Conserved Protein Domain Family
TMEM43

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pfam07787: TMEM43 
Transmembrane protein 43
This entry represents the transmembrane protein 43 family of proteins, which may function as tetraspanin-like membrane organizers.
Statistics
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PSSM-Id: 336810
View PSSM: pfam07787
Aligned: 67 rows
Threshold Bit Score: 134.305
Threshold Setting Gi: 156088401
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124453862  153 YQWIRKEETDGVG-----NNKKIK-VFFVPEWSAIKQGSYENF-----ENNeSDWTVKKKSKYAKDVYL-G-AYLLTKFQ 219
gi 124472315  126 YQWVQKSREEGSK-----KNKRTV-YYYESEWSSKIEGSYPNH-----ENRrEDLTVQEQELTAENVYI-G-AYKLTDYL 192
gi 124462088  121 YQWVVGEKQK------------------EQQWVDHYVENSFGY-----NNDkSKWILNSETFLNISVKL-H-QFELPEDM 175
gi 124452967   28 YQWVKGDQKQ-----------------YEQKWVDHHVENHFGY-----NNDkSKWVLKAQTFLNQCVKL-H-QFMLEEDM 83
gi 502676456  107 YQWKESKSERRVDkvgggTQMITE-YHYAVGWHEDLIRSNSFQtprghENP-ESIPFTSQVFDAKEVLL-G-AFRLDPSQ 182
gi 144897756  112 YQWVETEEQKTEKsvgggETTTTT-YRYSRQWREGAVESSRFKrpeghHNP--AMHHTSRRIDVQGAKI-G-AFTLDHSQ 186
gi 255075079   88 YQWVERTHKRRVRedehrTRVETS-YTYDTRWREGTVRSSNFRyphghANP-GPSPFDSRTYVAREVGV-GdGFTLTPTL 164
gi 170659312  126 YQWEEREENSGSN---------RR-YEYRRVWSENAIASSRFHqqgyhDNP-PFPQTGSQSFGAGDARI-N-AFPVGAMA 192
gi 471223080  133 YCWQEYKHSRRISnn----yEEIY-YTHNIDWRNEFIDSQYFHenighQNYkQDWLYDSKVIYAPNVFF-G-TFKLSEKQ 205
gi 397597068  736 YEWRETKSQRRQRis-psQTRVTTeYSYDTRWGSRHRDSNRFEapsghYNPlPRYFVGERTYTAKDARLsN-GMRVGPEL 813
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124453862  220 LKQAKNFQEIQPSQEWVTACAka-fpKKTQEHTKIKDe---------------yIYF------NKV------------YG 265
gi 124472315  193 KSKAVDYVQVDSISQQQCEAAkvafqSRTQQYIFFDGr---------------yIQF------RKS------------EN 239
gi 124462088  176 KTQLNTPLETVKLNQANVQIFqqrykDKGYRRFLLQDd---------------yIYM------HQV------------ED 222
gi 124452967   84 IKELNTPLQNVKFNQANVQIAqqkykDSGFSRFLLQDd---------------yIYM------HQV------------DD 130
gi 502676456  183 LKQLDTRTDLSLDWLKPDEIP-----QEISARPLLLRd---------------qLYFpreilrGKGapeepvkltaerPQ 242
gi 144897756  187 ITQLDAFEPLPVTGDTPAPQG-----------FRWVGe---------------qLYR------GTS------------PQ 222
gi 255075079  165 VDELTRAHNMPVAIRSPLPDG-----------WTIRGg---------------vVYS------GSD------------SA 200
gi 170659312  193 TSRLPATDDLRPDPSVASNLQ-----RTLGRPIHIAGg---------------aYFA------GRN------------PS 234
gi 471223080  206 KEMCENSEIIRMNQQQYQ----------GHKQIQIIQd---------------yIYF------RKI------------PN 242
gi 397597068  814 VDQLTASDWLLNLANSAPQLD-----GGHHHKVPVNLenlhlqseekavislnkLYI------SDS------------IQ 870
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124453862  266 ------------------------------NLTVGDQRIKFQKV--KC-GDATIVSQQ-KGNTFEPYslhvneskllndy 311
gi 124472315  240 ------------------------------SQSIGDQRVLFEKV--PC-NYAAIVARQ-HKESFKPYlfkdsfsddvnqd 285
gi 124462088  223 ------------------------------QIVNGDLRICFKQV--IC-SDATIVARA-IINSLLVWqfedtynktvskq 268
gi 124452967  131 ------------------------------QIVNGDLRISFKQV--IC-SDATIVARG-DTNRLLVWqfedtfnktvard 176
gi 502676456  243 ------------------------------RPEVGDVRIRYQVV--PP-QEVTIVAKQ-SAGTFVEY------------- 275
gi 144897756  223 ------------------------------DPQVGDLRVSFSMV--PA-TSLSVVAAQ-SGSTLAEY------------- 255
