Conserved Protein Domain Family
TraG_N

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pfam07916: TraG_N 
TraG-like protein, N-terminal region
The bacterial sequences found in this family are similar to the N-terminal region of the TraG protein. This is a membrane-spanning protein, with three predicted transmembrane segments and two periplasmic regions. TraG protein is known to be essential for DNA transfer in the process of conjugation, with the N-terminal portion being required for F pilus assembly. The protein is thought to interact with the periplasmic domain of TraN to stabilize mating-cell interactions.
Statistics
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PSSM-Id: 336864
View PSSM: pfam07916
Aligned: 62 rows
Threshold Bit Score: 120.918
Threshold Setting Gi: 81377823
Created: 26-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81626735    11 TIHTYGGGEILQKVFvaiamlsgeggMVfPLMFLCAA-LGFGFMVCQ---L---LVTLsf-----dRF---F---THYFV 72
gi 123516702   30 EYYTYNGFGAVVTAFqkislifsdngYR-ALFFTVTA-LGIFIAGAA---A---YFhLlkgarfspLS---W---AWPVG 95
gi 500054275   28 EFYVWGGHDAVVNAFgklalifgdnaYK-SLYFVVIT-AGLFFGGVT---V---FARLlgtgsgsvTT---W---IVPTL 93
gi 505934718   26 EYYTYGGFNPIVQAFtrvalifsdagYQ-GLITVMTI-MGVLAGSGA---WiarAATGarv---ipLT---W---TVPVL 91
gi 502774930    4 dFYVYGDFTSIVNAFkmvagifssnsYK-SWITILMI-FASAAFAFH---M---NMERafg---akMNdsvW---IKRLF 69
gi 500053958   30 EYYCYGSFGPVVSAFkliatifgnnsYQ-SLFYTVII-SAAVFTGLAvytK---IASGgqt---siLG---W---SVPMA 95
gi 503271434    2 EITIYGGFNTVTGIMqqialf-fsdssL-PMVFIAMFvAGVLGAGIN---E---FYSGiqr---gkST---IvaaLITCL 67
gi 503674460    5 pitvhGEFETMRQVLvfisslvgssaYK-GGITAFFI-LALTLTMAT---G---MFDLlfgdqrslTS---W---VKLFF 70
gi 779845180    5 SIHSIGDSAFLEQILiavsmitgtgdFE-KMVSIGLL-LGVLMICIQ---S---VFqg------akQI---N---LQQVL 64
gi 499390539    4 TIYTTGSAEFLEIMLnacamitgsgdAE-DLARIGAL-IGLFLLAFQ---A---VFnn-------qAI---T---FGKAG 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81626735    73 PFLVIYTAFIIPKTTIHIEDalHKPKIYK-VDHVPRLLAHFAEIASSIGYYATCGVEKAmhtVDDvkysqt--------- 142
gi 123516702   96 LGICLYLGLMVPTGNITIYD--PVLNRFQtVGRIPDGIVVVAGTLNKIERGLVDIISTSgtpqnfqdy-----------a 162
gi 500054275   94 IGIMVYLALVVPKGTIHVYD--PVYNKNQaVGGIPDGVVAVAGILNKIERGLVDIVTTAgdpLNYqsqagg--------- 162
gi 505934718   92 FGAVVYLAVFVPKGSLTVYD--PVLNRFQtVGDLPDAIVFTAGALNLIERGLVDIIDTAaapDAAysrta---------- 159
gi 502774930   70 WGMALYSIFMVPTVTMHIYD--PVKNRYEaVGGVPLGAGMIASVTSSASRELTDIIETAgspIMSandigf--------- 138
gi 500053958   96 IGIVMYIAFFVPKGSLQVYD--EVMNKTElVTQVPEGVVLVAGTFNLIERGLIEIVSTSgsiGSYqtqagg--------- 164
gi 503271434   68 LGLALSKVFIFNTGNLVIYDr--tSNQHAiISDVPDGLRIMYRLFNTLENFFVERWYTAshhPALdyrdnan-------- 137
gi 503674460   71 VAIFLYAAFLSGSARVALYD--DVTGRSHvQGNIPPGIAAMMAIPNWVATEFEDLITSYl-aPSLpispfayeygikmig 147
gi 779845180   65 VGWILYACFFGPTTTVTIED--AYTGQVRvVANVPIGVGFAGGVISNVGYTITNLFETGygvivpnv------------t 130
