Conserved Protein Domain Family
OGG_N

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pfam07934: OGG_N 
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8-oxoguanine DNA glycosylase, N-terminal domain
The presence of 8-oxoguanine residues in DNA can give rise to G-C to T-A transversion mutations. This enzyme is found in archaeal, bacterial and eukaryotic species, and is specifically responsible for the process which leads to the removal of 8-oxoguanine residues. It has DNA glycosylase activity (EC:3.2.2.23) and DNA lyase activity (EC:4.2.99.18). The region featured in this family is the N-terminal domain, which is organised into a single copy of a TBP-like fold. The domain contributes residues to the 8-oxoguanine binding pocket.
Statistics
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PSSM-Id: 311749
View PSSM: pfam07934
Aligned: 60 rows
Threshold Bit Score: 65.3255
Threshold Setting Gi: 74594200
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3I0X_A        13 VIVRNVEN--FELKDIF--DCGQCFR--WHRQENGn--YIGIAFE-----KVVEVQk-IG--EDVVIYNIN--------- 67
gi 123583035   5 FIEHSEA---VDINHCL--FSGQSFS--WQKHGNDgryVSAIING-----SAVVIEn-TN--DGGVVLHTDgnt----ig 65
gi 123579872   6 LITHNKE---LEIEKSL--FSGQSFL--WKKHQSNldsFVTVMDK-----RLVIISq-LS--PYTIRVHCDsev----ly 66
gi 81791361   14 SLLNTKSR--LNFKDTV--QSGQSFR--WNLNETLksyYSSVIYN-----SIIFICe-IN--SEMIEVLCTdqe----ls 75
gi 121725524  11 IVDFNEYVgdFDLILTM--NSGQTSQppWKMDDNN---YYEII-LidnidVLVKISq-EKlnDPLIVKYFSkee----fn 79
gi 81580521   10 SIAVPKE---FCFQENLryLSRSNNEcmFHIEDNK---IYKVI-PvqdvnPLVEISvnTD--GNIQIRCLEepytseksi 80
gi 81600734   11 IIALPEE---FDMNANLgyLKREKNEcmYETENDH---ITRMI-AigeirSLIQISviDN--KQMVVQFLNdsrpseewq 81
gi 501009195  12 VIIKEIHT--FEPKHTF--ECGQCFR--WEREEDGs--YTGVVYD-----KVLNVKk-IG--NDVILYpt---------n 66
gi 748194597   9 fIRISGVH--IDFDATF--FSGQCFR--WKKMDDF---YIGVVDE-----KIIFIKpqDE--DTFDIYNCSp-------- 64
gi 501155434   1 MYQITVEN--FDIRKIC--YSGQCFR--MKEISETs--YEVVAYG-----HYLRISq-QD--NELTFSCT---------- 54
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
3I0X_A        68 EEEFKNVWSEYFDLYRDYGEIK-KELSR-DPLLKKSVdfgEGIRI-LRQDPFEIL 119
gi 123583035  66 VESPQVWFRRYFSLDVDTETLFsEPFRNaHPELALQLeryRGLRV-LRQDPYETM 119
gi 123579872  67 GQKISAFISHYFTLDVPFQKIFsSSFKSnYSEVWRLLdgyKSIAL-LRQHPFETL 120
gi 81791361   76 GKPINEFLKHLFSLDFQEETVFsSRFQQeFPEVWNLVqsyRSVRV-MRQDPFEIM 129
gi 121725524  80 VEKLRTKLFYIFDLDYNINEVY--DFLEeNSQLSDVYefnRGLRLfKSQFPFECI 132
gi 81580521   81 REAVVNYVKEWFDLTTDLAPFY--TLAKhDLLLQGPIeqyYGLRTlGIPDLFEAL 133
gi 81600734   82 REKIVKYIHEWFDLNTDLTPFY--EMAKaDPLLKKTVetfYGLRVvGIPDLFEAL 134
gi 501009195  67 QLDFENIWIEYFDLHTDYQMIQ-EHLQAiDPVMKKAIgfgRGIRI-LRQDPWETI 119
gi 748194597  65 -DEFKKSFYWYFDLDKDYDEIL-EKLSGhDSILKEAVekyRGMRL-LNQEPFECM 116
gi 501155434  55 EGEFHSIWNEYLGLNVDYDTIT-GLVNEdDRYMKSAMsfgWGIRI-LKQELWETI 107
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