4K6J


Conserved Protein Domain Family
WAPL

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pfam07814: WAPL 
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Wings apart-like protein regulation of heterochromatin
This family contains sequences expressed in eukaryotic organisms bearing high similarity to the WAPL conserved region of D. melanogaster wings apart-like protein. This protein is involved in the regulation of heterochromatin structure. hWAPL, the human homolog, is found to play a role in the development of cervical carcinogenesis, and is thought to have similar functions to Drosophila wapl protein. Malfunction of the hWAPL pathway is thought to activate an apoptotic pathway that consequently leads to cell death.
Statistics
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PSSM-Id: 336822
View PSSM: pfam07814
Aligned: 67 rows
Threshold Bit Score: 139.723
Threshold Setting Gi: 31340489
Created: 24-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4K6J_A          16 HVKHFNDVVEFGENQEFTDDIEYLLSGLKSTQPL-NTRCLSVISLATKCAMPSFRMHLRAHGMVAMVFKTLdDSQHHQ-- 92
gi 75169646     77 SNSTLMEAQEFGELIENEDEVNFALDGLKKGHKV-RIRRAALSSLLSICESQYQRRSLRALGISQSIIDAIlGLCLDDip 155
gi 541047383   287 NVKEAHQCLESGEHDDYRQDIDYVLSTLLDPASTaNLKCLSVISLAKKCVSAEFRQFFRTENFFPRTIKALtDSASc--p 364
gi 17541846    215 HIKEANELRESGEYDDFKQDLVYILSSLQSSDASmKVKCLSAISLAKKCVSPDFRQFIKSENMTKSIVKALmDSPEDDl- 293
gi 1133447891  643 NVRQAHECLQHGENLRFRDDVIYLLDSMKTEEPL-LVRCLSTLNLAEQCLNVDFMRQMRSLGLVKKSLLLLkDAQTHP-- 719
gi 402594000   280 DVKEAHECLKSGEQDDFSDDVKYILSTLLDSSSSnNLKCLSIISLAKKCVSSEFRRFFRSNNLISRTLKAIpDSPKSP-- 357
gi 954368265   705 NVKQAHECHESGEAQEYNDDVVYLLGALSEENTS-NMRCLSLITLLQKCVSAAFRNFLKAHGYAKQVLYALkDAHGNDvc 783
gi 196004538   227 HVRESHQCLEQGEDEQLADDIEYLLDGLNPSYPK-NLRCSSITALAKRCTESPFRMYIRAHEIIPKILDLLvDSPSDY-- 303
gi 30682037    149 FTSTLLEAQEFGELMEHEDEVNFALDGLRKGHQL-RIRRASLSSLLSICASQHQRRSLRAQGISQSIIDAIlVLSLDDip 227
gi 297742900   104 ataTLMETQEFGEMMEHVDEVNFALDGLRKGQPA-RIRRASLLSLLSICGTAQQRRLLRTQGMAKTIMDAViGLSFDDsp 182
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4K6J_A          93 NLSLCTAALMyilsrdrl-nmdldraS--LDLMIRLLELEQDASsakll---------------------nekdmNKIKE 148
gi 75169646    156 S-NLAAATLFfvlttdgq-ddhfmesPnsIKFLVKLLRPVVSAStkvkprnigsrllsiikdvdaardaasmhdlSSCD- 232
gi 541047383   365 SVAISTSAVIylmardkv-cvsldatS--LRLLSQMLKMEKPKNnd---------------------------eyNKYSK 414
gi 17541846    294 -FALAASTVLylltrdfn-sikidfpS--LRLVSQLLRIEKFEQrpedkd---------------------------kvv 342
gi 1133447891  720 ALKVALVTLSfvmtqsnvepseldkkC--TELLVMALSVKDQFLvspageeeppplegkaateykkitdkskallKKCSP 797
gi 402594000   358 SLALCISVVVyllsrdtt-svfvdapA--LRLFSQLLKLENLNLse---------------------------ecVKYSK 407
