Conserved Protein Domain Family
TMPIT

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pfam07851: TMPIT 
TMPIT-like protein
A number of members of this family are annotated as being transmembrane proteins induced by tumor necrosis factor alpha, but no literature was found to support this.
Statistics
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PSSM-Id: 311687
View PSSM: pfam07851
Aligned: 42 rows
Threshold Bit Score: 321.077
Threshold Setting Gi: 74852511
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160358717  10 VRDWGELQENYQDIQETHrlykqkleelAKLQTRCSGTIARQKKKLKELSVELKKYKSSVKn-----vE------EEEEQ 78
gi 74852511   34 KNEVFELKKSHEQCKEKGikvkkdindvFKHADDITNTLAKHEKESSQLISRIKHLNAK---------E------KQLDI 98
gi 75163488    4 EEEVKQIIDEVKELHDSA----------ASFISSSSQQELSLRQKASAVDSSIRRLHSTIVsn----kN------LDPKL 63
gi 586709601  11 LEEVSHLLDRAKELQDSA----------SSFLSKMKHEEQSILQRVSALQSDLKKLQACVA-------SasasetLDKRE 73
gi 168062686  23 EDRVASLAKSCRSLKEAA----------SAHSSRWQHEADTLSKQAINHVSTLKKLQVDVGsas-ekdE------IDQQT 85
gi 470241704  16 kkeleelekSQNGVKEKGlkfkeqiavgFKSLDEICNTLDKQEKESSKLLQRITLLQSGGG-------D------KSNDA 82
gi 569366144  10 MKSIDEISNELKAVSETFetstqqlnqkFKQIDQCISKTKTKTKMYNDLWSEWQEMNVQVGngsenerS------KYEKQ 83
gi 66805725   34 KNEVFELKKSHEQCKEKGikvkkdindvFKHADDITNTLAKHEKESSQLISRIKHLN--AK-------E------KQLDI 98
gi 255555863  14 EEEVERVVEQAKQVQEAA----------ASLISRSTNDEQSLRQRALSLESSIRRCRSLFDsll-srnL------IHPKL 76
gi 695077278   8 meeaarlaeaareldDAA----------AALISRTWNEEQSLRQRALALESDLRRLQSSLDsaakkkgA------IDSKI 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160358717  79 ISVLNNQIRIREKTFF--E--MESFL-PKK-NGLYLSLVLGNVNVTLLSKQSKFAYKDEYEKFKLYLTMILMVLSFICRF 152
gi 74852511   99 TKELSAHLDQIKVNVK--R--AKVSF-TPEtGSIFVRLFLGQVNVKHMRENEKFRLKQEYEKFKKKTNPQFILFVVLLLL 173
gi 75163488   64 VEKLEEDLHRARCMLVdgE--TSSFL-PSKpQGRFVRMFCGPVNVRALRKDVQLKVKEEYNRYRDKTALLFLFFPATLLI 140
gi 586709601  74 AEKLEEELSRAKCMIA--DgdVSSLL-PSKsNGKFLRMFLGPISVRATRKDVQLKVKEEYNNYRDRTAVMFLLFPFALLI 150
gi 168062686  86 ADKLEEELYRARTMLYngE--VSSLL-PAKaNGVFLRMLLGPTNVRATLKDGRYKVKEEYNAYRDRTALMFLAFPVILLV 162
gi 470241704  83 VVEMKQKIQSIKTSIK--Q--SKKTFtPET-GGVFVRLFLGQVNVKHYREGERFRLKTEYEKFKFKTNPQFILFVALLFM 157
gi 569366144  84 MEEMKKDLELTKKISE--S--ISSY--EQN-RSYFLIGLMGNAPMKLWNEIDRAKFKTEYNRFKQHTLWVFLLFPLLQLY 156
gi 66805725   99 TKELSAHLDQIKVNVK--R--AKVSFtPET-GSIFVRLFLGQVNVKHMRENEKFRLKQEYEKFKKKTNPQFILFVVLLLL 173
gi 255555863  77 ADKLDEDLQRARCMMVdgD--AAAFL-PSKaQGGFLKMFLGPINVRASRKDVQLKVKEEYNSYRDRTALLFLLFPSLLLI 153
gi 695077278  72 AEKVDEELYRVRCVINdgD--VASLL-PSKaHGRFLKMFLGPVNVRATRKEVQLKVKEEYNSYRDRTAFLFLIFPSTLLL 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160358717 153 VLNSR---VTDA----V----FNFLLVWYYCTLTIRESILINNGSRIKGWWVLNHYISTFLSGVMLTW-----PDGLMYQ 216
gi 74852511  174 YPQSS---FVTT----S----WQIWLLYYYITLALRENILLVNGSSIKPWWIMHHYLSIAGSLTNLLF-----PLSESFS 237
