Conserved Protein Domain Family
Glyco_hydro_92

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pfam07971: Glyco_hydro_92 
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Glycosyl hydrolase family 92
Members of this family are alpha-1,2-mannosidases, enzymes which remove alpha-1,2-linked mannose residues from Man(9)(GlcNAc)(2) by hydrolysis. They are critical for the maturation of N-linked oligosaccharides and ER-associated degradation.
Statistics
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PSSM-Id: 311776
View PSSM: pfam07971
Aligned: 739 rows
Threshold Bit Score: 381.437
Threshold Setting Gi: 0
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WW2_A         219 LKFDvPAg-eK--LTIRTASSFISPEQAAINFNREVADaDVQLISGKAREQWNNYLGRVEAEGGTDEQLRTFYSCLYRTL 295
31_pfamImport    1 IHF---DktkEqvL-MKVGISYTSIENANNNIETELPYwDFNKTTADSQKEWSNLLGRIKIEGGTETDQRRFYTDLWHAL 76
673_pfamImport   1 VNL---GdsvDevL-MKAGISYTSVENAEVNIQEELPDwNFNSCVARANEEWNSMLGRIQVEGGTEKEQRRFYTDLWHAL 76
81_pfamImport    1 LRFV-TTqdeQ--VLVKVATG-VSYEQAEQRLTQEDPSwDFNRVHAAARAAWASKLNRVRVEGGTAKQKMLFYSCLYHSF 76
300_pfamImport   1 LDLT-TTageQ--VLVKIAHG-TSYEQAEQRLQSEDPGwDFDRVHRQAEDAWAAKLNQIEVEGGSEKEKMLFYSCLQHSF 76
17_pfamImport    1 LSLS-DQdagV--VTMKIGISYVSIANAKENLESESIDaSFEEVQTAAEKEWDGLLSKISVKSDSRRDKEMFYTSLYRTF 77
221_pfamImport   1 VHLT-NEskaP--VELKIGLSFVSMENAKQNLLQEIGNkSFVEIQEEASRQWNEILSSIEVTGGTKKQKEMFYSSLYRSL 77
107_pfamImport   1 VHLA-DGnkgP--VEMKIGLSFVSTENAKQNLEKEIGQhSFDDIRHEATDKWEKLLSAVEVKGGTEKQRTMFYSCLYRSF 77
678_pfamImport   1 VSFN-ESde---eLELKLALSFVSIENAKQNLEAELAGkSFEEVKNEASETWENLLSKIKVEGGTDKQKSLFYSSLYRSF 76
148_pfamImport   1 VDFLnNKgsrA--LELKIGFSFVSIANAKQNLEAEMLGkSFEQVRQEADNIWNKQLGHIQVEGGTQKQQTMFYSTLYRAF 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WW2_A         296 LFPREFYEfdsQgnpvyYSpyD-----GNvhd----------gymYTdngfWDTFRAVHPLFTLLYPEVSERVTQSIINA 360
31_pfamImport   77 QGRKMISDangA-----YP--DntgdiFRighlplkadgkpkfnhYNsdafWGAQWTINNLWGLVYPEIMEEFVYSLMQY 149
673_pfamImport  77 QGRRIISDvngA-----YP--DntkehFRigqipldengkpgfnhYNsdsfWGAQWTINTLWGLVYPEIMDDFVHSLMQY 149
81_pfamImport   77 DSPRLVAGkgaQ-----FIgnD-----GKihta--------qhdrYGeipfWDTGRNQVVLLMMLEPKIMASILRSQLDM 138
