Conserved Protein Domain Family
tRNA_SAD

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pfam07973: tRNA_SAD 
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Threonyl and Alanyl tRNA synthetase second additional domain
The catalytically active from of threonyl/alanyl tRNA synthetase is a dimer. Within the tRNA synthetase class II dimer, the bound tRNA interacts with both monomers making specific interactions with the catalytic domain, the C-terminal domain, and this domain (the second additional domain). The second additional domain is comprised of a pair of perpendicularly orientated antiparallel beta sheets, of four and three strands, respectively, that surround a central alpha helix that forms the core of the domain.
Statistics
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PSSM-Id: 311778
View PSSM: pfam07973
Aligned: 209 rows
Threshold Bit Score: 30.8754
Threshold Setting Gi: 29839437
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
2ZZF_A      704 IRVVKI-EDWDVQACGGTHLPSTGLVGPIKIL-------R-------TERIQDGVERI 746
gi 81572846 100 VNLATVdN-HHYYLPMAQLVDNTKLVKAFNFQsvggayfK-------GDKDNLVMVRL 149
gi 38258312 169 MGLYYH-E-EYVDMCRGPHVPNTRFLKSFKLTklsgaywR-------GDAKNEQLQRV 217
gi 31340445 171 PGLYHH-EE-YIDMCRGPHVPNMGFCQHFTLLnvagaywR-------GNSDNKMLQRI 219
gi 67473036 170 pgLYFH-EE-YVDMCRGPHVPNMRFCHHFKLMktagaywR-------GDSNNKMLQRI 218
gi 31340448 169 LYIYHQ-E-QYVDLCTLPHVPNIKFCMFFKIQkisgaywK-------GNKKNKMLQRI 217
gi 29839437 171 VSLCFH-EE-YIDIQKKISVPNIFLCRNFRLQkfsgvywK-------GKRENKVLQRI 219
gi 73919817 169 IKLYRH-Q-EYTDMCRGPHVPNTRHLRTFKLMkvsgaywR-------GDSNKTMLQRI 217
gi 73919818 169 INLYKH-EE-YIDMCRGPHVPNTCHLRHFKLLklsgsywR-------GNSENESLQRI 217
1TJE_A      170 pgLYFH-EE-YVDMCRGPHVPNMRFCHHFKLM-------KtagaywrGDSNNKMLQRI 218
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