gi 75163488  141 LRSYYwggCLPAfpvqL----YEAWLLFLYAGLAMRENILRANGSDIRPWWLYHHYCAMAMALVSLTWeikgqPNCVQKQ 216
gi 586709601 151 LRYAIwkgCFPAwavqL----YQAWLLFLYTSLALRENILRINGSDIRPWWIYHHYCAMMMALVSLTWeikgqPDCYQKQ 226
gi 168062686 163 LKNKIwngCFPA----LpvqvYQAWLLFFYTSLALRENILRVNGSDIRPWWVYHHYCAMVMALVSLTWg---hPSCIRKQ 235
gi 470241704 158 FPSNS---FITT----S----WQIWLLYYYVTLALRENILLVNGSSIRPWWIMHHYLSIAGALTNLLW-----PLSTSFT 221
gi 569366144 157 FHFNI---FLHQ----I----HSLYLFYYYTSLAIRENILKQNGSRIDYWWIVHHYITLFVSLLFLVNltpthPAVVTGG 225
gi 66805725  174 YPQSS---FVTT----S----WQIWLLYYYITLALRENILLVNGSSIKPWWIMHHYLSIAGSLTNLLF-----PLSESFS 237
gi 255555863 154 LRSWLwdgCLPAfpvqL----YQAWLLFLYTGLALRENILRSNGSDIRPWWIYHHYCAMVMALVSLTWeikgqPNCAQKQ 229
gi 695077278 149 LRSWVwdgCLPAlpvqL----YQVWLLYLYTTLALRENILSVNGSDIRPWWIYHHYCAMLMALISLTWeirrqPDCAYKQ 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160358717 217 MFRNQFLSFSMYQSFVQFLQYYYQSGCLYRLRALGERHNMDLTveg-----fqsW----M----WRG-LTFLLPFLFFGQ 282
gi 74852511  238 YFLPQVTYFSGCQGLVQILTNRYQQGRLYKLVAMGKANIIDVTgesegwgndpgW---------TPS-ALFLFPFLLFVQ 307
gi 75163488  217 RGVHLFLQWAMMQGVAMLLQNRYQRQRLYTRIALGKAKRMDVV-----------W----GetagVDGqLWLLCPILFILQ 281
gi 586709601 227 RGIELFLTWAMMQGVAMLLQNRYQRQRLYTRIALGKANRMDVVwgeta---------------svegqLWLLYPVLFILQ 291
gi 168062686 236 QGVQLFLGWAVMQGVAMLLQNRYQRRRLYTRIALGKAGRMDVV-----------WgetaG----VKGqLGILYPLLFILQ 300
gi 470241704 222 DLLPMMTMFSGAQGIVQILTNRYQQGQLYRMVAIGKANIMDVTsenmi--sdpgW---------TPS-ALFLLPFLLFVH 289
gi 569366144 226 VYLIDY--FMLWQGIVIVLQMRYQEKRHYVRKALAKKNAMDVRtte-----vidE----R----PHGdFEFLVPALYITY 290
gi 66805725  238 YFLPQVTYFSGCQGLVQILTNRYQQGRLYKLVAMGKANIIDVTgesegwgndpgW---------TPS-ALFLFPFLLFVQ 307
gi 255555863 230 RGVQLFLQWAMMQGVAMLLQNRYQRQRLYTRIALGKAKRMDVV-----------W----GetagVDGqLWLLCPILFILQ 294
gi 695077278 225 RGVQLFLVWAMMQGVAMLLQNRYQRQRLYTRIALGKAKRMDVV-----------W----GetagVEGqLLLLCPILFILQ 289
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 160358717 283 FWQLYNAITLFKLA---RH-PECK----EWQVIMCGLPFLVHFLGNFFTTLRVVHQKFQKQ 335
gi 74852511  308 FFQLYNSFSFFAFA---YQrSGYV----EWQVFSCGFIFLCLGLGNLLTTLSVYYQKWKNF 361
gi 75163488  282 VFEAYVGLLLLRKT---VT-GVVN----EWQVMVCGILLVVMAVGNFINTVETLMAKSRVK 334
gi 586709601 292 GFEAYIGILLLMTA---VT-SSVS----EWQVVVCGGLLVIMASGNFANTVQTLSAKLRFK 344
gi 168062686 301 GFQFFIGILLLKTA---IV-EDKS----EWQIVVCGLLLVLMACGNFINTVATLVAKAKIK 353
gi 470241704 290 CFQMYNGFVFLTYSyfkYH-TYYI----EWQVIACGLILVSLGIGNLVTTSNIYLNKWKsy 345
gi 569366144 291 FFQLIIAFYFAYVC---CA-QEFScfydRAQMGLLAMCWTILPIGNLSTLVKVLYRKRvih 347
gi 66805725  308 FFQLYNSFSFFAFA---YQrSGYV----EWQVFSCGFIFLCLGLGNLLTTLSVYYQKWKNf 361
gi 255555863 295 GFEAYVGLQLLRTA---FV-RVVS----EWQVIFCGMLLVFMAVGNFFNTVQTLMVKSRFK 347
gi 695077278 290 GFEAFIGLLLLRTA---FV-GVTC----EWQVIVCGILLVLMAIGNFANTMQTLIAKSRFK 342
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