Conserved Protein Domain Family
Glyco_transf_52

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pfam07922: Glyco_transf_52 
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Glycosyltransferase family 52
This family features glycosyltransferases belonging to glycosyltransferase family 52, which have alpha-2,3- sialyltransferase (EC:4.2.99.4) and alpha-glucosyltransferase (EC 2.4.1.-) activity. For example, beta-galactoside alpha-2,3- sialyltransferase expressed by Neisseria meningitidis is a member of this family and is involved in a step of lipooligosaccharide biosynthesis requiring sialic acid transfer; these lipooligosaccharides are thought to be important in the process of pathogenesis. This family includes several bacterial lipooligosaccharide sialyltransferases similar to the Haemophilus ducreyi LST protein. Haemophilus ducreyi is the cause of the sexually transmitted disease chancroid and produces a lipooligosaccharide (LOS) containing a terminal sialyl N-acetyllactosamine trisaccharide.
Statistics
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PSSM-Id: 311739
View PSSM: pfam07922
Aligned: 10 rows
Threshold Bit Score: 223.438
Threshold Setting Gi: 81454072
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2YK6_A        26 ERFYVVLMSENRNeKYDYYFNQIKDKAEWAYFFHLPYGLNKSFnfiptMAELKVKaMLLP----KVKRIYLASLEKVSIA 101
gi 14285526   25 MPFYGVMLSTVSNkKFDFYAKRLAQQCQGFFSMVQHKDRFNLL-----KEILYLK-RTFSg--kHFDQVFVANINDLQIQ 96
gi 14285525   25 EQFFGVMFGGVWDkKRTLYASKLAEVCSDSMNIDTGKDLKGFDf---lKLMRQLK-NKITh--kGFDKVFLANLNSLWLQ 98
gi 75355902   74 ERFYVVLMSENRNeKYDYYFNQIKDKAERAYFFYLPYGLNKSFnfiptMAELKVKsMLLP----KVKRIYLASLEKVSIA 149
gi 1175319    26 ESCLYIFDENIRGvNITPTFVSTRAKGLFDLFIKKLRSRVALSf------------fLLKrkikLEETIVYGADHLSHSL 93
gi 81454072   22 KENTRIFICDTIT-NYETWVKTLNEQGIRTEAVKEFAYREQLQsknieEVMELVDsDLNHyferVDTQVYLFNDDTLIGR 100
gi 493291829  25 EKFLGVFLGSEKNdKINFYFDKMSSFCERTIYIDISVETNKLGyl--fSLINFPK-NYLPi--sFFEKVFFANVNSLWIQ 99
gi 835334059  29 ARFHIIYLKTKVElK-SYIYETVNNEFSSGLVASMDYGf---------INMLKIN-RFLSh--kTIHYVYMANISHLSVQ 95
gi 499247117  25 EDVFFIFEKGAMPnNLTSI--------SHFIVLDHSKSECYDFf---yFNFISCKy-------rLRGLDVYGADHIKGAK 86
gi 493290178  25 ERFYGVMLSTVKNaKFDFYQARLAQKCEQFFAMQQHSERIQLL-----KEIIYLK-RTFGg--kKFNKVFLANINELEIQ 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2YK6_A       102 AFLSTYPd-aEIKTFDDGTINLIQSSSYLGDEFSVNg------------tIKRNFARMMIGDWSIAKTRNASDEHYTIFK 168
gi 14285526   97 FLLSAIDf-nLLNTFDDGTINIVPNSLFYQDDPATL--------------QRKLINVLLGNKYSIQSLRALSHTHYTIYK 161
gi 14285525   99 TYLSHVSf-kELYTFDDGSDNIFPHPNLLREPGTFK---------------YKLIKAFIGDKYSVNKLFKKIKKHYTVYP 162
gi 75355902  150 AFLSTYPd-aEIKTFDDGTNNLIRESSYLGGEFAVNg------------aIKRNFARMMVGDWSIAKTRNASDEHYTIFK 216
gi 1175319    94 LFLKKC----SFFLIEDGTENYHQKSYKRSWKNKLFsipk-------fgmYKNVKRIYLTKRENVPDCIK-SKVEYINIK 161
gi 81454072  101 YMVYLGK---NYHLIEDGYNCFQAKLFLGGSVVKRViktylfkkyvpygfSKYCLSIEVNSLVGLPHDIRSKKYKELPRK 177
