Conserved Protein Domain Family
NuiA

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pfam07924: NuiA 
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Nuclease A inhibitor-like protein
This family consists of protein sequences that are similar to the nuclease A inhibitor expressed by bacteria of the genus Anabaena ((NuiA). This sequence is organised to form an alpha-beta-alpha sandwich fold, which is similar to the PR-1-like fold. NuiA interacts with nuclease A by means of residues located at one end of the molecule, including residues making up the loop between helices III and IV and the loop between strands C and D. The mechanism of inhibition of nuclease A by NuiA is as yet incompletely understood.
Statistics
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PSSM-Id: 311741
View PSSM: pfam07924
Aligned: 28 rows
Threshold Bit Score: 116.96
Threshold Setting Gi: 504944592
Created: 23-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2O3B_B         7 SEILEQLKQASDGL-LFMSESEYPFEVFLWEGSAP-PVTHEIVLQQT------GHGQDAPFKVVDIDSFFSRATTP-QDW 77
gi 81709671   13 QGAAAELERAAHGL-LFPSETDAPFEAFEWPVF---ELNPEQLLENT------GHPPDMAVSALDLDAFFAPACRE-ADW 81
gi 159894523  24 ETSVEKITAAANGL-LMMSETDAPFTPFAWDAAT--PFSPEALAN------------GQPIQTISLEQFLGNATTV-QEW 87
gi 554673005   8 ddpAALLQEAAAGL-IFISESEAPFRALRWPVAT---IDSAQLLKRT------GHATGMRVRKLALREFFSSACRE-EDW 76
gi 504964488   6 TPLTEQLAELTNRL-FWLSESEFPFQVIIWDTD---RVTIEQLLKLT------YHPPNTPVQTLTIHEFFAPALEGlGSF 75
gi 373894392  10 ENTQTKLENAADGL-LMMSESDYPFDYFTTTDEV---VDDNLILKLA------GKPAGTLVEKTTLDYLLRNMTNP-AS- 77
gi 586956450 170 DPALATLRDMTTGL-VYMSEGDAPLEPVSFAAPAG-SLTDATLAQLA------GLPADTKVEKQELTYFLRNHTAD-NGV 240
gi 752565197  45 lRIYRDLNTLTEGL-LYPSESDYALNLIRLPLNAI-P-TNERLADLL------GL-GNKTVTSEQLDRFIRRRFTD-FAG 113
gi 504944592   6 ANLLAQLEELTPGIcLYYSDSDYTFKPIIWEVDTKgELTIENLLREVtppfdeYRPGGKIIKSANLDNYLQMIYQEaRKY 85
gi 501191540   4 EELLASLAEAAQGL-LFPSESDHELRPFRSRGD---ASSPAALLAAE------GLGAATPVEVTTAGDFFAPVIDV-PGD 72
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
2O3B_B        78 YEDEENAVVAKFQKLLEVIKSNL--KNPQV------------YRLGE-VELDVYVIGETPAGNLAGISTKVVET 136
gi 81709671   82 QEPRQRATAQRFQALLGTLKNAL--DEIKV------------YRVGG-VEADVYIVGLNQEGTLSGLKTRIVET 140
gi 159894523  88 HGEAEKATVSQFQQLVEVLKAEL--TDIQV------------YRVGE-INIDAYIVGKDSAGNLVGLKTQLVET 146
gi 554673005  77 YGPEEQQTAARFRHLVQTIEQNL--NDVQV------------YRVGD-TEADIYIVGRNRKGTLSGLSTQVVET 135
gi 504964488  76 SYLLDQALIGRYRILYNYLTYYL--DNIKV------------YRVGT-HPIYIYIMGITRDENLAGIATQIIET 134
gi 373894392  78 -GSVSPEIATRFSQLSTALKQEL--SEPEV------------YRVGD-RQIDVFILGKTNEGVIAGMRTKLIET 135
gi 586956450 241 LGNPELA--NRFKALQMYLKQEL--SGTQV------------YRLGTgPQVPVLVLGEAEGGKLQGFKTVLTET 298
gi 752565197 114 IDPETRTTYRRFRELGAYFNRTFgaTNCHA------------YRIDT-IQVKVLFLGFKPGCGYIGIQTVAIET 174
gi 504944592  86 DPDIAVEIAQIYQTVIKLLQSSL--TFLEVaeirelndpnstFRI---------IFGSTKSGEWIGIAPQLeae 148
gi 501191540  73 AGDAALAEAGRYRRLVDLLERHL--TDVRV------------YRVGR-VAIDVYVVGRHPSGAWLGLVTKVVET 131
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