300_pfamImport  77 ASPRLVAQkgeP-----FVtrD-----GTvtta--------tydrYNevpfWDTGRNQIVLLTLLEPKVKTDILHSQLDM 138
17_pfamImport   78 LWPALRSDangE-----FSdeA-----GKiqkq--------dfkyYTipslWDTYRNKLVLLSILSPEVTGDVISSLINR 139
221_pfamImport  78 LWPALRSDvngE-----FTdaK-----GNvdka--------dfnyYTepslWDTYRNKDVLLGLLAPQVALDVIKSMKDV 139
107_pfamImport  78 LWPALRSDvngE-----FSdaK-----GKvvka--------dfnyYTepslWDTYRNKDVLLGLISPQVTLDVIKSMKDV 139
678_pfamImport  77 LWPALRSDvngE-----FTdaS-----GEvvnk--------gfryYTnpslWDTYRNKLVLLGMLSPDVTADVIQSLIDK 138
148_pfamImport  79 LWPALRSDvngE-----YTdeQ-----GRvcka--------dfryYTnpsfWDTYRNKLILLGMINPDVATDIIKSIIDK 140
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WW2_A         361 YNEs---GFMPEWASPG-HRGCMIGNNSVSLLVDAWMKgiQTVDaeKALE---------------AMIHQTQarh---ae 418
31_pfamImport  150 YKDg---GIIPRGPSGGnDTYVMTGASTTPFIVSAIQKgiVKENleKIYI---------------ALKKNHMpggimeka 211
673_pfamImport 150 YKDg---GLIPRGPSGGnYTYVMTGASSTPFIVSAIQKgiVTDSleNIYN---------------ALKRNHMpngimgka 211
81_pfamImport  139 AREngymG------------TSFHGDHADLVYLGAWERg-iPFDheAVYR---------------YLYKNATdpkgprpy 190
300_pfamImport 139 AREsgymG------------TSFHGDNAVFMYLGDWERg-lDFDwaGTYE---------------YLRKNATdpagprgy 190
17_pfamImport  140 AEIt---GFVPTFFHg--D-------HGAPFIAGSYKRgiSNFDvqKAYSfllnnay-nakgpraHVEE----------- 195
221_pfamImport 140 GDKt---GFIPTFFHg--D-------HGASSIVGAYLRgiNDFDvqGTYKlllrnan-asngarpYVDE----------- 195
107_pfamImport 140 GDKt---GFIPTFFHg--D-------HGTSSIAGAYLRgiDNFDikGTYAtllrnan-vangarpFVTE----------- 195
678_pfamImport 139 GEKt---GFMPTFFHg--D-------HAAPFISGSYLRgiRDYDvqSAYQlllnnat-keggtrpHIAE----------- 194
148_pfamImport 141 GEKa--gGYMPTFFHg--D-------HASTFVAGLWLRgiKGFDlqRAYKlllknatvpgrggrpWLEE----------- 198
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WW2_A         419 IAsv------gRdgfEYYDKLG----YVPY-----------Pev-pEATAKTLEYAYADWCIARFAESLGKQdIA-DQYY 475
31_pfamImport  212 GYehntnigggL---KYYLEKG----YVPYplp-----dgnFgsheDGASQTLEYAYQDWTLAQLAKKLNHE-EDyLYFM 278
673_pfamImport 212 GYehrtntgggL---AYYIKNG----YVPYplpe----gdnFgahqEGAGQTLEYAYQDWALAQLAKKLNKP-NDyGYFL 279
81_pfamImport  191 LA-------------EY-EKQGwisdYIPKgnp-----dppYaggkAGVATTLEYSWDDHALALYAQRLGKQ-ADyQRFL 250
300_pfamImport 191 LA-------------EY-MKNGwisdIIPPgnp-----sppYaggkAGAATTLEYSWDDYAMAIYAKRLGKQ-ADyEMFL 250