gi 493291829 100 KILSNIIf-eELYTFDDGLGNVIKNPPILVEKWLV----------------RKIISCVIRNSYSVKKLLEINKKHFTIYP 162
gi 835334059  96 YILKMLSddvKIRTFDDGILSINSAGYLDKQIKLRKg------------pGRKLTRMWLGQHYNIRDIAKRSELHFSIVK 163
gi 499247117  87 FFLERH----RFFVVEDGMMNYSKNMYAFSLFRTRNpvil------pggfHPNVKTIFLTKDNPIPDQIA-HKREIINIK 155
gi 493290178  97 FLLSAISf-qELNTFDDGTANIVQNSIFYQAENIGL--------------NRKLINFFLGNKYSLEKLKQRSKTHYTIYK 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2YK6_A       169 Gl---KNIMddgrRKMTYLPLFDasELKAGDETgg-----tvRILLGS---P----------------DKEM----KEIS 217
gi 14285526  162 Gf---KNII----ERVEPIELVA--ADNSEKVTsa-----viNVLLGQ---Pvf------------aeDERN----IALA 208
gi 14285525  163 Ny---KNIV----SNIEPISLWD---NQIDCEIdg-----evSFFIGQ---Pll------------ntKEEN----ISLI 208
gi 75355902  217 Gl---KNIMddgrRKMTYLPLFDasELKAGDETgg-----tvRILLGS---P----------------DKEM----KEIS 265
gi 1175319   162 DlwfkKTEE----EKLEILYLLGidMKKIQLLIge------pFILFTQ---Plsed--------yiltENEK----IELY 216
gi 81454072  178 KlfdsLNKE----QKSLIFKIFKtkPLTITPKS---------VLLLTQ---PlaqdkcyktpterfqsIQEQ----YDYF 237
gi 493291829 163 Ky---KNII----SNVETLNIFS--DRNLSDLPsvpk--deiSILIGQ---Pif------------sdEDRN----VSLI 212
gi 835334059 164 HksksRNVD----CDIVYIDVLSeeKQRLHTERsapvyageiNVFVGSkfkDild-----------vkNDSNlialIHKI 228
gi 499247117 156 TlwqaKTAT----EKTKILSFFEidMQEISVIKnr------sFVLYTQ---Plsed--------klltEAEK----IDIY 210
gi 493290178 162 Nf---PNII----ENTVYIDLINq----vESVGtapsndditHILLGQ---Pife-----------rdDEKN----IALA 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2YK6_A       218 EKAAKNFNIQ----YVAPHPRQTYGLSgv-tTLNSPYVIEDYILREIKKnpHTRYeIYTFFSGAALTMKDFP-N-VHVYA 290
gi 14285526  209 ERVIKQFNIH----YYLPHPREKYRLAqv-nYIDTELIFEDYILQQCQT--HKYC-VYTYFSSAIINIMNKS-DnIEVVA 279
gi 14285525  209 KKLKDQIPFD----YYFPHPAEDYRVDgv-nYVESELIFEDYVFKHLSN---KKIiIYTFFSSVAFNLLSHP-N-VEIRF 278
gi 75355902  266 EKAAKNFNIQ----YVAPHPRQTYGLSgv-tALNSPYVIEDYILREIKKnpHTRYeIYTFFSGAALTMKDFP-N-VHVYA 338
gi 1175319   217 KSIIDKYDASk--lVIKPHPREKTDYSr--iFPNVKVFDETYPSEVLDIleVKFSrVITLFSTAAFSYPKEK-VdFYGTK 291
gi 81454072  238 DDIVQEYRTLgynvYLKVHPRDVVDYS----KLPVELLPSNIPMEIIELmlTGRFeFGITHSSTALDFLTCV-D-KKITL 311
gi 493291829 213 NKVFSVFNID----YYYPHPRECYHVSni-rYIYSKMIFEDYISELLLY--KSKIiVYTFFSSVALNIANFD-G-VEVRI 283
gi 835334059 229 ETLAAHYPSL----QYLRHPREYSQQVfgmtEITLNAISEDYICQLSSA--YQRVnVFGFASTCQLNVMKLE-N-VYITL 300
gi 499247117 211 RTILTKYNHSq--tVIKPHPRDKTDYKq--lFPDAYVMKGTYPSELLTLlgVNFNkVITLFSTAVFDYPKEKiD-FYGTA 285
gi 493290178 213 EKVIQQFGID----LYLPHPREKYELEnv-eYINTNLIFEDYIFQEFS---HKKCrVYTYFSSAVINILNKS-NhIEVVA 283

                 ....
2YK6_A       291 LKPA 294
gi 14285526  280 LKID 283
gi 14285525  279 IRTS 282
gi 75355902  339 LKPA 342
gi 1175319   292 IHPK 295
gi 81454072  312 VDLK 315
gi 493291829 284 IKLS 287
gi 835334059 301 LKTT 304
gi 499247117 286 VHPK 289
gi 493290178 284 LRVN 287
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