Conserved Protein Domain Family
GCFC

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pfam07842: GCFC 
GC-rich sequence DNA-binding factor-like protein
Sequences found in this family are similar to a region of a human GC-rich sequence DNA-binding factor homolog. This is thought to be a protein involved in transcriptional regulation due to partial homologies to a transcription repressor and histone-interacting protein. This family also contains tuftelin interacting protein 11 which has been identified as both a nuclear and cytoplasmic protein, and has been implicated in the secretory pathway. Sip1, a septin interacting protein is also a member of this family.
Statistics
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PSSM-Id: 311681
View PSSM: pfam07842
Aligned: 33 rows
Threshold Bit Score: 116.399
Threshold Setting Gi: 74852755
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74950000  416 LPQAERLFRELLVDYAAEFhEFGLADLAAGVIAPLLKRELVQWQPLENPT--EPLPLIKKWRGMLqq------------- 480
gi 74852755  631 INYIADKFKHWKSKDLKSYqKAQMPFIMPSILAPFIRLQMIDWSPLDDIY------------------------------ 680
gi 75148159  651 LRIVKDKFEGWKTQYPLAYrDAHVALSAPSVFTPYVRLELLKWDPLHETT------------------------------ 700
gi 75171892  598 LSKVKARFERWKRDYSSTYrDAYMSLTVPSIFSPYVRLELLKWDPLHQDV------------------------------ 647
gi 75173207  303 LSRVKSIFKRGARHPSPAFrAAYTSLTVPSMYSPYLRLELLRWDPLHQDV------------------------------ 352
gi 20141448  595 IDCIKSQFEAWRSKYYTSYkDAYIGLCLPKLFNPLIRLQLLTWTPLEAKC------------------------------ 644
gi 82264399  622 LDYIKCHFEVWRRDYAECYrEAYIGLCLPKLFNPLVRLQLITWNPLEGEC------------------------------ 671
gi 118572330 456 VQNILLKFQQWREKFPDSYyEAFVGFCLPKLLSPLIRVQLLDWNPLKMDS------------------------------ 505
gi 122064178 655 VGGILERFEQWREHDLPAYsDAYVSLCLPKILGPLIRLEHVCWNPLTMDA------------------------------ 704
gi 156053754 449 WDPVIEALKTVDGLDISGAnE-ELSNIAVAAVHPFLRQASEGWQPLEDPKlnGMVPNLYKIRHILgavtndkviisqdsf 527
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74950000  481 gDAAEQQPRNVFDPYSSLIWAGVMPSFR-SSAAAWQPKEHPPMASLLDAWAPLLPSWVLDSVLEQLVLPRLVAGVQE-WD 558
gi 74852755  681 --------------FDTMSWYNQLFSYG-GG-------GGDDDDILIP------------KLVEKIIIPKVETFITYiWN 726
gi 75148159  701 -------------DFFGMEWHKILFDYGeQNSESGTD-PNNVDKDLIP------------VLVEKVALPILHHRIMHcWD 754
gi 75171892  648 -------------DFFDMKWHGLLFDYGkPEDGDDFA-PDDTDANLVP------------ELVEKVAIPILHHQIVRcWD 701
gi 75173207  353 -------------DFSDMNWHGLLFHSRiVCGST----PVCTNPNFVS------------ELVKYVAVPILHHRIVRcWD 403
gi 20141448  645 ------------RDFENMLWFESLLFYGcEEREQE---KDDVDVALLP------------TIVEKVILPKLTVIAENmWD 697
gi 82264399  672 ------------DNFEYMLWFESLLFYGfDEHAALQ--KGDGDNGLLP------------SIVEKVILSKLAALAEQvWD 725
gi 118572330 506 ------------IGLDKMPWFTAITEFMeSSMDDIGK-EDGSDKKILA------------AVINKTVVPRLTDFVETiWD 560
