Conserved Protein Domain Family
Fucokinase

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pfam07959: Fucokinase 
L-fucokinase
In the salvage pathway of GDP-L-fucose, free cytosolic fucose is phosphorylated by L-fucokinase to form L-fucose-L-phosphate, which is then further converted to GDP-L-fucose in the reaction catalyzed by GDP-L-fucose pyrophosphorylase.
Statistics
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PSSM-Id: 311765
View PSSM: pfam07959
Aligned: 49 rows
Threshold Bit Score: 310.709
Threshold Setting Gi: 397625466
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302544  114 SGGYSQRLPNASALGKIFTALPL--------------GNPIYQM---LELKLAMYIDFPln-mNPGILVTCADDIE---- 171
gi 81894382    91 lilhmgRDFPFDDCGRAFTCLPVen-----------pQAPVEALvcnLDCLLDIMTHRLgpgsPPGVWVCSTDMLLsvpp 159
gi 327286368   90 lilhmgRDFSFDDCSRAFTCLPLed-----------pSAPVEALtcnLDNLLATLTCQIckgsPPGVWVCSTDMLL---- 154
gi 219114506   94 AGGESSRCPTQMILGKAWTSLPTmssvgspgvatcrlQTPVHVW---LRICERLFRGIP----NGSIVVLAADTLLr--- 163
gi 397625466  108 AGGESSRCPTQIVLGKAWTSLPVvdkma-----ctgvTNPTSIL---ISGLSEVFADVP----RGSVIVAASDVLL---- 171
gi 344290965   91 lilhmgRDFPFDDCGRAFICLPVen-----------pQAPVEAVvcnLDCLLDIMTHRLgpgsPPGVWVCSTDMLLsvpp 159
gi 965971091  115 lilhmgRDFPFDDCGRAFTCLPVen-----------pQAPVEAVvcnLDCLLDIMSHRLgpgsPPGVWVCSTDMLLsvpl 183
gi 449472525   89 lilhmgRDFSFDDCGRAFTCLPAed-----------pGAPAEALvcnLDSLLGTMTHRLcvgsPPGVWVCSTDMLLtvps 157
gi 941762263   91 lilhtgRDFPWSSCSRAFCWLPEek-----------pGQKVQAPvcvLDLLLDRLSTQIcpgsPPGVWVCSTDMILsvpt 159
gi 410907828   91 lilhtgRDFPWSSCSRAFCWLAVen-----------pDQSIHAPvccVDLLLNCLNHQVcpgsPPGVWVCSTDMILtipp 159
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302544  172 --------LYsi-------gEFEFIRFD--K---PG---FTALAHPSSLTIGTTHGVFVLDP-----------FddLKHR 217
gi 81894382   160 npgiswdgFR-------------------------G---ARVIAFPGSLAYALNHGVYLTDS-----------Q------ 194
gi 327286368  155 --------TV----------PSVPKIDWhgF---TG---ARVVAMPGSFSYAKQHGVYLADG-----------Q------ 193
gi 219114506  164 --------LP----------DSKFAIDW--EahaDT---VFGLAVPAPLATASNHGVFVLPPmrtnavpgasdQ--SSEP 218
gi 397625466  172 --------LFrsvgddasskKCEVINFD--Q---VDhckVLGLSVPAPLSTAKNHGVFVSDG-----------T--HCEG 225
gi 344290965  160 npgiswdgFR-------------------------G---ARVIALPGSSAYARNHGIYLSDS-----------Q------ 194
gi 965971091  184 dpgepaerna------------hvgnhgnvpslevP---AQPCPERVPPAYARSHGVYLTDS-----------E------ 231
gi 449472525  158 tpginwdgFQ-------------------------G---VRVIAVPGSPAYARNHGVYLTNE-----------Q------ 192
gi 941762263  160 hcvlswegFS-------------------------G---VRVLAVPGDVSYAADHGVYLSDS-----------Q------ 194
gi 410907828  160 dfvmswegFS-------------------------G---ARALALPGDISYALSHGVYLSDK-----------Q------ 194
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302544  218 D-LEYRSCHRFLHKPSIEKMYQF-NAVC------RPgnfcqqdfaggdiadlkldsD---YVYTDS-LFYMDHKSAKMLL 285
gi 81894382   195 -----GLVLDIYYQGTKAEIQ---RCVG------PD--------------------G---LVPLVSgVVFFSVETAEHLL 237
gi 327286368  194 -----GFVQDIIYQGSEDQIQR---CVG------SD--------------------G---KVPLVSgIVFFSSEAAEQLL 236
gi 219114506  219 V-IQVEPCHDVLQKPSQSTLQA--HCQF------KQ--------------------NgqaCAWIDTgVIVFLPTTATILR 269
gi 397625466  226 EgWNIQSTDKVLQKPSPDEMRSTaNCTFsldgggKN--------------------Q---VAWIDTgVVCFLPKSAATLR 282