gi 954368265   784 CLALATACLFyllsrdrl-clvvdecS--LGLLVNLVKPMKVDVtne--------------------------efLKCKE 834
gi 196004538   304 QLATYTAALFfvlsedrl-imdltddL--LDVLLKLLQCPNQDHndtn-----------------------dailKSSLQ 357
gi 30682037    228 S-NLAAATLFfaltadgq-dehfmesPkcIKFLIKLLKPVIVTStegkprnigfkllsllkdvdaardpvkmddpSSSD- 304
gi 297742900   183 S-NLAAATIFfvltsdsh-ddyllesPtcIRFLLELLKPPMSNAthgkapsigikllglrkdadplrdtnktidsSSTA- 259
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4K6J_A         149 K-IRR-L-CETV------HNkhl---------dlE---------------NITTGHLAMETLl------------SLTSK 183
gi 75169646    233 --IID-RaQEIL------VNc------------kElrlidsy-kiermrpELSTKWVALLVMekaclskisfddtSGTVK 290
gi 541047383   415 M-VWD-VmQEWLdktragLEqevqf-----dfteA---------------TLSPSLLILESLv------------YICTR 460
gi 17541846    343 nmVWEvF-NSYI------EKqevggqkvsfdmrkE---------------SLTPSSLIIEALv------------FICSR 388
gi 1133447891  798 LlIHA-KySDSS------NTn------------eTvdis-------lqpsTLSLGELATECFl------------SLTSS 839
gi 402594000   408 M-VMD-VlKEWL------EKs------------fAnteskkv-qfditekTLSPSFLILESLv------------YICAR 454
gi 954368265   835 K-IWK-VlCDWR------TEv------------eSsnirkvlimfdltekNLNTSFLALESLv------------FISSR 882
gi 196004538   358 N-ISL-ScKDYLkah---------------------------------vdSLNGKALALACIf------------NLVCS 390
gi 30682037    305 --ILS-RvQELL------VNc------------kEmrlndsy-itettrpELSTKWVALLAMeracvskisfddtSGSVK 362
gi 297742900   260 --IVH-KvQEVL------VSc------------kEiksssgd-dngvgrpELSPKWIALLTMekacfstisledtSGTVR 317
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4K6J_A         184 ragdwf--keelrLLGGLDhivDKVKECVDHLsr----------------dEDEEKLVASLWGAERCLRVLESVTVHNPE 245
gi 75169646    291 ksggmf--keklrELGGLDavfDVVMDCHTVMeswvthd------tlsvedIKDDLNKQSLMLLLKCLKIMENATFLSTE 362
gi 541047383   461 nnndqs-lknemlNLGVLQwivSKVDKTVLRLlhek-----------vaepET----LQCLITLERCFWILETCTVYNKK 524
gi 17541846    389 svnddn-lksellNLGILQfvvAKIETNVNLIadn-------------------adDTYSILILNRCFRILESSSVFHKK 448
gi 1133447891  840 mntsvsslkedlrTLGAIDviaNRAIALTRQCtgyltsgqeeegkeeeereGEEREVDVHFMKLFRQLKLLENILCMSKG 919
gi 402594000   455 khreqs-lqsellNVGILQwivSKMDKTVLRLlhe-------------kisDEDMLLC--LKVLERCFRVLESATVCNEK 518
gi 954368265   883 sdsdaf--kqemrLNGGVEiaaLRVADETKKIska--------------kgDEACIYP--LLCLQRALRILENVTTKASQ 944
gi 196004538   391 rnavwl--kdkvrSIGILDvicDLVIDHKYNLe-----------------mNPKANRIIVLREVELCCRILETVTFLNKE 451
gi 30682037    363 ktggnf--keklrELGGLDavlEVVMDCHAVMerwveyd------alsvqeKKDNLHKQSLMLLLKCLKIMENATFLSTD 434
gi 297742900   318 ktggnf--kekfrEFGGLDavfEVAMNCHSTLegwlkhg------spsirdAKDDANLQSLVLLLKCLKIMENAAFLSKD 389
