Conserved Protein Domain Family
TraG_N

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pfam07916: TraG_N 
TraG-like protein, N-terminal region
The bacterial sequences found in this family are similar to the N-terminal region of the TraG protein. This is a membrane-spanning protein, with three predicted transmembrane segments and two periplasmic regions. TraG protein is known to be essential for DNA transfer in the process of conjugation, with the N-terminal portion being required for F pilus assembly. The protein is thought to interact with the periplasmic domain of TraN to stabilize mating-cell interactions.
Statistics
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PSSM-Id: 311735
View PSSM: pfam07916
Aligned: 63 rows
Threshold Bit Score: 118.592
Threshold Setting Gi: 81377823
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81595656     3 EVYVIAGGEWLSNNLnaiaafmstrtWD-SIEKIALT-LSVLAVSVM---WVQrh------nvMD---LLGWVAVFVLI- 67
gi 123550487   21 SIYTWGYGELFYRVLqavtilsqdnyIFkSAVAIGGF-LLMIKNTVS---GASssd-----maVT---MGKYLFTITLIi 88
gi 123516702   30 EYYTYNGFGAVVTAFqkislifsdngYR-ALFFTVTA-LGIFIAGAA---AYFhllkgarfspLS---WAWPVGLGICLy 101
gi 502865944    4 TIYTTGSAEFLEIMLnacamitgsgdAE-DLARIGAL-IGLFLLAFQ---AVFnn-------qAI---TFGKAGLVLVLy 68
gi 500054275   28 EFYVWGGHDAVVNAFgklalifgdnaYK-SLYFVVIT-AGLFFGGVT---VFArllgtgsgsvTT---WIVPTLIGIMVy 99
gi 505934718   26 EYYTYGGFNPIVQAFtrvalifsdagYQ-GLITVMTI-MGVLAGSGA---WIAraat---garVIpltWTVPVLFGAVVy 97
gi 502774930    4 dFYVYGDFTSIVNAFkmvagifssnsYK-SWITILMI-FASAAFAFH---MNMeraf---gakMNdsvWIKRLFWGMALy 75
gi 500053958   30 EYYCYGSFGPVVSAFkliatifgnnsYQ-SLFYTVII-SAAVFTGLAvytKIAsggq---tsiLG---WSVPMAIGIVMy 101
gi 503674460    5 pITVHGEFETMRQVLvfisslvgssaYK-GGITAFFI-LALTLTMAT---GMFdllfgdqrslTS---WVKLFFVAIFLy 76
gi 503271434    2 EITIYGGFNTVTGIMqqialf-fsdssL-PMVFIAMFvAGVLGAGIN---EFYsgiqrgkstiVA---ALITCLLGLALs 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81595656    68 SLLVTIRTSVQIIDNSDLVRVYR-VDNVPVGLALPLSLTTRIGHAMVASYEMIfa-----qPDSvtyskt--gmlfgANL 139
gi 123550487   89 GLFSTSTKRYIIED--EVTNQTFiVNNVPIGIGETFSLFTNLERNLARGFQSAma-----tPNSlnytdv--glgftMAA 159
gi 123516702  102 LGLMVPTGNITIYD--PVLNRFQtVGRIPDGIVVVAGTLNKIERGLVDIISTSgtpqnfqdy-------aggigfdmLLK 172
gi 502865944   69 MMFYGPTATTVIED--TVSSQVRvVDNVPLGPAFVGSVISTVAYGITKTAEQAfs-----tPSMtdyg-----lfssLST 136
gi 500054275  100 LALVVPKGTIHVYD--PVYNKNQaVGGIPDGVVAVAGILNKIERGLVDIVTTAgd-----pLNYqsqagg--kgflgLAQ 170
gi 505934718   98 LAVFVPKGSLTVYD--PVLNRFQtVGDLPDAIVFTAGALNLIERGLVDIIDTAaa-----pDAAysrta----ggigfKA 166
gi 502774930   76 SIFMVPTVTMHIYD--PVKNRYEaVGGVPLGAGMIASVTSSASRELTDIIETAgs-----pIMSandigf-gdgfelLAA 147
gi 500053958  102 IAFFVPKGSLQVYD--EVMNKTElVTQVPEGVVLVAGTFNLIERGLIEIVSTSgs-----iGSYqtqagg--kgflgLYA 172
gi 503674460   77 AAFLSGSARVALYD--DVTGRSHvQGNIPPGIAAMMAIPNWVATEFEDLITSYlapslpisPFAyeygik--migesYSG 152