gi 344290965  195 -----GFVLDIYYQGTEAEIQ---RCAR------PD--------------------G---RVPLVSgIVFFSVETAERLL 237
gi 965971091  232 -----GFVLDIYYQGTEAEIQRW---------------------------------G---RGALVSgVVFFSVETAECLL 270
gi 449472525  193 -----GLVRDIIYKGTEAQIQ---QCAG------PD--------------------G---TVPLVCgIVFFSSDAAEQLL 235
gi 941762263  195 -----GRVRDIIYRGTREEIQ---RALM------PD--------------------G---KVPLVSgPVFFCRSVSEKLL 237
gi 410907828  195 -----GHVRDIIYRGTEDQLR---PALM------PD--------------------G---KVPLVSgPVFFSSLVSEKLL 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302544  286 AFYEkiGTLSCE--------------------------------IDAYGDFLQALGPGATVEYTRntsnvi--------k 325
gi 81894382   238 ATHVs-PPLDACtymglds-------------------gaqpvqLSLFFDILLCMARNMSRENFLagrppelgq--gdmd 295
gi 327286368  237 ATHVi-PPLNACtylglds-------------------gappiqLSLFFDILLSMARGVSEEAFVnglgprtggsgdntq 296
gi 219114506  270 RLAFddELLSRCtastlqsmqnrhladgdspesalikaqdasfrFDLYTDLLQALPMVASMDDRLdngkvtqgp--syav 347
gi 397625466  283 DLSGs--sMKCCtrtgiaelygqggts---hssieafavqksikLCLYGDMLRALKTASSQGPTGmt------------- 344
gi 344290965  238 ATHVs-PPLDACtymglds-------------------garpvqLSLFFDIVLSMARNVSKEDFLvgrppemgq--gdvg 295
gi 965971091  271 ATHLs-PPLDACtymglds-------------------gaqpsqLSLFFDILLCMARNVQREDFLvgrppemgq--gdad 328
gi 449472525  236 ATHVv-PPLDACtymglds-------------------gappiqLSLFFDIVLCMAGGMTEEDFVkggg----------- 284
gi 941762263  238 QTHVs-PPLDGCtylgvds-------------------gapplqISLFLDLLKCLCSDLTQDQFVnegragcsp--tdgl 295
gi 410907828  238 RTHVt-PPLDGCtylglds-------------------gapplqVSLFLDVLKCLCSDVTQDQFVreertgcss--pvgp 295
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302544  326 eeselVEMRQRIFHLLKGTSLNVVVLNNSKFYHIGTTEEYL-FYFTSDNSLKSElGLQSITFS-IFpdip---------- 393
gi 81894382   296 vasylKGARAQLWRELRDQPLTMVYVPDGGYSYMTTDATEF-LH-----------RLTMPGVA-VAqivhsqv------- 355
gi 327286368  297 seaalWSARAVLWKTLHTMPLIMAYVPDGSYDYMTSSASDHiHHLTTSVGNAHGgSFSKVAHShVEepg----------- 365
gi 219114506  348 lresfRSCR-----------LSVMTIPSGRFLHLGTTRELL-DFYTHGCHSNTEp-LTASMSP-PQalc----------- 402
gi 397625466  345 -------gTLAAVNKLSQHEICICSYSSGSFVHLGTTRELV-DFLTVGASVAAT-SSRDVKPS-AWkryqnfgktmkltr 414
gi 344290965  296 iaaylQGARAELWRELRDQPLTMAYVPDGSYSYMTSLASEL-LH-----------SLTVPSTP-RAqtvhsqv------- 355
gi 965971091  329 iagylHGARAELWRQLRGQPLTVAYVPDGSYSYMTNSASEF-LH-----------SLTSPGAP-GAqvihsqv------- 388
gi 449472525  285 -dasvRNARSVLWTALRGFPLSMACIPNASYDYMTASASDH-IR-----------SLTLLPSS-AShlrfcktah----- 345
gi 941762263  296 qgatvRAGRAELWRILRGAPLSLVYVPGGCYDYLTLSGKQH-VD-----------RLTSDWTV-GNtlshiq-------- 354
gi 410907828  296 qgetvRQCREELWRILRGTPLTVAYVPDGCYDYLNLSGKRH-VE-----------RLSQNCTD-GNvlshiqk------- 355
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302544  394 ---------ecsGKT------------------SCII------QSILD-S--------------------RCSVAPGSVV 419
gi 81894382   356 ------eepqllEAT------------------CSVV------SCLLE-G--------------------PVHLGPRSVL 384
gi 327286368  366 ----------llEEG------------------CSVT------NSLLE-G--------------------AVFVGPGTAI 390
gi 219114506  403 ----------reFGT------------------SLALtrrleaFTLVG-P--------------------YGQIDPSAII 433
gi 397625466  415 rsgsfvsgldtqADG------------------HVVL------NSVLTcS--------------------RGRLGANCVV 450
gi 344290965  356 ------eelellEPG------------------SSVV------SCVLE-G--------------------PVWLGPGSVL 384