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4K6J_A         246 NQsyliay-----------kdsqlIVSSAKALQHCEELIqqynraedsicladskplphqnvtnhvgkaV---------- 304
gi 75169646    363 NQihllrlnksmgshesrlsftelMISVIKIL------------------------------------------------ 394
gi 541047383   525 NQaylish-----------rgsalIQSCGRLMAFCHETV------------------------------D---------- 553
gi 17541846    449 NQaflish-----------rsnilISSLAKFLQVILDRV------------------------------Hqlaeeevkky 487
gi 1133447891  920 NQsyltmf-----------dgsifISEISKFLvllgdyliskdl------------------------------------ 952
gi 402594000   519 NGaylish-----------rgsalIQSCGRLMsllfrtvgrlgddi---------------------------------- 553
gi 954368265   945 NKgylvtn-----------dslgmLDSLLTLFdfclngiiakeksmpnved----------------------------- 984
gi 196004538   452 NQdyvigw-----------kgytlVGNVSRIFslcvekimsqdkn----------------------------------- 485
gi 30682037    435 NQnhllgfkkclgshdsrmsftelTISVIKML------------------------------------------------ 466
gi 297742900   390 NQshllgmkgkgncngsrlsfiklILSIIKTL------------------------------------------------ 421
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4K6J_A         305 E-------------DCMRAIIGVLLNLTNDN-----EWGSTKtgeQDGLIGTALNCVLQVpk-yLPQEQR-FDIRVLGLG 364
gi 75169646    395 --------------------SGLQLR------------AHRNekhPHPQPHLASAVKKGFvtiiSSDTCS-----TTGFS 437
gi 541047383   554 RlgdkdsafvkaniTCLCRISGILTNLSHEN-----ELCSTKlgqMNSFLPLCMSTFTYLaprfAPDNKR-FDLAVLMSS 627
gi 17541846    488 I-------------SCLALMCRLLINISHDN-----ELCCSKlgqIEGFLPNAITTFTYLap--kfGKENsYDINVMMTS 547
gi 1133447891  953 -----strhtcivtetLLGTLRVFLNITHDN-----ALASYRvgeQEKIIDSICNFTFKLaq-sVPVIQQ-FDILVLCLS 1020
gi 402594000   554 ------nelkeqnitclnrmVGLLMSLSYEN-----ELCCTKlgqMNDFLSLCVSCFTYLvpkyVRKEKQ-FDLIVLLCS 621
gi 954368265   985 -knspsaqvsslllivfselFRLLCNLSNNN-----EICCSKlsaSGGFIRRCVECVTFYipryLPESKR-YDMQILFMS 1057
gi 196004538   486 -------tainedsacllasVRLLLNITHEN-----EIGCKQvgrDKSTIKAAMECIDEIhe-kVDDVRR-FDLVILALG 551
gi 30682037    467 --------------------SGLHLRGGFSSpntnnVNSHYSnggNHDSVLEANRKVTNEvvtiSSDTYS-----TVGSI 521
gi 297742900   422 --------------------SGLSLSKSSSTisideKSRNISdgiSHDSQVDCMADYKGTv------TDS-----VCVLE 470
                          490
                   ....*....|..
4K6J_A         365 LLINLVEYSARN 376
gi 75169646    438 SIKSLSVSKRNQ 449
gi 541047383   628 LLVNLVERCNSN 639
gi 17541846    548 LLTNLVERCNAN 559
gi 1133447891 1021 LLINLLEESSTN 1032
gi 402594000   622 LLVNLLERCNFN 633
gi 954368265  1058 FVINYIEHHQSg 1069
gi 196004538   552 LLINLVESNKES 563
gi 30682037    522 STRNGSVSQRSQ 533
gi 297742900   471 SNGNLFVnysrk 482
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