Conserved Protein Domain Family
WAPL

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pfam07814: WAPL 
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Wings apart-like protein regulation of heterochromatin
This family contains sequences expressed in eukaryotic organisms bearing high similarity to the WAPL conserved region of D. melanogaster wings apart-like protein. This protein is involved in the regulation of heterochromatin structure. hWAPL, the human homolog, is found to play a role in the development of cervical carcinogenesis, and is thought to have similar functions to Drosophila wapl protein. Malfunction of the hWAPL pathway is thought to activate an apoptotic pathway that consequently leads to cell death.
Statistics
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PSSM-Id: 311661
View PSSM: pfam07814
Aligned: 67 rows
Threshold Bit Score: 139.723
Threshold Setting Gi: 31340489
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4K6J_A         16 HVKHFNDVVEFGENQEFTDDIEYLLSGLKSTQPL-NTRCLSVISLATKCAMPSFRMHLRAHGMVAMVFKTLdDSQHHQ-- 92
gi 75169646    77 SNSTLMEAQEFGELIENEDEVNFALDGLKKGHKV-RIRRAALSSLLSICESQYQRRSLRALGISQSIIDAIlGLCLDDip 155
gi 541047383  287 NVKEAHQCLESGEHDDYRQDIDYVLSTLLDPASTaNLKCLSVISLAKKCVSAEFRQFFRTENFFPRTIKALtDSASc--p 364
gi 954368265  705 NVKQAHECHESGEAQEYNDDVVYLLGALSEENTS-NMRCLSLITLLQKCVSAAFRNFLKAHGYAKQVLYALkDAHGNDvc 783
gi 17541846   215 HIKEANELRESGEYDDFKQDLVYILSSLQSSDASmKVKCLSAISLAKKCVSPDFRQFIKSENMTKSIVKALmDSPEDDl- 293
gi 393910292  278 dVKEAHECLKSGEQDDFSDDVKYILSTLLDPSSSnNLKCLSVMSLAKKCVSSEFRRFFRSNNLISRTLKAIpDSPKs--p 355
gi 196004538  227 HVRESHQCLEQGEDEQLADDIEYLLDGLNPSYPk-NLRCSSITALAKRCTESPFRMYIRAHEIIPKILDLLvDSPSDY-- 303
gi 761900802  643 NVRQAHECLQHGENLRFRDDVIYLLDSMKTEEPL-LVRCLSTLNLAEQCLNVDFMRQMRSLGLVKKSLLLLkDAQTHP-- 719
gi 30682037   149 FTSTLLEAQEFGELMEHEDEVNFALDGLRKGHQL-RIRRASLSSLLSICASQHQRRSLRAQGISQSIIDAIlVLSLDDip 227
gi 297742900  104 ataTLMETQEFGEMMEHVDEVNFALDGLRKGQPA-RIRRASLLSLLSICGTAQQRRLLRTQGMAKTIMDAViGLSFDDsp 182
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4K6J_A         93 NLSLCTAALMyilsrdrl-nmdldraS--LDLMIRLLELEQDASsakll---------------------nekdmNKIKE 148
gi 75169646   156 S-NLAAATLFfvlttdgq-ddhfmesPnsIKFLVKLLRPVVSAStkvkprnigsrllsiikdvdaardaasmhdlSSCD- 232
gi 541047383  365 SVAISTSAVIylmardkv-cvsldatS--LRLLSQMLKMEKPKNnd---------------------------eyNKYSK 414
gi 954368265  784 CLALATACLFyllsrdrl-clvvdecS--LGLLVNLVKPMKVDVtne--------------------------efLKCKE 834
gi 17541846   294 -FALAASTVLylltrdfn-sikidfpS--LRLVSQLLRIEKFEQrpedkd---------------------------kvv 342
gi 393910292  356 SLALCISVVVyllsrdt---tsvfvdGaaLRLFSQLLKLEHPNPne---------------------------dcVRYSK 405
gi 196004538  304 QLATYTAALFfvlsedrl-imdltddLldVLLKLL--QCPNQDHndtn-----------------------dailKSSLQ 357
gi 761900802  720 ALKVALVTLSfvmtqsnvepseldkkC--TELLVMALSVKDQFLvspageeeppplegkaateykkitdkskallKKCSP 797
