Conserved Protein Domain Family
Hepar_II_III

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pfam07940: Hepar_II_III 
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Heparinase II/III-like protein
This family features sequences that are similar to a region of the Flavobacterium heparinum proteins heparinase II and heparinase III. The former is known to degrade heparin and heparin sulphate, whereas the latter predominantly degrades heparin sulphate. Both are secreted into the periplasmic space upon induction with heparin.
Statistics
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PSSM-Id: 311752
View PSSM: pfam07940
Aligned: 75 rows
Threshold Bit Score: 78.9936
Threshold Setting Gi: 123319323
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4NEI_A       375 ILLGDGADGDQGALSIHRLge--ghNH-MALVAKNTSQGmg--------hgHFDKLNWLLYDNGNEIVTDYG---AARYL 440
gi 123517431 435 TGTRKDFAAPDGGYYVLRA------DT-GFAFTRCATFRdr--------pgQADILHCDLWWQGQNIALDAG---TYSYN 496
gi 81758538  380 LNKPSSFHFAQGGYAGLRS------QTgAFVLFNYPIFRfr--------paQNDALHVDFWLDGVNLLRDGG---TFSYN 442
gi 81500915  388 VPPARSTHMEAGGYGLLRY------GR-AFALFNLPHHRhr--------psQADALHVDFWLGGKNLLRDAG---SFSYA 449
gi 123319323 386 APSLGSELMEAAGVAILRVa-----GSdHTVAVKFGPHGgg--------hgHYDKLTFISYAEGARQAADPG---TQAYG 449
4FNV_A       418 TPNNDMKLFDQAGYYVLRNgw--tpAS-TVMILSNNKSNdasnslsayshnQPDNGTFELYHNGRNFFPDSGvctYYTSG 494
4MMH_A       362 APNFLSKALSNAGFYTFRSgw--dkNA-TVMVLKASPPGef--------haQPDNGTFELFIKGRNFTPDAG---VFVYS 427
gi 81442627  393 LPDYMSKGFLKSGFFVFRNsw--gmDA-TQMVVKAGPKGfw--------hcQPDNGTFEMWFNGKNLFPDSG---SYVYA 458
gi 81837547  308 APTEDDKVFPKSGYAIFRNdwskeeKA-TYVLFTAAYHVdy--------hkHSDDLNLYIYSNGE-IITEAG---PNGYN 374
gi 81436605  334 MKPKELFRGESSGLMAYKA------ED-IYFTLFNGLHGsa--------hgHASTGGFTLQLQGDDLFSDSG---RYSYV 395
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4NEI_A       441 NveakygghylAE-NNTWAKQTIAHNTLVVNEQ--S--HFYGDVTTADLHHPEVL----SFysgED-YQLSSAk--EANA 508
gi 123517431 497 Ap---------EP-WNNPLAHTAYHNTVTVDDR--DqmDRAGKFLWFPWLKGKVRcmkrSE---TGhLAYWEG---THDG 558
gi 81758538  443 Ag---------QA-YIDYYGGTQSHNTVQFDEH--EqmPRLSRFLLGAWLKAENV----HW---DEaRQYCSA---SYRD 500
gi 81500915  450 S----------AE-SAGYFSGTASHNTVQFDQR--DqmPRLSRFLFGAWLKARDVepvkQT---ADgVTCAAG----YRD 509
gi 123319323 450 A----------KT-HGTWDKTTVAHNTISVDGK--QqaEAAG--KLLEWNPGAKV---------TEiRLAAGP---VYPG 502
4FNV_A       495 Gd---------ND-LRYWFRGIDKHNTLSIGKQ---------NIKKAAGKLLKSE---------EGaTELVVF---ENQG 543
4MMH_A       428 Gde------aiMK-LRNWYRQTRIHSTLTLDNQ--N--MVITKARQNKWE----T---------GNnLDVLTY---TNPS 480
gi 81442627  459 Geg------evME-QRNWHRQTSVHNTVTLDNKnlEttESVT--------KLWQP---------EGnIQTLVT---ENPS 511
gi 81837547  375 Y----------KDpFTEYAYSSFAHNTLIVDGK--GlpRTDRQYEKVYLSDYEIN---------KDkVEATGI----NLR 429
gi 81436605  396 N----------KS-ERLQLKECASHNTMFIAEN--PhtLVSDTWGYDKL-PTPLF---------QQiKELSVGffaECGW 452
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4NEI_A       509 Y-----DGVEFVRSMLlvNVPSl-EHPIVVDVLNVSADKAstfdlplyfngqiIDFSFKVkdnKNV-------MKMLGkR 575
