Conserved Protein Domain Family
Toxin_16

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pfam07945: Toxin_16 
Janus-atracotoxin
This family includes three peptides secreted by the spider Hadronyche versuta. These are insect-selective, excitatory neurotoxins that may function by antagonising muscle acetylcholine receptors, or acetylcholine receptor subtypes present in other invertebrate neurons. Janus atracotoxin-Hv1c (J-ACTX-Hv1c) is organised into a disulphide-rich globular core (residues 3-19) and a beta-hairpin (residues 20-34). There are 4 disulphide bridges, one of which is a vicinal disulphide bridge; this is known to be unimportant in the maintenance of structure but critical for insecticidal activity.
Statistics
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PSSM-Id: 116555
View PSSM: pfam07945
Aligned: 2 rows
Threshold Bit Score: 26.9158
Threshold Setting Gi: 7994703
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                      10        20        30
              ....*....|....*....|....*....|....*.
gi 7994701  1 TICTGADRPCAACCPCCPGTSCQGpEPNGVSYCRND 36
gi 7994703  1 AICTGADRPCAACCPCCPGTSCKA-ESNGVSYCRKD 35
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