Conserved Protein Domain Family
Phe_hydrox_dim

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pfam07976: Phe_hydrox_dim 
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Phenol hydroxylase, C-terminal dimerisation domain
Phenol hydroxylase acts a homodimer, to hydroxylates phenol to catechol or similar product. The enzyme is comprised of three domains. The first two domains from the active site. The third domain, this domain, is involved in forming the dimerisation interface. The domain adopts a thioredoxin-like fold.
Statistics
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PSSM-Id: 311779
View PSSM: pfam07976
Aligned: 256 rows
Threshold Bit Score: 103.386
Threshold Setting Gi: 134082766
Created: 19-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DKH_A       441 FTAGVGTHYAPSLLtgqakhqALASGFTVGMRFHSAPVVRVCDAKPVQLGHCGKADGRWRLYAFAaqNDlaqpE--SGLL 518
gi 597933512 420 FITGIGVQYCSSSIiip-thqWCAENILVGQRMPPQIFVRASDGRPYELQDLLPADMRFKILLFL--GNtadpSqlEKVQ 496
gi 242210298 465 FTSGIGVHYQPSTIvnp-khqSVASNLLIGQRMLPHVFVRAADCQPMEMQDLLPADARFKVVVFT--GDttdqVqlKKVR 541
gi 336368700 413 FTSGIGVHYSNSAIvnn-ahqSYASNLIIGERVPPRVFVRAADAWPYELQDLLPSDSRFKVIVFT--GNyndtAqrGNVD 489
gi 599347558 392 FSSGTNVHYPPSAIvnd-ahqQLASNLVIGERMLPHAFICAADARPFDVQDFLPADARFKILVFL--GDisnsQqtARVQ 468
gi 568457864 409 FTTGIGIHYTGTSIvdt-kyqSLASGLVIGQRILPQIFLRATDSRPYEIQDLIISDTRFKVLVFV--GDtgdaKqrDKLN 485
gi 443925149 501 FTSGIGIHYAPSAIvet-rhqSLASKLIIGQRLIPQTIIRTADARPFEIQDLIPSDIRYKLIVFA--GNtkdvTqkARIQ 577
gi 599400434 336 FTSGIGIHYAPSAVvnt-thqAHAPALVIGQRMLPHVFVRTADGRPFEVQDLLPADTRFKVLVFA--GDtsdaAqlARVR 412
gi 527302182 412 FTSGIGVHYQPSAIvad-khqSCASKLVIGERMPPHIFIRAADSQPVQIQDLCPSDTRFKIFVFT--GNttdrAqlQKVK 488
gi 527302159 415 FTSGIGVHYQPSVIvns-ayqSSASNLVIGQRVPPHVFVRASDARPYEIQDLLPSDARWKVLVFA--GDvvapAqsARVH 491
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DKH_A       519 ALCRFL-EGDaaSPLRRFTPAGQDIDSIFDLRAVFPQaYTEVALETLPALLLppkgqlgmiDYEKVFSPDLKn-----Ag 592
gi 597933512 497 LLAKDM-ESSe-SFLRRYLRNDN-ITSMFDILTILAEkKELVNIMDLPKLFRl--------HWSQVFVDDLDvt--rsKg 563
gi 242210298 542 ALAEEM-DKPe-GFLKRFGKSNG---SAFDVISVSSAkKKYSNYTDAPPLFRs--------HWSKFLLDDQDmyk-rtSa 607
gi 336368700 490 ALAKEL-EKPe-RFLKVYVPGGKE--SMFDIITISQGkKEEVDYLEFPDVLRp--------HWSKVLIDD-Tdvt-gnIg 555
gi 599347558 469 KLAEDF-ASPk-SFYRKF--GGEDPSRVFDIVSIGSGsKDQVNYTDVPLGLRt--------HWSKILLDDTDmfa-rnGg 535
gi 568457864 486 KLAEEM-KGVl-SP----RAPGGDVSKLFDIMTFGTTkKEKVIYNDVPPFFRt--------HWSKVFIDDVDtl--gkIg 549
gi 443925149 578 QFADELdKPE--RFYKKYTPAGAqVDTVFEIIVVSSMtKTTGDYTDIPPTLRt--------HWSKVFMDDEAvqsrlgG- 646
gi 599400434 413 RLAEDIeG----GFYRRF--GGQdPSKVFDVLALCSAsKEKVNYTDLPSVFRa--------HWSKVLVDDTDmfs-riG- 476
gi 527302182 489 ALAEDMqKPE--HFYKHF--GHGdSSKVFEVLAISSAdKMISNYTDVPAFFRp--------HWSKFLLDDEDmyk-raG- 554
gi 527302159 492 ALAEQMaRPE--GFLKRYSGARGnVEKVFDVLTIASGdKLKVITADVPALFRp--------HWSKLLVDDQDmyk-rsG- 559
                        170
                 ....*....|....
2DKH_A       593 QdifelrgidRQqG 606
gi 597933512 564 GqgysafgidPSqv 577
gi 242210298 608 GggyeaygidPhga 621
gi 336368700 556 GqgysyygvgPEga 569
gi 599347558 536 Ggydkygidslsgv 549
gi 568457864 550 GngyeyygidKKeG 563
gi 443925149 647 GrlyetygigPe-G 659
gi 599400434 477 GggydaygidKQkG 490
gi 527302182 555 GggyktygigPd-G 567
gi 527302159 560 GggyeyygvdPr-G 572
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