Conserved Protein Domain Family
HipA_N

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pfam07805: HipA_N (this model, PSSM-Id:311654 is obsolete)
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HipA-like N-terminal domain
The members of this family are similar to a region close to the N-terminus of the HipA protein expressed by various bacterial species. This protein is known to be involved in high-frequency persistence to the lethal effects of inhibition of either DNA or peptidoglycan synthesis. When expressed alone, it is toxic to bacterial cells, but it is usually tightly associated with HipB, and the HipA-HipB complex may be involved in autoregulation of the hip operon. The hip proteins may be involved in cell division control and may interact with cell division genes or their products.
Statistics
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PSSM-Id: 311654
View PSSM: pfam07805
Aligned: 391 rows
Threshold Bit Score: 37.132
Threshold Setting Gi: 81534750
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WIU_C       150 SVAGAQEKTALLRIGndwcipkgITPTTHIIKLpigeirqpnatldLSQSVDNEYYCLLLAKELGLNVPDAEIIkagNv- 228
gi 123165136 217 SAGGEFPKFTAFREVa-------GKPIHVIVKFsgsdea-pgtvrwSDLLVCEHLALCAVAEHLGLEAAVSRIHqag--- 285
gi 504241213 219 SAGGEFPKFTAWREGa------dGRPQAVLVKFsgsdds-pgtrrwSDLLVCEHLA-GGVLPVLGLPAAVSRIVqag--- 287
gi 170776295 185 SAGGEFPKFTAYRSLg-------DTASHVIVKFsgsdps-pgtqrwSDLLVCEHLALAVVAEQLQMDASTSRILqag--- 253
gi 503270660 221 SIAGEFPKFTAMRELt------gSATPHVIVKFsgaens-aavtrwRDLLVCEHLALQHIQELPGQIAAPSRILrhn--- 290
gi 502734684 205 SAGGEQPKFTTFAETpd-------gPRHVIVKFtepvdg-lvserwSDLLLAEHLALETLREA-GVAAARTRVIdhg--- 272
gi 654311129 205 SAGGEQPKFVSYVQTpd-------gPRHVIVKFtlddhn-pvtgrwRDLLLAEHLALETLNES-GIPAVRTRIVdsg--- 272
gi 501408852 201 SAGGEQPKFASLAELpd------gsLAPVLVKFtpartn-ensqrwCDLLRAEALALRLMQQH-GLAAARATVI---Aad 269
gi 502965672 197 SAGGEQPKFACYTQLad------geNAHVLVKFtparrn-ensqrwCDLLRAEALALQVLREE-GVSAAEATIL---Sga 265
gi 503273113 201 SAGGEQPKFLCYATTss-------gDRHCLVKFtlarqg-ensqrwRDLLRAEHLALQQLQSS-GLAAARSQLItvg--- 268
                         90
                 ....*....|...
2WIU_C       229 ---rALAVERFDR 238
gi 123165136 286 -grtFLEVERFDR 297
gi 504241213 288 -grtFLEVERFDR 299
gi 170776295 254 -grtFLEVARFDR 265
gi 503270660 291 -nrtFLEVERFDR 302
gi 502734684 273 -qqrFLEVERFDR 284
gi 654311129 273 -fqrFLEIERFDR 284
gi 501408852 270 sgqlFLEVVRFDR 282
gi 502965672 266 eeqlFLEVVRFDR 278
gi 503273113 269 -gqlFLEVERFDR 280
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