17_pfamImport  196 -----------------YIAKG----FISDpqvenphvetkAk---AGVSKTLEYAYDDYSLAILADTLGDK-EHfQDLM 250
221_pfamImport 196 -----------------YIQKG----YISDpdianphvetkGk---AGVSKTLEYAYDDYSLAQMAKKLGDE-VNyKRLI 250
107_pfamImport 196 -----------------YIEKG----YISDpdianphvetkAk---AGVSKTLEYSYDDYSLAQIAKKLGDT-ANyRILM 250
678_pfamImport 195 -----------------YIEKG----YISTpevenphveskAk---AGVTKTLEFAYDDYAVALLAEELGKQ-DDyKMLM 249
148_pfamImport 199 -----------------YLKQG----WIAEkdttnvptwdeYk---ASVTKTQEYAYDDYATALIARELKDK-KNyQLLM 253
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WW2_A         476 QKAPNYRNLYYPEHGFMWTKDAKGNWRdrFdatEW-GGp-fT----EGSSWHWTWSVFHDPEGLSELMGGHEPMIARLDS 549
31_pfamImport  279 KRAKNYKNVFDAEIGWMRPKNADGKWRenYdpyQY-ENg-fI----ESNGAQSTWFVPHDILGLADLMGGKEKAAAKLNA 352
673_pfamImport 280 NRSENYKHVYNKQSGWMTPKDINGNWPenYdvySY-ENg-fV----ESNAAQSTWFVPHNIDGLARLMGGKAAATDKLNA 353
81_pfamImport  251 RRSHNYRNVFDSQDGFMRGRLADGQWItpFdpeEPyYNfmmK----EASGWGTLWLVPHDVQGLINLLGGREKFDAKLDQ 326
300_pfamImport 251 KRAQNYRNVFDSSIGFVRGKTEDGKWIapFdpgEPyYNfmmK----EASGWSTLWLVPHDVQGLANLLGGREKFAAKLDE 326
17_pfamImport  251 SRSQNYKNVFDPSINFMRGRLENGDWIspFdteYP--Yy--EymfrEANAWQVSFYAPHDMPGLVSLYGGPDMFEEKLDE 326
221_pfamImport 251 ARSKNYRNVFDPTTKLMRGRLDNGDWItpFnpqYP--Yy--EymyrEANAWQVSFFAPHDMEGLIELYGGKKAFESKLDS 326
107_pfamImport 251 ARSKNYRNMFDPSTRFMRGRLENGEWIknFnpqYP--Yy--EymyrEANAWQVSFFAPHDMPGLIKLYGGPKPFESKLDS 326
678_pfamImport 250 KRTSNYKNLFDPSTGLMRGKLENGDWVpdFnaeYP--Yy--EymyrEANAWQSSFFAPHDTKGLIGLYKSEAEFEEKLDS 325
148_pfamImport 254 QHSQNYKNLFDASTGFWRGRIADGSWIkdFdpwYP--Yy--AymyrEADAWNSLFFAPHDPEGMVALYPSKKAVELKLDS 329
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WW2_A         550 MFv--ApntynygtygfviheiaemvalnMGQYAHGNQPVQHAIYLYDYIGQPWKTQYHLRNVMDKLYN--S-GS-K-GY 622
31_pfamImport  353 QF---Etakkqnytsgt-shdaelhpefsRIPVNFGNQPSMQTSNIFTILGRPDLTQYWTRNVVKETFS--GlSP-AtGY 425
673_pfamImport 354 QF---Esaeksgftsgk-sheaelhpeyrRIPVNYGNQPSIQTAFVFNQLNRPDLTQHWARKVASGVFS--DlST-KrGY 426
81_pfamImport  327 FFstpYhpqgic-----------rdctgvIGQYVQGNQPDQQAAYYYDWGGQPWKTQKLAREIMRLMYG--S-DAsGyAF 392
300_pfamImport 327 FFstpYtakgvc-----------rdctglVGEYVQGNQPDQQAAYYYDWAGQPWKTQALVRRILREMYG--S-DKtGyAF 392
