Conserved Protein Domain Family
GCK

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pfam07802: GCK 
GCK domain
This domain is found in proteins carrying other domains known to be involved in intracellular signalling pathways (such as pfam00071) indicating that it might also be involved in these pathways. It has 4 highly conserved cysteine residues, suggesting that it can bind zinc ions. Moreover, it is found repeated in some members of this family; this may indicate that these domains are able to interact with one another, raising the possibility that this domain mediates heterodimerization.
Statistics
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PSSM-Id: 336815
View PSSM: pfam07802
Aligned: 30 rows
Threshold Bit Score: 69.632
Threshold Setting Gi: 297849644
Created: 26-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75181295   76 EDQKFVEFMKGGGCKESFTAWnDDCnfteEEAEkn----kDLVTKCAGLFGTFSKCMDTHSDY--YHPILAVKKTTEEHL 149
gi 75171274   82 GECPLCQFIKGGECKEAFTEL-ENCc---DEAKkn---neDHVSKCKEARLIFKTCMYDNPVY--YEPLLAGEARAMAKM 152
gi 75171277   51 GECRLCRFIKGGECKESFIAL-EQCv---DEAEesg--eeSDFTKCKEVRAKFKTCMYENPVY--YEPILAGEARAIAKM 122
gi 297850214  74 iELRVSEFMIKGACKESFTAL-KDCv---DEAK-------SHPKKCDEFFPRLNKCMHAHSDY--YQPILALVKASEEMM 140
gi 297845388 102 RDELLGKFITRGGCKEAFMAW-RDSy---EEAKkn---kgSLYTPALN---TLSKCMEAHSDY--YQPLLAVVKNYEEHY 169
gi 685373928  53 EECSFCTYIKAGECKESWIEL-EKCl---DEAKkkd--geSDVTKCKEARKMFKTCIYDNPVH--YEPVIAAETYMFAKM 124
gi 297849644 104 kakqVSEFMRD-PCRESIRSF-RR-----RDAEytrnnntLTFHRKLEAFDTVYKCMEAHSDYnqYQAFLASMKRRYEYY 176
gi 297849806 178 EEERLLAMLKGGGCKESFMAW-LDCs---EEAEkn---kqDFITKCAGVSAKLDKCLDAHSEY--YQPYFAVVKTAEEHM 248
gi 297844160 121 lEEKVLAFMKGGGCEEQCTAW-RDCf---EEAEkn---keDVDIKCAGVHAMWFNCMDAHSDY--FHPFLAPLKTAGEDF 191
gi 297845382 104 RDEMFTKFMIRGDCKEAFMAW-NDFc---KEAKknn--ksCLHTPTMD---TLFKCMKAHSDY--YHPLLTVFKNAEEHF 172

                 ...
gi 75181295  150 EKE 152
gi 75171274  153 LSE 155
gi 75171277  123 LNG 125
gi 297850214 141 KKE 143
gi 297845388 170 SKE 172
gi 685373928 125 LSD 127
gi 297849644 177 DKE 179
gi 297849806 249 ENE 251
gi 297844160 192 EKK 194
gi 297845382 173 KKE 175
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