2WIU,4PU5


Conserved Protein Domain Family
HipA_C

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pfam07804: HipA_C 
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HipA-like C-terminal domain
The members of this family are similar to a region close to the C-terminus of the HipA protein expressed by various bacterial species. This protein is known to be involved in high-frequency persistence to the lethal effects of inhibition of either DNA or peptidoglycan synthesis. When expressed alone, it is toxic to bacterial cells, but it is usually tightly associated with HipB, and the HipA-HipB complex may be involved in autoregulation of the hip operon. The hip proteins may be involved in cell division control and may interact with cell division genes or their products.
Statistics
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PSSM-Id: 336816
View PSSM: pfam07804
Aligned: 393 rows
Threshold Bit Score: 97.7178
Threshold Setting Gi: 123651910
Created: 24-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WIU_A       149 IS-VAGAQEKTALlrigndwcipkgITPTTHIIKLpigeirqpnatldlsqsVDN--------EYYCLLLAKELGLNVPD 219
gi 123355886 159 TS-LGGERPKLTVl-----------hKGQLWIAKLq---------------dRGDppha-plrEFVAMRLAAQCGITAAE 210
gi 500121793 155 TS-AGGERPKVTLq-----------hDGRLWLAKLq---------------dRGDvphl-parEFVVMQMAEELDIQVPR 206
gi 502888514 193 TS-LGGMRPKATVl----------kPDGTLAIAKFp---------------sVNDtrdm-argEVLALLLAKEAGLNASE 245
gi 501205318 182 TS-LGGMRPKSTVv----------dEDGALAIGKFp---------------sVGDarsv-trgEVLALRLAQRAGIDAAP 234
gi 551031961 186 TS-LGGMRPKCTVl----------dEEGQLCIGKFp---------------sVQDrisv-praEVLALRLADLAGIRTAP 238
gi 760000916 174 TS-LGGARPKSTVr----------dTDGRLAVGKFp---------------sQADrrdv-irgEVLAMQLADKAGIRVAP 226
gi 501977468 180 TS-LGGMRPKCSVr----------dDTWGLCLGKFp---------------sIADerpy-tkgEVLALRLARQAGIYAAD 232
gi 497193428 181 TS-LGGMRPKCTVv----------dEDGCLAIGKFp---------------sVHDerpv-tkgEVLAMQLAQAAGIHAAD 233
gi 524781832 153 LSaLPGERFKLGYq----------sGKNKNFISKFn----------------IPDpqrnlviwEAITLSLARRMGLQTVS 206
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WIU_A       220 AEIIKAGnVRA-LAVERFDRRwnaertvlLR---LPQEDMCQTFGLP---SsvkyesdggpGIARIMafLMgs------s 286
gi 123355886 211 VEFVQQg-EREiLLVRRFDRHrdam-gnvfR---SLYASAHTVLRLDtqtRger-----qrSYVGFSheIQrwcglgdvd 280
gi 500121793 207 ILLEQHe-GREvFLVERFDRCgdpv--qpqR---HLFASAHTVLGLEantTpgd----arrSYLVLAeqMRrwi----ad 272
gi 502888514 246 AEVVMAgtQ-AvALIVRFDRPrt-----ggR---IPYLSAASLLQLDsre---------dgAYTQIAeaIDrf------- 300
gi 501205318 235 ARIVEIegT-PvAVIRRFDRDgv-----dgR---IPYQSAASLLQASree---------drSYTEIAdaIRsv------- 289
gi 551031961 239 ARCVLLqgT-PaALIRRFDRTaq-----qqR---IPYLSAASMLQASrne---------drAYSELVdvMRqr------- 293
gi 760000916 227 ARVEVIggT-AvAIIRRFDRTdd-----gaR---IPYVSAATMLQSDgrdAt--------hAYTELVdvLLqa------- 282
gi 501977468 233 ARLVDSdgV-PvALVRRFDRVwdatiakeRR---LLYVSAATLMSLApgdAde-------hAYTEVAdvIRqh------- 294
gi 497193428 234 TRLVASdgL-PvALIKRFDRPqg-----ggR---LMYVSAATMVGAEpddSqd-------hFYTEIVdaLRih------- 290
gi 524781832 207 AELTSMRgm-dtIISKRFDRT--------TDghpIGFASARALLAAHddnH----------SYLEVAdiLNq-------- 259
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WIU_A       287 EAL----KDRYDFMKFQVFQWLIGATDGHAKNFSvFIQ---AGgsYRLTPFYDIISAfpvLggtgihisdlklAMGLNAs 359
gi 123355886 281 TREm-----qRELWRRMAFNALCGNGDDHPRNHG-LVYrdgR---WGLADAFDIAPYitfs---------gtlAMAITRe 342
gi 500121793 273 KAAl--qIDLQELWRRMAYNALVGNGDDHPRNHG-LIHegrG---WRLSKAFDITPLptfi---------rvlALSVAPd 337
gi 502888514 301 spRp--lEDKQELWARICFNMLITNVDDHMHNHG-FLHsggGQ--WRLAPLFDVNPFp-dKep--------ilKTAVTEa 366
gi 501205318 290 ghSp--tADVQQLWRRLVFNLLITNVDDHLQNHG-FLHvenGL--WRLAPAFDINPFp-dKdr--------esKTWLSEq 355
gi 551031961 294 caAp--aDDVRELWRRLLFNLLITNTDDHLQNLG-FLYdgaGH--WRLAPAFDLNPMp-gRlr--------esKTWLSEd 359
gi 760000916 283 gaDp--iAEIHELWRRLVFNFLICNTDDHLRNTG-FLYdarQRg-WRLSPAFDLNPMp-gDrr--------esKTWLTEd 349
gi 501977468 295 saDa--kADLEELWRRMAFSILITNVDDHLHNHG-FLHvegAL--WRLSPAFDVNPFp-dRar--------elKTWISEd 360
gi 497193428 291 gaAa--qDDIDELWRRMAYSILITNVDDHLRNHG-FLHfnrGL--WRLAPAFDLNPFp-dRvr--------elKTWISEe 356
gi 524781832 260 -dGakpkMDLLELWRRMVFNMCVGNVHDTLDNIG-FIRdgdG---WRLSPLYSLKPE----------------PISIPRr 318
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
2WIU_A       360 k-gKKTaidkiyprhflaTA-K--VLR-----FPEVqMHEILSDFARMIPAAL 403
gi 123355886 343 gdsAAT------------Tv-NllKNCdnfgyEKAE-ALHYLEQTMQKISTGW 381
gi 500121793 338 gsqECS------------Vl-NllDACphfgfDPRE-AATWLGDAAVHVASHW 376
gi 502888514 367 sgeTGD------------Iq-EalEAAayfgvSDDD-AHAILTRM-AAALTDW 404
gi 501205318 356 dgpITD------------Le-MllARSayfslSRND-ALAVLAEV-HAAVLDW 393
gi 551031961 360 tgpIDS------------Vv-LliERCahfdlRRDE-ALHTLAEV-HGAVARW 397
gi 760000916 350 tgvIDS------------Rd-MlmAAApyfrlDAVQ-AGAIWSEV-AQSVAGW 387
gi 501977468 361 agpEAS------------Ia-AlmGTApyfnlAPTR-AIEILGEV-EHAVALW 398
gi 497193428 357 sgpEAT------------Id-AllSVIayfriPLRR-AKTILGEV-ERAVSGW 394
gi 524781832 319 hhaTAVtddc-----drpdLsKavEIApyfgiSQRK-AEALALEISSFCAQNW 365
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