1QD1


Conserved Protein Domain Family
FTCD_N

?
pfam07837: FTCD_N 
Click on image for an interactive view with Cn3D
Formiminotransferase domain, N-terminal subdomain
The formiminotransferase (FT) domain of formiminotransferase- cyclodeaminase (FTCD) forms a homodimer, and each protomer comprises two subdomains. The N-terminal subdomain is made up of a six-stranded mixed beta-pleated sheet and five alpha helices, which are arranged on the external surface of the beta sheet. This, in turn, faces the beta-sheet of the C-terminal subdomain to form a double beta-sheet layer. The two subdomains are separated by a short linker sequence, which is not thought to be any more flexible than the remainder of the molecule. The substrate is predicted to form a number of contacts with residues found in both the N-terminal and C-terminal subdomains.
Statistics
?
PSSM-Id: 336833
View PSSM: pfam07837
Aligned: 171 rows
Threshold Bit Score: 111.765
Threshold Setting Gi: 552842641
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1QD1_A          6 CVPNFSEGKNQEVIDAISRAV------AQT------PGCVLLDVDSGPSTNRTVYTFVGRPEDVVEGALNAARAAYQLID 73
gi 612020332   13 CLLNISEARRKNLVEKIAKAAlfeengKEY------SEVTVLNIFSDHDYNRSVITIAATIEKLGSAVLATCVEAFQVID 86
gi 1079730173  13 CLLNISEARRKDLVETVAKAA------LYNtegvrrEGTTVLNIFNDHDYNRSVITIVAGIDSIREAVLSACEKACGLID 86
gi 992184647   12 CLLNISEARQKSLVESVAQAAitdkhgRRR------KGTTVLNIFSDYNYNRSVITIVASITLIKEAVFCACEKAFSLID 85
gi 115497136   13 CLLNISEARRKDLVETVARSA------ITDikgekrEGVTVLNIFNDSDYNRSVITVVANIELIREAVLSACECACSLID 86
gi 410897499   13 CLLNVSEARKKDLVETVAKAA------VYDtdgvrrDGTTVLNIFNDRGYNRSVITIVASVDSIREAVLSACVKACGLID 86
gi 163914889   13 CLLNVSEARKKYVVEKIARAA------LYDkngkmhPNTAVLNIFSDYDYNRSVITIAATAEQIGKSVLSACIEGFASID 86
gi 573897544   12 CLLNISEARSKEVVERVARAA------VYEkqggrrEGITVLNIFSDHDYNRSVITIVATIDQIGGAIVSACVQACELID 85
gi 637343755   15 CLLNVSEGRRKDVVEKIAKAA------VCKdkgqecLQATVLNIFSDYEYNRSVITIAAPIDRLGSSVVAACMEAFSSID 88
gi 556956705   13 CLLNISEARRKDIVEKVAKAA------IQNkhglrnLQATVLNIFSDFDYNRSVITIAAPIDEIGNSVVAACVEAFQSID 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1QD1_A         74 MSRHHGEHPRMGALDVCPFIPVr-gVTMDECVRCAQAFGQRLAEE-L-GVPVYLYGEAARtaGRQSLPALRA--G--EYE 146
gi 612020332   87 MEVQEGIHPCLGAVDLIPIYPLs-eVGVEECGMVARSLAEKLTIQ-VpGCSVFLFGEADQp-EKRSLVQRRKelG--WF- 160
gi 1079730173  87 MSAHTGVHPCMGAVDLIPIYPLgeeVRVEDCAKEARAVAQGLTER-VqGTSAFLFGWADTp-LQRGLAQRRKevG--WFK 162
gi 992184647   86 MDQHVGVHPCMGAVDLVPFYPLgeeVDLEDCGKEAQGLATALTERvL-GTSAFFFGWADv-pLRRGLAQRRKemG--WFQ 161
gi 115497136   87 MSVHEGIHPCMGAVDLVPLYPLgedVGLQDCGEEAQALALTLAER-VaGTSAFLFGWADSp-QHRGLAQRRKeiG--WFr 162
gi 410897499   87 MRAHSGIHPCMGAVDLVPIYPLgeeVGVEECAKEARALAQALTER-VqGASAFLFGWADYp-LQRGLAQRRKemG--WFQ 162
gi 163914889   87 LAEHDGIHPCLGAIDLVPIYPLs-gVTLEKCGEVARDIAEGMATS-IpGCSIFLFGYADLq-DQKSLAEKRRdlG--WFK 161
gi 573897544   86 MRRHSGAHPCLGAVDLVPIYPLgecVGLEECGQEARAVAVSLTER-VpGTSVFHFGFADTp-QQRSLVQRRK--ElgWF- 160
gi 637343755   89 MAAHVGIHPCLGAVDLVPIYPLs-gVDLEECGMVARNIAECLAHC-VpGCSIFLFGHADLp-KKQSLVQRRK--QmgWF- 162
gi 556956705   87 METHDGIHPCLGAVDLVPIHPLsqsVALEECGTVAQNIAETLAAL-VpGSSFFHFGYADQp-QMRSLVQRRK--ElgWFR 162
                         170       180       190
                  ....*....|....*....|....*....|....
1QD1_A        147 ALpEkL-KqaeWAPDFG-PSAFVPSWGATVAGAR 178
gi 612020332  161 ---SrR-EfssLKPDIG--TTPNKRCGLTGIGAS 188
gi 1079730173 163 KTtDlq----eIRPDLG--TQPQKRFGLTGVGAS 190
gi 992184647  162 KIp----NmaaSQPDIG-P-QPTRQYGLTGIGAS 189
gi 115497136  163 ---KvL-NvsnIKPDIG--SQPTRRYGITGVGAS 190
gi 410897499  163 k--SlD-LqtvR-PDVG-P-EPRRRFGVTGVGss 190
gi 163914889  162 -NkTgI-DlnkLKADVG--AQPSRRYGITGVGAS 191
gi 573897544  161 -RkNpDlRa--MQSDVG--AMPGKRYGLTGVGAS 189
gi 637343755  163 NKgAsKaAh--IIPDVG--LAPTSRYGLTGVGAS 192
gi 556956705  163 KKsSlNsNe----VKAGgEATLSSKWGLTGIGAT 192
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap