Conserved Protein Domain Family
TMEM43

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pfam07787: TMEM43 
Transmembrane protein 43
This entry represents the transmembrane protein 43 family of proteins, which may function as tetraspanin-like membrane organisers.
Statistics
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PSSM-Id: 311639
View PSSM: pfam07787
Aligned: 66 rows
Threshold Bit Score: 145.882
Threshold Setting Gi: 156088401
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81779879  139 WKEESKSETTKKLGGGEE-----TETTYSYSKVWDDSQIDSSDFKKPDGHQNP-P-MAIHSRVFQIPQGKL---V-AFDL 207
gi 124462088 123 WVVGEKQK----------------------EQQWVDHYVENSFGY-----NNDkSkWILNSETFLNISVKL---H-QFEL 171
gi 124452967  30 WVKGDQKQ---------------------YEQKWVDHHVENHFGY-----NNDkSkWVLKAQTFLNQCVKL---H-QFML 79
gi 81467643  118 WDEQVKTEGSGSNKKEVR----------NCVLKWTSSPENPSSFKLSGCRTKRyYrKSVQDQSDSASGALVhadGkNYSV 187
gi 504948235 106 WVEQSSTETKKNTGGSET-----KTTTYSYEKRWTASPANSANFEQPSGHQNP-Tk-TIDNESFKVGAANV---G-DYKL 174
gi 662038117 114 WEENSRTTTQKNAGGSET-----KTTTYTYAKEWAENPDDSSRFKNPTGHNNPa--KSIESQELRVSQAQV---G-DYQL 182
gi 488736699 101 WKEDKDSKTKKNIGGSET-----TTTDYSYRKVWTSSPENSSNFKVDGYH-NP-S-MSISGEELRAKEMEM---E-GFRL 168
gi 291001673 143 WIESSRDETVKNRDGSET-----TVRTYYYTKGWVDHLIPSLAFDQPAAHHNP-QrNPFPSMKSHASGVSV---G-KYHI 212
gi 504944584  85 WVEEQSQVSENNPP------------EYTYTQLWLEYPPNSGKFKERENHKNP-TlK-IHSNSQSVQTANI---G-VYKI 146
gi 301121146 112 WVETSHTSTSSTPEDEDRrfdddRERIYMYDLRWRKEEIDSSAFNDISYRNPPsEaWVYKSRVVNAKDLVV---G-EFSL 187
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81779879  208 D-TPvLDRIDGDKAYSLSANQ-SATIKa-----------aYTGTKPLSI--------------VDgrIYLGN-DNT---- 255
gi 124462088 172 P-EDmKTQLNTPLETVKLNQA-NVQIFqqr--------ykDKGYRRFLL--------------QDdyIYMHQ-VED---- 222
gi 124452967  80 E-EDmIKELNTPLQNVKFNQA-NVQIAqqk--------ykDSGFSRFLL--------------QDdyIYMHQ-VDD---- 130
gi 81467643  188 Q----LEDVDFTSQVPSRDAN-ENEIL----------------AGRFVY--------------GDgyLYSSK-SCV---- 227
gi 504948235 175 DlARlSYPVSTGVSLSPENVL-PEYKS--------------------KQ--------------SGnyLFLGQ-GTL---- 214
gi 662038117 183 DvNQlQFPINQPVNLTAAQIP-AESKN--------------------KL--------------NGsyLFFGTgSLG---- 223
gi 488736699 169 E-Q------PEDLSLASDELSlSQSML-------------KGQDGVVWA--------------ADryLFSGR-GSL---- 209
gi 291001673 213 G-PTlITKNQIPERTISFSKN-QLESIrg---------tvANTQHNFKY--------------IGsgYFFSA-YEPsnfe 266
gi 504944584 147 D-Pl-QISLPEPTEIQLTDSD-VVIPK-------------PKTKTDLILsptflslvgsiprrEGnyIYIGS-GLL---- 205
gi 301121146 188 P-DDlVDQIQRRDGVHLDTAS-RRVMAnlldqrlggaweaGSALANVTM--------------EDniFYFRN-EMR---- 246
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81779879  256 ------------------------T-PALGDYRIGYELA--P---LG---VVSIVARQ-A--GSRFEPYQ---------- 289
gi 124462088 223 ------------------------Q-IVNGDLRICFKQV--I---CS---DATIVARA-I--INSLLVWqfedtynktvs 266
