWMQLVILIYHISGASAFIPVYMHVRVLVAAYLFQTGYGHFSFFWLKGDFG 522
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74604759   493 LKRATSVLFRMNFLSILLAYVMDTDYLFYYFAPLVSFWFCVVWITFRVL--PSWNSIDtsv------------------g 552
gi 198430770  473 VHRVFGVMFRLNFLTVMLCLTMDRSYQFYYFVPMCSFWFLVLYLFMALW--PRAYMVAtnkettlsdgetkevtftspif 550
gi 675888464  443 FHRLCTVLVRFNLLVVLLCLSMNRPYQFYYFVPLVTFWFIVIFIVMALP--PRSSSSmsis----------------sff 504
gi 754348346  656 ITRIIQVLTRLNVLTIGLCMVMDKPYQFYYFVPLSSFWFLVVYAIMAFPsiPAVQKRFpg-------------------l 716
gi 629655651  399 LQRIVSVLVRLNLLSCLLAYVMRTDYNFYYFPALSSFWFLVVYLTIRVHhqPNVVPRV---------------------- 456
gi 527303253  497 FSRIAQVMIRLNFLTLLLAYTMNTDYISYYFAPLVSWWFLIIYGTMV----PGSQYNDrt-------------------a 553
gi 557022910  489 LYRLCQILFRLNFLVVVLCLVMDRPYQFYYFVPLVTFWFVVIYVVFALW--PPIVNRTasgsc-------------fwnl 553
gi 931574282  418 IHRVCQVLFRLNFLVVVLCIVMDRPYQFYYFVPLVTVWFMVIYVTLALW--PQIIQKKangnc-------------fwhf 482
gi 847140131  417 IYRISQVLFRLNFLVVVLCVVMDRPYQFYYFVPLVTFWFMFIYATMAVW--PQILQKTanans-------------lwnc 481
gi 908530417  523 LYRVCQVLFRLNFLVLVLCVVMDRPYQFYYFVPLVTFWFVVIYTTMAIW--PQILQKTanssg-------------vwhf 587
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74604759   553 pVLAKISASAVILNILVRFQL------------PFQIVFAV--LKYLF-N-IQWNLREWRFRLILDIYIVYIGMFAAVAT 616
gi 198430770  551 vMCAKLSLLLFTIVLVFLSQE------------LFESMFSWwpVIRLF-ElPPGMVREWWFRCHLDRFAMLHGAVFAFGY 617
gi 675888464  505 wIFLKIVGLAVVVTLLYSSEV------------FFDQLFLStsLKPLFvT-SDESIHDWRFRWNLDRYSSIYGLLFALAL 571
gi 754348346  717 dAPARILALFTICSIVWLPFSgnykstsaddfpIFQFLFDWwpIKELF-S-VSDSLYEWRFRSGLDCFIVAHGMLIAYAY 794
gi 629655651  457 -LVLKVFVSVIVVQLLLHTPG------------VLEFVFEL--LQKTC-K-VNVDVHELRFRLSLDAYVVYIGMFTAILH 519
gi 527303253  554 fVLVKILLSMTLVTWFMSEHW------------ILEAIFDF--LSRTC-G-IHWSAREWAFRVNLDLWIVYFGMLAALAV 617
gi 557022910  554 sLLLRLGLLLTCICILAYFQS------------TFEAVFATwpVSKLF-E-LQGSVHEWWFRWKLDRFAVFHGMMFAFLY 619
gi 931574282  483 gLLLKLGFLLLFICFLAYSQG------------AFEKIFSLwpLSKCF-E-LKGNVYEWWFRWRLDRYVVFHGMLFAFIY 548
gi 847140131  482 gLIIKLTFALLCIIFLSYSQG------------AFENVFSLwpLSKLF-E-LNGNVYEWWFRWKLDRFAVIYGMAFAFIY 547
gi 908530417  588 gVLAKLLGLLIFICFFAFSQG------------IFERVFSVwpISKLF-E-LNGSIHEWWFRWKLDRFAVIHGMVFAFIY 653
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74604759   617 LRYKQGNFPLK-----------------------NLvTN------------RLVLGVVALITFIVYIAVAASFGIKQNYN 661
gi 198430770  618 IILKRLSIVDDsrqg----------------cllST-KV------------SLIAVTASILCTLFYSVWALQCSDKQSCN 668
gi 675888464  572 VMAKRFKLIDDsvsd----------------lvaSR-KV------------NMLSMALSICGLVGYAVFTSLCNSKEQCN 622