gi 30682037   228 S-NLAAATLFfaltadgq-dehfmesPkcIKFLIKLLKPVIVTStegkprnigfkllsllkdvdaardpvkmddpSSSD- 304
gi 297742900  183 S-NLAAATIFfvltsdsh-ddyllesPtcIRFLLELLKPPMSNAthgkapsigikllglrkdadplrdtnktidsSSTA- 259
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4K6J_A        149 K-IRR-L-CET--------V------HN-----K-------Hld----lE--------------NITTGHLAMETLl--- 178
gi 75169646   233 --IID-RaQEI--------L------VN-----C-------K-------ElrlidsykiermrpELSTKWVALLVMekac 276
gi 541047383  415 M-VWD-VmQEW--------LdktragLE-----Q-------EvqfdfteA--------------TLSPSLLILESLv--- 455
gi 954368265  835 KiWKV-L-CDWrtevessnI------RK-----V-------LimfdlteK--------------NLNTSFLALESLv--- 877
gi 17541846   343 nmVWEvF-NSY--------I------EKqevggQ-------KvsfdmrkE--------------SLTPSSLIIEALv--- 383
gi 393910292  406 MvMDV-L-KEW--------L------EK-----SfanteskKvqfditeK--------------TLSPSFLILESLv--- 447
gi 196004538  358 N---------I--------S------LS-----C-------KdylkahvD--------------SLNGKALALACIf--- 385
gi 761900802  798 LlIHA-KySDS--------S------NT-----N-------E-------Tvdis------lqpsTLSLGELATECFl--- 834
gi 30682037   305 --ILS-RvQEL--------L------VN-----C-------K-------EmrlndsyitettrpELSTKWVALLAMerac 348
gi 297742900  260 --IVH-KvQEV--------L------VS-----C-------K-------EiksssgddngvgrpELSPKWIALLTMekac 303
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4K6J_A        179 ---------SLT-S---------Kragdwf--keelrLLG--------GL-DhivDKVKECVDHLsr------------- 215
gi 75169646   277 lskisfddtSGT-V---------Kksggmf--keklrELG--------GL-DavfDVVMDCHTVMeswvthd------tl 329
gi 541047383  456 ---------YIC-T---------Rnnndqs-lknemlNLG--------VL-QwivSKVDKTVLRLlhek----------- 495
gi 954368265  878 ---------FIS-S---------Rsdsdaf--kqemrLNG--------GV-EiaaLRVADETKKIskak----------- 916
gi 17541846   384 ---------FIC-S---------Rsvnddn-lksellNLG--------IL-QfvvAKIETNVNLIa-------------- 420
gi 393910292  448 ---------YICaR---------Kh-----------rEQSlqsellnvGIlQwivSKMDKTVLRLlhek----------- 487
gi 196004538  386 ---------NLV-CsrnavwlkdKv-----------rSIG--------IL-DvicDLVIDHKYNLe-------------- 421
gi 761900802  835 ---------SLT-S---------SmntsvsslkedlrTLG--------AI-DviaNRAIALTRQCtgyltsgqeeegkee 886
gi 30682037   349 vskisfddtSGS-V---------Kktggnf--keklrELG--------GL-DavlEVVMDCHAVMerwveyd------al 401
gi 297742900  304 fstisledtSGT-V---------Rktggnf--kekfrEFG--------GL-DavfEVAMNCHSTLegwlkhg------sp 356
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4K6J_A        216 ---dEDEEKLVASLWGAERCLRVLESVTVHNPENQsyliay-----------kdsqlIVSSAKALQHCEELIQqynraed 281
gi 75169646   330 svedIKDDLNKQSLMLLLKCLKIMENATFLSTENQihllrlnksmgshesrlsftelMISVIKIL--------------- 394
gi 541047383  496 vaepET----LQCLITLERCFWILETCTVYNKKNQaylish-----------rgsalIQSCGRLMAFCHETVD------- 553
gi 954368265  917 gdeaC-----IYPLLCLQRALRILENVTTKASQNKgylvtn-----------dslgmLDSLLTLFDFCLNGII------- 973
