Conserved Protein Domain Family
A1_Propeptide

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pfam07966: A1_Propeptide 
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A1 Propeptide
Most eukaryotic endopeptidases (Merops Family A1) are synthesized with signal and propeptides. The animal pepsin-like endopeptidase propeptides form a distinct family of propeptides, which contain a conserved motif approximately 30 residues long. In pepsinogen A, the first 11 residues of the mature pepsin sequence are displaced by residues of the propeptide. The propeptide contains two helices that block the active site cleft, in particular the conserved Asp11 residue, in pepsin, hydrogen bonds to a conserved Arg residues in the propeptide. This hydrogen bond stabilizes the propeptide conformation and is probably responsible for triggering the conversion of pepsinogen to pepsin under acidic conditions.
Statistics
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PSSM-Id: 311771
View PSSM: pfam07966
Aligned: 128 rows
Threshold Bit Score: 33.0753
Threshold Setting Gi: 341884635
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30
                 ....*....|....*....|....*....|
2PSG_A         1 LVKVPLVRKKSLRQNLIK-DGKLKDFLKTH 29
gi 332264729  21 LVRIPLHKFTSIRRTMSEvGGSVEDLIAKG 50
gi 395851770  21 LIRIPLYKFKSIRRTMSEaAGPVEELIAKG 50
gi 16119024   19 VIRIPLTGFKNVRRRLMEvGTPVEQLNFTS 48
gi 47213062    8 LPRIPLNKFRSIRRELTDsGRQVEELLADR 37
gi 597773809  19 IVRIPLKKFRSIRRSMTDsGRAMEELLADS 48
gi 808884169  21 IIRVPLHKTRTLRRLMSDnGMSVEELRALA 50
gi 831552042  21 VVRVPLYKTRSLRRLMSDnGRTVEELRALA 50
gi 158254091  21 IIRIPLHKMRTVRRMLADnGKTIDEIKSLA 50
gi 947201402  21 LIRIPLHKFPSIRRTLTEmGGPVENLIAHE 50
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