gi 122064178 705 -----------LVELENEKWYRTAAQYGcSA-TTEAALAADPDVRLIP------------TLVEKIFLPKLTALVEQyWD 760
gi 156053754 528 mNALHKNRVKSTTPYESMIYKIIFPKIVsSINKNWDVYNPAPVLAFLDAWQGLLPKFVRSQILDQAIVGKLNDAVSS-WN 606
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74950000  559 PltDTV-----PIDsWVLPWHAILG-SKLEEa-------------------VYPQIRSKLGIALRAWSPHdRSARAMLTP 613
gi 74852755  727 PlsKSQttnlkNTIdEILIYINDENhQNNNNnnnnnnnnnnnnnnnnnnnnVNQEVKFLFSQILST-------------- 792
gi 75148159  755 IlsTQRtknavDAInMVISYLPTSSkALHQ---------------------LLAAVNSRLTEAIAD-------------- 799
gi 75171892  702 IlsTREtrnavAATsLVTNYVSASSeALAE---------------------LFAAIRARLVEAIAA-------------- 746
gi 75173207  404 IlsTREtrnvvAATsLVARYVFPSSeALAE---------------------LSLAIHARLVEAIIA-------------- 448
gi 20141448  698 PfsTTQtsrmvGITlKLINGYPSVVnAENKNtq-----------------vYLKALLLRMRRTLDD-------------- 746
gi 82264399  726 PlsRSQtarlvEFLhRLRKGYPTVLhGDNKY------------------------------------------------- 756
gi 118572330 561 PlsTSQtrsltVHCrVAFEQFAS-EnEVSKNkq-----------------dLLKSIVARMKKSIED-------------- 608
gi 122064178 761 PlsTTQtfrlvRLLkRFVRDYPSLR-SGCRPlr-----------------vLFQAILDKLKQSIDN-------------- 808
gi 156053754 607 P--KKRrnhelP-HlWLFPWLQYLPaYHADPkss---------------tgLVSDVKRKFRHLIDSWDFH-RGVIPGLKQ 667
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74950000  614 WQKAFPE----EEMQEFLQRYIVPKLQATL---GELIINPMH--QD--LELWQQVWEWHELIDPMYMAQL--LDRHFFPR 680
gi 74852755  793 ----LNY----SISNGNLL---IPYSNRDL---T-FSIKMYM--YS--LTMLDSIKIWSSNYQYIQLDSLmnLSDDIID- 852
gi 75148159  800 ---ISVP-----AWGSMVT-RTVPGASQYA---A------HRfgVA--IRLLKNVCLWKDIFAKPVLEKL--ALEELLK- 856
gi 75171892  747 ---ISVP-----TWDPLVL-KAVPNTPQVA---A------YRfgTS--VRLMRNICMWKDILALPVLENL--ALSDLLF- 803
gi 75173207  449 ---ISVP-----TWDPQVS-KDVPNAPQVA---A------YRfgTS--VRLMRNICMWKDVMELPVLEKL--ALSDLLF- 505
gi 20141448  747 --DVFMP-----LYPKNVLENKNSGPYLFF---Q------RQfwSS--VKLLGNFLQWYGIFSNKTLQEL--SIDGLLN- 805
gi 82264399  757 ------------------------------------------------TQLLGNILMWEGILSISCLKDL--ALDSTLN- 785
gi 118572330 609 --DIFIP-----LYPKSSEEGKMSPHSKFQ---E------RQfwGA--LKLFRNILLWNGLLPDDTLQDL--GLGKLLN- 667
gi 122064178 809 --DVFIP-----IFPKQAQ----EARSSFF---Q------RQfcSG--LKLLRNITSWQGILADAALKDL--AIGSLLN- 863
gi 156053754 668 WREVLHPspnnDTWTPLIMNHVLPSMAKFLkneKNFLVDPND--QApyMSSLQGIFAWKDVLKPRVVGQV--LIGTVFPM 743

                 ....*
gi 74950000  681 WMQVL 685
gi 74852755  853 --FQI 855
gi 75148159  857 --GKI 859
gi 75171892  804 --GKV 806
gi 75173207  506 --GKV 508
gi 20141448  806 --RYI 808
gi 82264399  786 --RYI 788
gi 118572330 668 --RYL 670
gi 122064178 864 --RYL 866
gi 156053754 744 WHNVL 748
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