gi 503271434   74 KVFIFNTGNLVIYDRT--SNQHAiISDVPDGLRIMYRLFNTLENFFVERWYTAsh-----hPALdyrdnangigfdmFLN 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81595656   140 IVKSTDF-LSRNP---------------EIINLFQDYVQNCVLGDI-Y-L-NH-KYSLEEL-M-ESD---DPYTLIFsrp 194
gi 123550487  160 PLNVKSL-IAADG---------------HTRRTFNEYMGNCIFS----------AIAMNEI----SA---DIINFSTilk 206
gi 123516702  173 ASGGHLK-IR-DQ---------------YIDESLKRYTKDCLFFEL-Q-RpGT-SLSVNDVtS-SST---DFMSQYAqaa 228
gi 502865944  137 LSKVRDA--LRNPmaldgfqnyrkadgwDLPRSVNEYMTFCSLNPV-A-L-RT-DKTLTDL-Y-RSP---GWAEVLSnqn 205
gi 500054275  171 LTSIPLS-AV-DS---------------NLDASLRRYVRDCVSYAL-MnP-NA-NLTVDEL-RkTTT---NFVSSLDkai 226
gi 505934718  167 LEAVKGS-TPKNN---------------HARTSMIRYVKDCVTFEL-M-R-PGtTLSLDDL-RnTST---DFLANLSqav 223
gi 502774930  148 SSAMGQIgNMNDH---------------FLAKSVYDYIEKC-FRQA-Y-A-NG-DITDKDI-W-TSN---NLLESFSlny 202
gi 500053958  173 LTTRPLS-SKTNI---------------YLEQNLNYYLKDCVTFAVnN-P-AS-NLTIDEL-R-RTPa--SFSTSLVkaa 229
gi 503674460  153 EMATALA-NIIDP---------------QMWESAGNYVRDCVA-LL-A-A-RE-ASYAKKL-Y-SGD---NPYRAWSeai 206
gi 503271434  147 ASKVGGI-P-NDP---------------LINRSLQRYWTDCVTFAL-KvP-AS-NLTMAEM-M-HGDapgGLIASFGkaq 204
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81595656   195 splrg------------vydknnhFVTCKDA-----------SVtlkdklnldtktggktwhyyvqqifgg---rpdpdl 248
gi 123550487  207 adlkvtgyl---tpyystanpngiDKQCEDV-----------WEllvntdirqqldvlepllaqemgi---------tqd 263
gi 123516702  229 npavftv-------wysesdrtgtTMSCADA-----------WTnlqgyfsdplnmgdtirfacanagfnadnageltkc 290
gi 502865944  206 ssmfiy----------vydgtagtMKSCAEArsflnahlqnvYT------------------------------------ 239
gi 500054275  227 npaiwtv-------yynaanpqgqTLTCTDA-----------WT------------------------------------ 252
gi 505934718  224 npsvftv-------yydsahpegaTMSCTQA-----------WN------------------------------------ 249
gi 502774930  203 rvfssvi--------ydnanpegvLYECADA-----------YT------------------------------------ 227
gi 500053958  230 npaiytl-------ylsptdsqgdSLNCTDA-----------WT------------------------------------ 255
gi 503674460  207 nyffytytsldsngnplppgtpneSVSCKEA-----------WDrldkyfqntrwqevvdkf------------------ 257
gi 503271434  205 hpmlqtqf-----yqsndthksgtWMSCRDS-----------WD------------------------------------ 232
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81595656   249 lfrelvsdsysyfygssqsasQ-------------I--------M--------------------------------R-- 273
gi 123550487  264 kyqgamaatsqllfstsknskD-------------Y--------L--------------------------------M-- 288
gi 123516702  291 teiisnyasyveggaftipapN-------------F--------M--------------------------------R-- 315
gi 502865944  240 ---------------------D-------------V--------Ledilqkgfsee----------aktnrmtsgiqV-- 265
gi 500054275  253 ---------------------N-------------IksaltpasL--------------------------------T-- 264
gi 505934718  250 ---------------------QlrplyaatsnygeA--------I--------------------------------R-- 266
gi 502774930  228 ---------------------N-------------Ist----rlM--------------------------------S-- 235