gi 499390539   63 LVLVLYMMFYGPTATTVIED--TVSSQVRvVDNVPLGPAFVGSVISTVAYGITKTTEQAfstpsmt-------------- 126
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81626735   143 --glifgSDTALDYRRF-QLT-NP-------------DLQKDFKEFSKQCVLYdla--lgRYSLKELk-tST---DLWKF 199
gi 123516702  163 ggigfdmLLKASGGHLK-IR--DQ-------------YIDESLKRYTKDCLFFelqrpgtSLSVNDVtssST---DFMSQ 223
gi 500054275  163 --kgflgLAQLTSIPLS-AV--DS-------------NLDASLRRYVRDCVSYalmnpnaNLTVDELrktTT---NFVSS 221
gi 505934718  160 ---ggigfKALEAVKGS-TPK-NN-------------HARTSMIRYVKDCVTFelmrpgtTLSLDDLrntST---DFLAN 218
gi 502774930  139 -gdgfelLAASSAMGQIgNMN-DH-------------FLAKSVYDYIEKC-FRqay-angDITDKDIw-tSN---NLLES 197
gi 500053958  165 --kgflgLYALTTRPLS-SKT-NI-------------YLEQNLNYYLKDCVTFavnnpasNLTIDELr-rTPa--SFSTS 224
gi 503271434  138 -gigfdmFLNASKVGGI-P-N-DP-------------LINRSLQRYWTDCVTFalkvpasNLTMAEMm-hGDapgGLIAS 199
gi 503674460  148 esysgemATALANII-------DP-------------QMWESAGNYVRDCValla--areASYAKKLy-sGD---NPYRA 201
gi 779845180  131 eshfsetLKLLNDVRRR-AYDtGVftalnsangggyvDVRRSWNNYIRECTLTkvd--lnLMSLDELm-nRS---T-DSA 202
gi 499390539  127 dyglfssLSTLSKVRDA-LRNpMAldgfqnyrksdgwDLPRSVNEYMTFCSLNpval-rtdKTLTDLy-rSP---GWAQV 200
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81626735   200 LKertstlgmiyycp-ptakggtkkeaceYLTCRQALEkfeplfskekayyakqeig--------------------knl 258
gi 123516702  224 YAqaanpavftv-------wysesdrtgtTMSCADAWTnlqgyfsdplnmgdtirfacanagfnadnageltkcteiisn 296
gi 500054275  222 LDkainpaiwtv-------yynaanpqgqTLTCTDAWT------------------------------------------ 252
gi 505934718  219 LSqavnpsvftv-------yydsahpegaTMSCTQAWN------------------------------------------ 249
gi 502774930  198 FSlnyrvfssvi--------ydnanpegvLYECADAYT------------------------------------------ 227
gi 500053958  225 LVkaanpaiytl-------ylsptdsqgdSLNCTDAWT------------------------------------------ 255
gi 503271434  200 FGkaqhpmlqtqf-----yqsndthksgtWMSCRDSWD------------------------------------------ 232
gi 503674460  202 WSeainyffytytsldsngnplppgtpneSVSCKEAWDrldkyfqntrwqevvdkfctlmhygtda--tsisacrdtmst 279
gi 779845180  203 LRfnsqlygtrl-------ylstanpdgaDYTCTDGWVaistatanlsspvvvdalnsllgidt------stgdnaltkl 269
gi 499390539  201 LSnqtssmfiy----------vydgtagtMKSCAEARSflnahlqnvytdvledilqkgfseevkt-nrmttgiqvqaat 269
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81626735   259 pltfqalthikqdsqT-------------L--------I--------------------------------SQ------- 278
gi 123516702  297 yasyveggaftipapN-------------F--------M--------------------------------RQ------- 316
gi 500054275  253 ---------------N-------------IksaltpasL--------------------------------TK------- 265
gi 505934718  250 ---------------QlrplyaatsnygeA--------I--------------------------------RK------- 267
gi 502774930  228 ---------------N-------------Ist----rlM--------------------------------SP------- 236
gi 500053958  256 ---------------A-------------I--------VadmtpaelsgnmetvctelgydvsdaaqfnqcKQ------- 292
