Conserved Protein Domain Family
HipA_C

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pfam07804: HipA_C 
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HipA-like C-terminal domain
The members of this family are similar to a region close to the C-terminus of the HipA protein expressed by various bacterial species. This protein is known to be involved in high-frequency persistence to the lethal effects of inhibition of either DNA or peptidoglycan synthesis. When expressed alone, it is toxic to bacterial cells, but it is usually tightly associated with HipB, and the HipA-HipB complex may be involved in autoregulation of the hip operon. The hip proteins may be involved in cell division control and may interact with cell division genes or their products.
Statistics
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PSSM-Id: 311653
View PSSM: pfam07804
Aligned: 449 rows
Threshold Bit Score: 56.4657
Threshold Setting Gi: 123651910
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4PU3_B       256 RRHIVDSCQALGFSVSK-----KYErnfgtgrdvkdiregVSFNRLFslaaK-CRNPVAAKQDMLQWALFNLLTGNADAH 329
gi 81376920  140 kLALEDFAQLSGEDRHT-----KYK---------------SSMEKVIavieQfCTFPKIEFVKLFKLTLFNFLVGNEDMH 199
gi 123046441 240 RTPQEDACQVMGMFPAA-----KYRlk-----------teSVITALAgvceRgGGSARVATLELLRLVAYSYAIGNGDLH 303
gi 81760925  216 kIPVEDAGQVLGIWPAD-----KYlvs-----------yeDIAQALTk----vCASPILAMRNLAFQIAVAWLSGNGDLH 275
gi 504358975 140 RIHQEDFAQVADLCSQNagsnfKYEs--------------ISYEEIAglikQhVSAYIVAAEEFFKIILFNYLVCNGDAH 205
gi 407310246 182 RLAQEDACQVLGRYPAA-----KYRit-----------lqEAIKALAdavtAgRGSAPFAVLTMLEIAAFSYLIGNGDLH 245
gi 644663827 243 KLAQEDACQVGGRYPAA-----KYRvt-----------lqDAMKSLAeavaAgGGSYPLAIVRMLEIAAFSYLIGNGDLH 306
gi 518343214 238 RLAQEDACQVANVYPAS-----KYRik-----------teVAIIGLAeacaRgGGSRTAAVAELLKTVVFSWLIGNGDLH 301
gi 524146570 147 mLAMEDFCQLDLRLTQD-----KYR---------------GSYERCAkiiqKySSRSGLDITEFFMRIVFSFIVGNSDMH 206
gi 503800011 139 kYAVEDFAQLTGNTRDT-----KYR---------------FTMERVVpvvdEfCSFPVVEKADFFKRIIFCYVTGNEDMH 198
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4PU3_B       330 GKNYSFFmtpsGM------EPTPWYDLVSVDMYedfe-qqlAMAIDDefdpNs---------IYAYQLAA--FM-DGLGL 390
gi 81376920  200 LKNFSLItkd------rkiSISPAYDLLNSTIAqkntkeelALPLKGkk-----------nnLTKSDFLKyfAI-EKLGL 261
gi 123046441 304 GKNFSVQ----LAasg-lwSVTPAYDLLCTQPYlgwr-dpmALDFYGka-----------nkLNRRHFVE---SgGRLGV 363
gi 81760925  276 AKNISII-----Nkgr-gfEISPIYDIPATAVYgdt---tmALEIQGsk-----------kdLSQKKFLK--FC-TSIGL 332
gi 504358975 206 IKNFSIYs---PNkeg-vfVLTPAYDLLNTSLHasd--ermALDLFAdeedYesdffsangfYGAPDFME--FA-KRIGI 276
gi 407310246 246 GKNLSVR----QSpdg-iwEVTPAYDLLSSQPYlnwa-dpmALSLYGrd-----------akLTYRWWKE---AaTRMGV 305
gi 644663827 307 GKNLSIR----QNptg-lwEVTPAYDLLTTQPYlswn-dpmALSLYGrd-----------gkLIYRWWIE---AaHHLGV 366
gi 518343214 302 GKNLSIY-----Npng-iwQPTPAYDLLCTQPYagwr-dpmALNLYGra-----------nkLNRANFIE---AgERLGL 360
gi 524146570 207 LKNFSLIe---TDegsgeyILSPAYDLLPVNVImpedkeqfALPMNGkk-----------mnIRKKDFLI--FA-DECGI 269
gi 503800011 199 LKNFSLItkn------gktTLAPAYDLLNSTISiknpeeeiALTLKGkk-----------snFIASDFIGyyAK-ERLQL 260
                        170       180
                 ....*....|....*....|.
4PU3_B       391 PRNLLISNLTRIARRIPQAIA 411
gi 81376920  262 NQNVIDGIVQEFHQVIPKWQE 282
gi 123046441 364 PERAVTRMLDGVRKGIGRGIE 384
gi 81760925  333 PEKTAMSVANAALLATENAAE 353
gi 504358975 277 VEKRAERFIREMTNHLDEMNE 297
gi 407310246 306 TERAIKRSMTRIVDASEPWID 326
gi 644663827 367 SERAIRRSLARIVDSSEQWID 387
gi 518343214 361 RQRAVSRMIDAVVDAAEPWPA 381
gi 524146570 270 PHASAEKMIVSLVAMLPKFIA 290
gi 503800011 261 NDRIIEVILGDMYQATPKWKE 281
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