gi 124452967 131 ------------------------Q-IVNGDLRISFKQV--I---CS---DATIVARG-D--TNRLLVWqfedtfnktva 174
gi 81467643  228 ------------------------EsEKEGCERIKISVIpiP---EG---DMTFVGDV-K--GNRVGQFV---------- 264
gi 504948235 215 ------------------------QaPQIGDIRLSYQSL--P---SDi--QTTVFGELgA--SQSLAPHD---------- 251
gi 662038117 224 ------------------------S-PEIGDLRLSYQAL--N---KNi--QATVFGDLgN--GNQLTPHQ---------- 259
gi 488736699 210 ------------------------EaPKVGDLRISYEAL--PspsPQ---LTLFAAYA-S--SASLAPFS---------- 247
gi 291001673 267 ktlrtlfgfvegslldwqvadlftS-CEAGDIRIKFIDQ--K---PAlgkGVTIIGRQ-VstNGEIELLK---------- 329
gi 504944584 206 ----------------------------AGDVRIHYEGV--P---QLk--NVTVFGKL-D--KNQIVPYP---------- 237
gi 301121146 247 ------------------------E-PVLGDLRVFFEVT--P---NY---PVTVCAKQ-N--GNELMPFR---------- 280
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81779879  290 ------------------TQAgDALLMVDTGNV-PADKMFAEAVSANTLITWLLRAGGLLLLTI---------------- 334
gi 124462088 267 kqnqvqekelsdtqlpnedKPiKQIYWIFQGLF-TPEECLQKVVNENALLFWVFRSIGYILIAV---------------- 329
gi 124452967 175 rdydahertccnlpvpndsKPiKDIYWIFQGLF-TPEECFSKVVNENALLFWVFRSIGYILIAI---------------- 237
gi 81467643  265 ------------------SSEgNKFLNASVGNF-A--ETMADIKSDDNTMKWVGRLIGFIAMFS---------------- 307
gi 504948235 252 ------------------T-RgISVYRLLKG---TREEAIASLASSHKTMTWILRFVGFGMMWA---------------- 293
gi 662038117 260 ------------------GKKnVTFYRLFPG---TRDQAIANLATQHKLITWGLRFGGFLLMWI---------------- 302
gi 488736699 248 ------------------NSEvNGFYRALKGDK---EQAVDYLQTEHNTIRWILRGLGFFLMWM---------------- 290
gi 291001673 330 ------------------ASNgYNVGEVHEGQFnSPRELFDATIS---IYRWSTLLGARILIII---------------- 372
gi 504944584 238 ------------------YKNsRIYNVYYGNRD-AAIAEINSQYKANLGFFLLMPIVGFLLMWIivysyspqptscrltf 298
gi 301121146 281 ------------------SSTgESIFLLEDGIM-TADELFDKKTHAEVRKNRFFRLFAAVLGFM---------------- 325
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 81779879  335 GFALFLSPIGVILDVIPFL----GSMARMGTG--IIAFFLAILVGTTTIAIAWFWYRP 386
gi 124462088 330 GSIILLSPVSQLSQLIQS-----DQLSGFGFI--IYGLIGAIPINIFSICFCWLYYRP 380
gi 124452967 238 GTIILLSPVSFLTDFIPI-----EKLTGISFF--IFGCIAAVPITIFAICFSWVYYRP 288
gi 81467643  308 SFTLMAGPLTSLLSFIPFVgdlgGGLIKVVLG------IVAFIITAITILLIKFWYiw 359
gi 504948235 294 GLSMMVEPLSVVLDFIPFL----GGLSRNASG--FVAFILAAILSSVTILISIILHSP 345
gi 662038117 303 GLNLVIEPLGVVLDVIPFL----GDLTRTATG--FATFIVAAILSGLTIIVSIILHSP 354
gi 488736699 291 GLAMISGPVSVFLDLVPIA----GRISRSLVG--FASFLISAVLSTVTIIVSLIIHsw 342
gi 291001673 373 --------WAVVISLV-ML----GDYITSGTD--I--FLSTISLSSLMIGLVWLsltf 413
gi 504944584 299 GIAIFISIVAIAVSCI--------------TY--NYFWVLFISLLLLVVALRWFQRRi 340
gi 301121146 326 GFLVLRKP---LIERFGP--------LAAGIQqhLLAATMSVALTFSIVGLNWVLYRP 372
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