Conserved Protein Domain Family
VKOR

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pfam07884: VKOR 
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Vitamin K epoxide reductase family
Vitamin K epoxide reductase (VKOR) recycles reduced vitamin K, which is used subsequently as a co-factor in the gamma-carboxylation of glutamic acid residues in blood coagulation enzymes. VKORC1 is a member of a large family of predicted enzymes that are present in vertebrates, Drosophila, plants, bacteria and archaea. Four cysteine residues and one residue, which is either serine or threonine, are identified as likely active-site residues. In some plant and bacterial homologs the VKORC1 homologous domain is fused with domains of the thioredoxin family of oxidoreductases.
Statistics
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PSSM-Id: 311711
View PSSM: pfam07884
Aligned: 292 rows
Threshold Bit Score: 38.7073
Threshold Setting Gi: 501195802
Created: 19-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4NV5_A        21 LILAILAGLGSLLTAYL---TYTKL-----TEQ---PAAf--AtG-DGG---CDLVLSSRWAEF-----LG-IPTAAVG- 76
gi 81472350    8 KISIILSVLGLIFSFLL---IQKYYg----DPS---SVGetiC-NaLSEsgsCDKVSESAYSAIrnvpgLGdLPIALFG- 75
gi 505939600  20 IPVIFFLLFGLTDTLYL---AWSHYkn-ytDLT---FSSf--C-A-LSKainCDTVSQSPWSIL-----LG-LPLSYWG- 81
gi 501124855  20 IPVFVIALIGFGDSIYL---AVSHYrn-yvDMG---YQSf--C-A-ISRslnCDTVSQSPYSIF-----LN-VPVPVWG- 81
gi 524181707   8 ltvqILALIGLALSIKLaciYYVANy---eKYA---LSSf--C-S-ISEfvdCDGAARSTVSQF-----WG-IPLAYWG- 70
gi 524857457   9 isIFLLALIGFITTIKL---AMIYYd---aNFNpyaLPSf--C-T-VNDlidCDGVAKTTESQF-----LG-IPLAYWG- 71
gi 524802472  15 asIIILVVIGFVLSIEL---AKIYYs---aNFDqyaLPSf--C-S-ISDfvdCDGVAKTTESQF-----LG-VPLAYWG- 77
gi 524476813   7 IVLTIIALVGFLTSVKL---TMIYWd---aNFNpyaLSSf--C-S-INDlidCDGVAKTGHSQF-----LG-VPLALWGl 70
gi 501356320   8 iggLVVGVLGLLFSFLL---AVEYFg---iGTD---NVAgaaC-SaLGGgdsCLKVAESSYSAIpgvpfLGnIPIALLG- 76
gi 524762176   9 VAIGIIAAIGFITTIKL---AIIYYnanfnPYA---LSSf--C-S-VNDfidCDGIARTTEAQF-----LG-IPLAYWG- 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4NV5_A        77 ------------------------LLGFLGVLALAVLPdglPLvk-------rwRWPALFGLVS--AMTAFEMYMLYLMV 123
gi 81472350   76 ------------------------FLFYGFVGFLFVFSe--IKkes-----aeaNLRLAFYVLV--LGLVADLGLFLLSV 122
gi 505939600  82 ------------------------FSAYSLFLFFALATlhrrn-------ysiyLWQCLFLLGF--GYSVAALYFGYISA 128
gi 501124855  82 ------------------------IFGYGFFLFLLGVAwhpta-------grkrVWTLLFVISL--AFSVYSVVLALISS 128
gi 524181707  71 ------------------------IFFYITILFLTIVDklkgirflkflevfknPMSYIAVLGT--IAFTVSMVLAGLSI 124
gi 524857457  72 ------------------------MFLYAFMFLMLIADklknfrlfkfmevfknPLDYIASLGI--ISFAISMILLCVSL 125
gi 524802472  78 ------------------------IFLYSFILLLMGADklkniklfkfmevfknKYHYIASLGL--ISFVISMILLCVSL 131
gi 524476813  71 flyfvflfftyvdklknieikgfrIFAYFdvf--------------------knPESYICALGI--IAFLISMILAGISV 128
gi 501356320  77 ------------------------FGFYGLLVYTFYLIy--KStns-----eeiSKLISLVLPVliLGFIFDLILFGISV 125
gi 524762176  72 ------------------------MFFYSFVFLMLFAQklknfrlfkfmevfknpldYIASLGL--ISFLISMILLCLSL 125
                        170       180
                 ....*....|....*....|....*
4NV5_A       124 AVLRQFCMYCTTAIILVAGLGLVTV 148
gi 81472350  123 GVIKALCGLCAATYVVTIALLIVNF 147
gi 505939600 129 TKIKAHCILCLGSHAASFALLFLSW 153
gi 501124855 129 YLIRSYCIMCILSYAVNLALLFYAW 153
gi 524181707 125 FKIHKLCILCVITYFIDLIIALVAF 149
gi 524857457 126 FQINKICILCAFTYVLNLLIALVAL 150
gi 524802472 132 FGIKKLCLLCACTYVLDLLIGLVAV 156
gi 524476813 129 FEIHKLCILCFFTYILNLLIGLIAk 153
gi 501356320 126 GIIGTICQLCFITYIVTISLLAIVF 150
gi 524762176 126 FEIKKLCVLCAFTYILNLLIGCIaa 150
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