17_pfamImport  327 FF---Tkpwnpnhi--------arnvstfIGQYCQGNQPDHEAPFAYYYVNKPEKSQAILDKIMNELYGigP-EG-L-AL 392
221_pfamImport 327 LF---Tipwnptyi--------arnvetmIGQYCHGNQPDHEAPFAYYFIEKPEKSQRIIDYILNNLYGigD-EG-L-AL 392
107_pfamImport 327 LF---Tvpwnpnyi--------arnvetmIGQYCHGNQPDHEAPFAYYFINKPEKSQKIIDTILNSLYGvgD-DG-I-AL 392
678_pfamImport 326 LF---Sipwnadyi--------arnvssfIGQYCHGNQPDHSFPYLYTFIGKQEKSQMYLDSIMNRFYGmgE-WE-N-AF 391
148_pfamImport 330 LF---Tqpnhgye---------awnltgfLGTYCHGNQPGHSIPYTYYFADKQEKAQVVIDSLLNHYYGmgE-EG-L-AY 394
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2WW2_A         623 CGDEDNgQTSAWYVFSAMGFYPVcPGM---PEYAIGSPLFKKVTLHL----PEGKNFVVsaAdNAadRpYIRKALLNGQE 695
31_pfamImport  426 NGDEDQgLMGSLNVLLKLGLFQMnGGTdqdAVYQIGSPIFNKITITLnpkyYSGKTFVInaQkNSpeNvYIKDIKYNNKH 505
673_pfamImport 427 NGDEDQgLMGSLAVLMKIGLFQMnGGTeenPEYQIGSPVFDKITIQLnedyYPGKTFEIncInNSayNvFVNEVTLNNSP 506
81_pfamImport  393 PGMDDQgSTSSWYVMSAMGFYPVdPSS---PDYILGSPIFRKTTIEM----GNGYTFMIvaRhNSaaNiYIQSATLNGKP 465
300_pfamImport 393 PGMDDQgSTSSWYVMSAMGFYTVdPSS---PNYILGSPLFTHTVMHM----GNGKTFEMvaNhNSekNiYIQSATLNGKA 465
17_pfamImport  393 SGMDDAgEMSSWFVCAAVGLYPMsPAD---ADYLVTVPLFDDVTWKV----DNGNDLVIlnPn---rGrKLQEIKVNGKT 462
221_pfamImport 393 CGMDDAgEMSSWYVLSALGLYTYsATD---PTYLVTVPLFDKVKWHR----MGGKELTIikAg---eGrVLKNIIVNDKP 462
107_pfamImport 393 CGMDDAgEMSAWYVFSAAGLYTFsATD---PEYLVTVPLFDEVKWRT----STNKILTIthQg---kGrKMTAIKVNGKP 462
678_pfamImport 392 CGMDDAgEMSAWYVFAAMGIYPYsPGD---AEYIVSVPLFNSVKLDL----GEQSEFKIskTn---sGrKIKDLTIDGNL 461
148_pfamImport 395 AGMDDAgEMSSWYVLNAIGIYTYsPAD---PQYIVTVPLFNKVRFTLg---TTGNTFTIrrEg---sGrKISQITVGGKP 465
                          570       580
                   ....*....|....*....|...
2WW2_A         696 FT--RnYLTHDelkQGGELNLSM 716
31_pfamImport  506 VKdfT--LTHKeitNGGELILQM 526
673_pfamImport 507 IKqyK--ITHQdiiNGGSIQLKM 527
81_pfamImport  466 WK--KpWFSWDdirDGAVLTLTM 486
300_pfamImport 466 WN--KpWFSHSdieAGGKLVLNM 486
17_pfamImport  463 LD--GyFVGHDlfrKGGKIELVT 483
221_pfamImport 463 NK--GyFVSHDlflKGGEIRVET 483
107_pfamImport 463 IK--GyFVPHDlfkNGGKIEVVT 483
678_pfamImport 462 VE--GyFVSHEqlkKGKELIILT 482
148_pfamImport 466 LK--GwFVPHAqlaKGAEMLIKT 486
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