gi 500053958  256 ---------------------A-------------I--------VadmtpaelsgnmetvctelgydvsdaaqfnqcK-- 291
gi 503674460  258 ----ctlmhygtdatsisacrD-------------T--------M--------------------------------Stv 280
gi 503271434  233 ---------------------Nir----------pY--------I--------------------------------T-- 239
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81595656   274 -K------------------NV----------------------T--------------------------MN----ALK 282
gi 123550487  289 -Q------------------QT----------------------L--------------------------IN----MTK 297
gi 123516702  316 -Q------------------VY----------------------M--------------------------AE----VLN 324
gi 502865944  266 -Q------------------AA----------------------T--------------------------DQ----AIQ 274
gi 500054275  265 -K------------------NIysvctnlgydvtdaaavtqcktV--------------------------LN----NVN 295
gi 505934718  267 -KvcskayfdpdnsaelttcRN----------------------L--------------------------IN----ATM 293
gi 502774930  236 -P------------------TF----------------------T--------------------------EN----VMY 244
gi 500053958  292 -Q------------------AV----------------------Tdakdt-----------------vglsAL----TLD 309
gi 503674460  281 fS------------------RY----------------------V--------------------------INgltvSPE 294
gi 503271434  240 -Np----------------aNF----------------------TqsrdricasagvdindplqlqsceqkIN----QHI 276
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81595656   283 ---------------EGitsnaarngdT---------------------------------------------A------ 296
gi 123550487  298 ---------------DGikatalaaggDvq------------------------------------------aL------ 314
gi 123516702  325 ---------------DMllda----------------------------------------------------------- 330
gi 502865944  275 slalssksaqdyvltSLiapif-ndsrVda------------------------------------------mN------ 305
gi 500054275  296 ---------------SGtglga-asidDfl------------------------------------------rQ------ 311
gi 505934718  294 ---------------TFatgta-vppeRll------------------------------------------qQrqiaei 315
gi 502774930  245 ---------------KFcsqsgfnvsnTseyqackdkftglvdsfatdigfsitlsnyvasafiarqylmggvN------ 303
gi 500053958  310 ---------------EFvkqvf-iknrLds------------------------------------------sY------ 325
gi 503674460  295 ---------------NIaknvf-agkvFys------------------------------------------fL------ 310
gi 503271434  277 ---------------QFisngq-vtggLgh------------------------------------------fN------ 292
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81595656   297 --------S----L----------VNLATT----------SSMEKQRLS-----HVSIGYVTMRNLPMVQTILLGIAIGI 339
gi 123550487  315 --------A-----------------YASA----------AAEANQQQT-----LMTMGKMAQKNLPLYKAILTVLVLGI 354
gi 123516702  331 ----------------------npdlAVKG----------LASRSIMTG-----GLGMGIVANEWLPVARAVITAVAIGL 373
gi 502865944  306 --------H----Wqe------qrAAMALR----------ESLNQQEIQ-----WAGKGDSFKHYMRPMIAFFEGMLYAM 352
