2DKH


Conserved Protein Domain Family
Phe_hydrox_dim

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pfam07976: Phe_hydrox_dim 
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Phenol hydroxylase, C-terminal dimerization domain
Phenol hydroxylase acts a homodimer, to hydroxylates phenol to catechol or similar product. The enzyme is comprised of three domains. The first two domains from the active site. The third domain, this domain, is involved in forming the dimerization interface. The domain adopts a thioredoxin-like fold.
Statistics
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PSSM-Id: 336888
View PSSM: pfam07976
Aligned: 256 rows
Threshold Bit Score: 106.861
Threshold Setting Gi: 134082766
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DKH_A       441 FTAGVGTHYAPSLLtgqakhqALASGFTVGMRFHSAPVVRVCDAKPVQLGHCGKADGRWRLYAFAaqNDlaqpESG--LL 518
gi 597933512 420 FITGIGVQYCSSSIiip-thqWCAENILVGQRMPPQIFVRASDGRPYELQDLLPADMRFKILLFL--GNtadpSQLekVQ 496
gi 336368700 413 FTSGIGVHYSNSAIvnn-ahqSYASNLIIGERVPPRVFVRAADAWPYELQDLLPSDSRFKVIVFT--GNyndtAQRgnVD 489
gi 242210298 465 FTSGIGVHYQPSTIvnp-khqSVASNLLIGQRMLPHVFVRAADCQPMEMQDLLPADARFKVVVFT--GDttdqVQLkkVR 541
gi 599347558 392 FSSGTNVHYPPSAIvnd-ahqQLASNLVIGERMLPHAFICAADARPFDVQDFLPADARFKILVFL--GDisnsQQTarVQ 468
gi 568457864 409 FTTGIGIHYTGTSIvdt-kyqSLASGLVIGQRILPQIFLRATDSRPYEIQDLIISDTRFKVLVFV--GDtgdaKQRdkLN 485
gi 443925149 501 FTSGIGIHYAPSAIvet-rhqSLASKLIIGQRLIPQTIIRTADARPFEIQDLIPSDIRYKLIVFA--GNtkdvTQKarIQ 577
gi 599400434 336 FTSGIGIHYAPSAVvnt-thqAHAPALVIGQRMLPHVFVRTADGRPFEVQDLLPADTRFKVLVFA--GDtsdaAQLarVR 412
gi 527302182 412 FTSGIGVHYQPSAIvad-khqSCASKLVIGERMPPHIFIRAADSQPVQIQDLCPSDTRFKIFVFT--GNttdrAQLqkVK 488
gi 527302159 415 FTSGIGVHYQPSVIvns-ayqSSASNLVIGQRVPPHVFVRASDARPYEIQDLLPSDARWKVLVFA--GDvvapAQSarVH 491
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DKH_A       519 ALCRFL-EGDaaSPLRRFTPAGQD-IDSIFDLRAVFPQaYTEVALETLPALLLppkgqlgmiDYEKVFSPDLKn-----A 591
gi 597933512 497 LLAKDM-ESSe-SFLRRYLRNDN--ITSMFDILTILAEkKELVNIMDLPKLFRl--------HWSQVFVDDLDvt--rsK 562
gi 336368700 490 ALAKEL-EKPe-RFLKVYVPGGKe---SMFDIITISQGkKEEVDYLEFPDVLRp--------HWSKVLIDD-Tdvt-gnI 554
gi 242210298 542 ALAEEM-DKPe-GFLKRFGKSNG----SAFDVISVSSAkKKYSNYTDAPPLFRs--------HWSKFLLDDQDmyk-rtS 606
gi 599347558 469 KLAEDF-ASPk-SFYRKF---GGedPSRVFDIVSIGSGsKDQVNYTDVPLGLRt--------HWSKILLDDTDmfa-rnG 534
gi 568457864 486 KLAEEM-KGVl-SP-----RAPGgdVSKLFDIMTFGTTkKEKVIYNDVPPFFRt--------HWSKVFIDDVDtl--gkI 548
gi 443925149 578 QFADELdKPE--RFYKKYTPAGAQ-VDTVFEIIVVSSMtKTTGDYTDIPPTLRt--------HWSKVFMDDEAvqsrlgG 646
gi 599400434 413 RLAEDIeG----GFYRRF--GGQD-PSKVFDVLALCSAsKEKVNYTDLPSVFRa--------HWSKVLVDDTDmfs-riG 476
gi 527302182 489 ALAEDMqKPE--HFYKHF--GHGD-SSKVFEVLAISSAdKMISNYTDVPAFFRp--------HWSKFLLDDEDmyk-raG 554
gi 527302159 492 ALAEQMaRPE--GFLKRYSGARGN-VEKVFDVLTIASGdKLKVITADVPALFRp--------HWSKLLVDDQDmyk-rsG 559
                        170
                 ....*....|....*
2DKH_A       592 gQdifelrgidRQqG 606
gi 597933512 563 gGqgysafgidPSqv 577
gi 336368700 555 gGqgysyygvgPEga 569
gi 242210298 607 aGggyeaygidPhga 621
gi 599347558 535 gGgydkygidslsgv 549
gi 568457864 549 gGngyeyygidKKeG 563
gi 443925149 647 -GrlyetygigPe-G 659
gi 599400434 477 -GggydaygidKQkG 490
gi 527302182 555 -GggyktygigPd-G 567
gi 527302159 560 -GggyeyygvdPr-G 572
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