Conserved Protein Domain Family
PGAP1

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pfam07819: PGAP1 
PGAP1-like protein
The sequences found in this family are similar to PGAP1. This is an endoplasmic reticulum membrane protein with a catalytic serine containing motif that is conserved in a number of lipases. PGAP1 functions as a GPI inositol-deacylase; this deacylation is important for the efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi body.
Statistics
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PSSM-Id: 311666
View PSSM: pfam07819
Aligned: 19 rows
Threshold Bit Score: 156.756
Threshold Setting Gi: 81544604
Created: 25-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335485   109 KLSGVPVLFIPGNAGSYKQVRSVAAESDRAFQGgpfertfyqeasllrgggadtesVDYD-------------------- 168
gi 74632922    73 EVGGRPVLFVPGNGGSMRQIRSIAGEAAVQYWHdprragadadtwangstarpksaLQKLntfafgdtesdtegvrglgd 152
gi 81544604    10 EGSGETVVLIHGLFGSLDNLGLLARDLKNDHQV-----------------------LSLD-------------------- 46
gi 82181302    77 TLTGVPVLFLPGNAGSYKQARSFASVA-----------------------------LRKA-------------------- 107
gi 74758940    82 PLTGIPVLFLPGNAGSYKQVRSIGSIA-----------------------------LRKA-------------------- 112
gi 74800250    76 LFTGAPVLFVPGSGGSYKQVRSLASVA-----------------------------LRKG-------------------- 106
gi 75027962    79 RMTGAPVIFVPGNAGSYKQVRSLASVA-----------------------------LRKA-------------------- 109
gi 75115871    79 NLNGVPVLFIPGNGGSYKQVRSLAAESFRAYQNgpleptfyre---astafsvnelEGFS-------------------- 135
gi 74625904   151 EPSGIPILFIPGNAGSYKQVRAFAAQAAHVYANay-------------------aeDADG-------------------- 191
gi 392920696   92 EAGQIPVLFIPGSQGSGKQIRSLASVM-----------------------------QNKT-------------------- 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335485   169 ------------------------LPSQYSNR--LDWFAVDLEGEHSAMDGRILEEHTEYVVYAIHRILDQYkeshdtre 222
gi 74632922   153 avtardmsgddrrdaverplsngkLPSQWPDDlpLDFFTVNFQEDLTAFDGTTVIDQAEYLNQAIAYILSLY-------- 224
gi 81544604    47 ------------------------LRNHG-----LSFHSDEHNYALMAQDVNQLLEHLNL-------------------- 77
gi 82181302   108 ------------------------ENIGNRYH--FNIFTVNFNEELVALYGGSLRRQTRFVHECIKTILSLY-------- 153
gi 74758940   113 ------------------------EDIDFKYH--FDFFSVNFNEELVALYGGSLQKQTKFVHECIKTILKLY-------- 158
gi 74800250   107 ------------------------LDNNWQAH--LDYFSVDLNEELSGVYGGYLQDQTDFLDLCIQEITRLY-------- 152
gi 75027962   110 ------------------------MSNDAGIH--LDYYTIDYDEELSALYGGYLHRQQSYLKLCIRTILSIY-------- 155
gi 75115871   136 ------------------------IPSRYGRM--LDWFAVDLEGEHSAMDGRILEEHTEYVVYAIHRILDQYkeshlars 189
gi 74625904   192 ------------------------TLNAGKLV--PDFFVVDFNEDFSAFHGQTLLDQAEYVNDAIPYILSLYrqnrki-s 244