gi 965971091  389 ------evrpawRRRpllgwdnvvscllgglpcGWAP------GRRSL-GsgqlrveawracgesgrgrpVGRPAPGRTW 455
gi 449472525  346 ---shvdqpcllEDG------------------SSVT------NCVLE-G--------------------AVQLAAGSVI 377
gi 941762263  355 -------nenllSEG------------------ARII------NSILD-G--------------------GVTVATRAVV 382
gi 410907828  356 ------vggvnpGAS--------------------II------NSVLD-G--------------------DVTVATGAVV 382
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302544  420 E-------YSRL-GPDV---SVGENCIISGSYILTka------aLPAHSFVCSLSLKMNRCl------------kYATMA 470
gi 81894382   385 Q-------HCHL-RGPI---RIGAGCFVSGLDTAHseal-hgleLH-DVILQGHHVRLHGSl------------sRVFTL 439
gi 327286368  391 Q-------HCCL-KGPL---QIHSGCLLTGLDGDSseal-rghhLK-DVVIQGHAVRLKGLs------------cKVFTL 445
gi 219114506  434 M-------HSSI-QDSLsmeSVGSLPMV----------------IPDNTIVQQVRRVPQDEadt---------caCTLVV 480
gi 397625466  451 E-------HCDLrSDEI---SIGENSLVSGVRDTGgv-----fsIGGDLCLQLLPVRQSWKdanlpassdvarpcFVCLC 515
gi 344290965  385 Q-------HCHL-RGPI---HISTGCFLSGLDIAQseal-hgmeLR-DLILQGHHMRLHGSl------------gRVFTL 439
gi 965971091  456 AplstqtlSSPR-QGPI---HVGTGCFVSGLDVAQsqal-hgveLR-DLILRGHHVQLHGAp------------sRAFTL 517
gi 449472525  378 Q-------HCHL-QGPL---VIGPGCLLSGLDVDSspal-rgcpLR-DVVLQGHHVRLRDLp------------cRVFTL 432
gi 941762263  383 Q-------HCHL-QGPL---DVPSGCLLSGVDVSAsacl-rrlaLSSDIIIQGHRIQLGELk------------lNMYTV 438
gi 410907828  383 Q-------HCHL-KGPL---KVPTGCLLSGLNMMTlqcplwqldLASDIIIQGRFIELGELk------------lKVFTV 439
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126302544  471 FGVQDNLKKSVKtlsdiklL----QFFGVCFLSC---------LDVWNLK------------------------------ 507
gi 81894382   440 AGRLDSWERQGA-------G----MYLNMSWNEF---------FKKTGIR------------------------------ 469
gi 327286368  446 SGRHNRWESLAEe-----dG----TYLNARWSDL---------FLRTGIR------------------------------ 477
gi 219114506  481 LGVDDKIKSLDG-------------LYGRPLQDF---------MSWAGLS------------------------------ 508
gi 397625466  516 FGINDGIKDFPMk-----------TVYGVDLRALtrgfataneCGIISIK------------------------------ 554
gi 344290965  440 TGRLDNWEr---------qGtgtyLNMP--WSEF---------FQKTGIR------------------------------ 469
gi 965971091  518 VGRLDSWERQGT-------G----TYLNMSWSKF---------FQKTGIR------------------------------ 547
gi 449472525  433 TGRLDDWQSPVEk------A----TYLNVPWAEF---------FQRTGLR------------------------------ 463
gi 941762263  439 TGAHDDLQVPFNds----gA----SFLNQTWTVF---------FSSSGIKxdpnlstdfvlclflyiqqiipvccffvls 501
gi 410907828  440 MGAQDDLESSFDda----rA----SFLNQSWNHF---------CSRTGIQ------------------------------ 472
                         650       660       670
                  ....*....|....*....|....*....|...
gi 126302544  508 ------VTEELFSGNKTC-L-SLWTARIFPVCS 532
gi 81894382   470 ------DWDLWDPDTPPS-DrCLLTARLFPVLH 495
gi 327286368  478 ------REDLWSGDVLPG-RgCLLNAHLFPVLH 503
gi 219114506  509 ------ESDLWDEEADH--K-MVWNARLHPSIK 532
gi 397625466  555 ------ESEIWNENVPSSrR-MLWNANMHPIIe 580
gi 344290965  470 ------DWDLWDPDTPPT-ErCLLSARLFPVFH 495
gi 965971091  548 ------DWDLWDPDVPPA-ErCLLSARLFPVLH 573
gi 449472525  464 ------EGDLWDAEMPRG-SrCLLSARLFPVLH 489
gi 941762263  502 sslllrPEELWVKGEHC----SLLEARLFPVLH 530
gi 410907828  473 ------PEELWVKKEQR----SLLEARLFPVFS 495
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