gi 503271434  233 ---------------Nir----------pY--------I--------------------------------TNpanftqs 247
gi 503674460  280 vfsryvingltvspeN-------------I--------A--------------------------------KN------- 299
gi 779845180  270 tdslqamgatttssiD-------------Y--------L--------------------------------KA------- 289
gi 499390539  270 dqaiqslalssksaqD-------------Y--------V--------------------------------LT------- 289
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81626735   279 -----------------------------Q----------------------L------------------MM------- 282
gi 123516702  317 -----------------------------V----------------------Y------------------MA------- 320
gi 500054275  266 -----------------------------N----------------------I------------------YSvctnlgy 276
gi 505934718  268 -----------------------------V----------------------CskayfdpdnsaelttcrnLI------- 289
gi 502774930  237 -----------------------------T----------------------F------------------TE------- 240
gi 500053958  293 -----------------------------AvtdakdtvglsaltldefvkqvF------------------IK------- 318
gi 503271434  248 rdricasagvdindplqlqsceqkinqhiQ----------------------F------------------IS------- 280
gi 503674460  300 -----------------------------V----------------------F------------------AG------- 303
gi 779845180  290 -----------------------------A----------------------V------------------LE------- 293
gi 499390539  290 -----------------------------S----------------------L------------------IA------- 293
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81626735   283 ------------H------------VLADS-------------------------------------------------- 288
gi 123516702  321 ------------E------------VLNDMl------------------------------------------------- 327
gi 500054275  277 dvtdaaavtqckT------------VLNNV-------------------------------------------------- 294
gi 505934718  290 ------------N------------ATMTF-------------------------------------------------- 295
gi 502774930  241 ------------N------------VMYKFcsqsgfnvsntseyqackdkftglvdsfatdigfsitlsnyvasafiarq 296
gi 500053958  319 ------------N------------RLDSS-------------------------------------------------- 324
gi 503271434  281 ------------NgqvtgglghfnaLMNLA-------------------------------------------------- 298
gi 503674460  304 ------------K------------VFYSFlssld--------------------------------------------- 314
gi 779845180  294 ------------P------------LYYEAa------------------------------------------------- 300
gi 499390539  294 ------------P------------IFNDSr------------------------------------------------- 300
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81626735   289 ---FSpe---------------------------kFAQERAHLQQNST-----YQAAGFTAAKGIVYMRVLFEALIYTSF 333
gi 123516702  328 --lDAnp--------------------------dlAVKGLASRSIMTG-----GLGMGIVANEWLPVARAVITAVAIGLI 374