gi 392920696  123 ------------------------EMRYAPFS--FRFFAVDFDEEMTFMNGHIVKRQIEYVMKAIRKIQSMM-------- 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335485   223 regaAASSKLPHDVILVGHSMGGFVARAAAVHPRLRKSAVQTILTLS-SPHQSPPLALQPSLGHYFAQVNREWKKG---- 297
gi 74632922   225 ----SSHPNPPTSVIVIGHSMGGIVARTMVTLDSYIHGSINTILTLA-TPHVLPPVSFDKGIVGLYHNVNEFWKTE---- 295
gi 81544604    78 -----------TSVVVIGHSMGGKVA---MKLADIAAEKVRQLVVLDmSPVAYSQRRHD----NVFAGLEAV-------- 131
gi 82181302   154 ----KNQTFPPESVAIIGHSMGGLVARALFTLKHFKPDLINVIITQA-TPHILPVLSTDIYLTDFYTMVNNYWI------ 222
gi 74758940   159 ----KGQEFAPKSVAIIGHSMGGLVARALLTLKNFKHDLINLLITQA-TPHVAPVMPLDRFITDFYTTVNNYWILN---- 229
gi 74800250   153 -----GARGRTTRLFIVGHSVGGKLAQAVVGARTSIGRHVAGIVTLS-APVDKPVALFDHYHYSFYDRIEQAWRTN---- 222
gi 75027962   156 -----EGRTEQPSIVLIGHSMGGKLAQSVLVDPA-IGQHINTIISIS-TPLDQPVLNLDTQLEEFYDQTDAVLSKLrtat 228
gi 75115871   190 kgraQSSDNLPSSVILVGHSMGGFVARAALVHPGLRKSAVETILTLS-SPHQYPPIALQPSLGQFFLHVNEEWRNG---- 264
gi 74625904   245 seydNEAFPPPTSVILLGHSMGGIVAQATFTMKNYVDGSVNTLITLA-TPHAMAPLPFDRHLVEFYESIKNFWSQS---- 319
gi 392920696  169 ----RGNRK----IVLVGHSYGGMIALLTTIYPEYQKD-VELIIVKG-APLNKQPLVNDWFSLRFNLLLVNQWNAL---- 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75335485   298 -------------YEVQTSPGgnyv-sdplLSGVVVVSISGGYNDYQVRSKLESLDGIVPSSHGFMISSTSMTNVWLSME 363
gi 74632922   296 -------------TVPGGK-----------LEDTLLVSVTGGIRDQMIPAEYSSVDTFLPPTNGFAVATTSIPDVWMSID 351
gi 81544604   132 -----------------------------------LVQKPTSRSEVMAILAQHIEQEGVRQFLGKSLMS----------E 166
gi 82181302   223 -------------YNSLK------------LRNITMLSVAGGYSDYQVRSGLTFLPTSSFHTSALSVVSSAVPITWASTD 277
gi 74758940   230 -------------ARHI---------------NLTTLSVAGGFRDYQVRSGLTFLPKLSHHTSALSVVSSAVPKTWVSTD 281
gi 74800250   223 -------------RSLAGAANaspshgllpLDGILFVTIGGGIRDIIVHDGLTA-----SRYADLHAMTHNIPNVWLSVD 284
gi 75027962   229 vptmttnvcdslhQRPPSVQRmasqdssarLDNVLLISTGGGNRDLLVRPGLTS-----SRFNDLHAMTSAIPKVSLSCD 303
gi 75115871   265 -------------YKTGLSRTss-----akLSNVVVVSVAGGIHDYQVRSKLALLDGIVPSTHGFMVGSSSMKNVWLSME 326
gi 74625904   320 -------------FLLSPEENs--------LDDVLLVSIAGGGLDTHVVPEYSSISTFVPPSNGLMVFTSGIPSVWAEID 378
gi 392920696  235 -------------QN----NN---------LSHVGVVAYSGGIRDYMIPDEWSILRNV---TNRPLWAIDGVSD--LGAD 283
                         330       340
                  ....*....|....*....|.
gi 75335485   364 HQAILWCNQLVVQVSHTLLSM 384
gi 74632922   352 HQAMVWCHQLRRVVAETLLVV 372
gi 81544604   167 QNVMTW----RFNVAALKAHY 183
gi 82181302   278 HLSIVWCRELVLVTARALFDL 298
gi 74758940   282 HLSIVWCKQLQLTTVRAFFDL 302
gi 74800250   285 HLCAMWCLQFVLVMNRFLFSM 305
gi 75027962   304 HLSAVWCLQFMQAINRFLFSV 324
gi 75115871   327 HQSILWCNQLVVQVAHTLLSM 347
gi 74625904   379 HQAMAWCENFRRVLIRGIFAI 399
gi 392920696  284 HLAILWCNEFVRHVSRVLWSY 304
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