gi 17541846   421 -----DNADDTYSILILNRCFRILESSSVFHKKNQaflish-----------rsnilISSLAKFLQVILDRVHqlaee-- 482
gi 393910292  488 isddDT----LLCLKVLERCFRVLESATVCNEKNGaylish-----------rgsalIQSCGRLMSLLFRTIG------- 545
gi 196004538  422 ---mNPKANRIIVLREVELCCRILETVTFLNKENQdyvigw-----------kgytlVGNVSRIFSLCVEKIM------- 480
gi 761900802  887 eereGEEREVDVHFMKLFRQLKLLENILCMSKGNQsyltmf-----------dgsifISEISKFLvllgdyliskdl--- 952
gi 30682037   402 svqeKKDNLHKQSLMLLLKCLKIMENATFLSTDNQnhllgfkkclgshdsrmsftelTISVIKML--------------- 466
gi 297742900  357 sirdAKDDANLQSLVLLLKCLKIMENAAFLSKDNQshllgmkgkgncngsrlsfiklILSIIKTL--------------- 421
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4K6J_A        282 sicladskplphqnvtnhvgkavE------------------D-------------CMRAII-----GVLLNLTNDNewg 325
gi 75169646   395 -------------------------------------------------------------S-----GLQLR-------- 400
gi 541047383  554 -----------------------Rlgdkdsa-----fvkaniT-------------CLCRIS-----GILTNLSHEN--- 584
gi 954368265  974 -----------------------AkeksmpnvedknspsaqvS-------------SLLLIVfselfRLLCNLSNNNeic 1017
gi 17541846   483 ------------------evkkyI------------------S-------------CLALMC-----RLLINISHDN--- 505
gi 393910292  546 -----------------------R------------------HgddtnelkeqnitCLNRMV-----GLLMSLSYEN--- 576
gi 196004538  481 -----------------------S------------------Qdkntai--nedsaCLLASV-----RLLLNITHENeig 512
gi 761900802  953 ----------------------------------------------strhtcivtetLLGTL-----RVFLNITHDN--- 978
gi 30682037   467 -------------------------------------------------------------S-----GLHLRGGFSSpnt 480
gi 297742900  422 -------------------------------------------------------------S-----GLSLSKSSSTisi 435
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4K6J_A        326 stKTGEQD-----GLIGTALNCVLQVpk-yLPQEQR-FDIRVL----------------------GLGLLINLVEYSARN 376
gi 75169646   401 ----AHRNekhphPQPHLASAVKKGFvtiiSSDTCS-----TT----------------------GFSSIKSLSVSKRNQ 449
gi 541047383  585 --ELCSTKlgqmnSFLPLCMSTFTYLaprfAPDNKR-FDLAVL----------------------MSSLLVNLVERCNSN 639
gi 954368265 1018 csKLSASG-----GFIRRCVECVTFYipryLPESKR-YDMQIL----------------------FMSFVINYIEHHQSg 1069
gi 17541846   506 --ELCCSKlgqieGFLPNAITTFTYLap--kfGKENsYDINVM----------------------MTSLLTNLVERCNAN 559
gi 393910292  577 --ELCCTKlgqmnDFLSLCVSCFTYLvpkyVR-KEKqFDLIVllcsllvnllercnfnrrkligltvpvydlenkaerqe 653
gi 196004538  513 ckQVGRDK-----STIKAAMECIDEIhe--kVDDVRrFDLVIL----------------------ALGLLINLVESNKES 563
gi 761900802  979 --ALASYRvgeqeKIIDSICNFTFKLaq-sVPVIQQ-FDILVLvslllkvknnaihmliainilhCLSLLINLLEESSTN 1054
gi 30682037   481 nnVNSHYSnggnhDSVLEANRKVTNEvvtiSSDTYS-----TV----------------------GSISTRNGSVSQRSQ 533
gi 297742900  436 deKSRNISdgishDSQVDCMADYKGTv------TDS-----VC----------------------VLESNGNLFVnysrk 482
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