gi 500054275  312 --------A----YisqrleeifrSGNATG----------ATNYQFLLN-----ASGAMKAANEWLPILKAALTAIAVGL 364
gi 505934718  316 lysfyfqdD----P----------ETAVLM----------ESDRRITAS-----GLGVGLTMNEWIPVIRAILTAIAIGV 366
gi 502774930  304 --------A----G----------TQNAID----------IAKSMATAA-----NTVAGGVADEYIPKLQGMIITILIAT 346
gi 500053958  326 --------Q----S----------GNTQVV-----------SNYQFLTN-----VSGSMKSFNEYYPVLRGVLTAVAIAL 367
gi 503674460  311 --------SsldpS----------VEAARI----------ASFARAQAE-----LSGKGIVAQEWLPVMKTIFYILACSL 357
gi 503271434  293 --------A----L----------MNLARStfevtkiggdHAINRFIQQdftvkGIGAIMGSSGYMGEARYAMFAIVGAM 350
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81595656   340 FPLLVLAAVFNKlTLSVLKGYVFALMWLQTWPLLYAILNSAMVF-----Y-----A----K-----Qngapvv------- 393
gi 123550487  355 FILLVLLSVIYG-DLGHIKMGFTLLFAMILWTPLAIILNAMTFI-----Ti---eS----Qliwpqvdg----------g 411
gi 123516702  374 IPILVIFIPTPL-AGKALGLVAGMFIWLTAWGVTDAITHGIATD-----Ya---yG----VfeyvrQnalgf-------- 432
gi 502865944  353 TPFMAFALLLGGpGLSILGKYLVLPLAVGLWMPLLSIVNAFTLW-----Ya---gS----Q-----Meavfngydptgsg 415
gi 500054275  365 LPFLALFIPTPLiG-KAVGIIAGFFIWLTAWGVTDAIVHQFAVD-----YanqayE----T-----Vrqnklg------- 422
gi 505934718  367 IPFLVLFLPTPIvG-KAASVLLGFFVFLSTWGVTDAVIHGAAMD-----Ya---aR----G-----Feevrqsn------ 422
gi 502774930  347 FIIVALFVYMAP--VDAFKWYIGMWIWVIMWFVVDAILNVNVQA-----Ha---yE----V-----Frdirstg------ 401
gi 500053958  368 IPILIIFLPTPMsG-KIASILFGFFIWLTAWGVVDAILHGFAME-----Ya---nS----V-----Fsqvrneg------ 423
gi 503674460  358 IPLALIFI---GtGTGPVKFLAGIFLWWAVWCGMDALMYCLWIS-----Ra---dGifqvV-----Sdgarlg------- 414
gi 503271434  351 SCVLMLLWPTPVfG-KAFAGIIYLWGFIFFWAIGDAIAHKIAVDrafdlYa---eL----R-----Atggtig------- 410
                         730       740       750       760       770       780       790
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 81595656   394 --lselsQIQLKYSDLASTAGYL----S----A-M----IP----PLSWM---MVK-GLGAGFSSVYSHFASSSISPT 448
gi 123550487  412 ltffrthKMHEDLALLIALIGYV----G----T-M----IP----VLAYS---IAKkSEQGFVSFFSGAGAVANSSAS 469
gi 123516702  433 ---aavmNMPDASLKALSMFGLI----R----TsG----IM----LATVItgmLVRfGGH-ALAMMAGTISGTVQSQG 490
gi 502865944  416 famlqlmDIDKAIGKALGIGGLL----A----A-S----VP----PLALF---IVS-GSAMVANSVMSQMTAGDKFKS 472
gi 500054275  423 --mdalyFFPDQTVKILGMFGTL----R----M-SgmmlAT----VITGM---LIR-FGGHAMAMMAGSLGSQVQSAG 481
gi 505934718  423 lgvyalaALPSVSTKMLAMFGVI----RsagiM-L----AS----LFSMM---LIR-FGGHALAMLAGNLSAIVQGAG 483
gi 502774930  402 vglnsmfYTGSDTLKVLAMYSNA----R----W-I----SMslasVISFG---IIKmGGSAAFASMTSALGQQYRSSA 463
gi 500053958  424 lgldalyFFPNASVKALAMFGTL----R----M-SglvlST----ALTGM---LVK-FGGNAITQMGSSLQGHIAAAG 484
gi 503674460  415 --lhgleELWFLSSKAFALLGGM----R----SfG----FM----LAGAFvytVFR-FGGSVMAHFASAMVGSLSSGA 473
gi 503271434  411 --intlfHIPSETAKALGVFGQMraysM----L-V----AT----IITGF---LFK-VSSPGMAQLGSRIGGAMSdig 469
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