Conserved Protein Domain Family
PBP5_C

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pfam07943: PBP5_C 
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Penicillin-binding protein 5, C-terminal domain
Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organised into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.
Statistics
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PSSM-Id: 311754
View PSSM: pfam07943
Aligned: 65 rows
Threshold Bit Score: 49.1175
Threshold Setting Gi: 81787161
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3MFD_B      243 YQTYLIAKKGDIP---KLKGTFYESKA----FIKRDITYLL-TEEEKENVKINTTLlkPKKaw----ekDASKIPDIVGH 310
gi 81342931 302 YSKFPLIVK-------LKEKVYNGTVDtvalFSKEPFYYIL-TKDEFDKINISYTV---DKl------vAPLSGDMPVGR 364
gi 81582894 266 FEQTKVLGQGALA---EITEKKYANHV----YTKNSFSVPL-TEEEKKSVVLKVEL----Dk------sAKLVDGVKVGK 327
gi 81787161 271 FGMTELLEEGKVK---GLKDEFYAGQV----YASHDVVYPL-TEEEREKVRKEITLy-RPPkd----rrEPLNLPSPIGK 337
gi 81746215 280 YETNPLFSKGDKV---TEVDLLKADQSkvdiVTDHSVSTIHkKGDEKKNISTEVKL--QESw------tFPIQKGDEVGK 348
gi 81787190 278 YQTHQVYERDTYM---MDLNVRKGNKKsvpiFTSESVSLVTkKGESIDNVTERVEW--KESl------lAPVHKGDVVGT 346
gi 34395963 280 YETHPLYKRNQTV---AKVKVKKGKQKfielTTSEPISILTkKGEDMNDVKKEIKM--KDNi------sAPIQKGQELGT 348
gi 81715029 287 YMTKKLYTRGEKI---KTVQVGKGKKEkvdlVASDNVSLLMkKGENMDKVKQEVIA--EKKv------kAPIKKGDALGT 355
gi 81583566 303 FEMKQMYKKGSSVkgqETVRVENAKDKdvavQTKQAISLPV-PKGSKEVYKTELKEs-SKGq------eAPIKKGAALGQ 374
gi 81580925 299 FEKQKLKVDKN-----NTLSVAQGKEDqvtvAPEKEITVIA-KKGSKNPYKIGTEV--DKSlaedghlvAPIKKDAKVGS 370
                        90       100       110
                ....*....|....*....|....*....|....*...
3MFD_B      311 X------EI-XFNDATIAK-------V-PIYYENERHQ 333
gi 81342931 365 A------MI-FLENEKIGD-------V-ALFSGK-VKR 386
gi 81582894 328 T------DV-YVGNEKVGE-------RnLFYSKRKLVA 351
gi 81787161 338 M------SF-FLDGYVLTE-------T-PLYYKGTEPK 360
gi 81746215 349 L------II-KDGDTIISE-------V-PLTVSKNIEK 371
gi 81787190 347 L------YL-ERDGEILSE-------T-PLIAGEDVAS 369
gi 34395963 349 L------VL-KKDGEVLAE-------S-PVAAKEDMKK 371
gi 81715029 356 L------VI-KKDKDVLLK-------Q-TIVAKEDVAA 378
gi 81583566 375 M------VItPKDTNDPGFltgkslqV-DLVTTSEVEE 405
gi 81580925 371 ItlestdKYgFLDGSNSMK-------V-TAKTTEEVEK 400
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