1KN7


Conserved Protein Domain Family
K_channel_TID

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pfam07941: K_channel_TID 
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Potassium channel Kv1.4 tandem inactivation domain
This family features the tandem inactivation domain found at the N-terminus of the Kv1.4 potassium channel. It is composed of two subdomains. Inactivation domain 1 (ID1, residues 1-38) consists of a flexible N-terminus anchored at a 5-turn helix, and is thought to work by occluding the ion pathway, as is the case with a classical ball domain. Inactivation domain 2 (ID2, residues 40-50) is a 2.5 turn helix with a high proportion of hydrophobic residues that probably serves to attach ID1 to the cytoplasmic face of the channel. In this way, it can promote rapid access of ID1 to the receptor site in the open channel. ID1 and ID2 function together to being about fast inactivation of the Kv1.4 channel, which is important for the channel's role in short-term plasticity.
Statistics
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PSSM-Id: 311753
View PSSM: pfam07941
Aligned: 5 rows
Threshold Bit Score: 35.8003
Threshold Setting Gi: 542235545
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1KN7_A         4 MEVAMVSAESSGCNSHMPYGYAAQARARERERL-----AHSRAAAAAAVAAAT-AAVE----GTGGSGGGP--------- 64
gi 341940858   1 MEVAMVSAESSGCNSHMPYGYAAQARARERERL-----AHSRAAAAAAVAAAT-AAVE----GTGGSGGGP--------- 61
gi 542235545   1 MEFAMVGAD-GGCNSHLPYGY-AQARARERERererqvaHTRAAAAAAAAEGG-TCTE----GGGGGGGGScggvggsts 73
gi 545537098   1 MEVAMVSAESSGCNSHMPYGYaAQARARERERl-----aQSRAAAAAAVAAATaAAAE----GVGGPGGGA--------- 62
gi 992203253   1 MEFAMVGADSGGCNPHMPYGY-AQARARERERer---erHSRAAAAAAAAAAAaAAADsgatGEGGGTGGT--------- 67
                         90       100
                 ....*....|....*....|
1KN7_A        65 ----------HHHHQTRGAY 74
gi 341940858  62 ----------HHHHQTRGAY 71
gi 542235545  74 ntsssahllnNRQHQSRAAs 93
gi 545537098  63 ----------HQQHQQHQQH 72
gi 992203253  68 ----------CIHGQQHQVR 77
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