4K91,5TR7,5J8X,3A3J,3MFD


Conserved Protein Domain Family
PBP5_C

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pfam07943: PBP5_C 
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Penicillin-binding protein 5, C-terminal domain
Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.
Statistics
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PSSM-Id: 336875
View PSSM: pfam07943
Aligned: 70 rows
Threshold Bit Score: 49.5071
Threshold Setting Gi: 81787161
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4K91_A      253 FESRNFYKKGTELTKGLVWKGSEH-----EVKAGLAEDL---TMTLPRGQMQKLQASMVL-EPQl------mAPIQQGQV 317
gi 81481601 269 FKPFKVFERNDVVKKVKVEKGKIE-----EIEVAVEKDC---IIPVSEEEIGKVNLEFHI-PDKl------eAPIKKGEK 333
gi 81342931 302 YSKFPLIVK----LKEKVYNGTVD-----TVALFSKEPF---YYILTKDEFDKINISYTV--DKl------vAPLSGDMP 361
gi 81582894 266 FEQTKVLGQGALAEITEKKYANHV---------YTKNSF---SVPLTEEEKKSVVLKVEL---Dk------sAKLVDGVK 324
gi 81787161 271 FGMTELLEEGKVKGLKDEFYAGQV---------YASHDV---VYPLTEEEREKVRKEITLyRPPkd----rrEPLNLPSP 334
gi 81412587 363 FKSFDIREHNKIKRSVSVLSSNLNvktsaFMPLLADEDFsqdYLTVFKNDERHIEQVIIL-PDVi------rAPLFAGQQ 435
gi 81766691 286 FSLVKLYSKNDVV--KEYYIDDKN-----TLSLVVPEDI---YKTFKNSEIENLSTDEIKkNLNidfsvkatKPISRGTD 355
gi 75541972 286 FELIKMYSRGDIV---TAYNEKDL-----SLNLIARDDF---YYI--KEKNDPSTAILNLeKKNln-----sISFHKGDT 347
gi 75542339 275 YEYKKLHSKGEVVAKAP---KDKK-----NIDLVCKEDI-----IIPTEKGTDYSVKINV-PNEi------nHNIYEGDK 334
gi 81530093 265 YEYKKMVSKGDVVYSGNVLNGGGK------VKLLAPSDI---YI--PCSKNKIYSKKVIV-SKDi------kSPILNNNM 326
                        90       100       110
                ....*....|....*....|....*....|....
4K91_A      318 IGKVEV-KLDDKVIRS------A-DLVALNAVEE 343
gi 81481601 334 IGHVVV-KIGEEKVCE------V-NCLSFQEVDR 359
gi 81342931 362 VGRAMI-FLENEKIGD------V-ALFSGK-VKR 386
gi 81582894 325 VGKTDV-YVGNEKVGE------RnLFYSKRKLVA 351
gi 81787161 335 IGKMSF-FLDGYVLTE------T-PLYYKGTEPK 360
gi 81412587 436 IGRIEYrIKDSDIVLK------TiPLICPLDIKE 463
gi 81766691 356 ILKDND-SFTGTLMIGntpyktL-NLLNSNDITY 387
gi 75541972 348 ILNAQV-LLNNNNVGT------L-NLASDRNHET 373
gi 75542339 335 VGSINV-FKEDKLIFT------E-SLVAKNSYKA 360
gi 81530093 327 IGRIEI-YCDNQCIYK--------NYLLGSFITK 351
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