gi 123517431 559 Ylr-lpSPVEHRRGIL--QLGP--ESWLVIDRLSGSKAHR-------------YRLRWLL---PDF-------NHVWD-E 609
gi 81758538  501 Y-----FGCGHKRYVS---LSN--STLRVVDDIHGVQKK--------------AILRWRLn--PGK-------WIIEG-- 545
gi 81500915  510 W-----QGASHHRALT---LGR--KSLRVVDRVGGFRRS--------------AVLRWRLc--PGA-------QLSGN-- 554
gi 123319323 503 ve--ieRTLVHTGEYTldIAEA--RSVDGAAHLFDWTYHNfg----------sLDTTLPLk--PYL-------GMPQA-- 557
4FNV_A       544 Y-----DNLKHRRAVF--YVNK--KFFVLVDEGIGNAEGT-------------INLSFNLcegTAS-------EVVMDtD 594
4MMH_A       481 Y-----PNLDHQRSVL--FINK--KYFLVIDRAIGEATGN-------------LGVHWQLk--EDS-------NPVFDkT 529
gi 81442627  512 Y-----KNFKHRRSVF--FVDN--TYFVIVDEVSGSAKGS-------------VNLHYQM---PKG-------EIANSrE 559
gi 81837547  430 Y-----TGVEHSRTVSy-MKDE--EKIVVKDLVKSDKRHE-------------YKLLWHVa--SDItvhvrdrIVELFrN 486
gi 81436605  453 LdkadqNPMIFERSFI---YLKsiNSVVIIDSFAGQKETE-------------ITSTYNLa--PSI-------NCQKEaH 507
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4NEI_A       576 NGYQh-------------LWLRNTApvgDAseratWilddrfySYAFVTStps----kkqNVLIAELGAN--DPNYN--- 633
gi 123517431 610 SIGL--------------LTLRTEA---GD-----Y-------HLQAGAEprngsytlvcADEDSPRGWR--APYYN--- 655
gi 81758538  546 -NRV---------------TNHTHS----------I-------TISSNTDi---------KRLELVEGKE--SRYYYq-- 579
gi 81500915  555 -------------------VVQSEAgnlTV-------------TADVPIR-----------RIELTSGRE--SRYYLq-- 587
gi 123319323 558 NGYQhl----------teTRAASID---DE-----W-------MVTFAQEksr----mrvQVMGAPGTTV--AAGNG--- 603
4FNV_A       595 KNGV--------------HTAFSNN---NN-----I-------IVRTFANkavtcspftgRIAYLVDGAYntRQSYT--- 642
4MMH_A       530 KNRV--------------YTTYRDGnnlMI-----Q-------SLNADRT-----------SLNEEEGKV--SYVYNkel 570
gi 81442627  560 DMTF--------------LTQFEDGsnmKL-----Q-------CFGPEGM-----------SMKKEPGWC--STAYRkry 600
gi 81837547  487 NHKVmemevttvtgvsirALNEQTKpqvSG-----W-------VFPKMGEkrg----attIEVDISGSNVecITEFR--- 547
gi 81436605  508 RFALttnkhkytllfaggQTQQSVAkgsEI-------------YNQLNEHprlsnkfcykTGKEIQATVIspLEDIQ--- 571
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
4NEI_A       634 LRQQQVLirrveka-kqasfvSVLEPHGKydgslettsgay-snvksvkhvseNGKDvvvVD 693
gi 123517431 656 YREPALS--------------LDLTVHGSqtffwtlfspesicveksedhvilRSPT---WQ 700
gi 81758538  580 ETSIPVLe-------------IEVTSDG-------------------------QITTeynYS 603
gi 81500915  588 TEPIPVLe-------------VELDRPG-------------------------TLTTefqFL 611
gi 123319323 604 LGPDLRTav-----------pFVMARRT-------------------------APSArfvAV 629
4FNV_A       643 IDMNKSAdeta------ryitVILPVNGs------------------------TDTSsisAK 674
4MMH_A       571 KRPAFVFekpkknagtqnfvsIVYPYDG-------------------------QKAPeisIR 607
gi 81442627  601 KRMNVSFnvkkdnenavryitVIYPVKKs------------------------ADAPkfdAK 638
gi 81837547  548 LKDFKLGrddl------ipynLEKTFKSTrnlryhfeeaknqkhkdklfvvfsAMAPeykFA 603
gi 81436605  572 ITPIKVSqtgeneqfcqakgfRIIAGSEKfdlfvm-------------redivKGNKllvSE 620
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