gi 255075079  201 at---------------------------tSPLVGDRRVAFSAV--PGkQTVSVLAKQgKNGSLRPW------------- 238
gi 170659312  235 ------------------------------SPQIGDLRIAYRYV--PA-GAASFIGKQ-EPAGLEPF------------- 267
gi 471223080  243 ------------------------------QNSCGDFRVQFTKC--TC-GESTIIAKQ-HQNTFEVF------------- 275
gi 397597068  871 tnnqlgsnllpsgnlstnedrripiartlpSPQVGDMRVSWKEVlpPK-EGVSVLAKQ-QGDELVPW------------- 935
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124453862  312 ddkgsdhsiy------vgqdlsqileekddenalkrqlK------------------------------HllE--PiKY- 352
gi 124472315  286 yaknpdmlksfnrfhelseeeqplnqidpssevssnifK------------------------------SyeA--PlNY- 332
gi 124462088  269 nq-------------------------------------------------------vqekelsdtqlpnedK--PiKQ- 290
gi 124452967  177 yd-------------------------------------------------------ahertccnlpvpndsK--PiKD- 198
gi 502676456  276 --------------------------------------A------------------------------T--KvkArRG- 284
gi 144897756  256 --------------------------------------T------------------------------T--T--QgYG- 262
gi 255075079  239 --------------------------------------T------------------------------S--P--SgRR- 245
gi 170659312  268 --------------------------------------R------------------------------T--H--TgQA- 274
gi 471223080  276 --------------------------------------HpgdynegdthfgdaqccsccfsicefcrflN--Q--AvDE- 312
gi 397597068  936 --------------------------------------S------------------------------L--G--GgRHr 943
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124453862  353 IDWLLEKMLTIHQVFDHKLNESRKLTMAVRFLGFLLMFFGLMLFFSPVVYVIS---WFP-----FLgrfmAEL----STL 420
gi 124472315  333 INWYFNRSFTLDQCFQSQLSKLVRMVWLCRVGGFFMFLFGFVLLFTPITTLLY---YIP-----LLggflSKL----TGI 400
gi 124462088  291 IYWIFQGLFTPEECLQKVVNENALLFWVFRSIGYILIAVGSIILLSPVSQLSQ---LIQ-----S-----DQL----SGF 353
gi 124452967  199 IYWIFQGLFTPEECFSKVVNENALLFWVFRSIGYILIAIGTIILLSPVSFLTD---FIP-----I-----EKL----TGI 261
gi 502676456  285 INLVAAGKKSSQEMFADARFANVAGLWMMRSFGGFLMFVAVGMFLQPIRALAS---VIP-----LL----GQI----VGW 348
gi 144897756  263 INLSAIGTHTAAAMFTQAKRDEATLTWILRGAGFLLMLFGLMLMSSPLHWLAS---LLP-----LL----ESL----VSA 326
gi 255075079  246 VVIVSHGRHSPNEMIASAERENAWKTWGLRALGFIVMIIGSALIVSPVREIVSylrWIP-----LV----GGIaagvVNL 316
gi 170659312  275 MLLAETGTHSAADLVAHGQERNQSEIWLWRAASILALFIGFFTLFMPVNILAS---YIP-----LV----GGI----VQG 338
gi 471223080  313 INWIKEKHISKEEFFNEKLQSQEFKTWLIRLCGYLLLVFGIFLMLSPIYKLLY---WFPfv-gkFL----GTI----GSL 380
gi 397597068  944 LYSLLPGRHSAKEMIGQQITKSKFITKALRIGGWLGTFLGLKLILSCIPALLR---LAPlgigqLL----APL----AGI 1012
                         410       420
                  ....*....|....*....|....*..
gi 124453862  421 LFALASFLISLPLTLITIALAWLRFHP 447
gi 124472315  401 VLAFLSGMISMPLTLGTIGIAWLYYRP 427
gi 124462088  354 GFIIYGLIGAIPINIFSICFCWLYYRP 380
gi 124452967  262 SFFIFGCIAAVPITIFAICFSWVYYRP 288
gi 502676456  349 GLALVAFFVSGGLTVMVVGLAWLYYRP 375
gi 144897756  327 ATFVMALAVAIPLTLVTIALAWLTYRP 353
gi 255075079  317 GVSLAAATASVSIACGVIGTSWLAHRP 343
gi 170659312  339 ATMLMALVAALTVGPAVSALAWLTYRP 365
gi 471223080  381 ICLLVGLIVAIPPAIIVIGLAWLFYRk 407
gi 397597068 1013 ATSTIALGVSVGLSGTIIAIAWLRFRP 1039
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