gi 754348346  795 QIAKSHGVIHDnqpavrpgttppppgpllsgllfNT-AT------------SAILSIVSIGIFCWYIMFTRSCTDKAYCN 861
gi 629655651  520 LQITggl-------------------------pcST-TClatqikkiptaaHVSAICASGVIVPTYLVLIQKFPDKYAYN 573
gi 527303253  618 IKIREHRLTDHp---------------------qWPlAV------------KGAIGASC-VVLLWFFAFELYQPDKFAYN 663
gi 557022910  620 LTLQKWQVFSEgnge----------------plfSH-MV------------SYCLLFVSVVSFLSYSIWAANCKIKAECN 670
gi 931574282  549 LALQKRQILSEgkge----------------plfSN-KI------------SNFLLFISVVSFLTYSIWASSCKNKAECN 599
gi 847140131  548 LWLQKHQVLFEgkge----------------alfST-KV------------SSVLLFFSVVSFFTYSIWASSCKNKSECN 598
gi 908530417  654 LVLQKRQVLSEgkge----------------alfSA-KI------------SNFLLFLSVVSFITYSIWASSCKTKTECN 704
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74604759   662 QAHPYISWMPIVAFVILRNITVRFRSHYSTWMSFIGTCSLETFTLQFHFFLAADTKGRLYILnTPtssgVlgmlqK---- 737
gi 198430770  669 EVHSFASLIPISAFILIRNIPGYLRAGYSSFFAWFGKISLELFIGQYHIWLAADTKGILVITsPQ----W-----P---- 735
gi 675888464  623 NNNNK----KILSYICLRNMMGCARRKFSAFFAWFGKMSLELFIAQYHIWLAADTHGILVLI-PS----Y-----P---- 684
gi 754348346  862 YIHTFSSPFLVAAFAFLRNLTGRSRAVYSRFFAYIGQLSLELFLLQFHIWLAADTKGILVLI-PGtsgfW-----R---- 931
gi 629655651  574 WWHPMISPMPIAAFAILRNATQPLRDFHSGLFAWLGRFSLETFILQYHIWLAADTKGLLSLG-LS----S-----Rdavv 643
gi 527303253  664 AWHPYMSFLPVGAFVVLRNANVVLRSASSRAFAWIGACSLETFIIQYHFWLAGDTKGVLLII-PGt--rW-----R---- 731
gi 557022910  671 EWHPYISVIQILAFVLIRNIPGYARSVYSTFFAWFGKISLELFICQYHIWLAADTRGILVLI-PG----N-----P---- 736
gi 931574282  600 ELHPSVSVVQILAFILIRNIPGYARSVYSSFFAWFGKISLELFICQYHIWLAADTRGILVLI-PG----N-----P---- 665
gi 847140131  599 EMHPSISVVQILSFVLIRNIPGYARSVYSSFFAWFGKISLELFICQYHIWLAADTKGILVLI-PG----N-----P---- 664
gi 908530417  705 EMHPYISVVQILAFILIRNIPGYARSIYSSFFAWFGKISLELFICQYHIWLAADTKGILVLI-PG----N-----P---- 770
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|.
gi 74604759   738 ----------YLNFGLVTVIFIIVSHAVAEQSNALTKLFVGNQDQQLPEHV 778
gi 198430770  736 ----------MLNLLVSTFVFVCVAHEISALTGTFAKYLVGPAKTADTKTV 776
gi 675888464  685 ----------VMNLIVTSFVFVCVAHEIKLLTSLLTPVLVPRSRLKLARNV 725
gi 754348346  932 ----------LLNAAFTTGLFVAVSEVASDSSALIVSLLAPGDNTRAVISR 972
gi 629655651  644 gtewidklglLCDFTLVTAFFLWVSWAVSHATNVVTSFIVNGQQPTKAPNL 694
gi 527303253  732 ----------PVNLVLTTIVFIYVSHRVAQATGEITNWMCGTVKAQSLPTv 772
gi 557022910  737 ----------VLNIIISTFIFVCIAHEISKITNDLVQIAIPKDDTALLKRL 777
gi 931574282  666 ----------MLNIIVSTFIFVCVAHEISQITNDLAQIIIPKDNSSLLKRL 706
gi 847140131  665 ----------MLNIIISTFIFVCVAHEISLITNDLAQIVVPKESSALTKRL 705
gi 908530417  771 ----------SLNILVSTFIFVCVAHEISLITNDLAQVVIPKDSMALLKRL 811
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