gi 500054275  295 ---NSgtglgaasiddflrq-ayisqrleeifrsgNATGATNYQFLLN-----ASGAMKAANEWLPILKAALTAIAVGLL 365
gi 505934718  296 ---ATgtavpperllqqrqiaeilysfyfqddpetAVLMESDRRITAS-----GLGVGLTMNEWIPVIRAILTAIAIGVI 367
gi 502774930  297 ylmGGvna------------------------gtqNAIDIAKSMATAA-----NTVAGGVADEYIPKLQGMIITILIATF 347
gi 500053958  325 ---YQsgn------------------------tqvV----SNYQFLTN-----VSGSMKSFNEYYPVLRGVLTAVAIALI 368
gi 503271434  299 ---RStfe------------------------vtkIGGDHAINRFIQQdftvkGIGAIMGSSGYMGEARYAMFAIVGAMS 351
gi 503674460  315 -------------------------------psveAARIASFARAQAE-----LSGKGIVAQEWLPVMKTIFYILACSLI 358
gi 779845180  301 --aGRyqdlq--------------------dygsaLMVNQAIQQRNTQ-----WAAEQSMFMTVVRPMLTFFEGFIYAIT 353
gi 499390539  301 --vDAmnhwq--------------------eqraaMALRESLNQQEIQ-----WAGKGDSFKHYMRPMIAFFEGMLYAMT 353
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81626735   334 LFVLPLSLLPS-GIKILMNWAWSVVWIQFWPPFYAILNYLASIVAKHTt-----AgiadglaekglsiftsvGIENFAND 407
gi 123516702  375 PILVIFIPTPL-AGKALGLVAGMFIWLTAWGVTDAITHGIATDYAYGVfeyvrqNalgf---------aavmNMPDASLK 444
gi 500054275  366 PFLALFIPTPLiG-KAVGIIAGFFIWLTAWGVTDAIVHQFAVDYANQAy-----Etvrqnkl----gmdalyFFPDQTVK 435
gi 505934718  368 PFLVLFLPTPIvG-KAASVLLGFFVFLSTWGVTDAVIHGAAMDYAARGf-----Eevrqsnl----gvyalaALPSVSTK 437
gi 502774930  348 IIVALFVYMAP--VDAFKWYIGMWIWVIMWFVVDAILNVNVQAHAYEVf-----Rdirstgv----glnsmfYTGSDTLK 416
gi 500053958  369 PILIIFLPTPMsG-KIASILFGFFIWLTAWGVVDAILHGFAMEYANSVf-----Sqvrnegl----gldalyFFPNASVK 438
gi 503271434  352 CVLMLLWPTPVfG-KAFAGIIYLWGFIFFWAIGDAIAHKIAVDRAFDLy-----Aelratggt--igintlfHIPSETAK 423
gi 503674460  359 PLALIFIGT---GTGPVKFLAGIFLWWAVWCGMDALMYCLWISRADGIfqv-vsDgarlg-------lhgleELWFLSSK 427
gi 779845180  354 PIIAFIIVMGSfGLQLAGKYVQTILWIQLWMPVLSIINLFVHTAASNEmsslsagg--------lnsmyalsSTGDVLQH 425
gi 499390539  354 PFLAFALLLGGpGLSILGKYLVLPLAVGLWMPLLSIVNAFTLWYAGSQmeavfnGydptgsg---famlqlmDIDKAIGK 430
                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 81626735   408 TFALAGYL----T----L-S----VP----FLSYV---LLQ-GGLSQFVQLAGTLTSPAQSAA 449
gi 123516702  445 ALSMFGLI----R----TsG----IM----LATVItgmLVRfGGH-ALAMMAGTISGTVQSQG 490
gi 500054275  436 ILGMFGTL----R----M-SgmmlAT----VITGM---LIRfGGH-AMAMMAGSLGSQVQSAG 481
gi 505934718  438 MLAMFGVI----RsagiM-L----AS----LFSMM---LIRfGGH-ALAMLAGNLSAIVQGAG 483
gi 502774930  417 VLAMYSNA----R----W-I----SMslasVISFG---IIKmGGSAAFASMTSALGQQYRSSA 463
gi 500053958  439 ALAMFGTL----R----M-SglvlST----ALTGM---LVKfGGNAI-TQMGSSLQGHIAAAG 484
gi 503271434  424 ALGVFGQMraysM----L-V----AT----IITGF---LFK-VSSPGMAQLGSRIGGAMSdig 469
gi 503674460  428 AFALLGGM----R----SfG----FM----LAGAFvytVFRfGGS-VMAHFASAMVGSLSSGA 473
gi 779845180  426 WIATGGML----A----A-A----TP----VISLF---IVT-GSTYAFTSLASRISGSDHVDE 467
gi 499390539  431 ALGIGGLL----A----A-S----VP----PLALF---IVS-GSAMVANSIMSQMTAGEKFKS 472
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