Conserved Protein Domain Family
RTP801_C

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pfam07809: RTP801_C 
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RTP801 C-terminal region
The members of this family are sequences similar to the C-terminal region of RTP801, the protein product of a hypoxia-inducible factor 1 (HIF-1)- responsive gene. Two members of this family expressed by Drosophila melanogaster, Scylla and Charybde, are designated by the GenBank as Hox targets. RTP801 is thought to be involved in various cellular processes. Its overexpression caused the apoptosis- resistant phenotype in cycling cells, and apoptosis sensitivity in growth arrested cells. Moreover, the protein product of the mouse homolog of RTP801 (dig2) is thought to be induced by diverse apoptotic signals, and also by dexamethasone treatment.
Statistics
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PSSM-Id: 311657
View PSSM: pfam07809
Aligned: 41 rows
Threshold Bit Score: 116.935
Threshold Setting Gi: 675854108
Created: 20-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3LQ9_A         17 LAQAR-LGSRRPARLLXPSQLVSQVGKELLRLAYSEPCGLRGALLDVCVE---QGkSCHSVGQLALDPSLVPTFQLTLVL 92
gi 240848621   45 LRAAK-RAQLSCGEVLLPPDLLHRIAHDVLKMAESEPCGLRGCTLYLNFEg-eQE--CRKIGTIKCDTNTVSTFELFLTL 120
gi 642931497   75 LRAAK-RTHLSCGEVLLPSGLLHRIARDVLGMAESEPCGIRGCLIYVNFEgv---eQCRKLASFKCDPETATTFELKLTF 150
gi 91088275    39 LKKAK-RAHFACGEVLLPADLTRALAKDVLAKAETEPCGLKGCTIFINFEs-gEEr--RRLSVVNCDPSTPTTFELYLTL 114
gi 91088273    48 iRKAK-RTHLSCGEVLLPCGLLQKVAEDVLEIAETELYGLKGCTLYLLYEg-eED--CRRLSNFKIDPTTPSTFEIYLTF 123
gi 72011141    59 LRKAK-D-KYFNGKLLIPSNLPDHVARDVLLMAREEPCGVRGCSLDIVYEd---GeSCRRLGRVAVDPDTVTTFEITVVV 133
gi 357623322   46 LRAAKgASDLATAEVLVPAELLARAARQALVLAEGEPCGARGAAVLVDV-------AGRRLAAFKIDPNTVTTHEIHLHL 118
gi 125979765  172 LRDAK-QRHLACTEVNLPADLTERIAAEIIRMSDREPCGERACTLFIEFEsepNN--VRRIASFKVDPDTVSIFELYLTL 248
gi 194748158  133 LRAAK-SRHLTCTEVSLPCDLTPNVARDIVRVSEKEPCGIRGCTIYIEFEdepQN--SRRIATIKVDPDTVSTFEVYLTL 209
gi 1009350796  37 LRRAK-HAQLACGEVLLPADLLPKIAKDVLTMAENEPCGLRGCTLFISFEtdsM---CRKLSRIQCDPSTVSTFELYLTL 112
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
3LQ9_A         93 RLDSRLWPKIQGLFSSANSPSQSLT-------LSTGFRVIKKKLYS 131
gi 240848621  121 KQNPRNAWSLIPLFIRNFTSGGTIV-------IDHEFTIEKRKLYr 159
gi 642931497  151 KQNPTGWN------FIPQFLKNLATggt--ivVSPAYVLTKKKLYr 188
gi 91088275   115 RQNVNGWNHF-----LPQFLKKMTRsgt--vmISSEYDLQKKKLYr 153
gi 91088273   124 KQANAGWT------FLPQFLKKITRgst--vvISTEYELTKKKLYr 161
gi 72011141   134 GRVSPKW--------FLTKMQSVLRnsveqtvLKSSYKLVKNKLYr 171
gi 357623322  119 EHDATNWTSL-----LPQFLKNLTRggt--iiISPQFTIEKKKLFr 157
gi 125979765  249 KQDKSGWTS---LLP--QFIKNLTRsnt--inISPDFTLTKNKLYS 287
gi 194748158  210 RQDHRGWTS---LLP--QFMKSLARti----tISPEYTITKNKLYS 246
gi 1009350796 113 KQDHTSWHM---LLP--QFLKNLTRggt--imISRDFTLQKKKLYr 151
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