Conserved Protein Domain Family
PP2C_C

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pfam07830: PP2C_C 
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Protein serine/threonine phosphatase 2C, C-terminal domain
Protein phosphatase 2C (PP2C) is involved in regulating cellular responses to stress in various eukaryotes. It consists of two domains: an N-terminal catalytic domain and a C-terminal domain characteristic of mammalian PP2Cs. This domain consists of three antiparallel alpha helices, one of which packs against two corresponding alpha-helices of the N-terminal domain. The C-terminal domain does not seem to play a role in catalysis, but it may provide protein substrate specificity due to the cleft that is created between it and the catalytic domain.
Statistics
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PSSM-Id: 311672
View PSSM: pfam07830
Aligned: 44 rows
Threshold Bit Score: 89.8555
Threshold Setting Gi: 761908665
Created: 19-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1A6Q_A       285 SVILICFPNAPKVSPEAVKKEAELDKYLECRVEEIIKk--qGEG--VPDLVHVMRTLA--S-E--N--IPSLPPGGELAS 353
gi 568250736 277 SIIIIAFPGAPVPSEEAQKREQALEAILRQRIEARLQq-----Ms-DVNFGDLLKELA--S-E--D--IPDLPPGGGIYA 343
gi 969463717 277 SIIIIAFPGAPKPTEEAIEAEHRLEKQIEKITRDEIEs-----Nq-ITDYLDLLKCMQ--NkD--D--IEGLPPGGGLQS 344
gi 195997001 312 SIILITFDGAITVDENAKLMEQELDRKIVKEVTDIHNr----LGs-NCNLYQVMTELS--Q-D--D--SLRLPPGGGIEC 379
gi 844868189 283 SVLLVALDAAPTVNPEAVCKEMELDTSLNNMIVDIINs--aGEDanFLNVDYVASAVK--S-M--N--LPNYPPGG-FNT 352
gi 211938619 286 tllllllPGAPKVDMDAVKAERSLDQTIVQITKEVIEkh------eIHDFETLIRLMK--R-MaiN--IPNLPPGGGLYA 354
gi 198416840 290 TLVLLALPSIPKPNDKAKEEEAKLDEQLRSLMKEACDevknTRGd-NMDFSLVLQTLV--G-D--EskIQGLPPGGGIYS 363
gi 576692643 285 TMLIVGLDSMPTPDPEMTKLDKELNTAIREMIENVIEm--yKDTd-RFTSSSISNVIE--N-R--S--LPNYPPGG-LVT 353
gi 269972995 272 TLMIVILPGAPTIDKDAVAADKNLDKNIAQMAREVMA-----KNe-IFDYEVLVHIMKrmA-S--N--IHNLPPGGGIFS 340
gi 198473066 273 SLLLVLLPGAPSVNVDAVAADQRLDHTIEQLTREAIQ-----KNe-LLDFEELLSLMHgmA-L--N--ITNLPPGAGIYA 341

                 ....*..
1A6Q_A       354 KRNVIEA 360
gi 568250736 344 KSTFVSd 350
gi 969463717 345 KYHVIER 351
gi 195997001 380 KQLLVEK 386
gi 844868189 353 KRAYVEN 359
gi 211938619 355 KYYIIEQ 361
gi 198416840 364 KRAFLEK 370
gi 576692643 354 KRALIES 360
gi 269972995 341 KYHVIEQ 347
gi 198473066 342 KYHIIER 348
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