Conserved Protein Domain Family
Cnn_1N

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pfam07989: Cnn_1N 
Centrosomin N-terminal motif 1
This domain has been identified in two microtubule associated proteins in Schizosaccharomyces pombe, Mto1 and Pcp1. Mto1 has been identified in association with spindle pole body and non-spindle pole body microtubules. The pericentrin homolog Pcp1 is also associated with the fungal centrosome or spindle pole body (SPB). Members of this family have been named centrosomins, and are an essential mitotic centrosome component required for assembly of all other known pericentriolar matrix proteins in order to achieve microtubule-organising activity in fission yeast. Cnn_1N is a short conserved motif towards the N-terminus. Motif 1 is found to be necessary for proper recruitment of gamma-tubulin, D-TACC (the homolog of vertebrate transforming acidic coiled-coil proteins [TACC]), and Minispindles (Msps) to embryonic centrosomes but is not required for assembly of other centrosome components including Aurora A kinase and CP60 in Drosophila.
Statistics
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PSSM-Id: 311790
View PSSM: pfam07989
Aligned: 93 rows
Threshold Bit Score: 34.796
Threshold Setting Gi: 378755841
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74685773    195 RDQEKQLEETKKEVFNLQLENHFLKErLSNMAPEHIEGALKENVKLKLEILTLGKELKKLKKLVMQQDK 263
gi 320034879   279 KEQSSTIDRLSKENFDLKMRIHFLNEaLNKRSEEGVKEMISENVELKSDKLKLQKDNQSLRKKIRELEK 347
gi 748543531   476 KEQSSTIERLSKENFDLKLKVMFLSDrLDKLSEDGIKEMIQENVEFRTNIAILQRDNKGLRRRVKELEK 544
gi 156042948   483 KEQSSTIERLSKENFDLKLKVMFLSDrLDKLSEEGVKEMISENVELKTGLAVMQRDNKALRKKVKDLEK 551
gi 549053575   470 KEQTASIDRLQKENFDLKIKVFYLNEkLEKQSDEGVKETLQENIDLKVKLAESMRERKSLKKRIRELEK 538
gi 629637612   454 KEHRSTVERLGKENFDLKMKIHFLDQaLQKRSDDSVKDMITENVQLKSDKLRLERDNHSLRKQIRDLEK 522
gi 748483780   518 KEQSGTIDKLQKENWDLRIKVFHLNNrLDKTSEESVKTLQNENGILAVENTQLKSHIKTLKKRIKQLEK 586
gi 296419771     4 KEQSTIIDRLQKENFDLKIKVFYLNDkLEKQSDEGVKEMMKENVDMKVKLAEGMRERKSLKRRIKELEK 72
gi 1002220621  152 KEQNAKTDALTKENFDLKLKIHYLSEaLHKHSEEGVDELIATNVQLQTDLANERKDANALRKKLREYET 220
gi 452837816    37 KEHTKHLDTLTKENFDLKLKITFLEDaIRTRSQDGVEDLINQTVSLQTELAHERRETQSMRRKVRTLEQ 105
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