Conserved Protein Domain Family
CPDase

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pfam07823: CPDase 
Cyclic phosphodiesterase-like protein
Cyclic phosphodiesterase (CPDase) is involved in the tRNA splicing pathway. This protein exhibits a bilobal arrangement of two alpha-beta modules. Two antiparallel helices are found on the outer side of each lobe and frame an antiparallel beta-sheet that is wrapped around an accessible cleft. Moreover, the beta-strands of each lobe interact with the other lobe. The central water-filled cavity houses the enzyme's active site.
Statistics
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PSSM-Id: 311669
View PSSM: pfam07823
Aligned: 7 rows
Threshold Bit Score: 203.46
Threshold Setting Gi: 74685924
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723762     1 M-AIALWYCPPQGSVAYETLQMLI-FSFQTLFPDS----------------PVFEPHVTVTSHLVCN-----SKDDVNKI 57
gi 74610247    1 M-SIALWYCPAPGTLDYEVLKTLI-NSLQLLVPGS----------------PSFEPHLTVVTHLQVQ-----NRGDVSKV 57
gi 74693841    1 M-AVALWYCPPANSPCYDTVNSLI-LSLQTLFPDA----------------VLFEPHVTITSQLRCD-----SADDAAAV 57
gi 74616270    1 MpGSSLWLIPPPSHPLYPILSFLIsQHLPSDFPSEagaad------arlipEFFAPHMTLSSGISPDl----YGDDPQRW 70
gi 223590184   1 M-GTSLWLQPPRNSPIWQQLATTI-QGLKPIFSDS----------------ENFEPHITLTSNISVN-----TQGQVDFV 57
gi 74685924    1 M--------PSA--NEKLHYQHLI-NRLSKLYNETicqkdedegrtrgsasPSFEPHITLFAFIPLDtpvgeISNTLRQV 69
gi 74607776    1 M-GISLWLCPYGHSPEYETFKTLI-ESLQTLFPNS----------------PVFEPHVTVCSGLSCE-----NMEEVHKV 57
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723762    58 LTS-CVAAIQSIRSHQtakkgrkgqvshavaaPLVSFNGCSVGKQYFKKIVLECNKNKILYGVAQVMREMYVEIDPETRs 136
gi 74610247   58 LQS-CSSCLKTIPKGH----------------SLIKYSNWSINKQYFKKIVLECEKDKYLLSLAQLMRELYVEIEDQKR- 119
gi 74693841   58 LAA-ACAALRACRPQLdar-----------gsPVVRFDAVAVGRRYFDKVHLACAHDRFLYGVAQVIRELFVQDPPDPA- 124
gi 74616270   71 LDSiPWPSADEV---------------------QVRFEGISSQDTYYRRCYARVKLDEGIKKIAGLARARGVNGEDDAKg 129
gi 223590184  58 LDR-AVAAAKCVPQGF-----------------QIHLSSVKYGSRFFKKVYLQVEPTPELLSLARICREDFVYMPEAMSq 119
gi 74685924   70 VARvTGSGLSSLGGGGh---------------FALGLLPAQSGRSYFQSVLAPVQPTAELLSLYDQTVAAFPPASPSSSp 134
gi 74607776   58 LEM-AHHAINAVKSKVds------------enALVEFDGFNIGKKYFEKCRLECKPNPMLYSLAKLIRSMFVGEL----- 119
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723762   137 --------------------sRAATWVHEEFHPHVSLLYSDiHPVSQ--ASLRVVQQRIEDALDVQLVprekrkgsgnad 194
gi 74610247  120 ---------------------RAEHWVIEEFQPHVSLMYND-SQITK--ATEMVVRQRIHDAMQLFSN------------ 163
gi 74693841  125 ---------------------AAADWVHSSFRPHLSLVYSDlYHVDQ--ALLRVLRQRIGDALGAALLphppapg----- 176
gi 74616270  130 ak-----------------tqEWLEWWRKEFGPHVSLMYGDvPISDDrlKEVAKVVEEAGVKLAEPEG------------ 180
gi 223590184 120 arnyqamsaeerqkidtqvgqRAAEWTRNEYDPHVSLVYSDlYPVED--ADRRTIETRLEDTFGSGYD------------ 185
gi 74685924  135 ---------------------DEKKKKKGGYFPHLSLFYGDcSLAKR--DEIAAIANGEDPCL----------------- 174
gi 74607776  120 ---------------------NIDTWLFEEFHPHLSLAYSDiYPMDQ--AMIRLIRQRIEDLFDVTTEeieshsr----- 171
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 1723762   195 gsnevqmrwdfdVSSSLSWNipgTFKVVNCVGPVQEWEVLGRVDV 239
gi 74610247  164 ------------NPSSKSWR---TFKVVSCEGPVEEWQVLGSVTL 193
gi 74693841  177 -----lqalwalQPPLDGWSipgSFKVVRCEGPVRDWHVLAAADL 216
gi 74616270  181 ------------NVEGNGWNg-gVVWLVPTDRDIRDWKPIAKRVL 212
gi 223590184 186 -------------ESGLGWKn-gRFALVRCEGPVDEWEVLGVRDF 216
gi 74685924  175 -------------GSGQATVtinELGIVKCAGEVEEWQLVESIVL 206
gi 74607776  172 -----dqdayklQHTLKGWSfplTFKVVRCEGPVEEWEVLSEVTV 211
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