2ISM


Conserved Protein Domain Family
GSDH

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pfam07995: GSDH 
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Glucose / Sorbosone dehydrogenase
Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.
Statistics
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PSSM-Id: 336894
View PSSM: pfam07995
Aligned: 95 rows
Threshold Bit Score: 269.415
Threshold Setting Gi: 123380600
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ISM_A        30 LEVPWALAFLPDG-GMLIAER-PGRIRLFR---EGRL-ST-YAEL--SV----------YHRGESGLLGLALHPRFPQEP 90
gi 123588226  69 LQSPWSMVELANG-TWLITER-DGHVVIIKnnaQSRV-KLnLEGL--------------YLAGQGGLLDIVLSPDYSNSK 131
gi 123516805  82 LNVPWSLVFLPDK-RALVSER-SGKIRLII---NGKLeSHpYATV--DA----------VRIGEAGLMGLAMHPRFPAEP 144
gi 74517189   96 LEIPWDLSFAADG-TLFLTER-VGRVLSFV---DGSV--RtVTEPaaVIdaessddgwwVTGGEGGTLGVAAHPTYPDPP 168
gi 122980669  59 LETPWGIAWLP-GgDALVTER-PGRIRLLK---DGVLqPRpVATVp--V----------ADAAEGGLLGIAAHPNFANNR 121
gi 123480831  65 LDHPWDAVQAPDG-AVLTGQR-SGGFFVRRa--NGST--GpVTADlsDL----------YAQSETGLMGIALASNFANTR 128
gi 119536933  50 LDHPWDVRPIGDG-RLIFTQRdRATVSIWD---GSRT--RlVQGFpsDSv---------WVSGETGLMGLEVDPSFASNR 114
gi 160339180  47 LKIPWGIDFAQDG-RIFFTER-PGTVNVIE---DGQV--SqIMSR--GV-----------GGGEGGMLGIALDPEFEKNH 106
gi 118195710  76 LDEPRHLAFYGD--RVFLTEK-AGRVRVVQ---DDVLlEEpLAVL--RV----------ADELDSGLLGIAVHPDFGENH 137
gi 160340370  49 LEKPRSIAVS-DN-RIFVTEK-DGSIVVIE---NDIQlESpLATF--RS----------ANVFDGGLLGIDLHPNFAENH 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ISM_A        91 YVYAYRTVAE--GGLRN-QVVRLRHLGEr---gVL--DRVVLDGIPARPHGLHSGGR-IAFGPDGMLYVTTGEVYE-REL 160
gi 123588226 132 EVIFTYAq-GdaNANWL-VVAKATFNGT-----RFskPQIIYKVATNKNTPQHYAGRaLVLP-DNTLLVSTGDGFDfREQ 203
gi 123516805 145 YIYAMYTEQk-kGALRN-RVVRFRDhg-----rTGsfDRVILDDIPG--GRFHDGGR-IAFGPDGMLYVTTGENFN-ADL 213
gi 74517189  169 VVYVYYTTM----TDDDeRVNRVVAMDVsaedpAAt-ESVLVDNIPG--SKIHNGGR-LTFGPENYLWITTGDAGD-GEL 239
gi 122980669 122 QFYIYVTTDa-gGTEEN-RIERWTLSEDh---tTAthERVIFGGIAS--AKYHDGGR-LRFGSDGMLYAGTGDARD-PDR 192
gi 123480831 129 TLYTCQGFQg--GGVTDiRIQSWTVDAGw---tTLtrGSAILTGIPV-NEGRHGGCR-ILTAADGTLFIGTGDTAQ-PTV 200
gi 119536933 115 TFYTCQGGFTagGGHDV-RIIRWTLRDDl---vSIsgSKRLLGGLPA-TSGRHGGCRlLAVGK--RLYAGTGDAAT-GST 186
gi 160339180 107 YVYVYYTYNe-lLGIKN-RLVQYVESDN-----KLnhEKILLEDIPG--APYHDGGR-IKFGPDEMLYVTTGDAVE-PEL 175
gi 118195710 138 KLYVYHSYIe-dGAAWN-RILQITERDN-----KLedAETVLDKIPG--SRFSNGGV-IKFGPDGKLYVGTGSVSDtLHL 207
gi 160340370 111 YLYVFLTYEe-dEALWN-KILRITESEN-----KLqdAETIFDKIPG--SSFTNGGF-IKFGPDGKLYVGTGATSDsSHL 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ISM_A       161 AQDLASLGGKILRLT-PEGEPAPGNPFLgr-rgARP-EVYSLGHRNPQGLAWHPKTGELFSSEHGPSGEqgy-ghDEVNL 236
gi 123588226 204 AQVITSQLGKILRIN-LNGSIPTDNPFInh-tnPNAhAVYSLGHRNPQGLVYDYDTQQIISHEHGPAGG------DELNY 275
gi 123516805 214 AQDRSSLAGKILRIS-PDGEIPADNPF------KDS-PVYSYGHRNPQGLAWQPETGRLFESEHGPSGEfahfghDEINR 285
gi 74517189  240 SADTDSLGGKVLRVT-PAGDPAPGNPELg----GDP-RVFTYGHRNPQGLAWLPD-GTLVASEHGPTGR------DELNR 306
gi 122980669 193 SQNANDPAGKLLRLT-PEGAVPQDNPI------PGS-PAFLTGIRNLQAFDWR-DASTLYIADHGPSGEtlrrghDEVSV 263
gi 123480831 201 SQDPNSLGGKTLHIN-TDGTPAAGNPD------PAS-PVYTLGHRNAQGLAQQPGTGRIYAVDQGTTRD------DEVNL 266
gi 119536933 187 PENKKSLGGKTLCLLaATGKPCGSNPFAgsknhNKR-YVHTYGHRNVQGLDRRRD-GTLWSVEQGSYRD------DEVNR 258
gi 160339180 176 SQNLNSVAGKILRIK-SDGTIPEDNPF------GSA--IYSIGHRNPQGIAWD-KSGNLIATEHGPSGWrgv-ahDEINW 244
gi 118195710 208 SQEMDSLGGKILRIN-DDGSIPSDNPF------EGS-PVYSLGHRDPQGMAWSSD-GTMYASDLGPSKN------DEINV 272
gi 160340370 181 PQDLDSLSGKILRIN-DDGSIPDDNPF------SNS-PVYSLGHRNPQGMTWDNN-GNLYVSEFGPEKN------DEINI 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2ISM_A       237 IVPGGNYGWPRV-----------VGRG--N-DPR-YRDPLY-FWPQG---FPPGNLAF----------FRGDLYVAGLRG 287
gi 123588226 276 LTAGNNYGWPVItngdd-ysqarISPF--RdYPG-MAKPSL-DWTPS---IAPSGMAYygskhaafpsLQNHVLITTLVD 347
gi 123516805 286 IVKGGNYGWPLVig--------------aPeIQP-YIDPLI-VWKEA---TPPGGIAFyngt--flphLKGDLFVATLKS 344
gi 74517189  307 LEAGGYYGWPDTrkha----------eylDaDPE-VRRPLAnTGNTGg--WAPSGSLFytgd--avpsLRNRLLTGGLNG 371
gi 122980669 264 ARRGDNLGWPGIys--------------cEtREG-QITPSI-TYKDA---MPPGGAAIytgt--aipeWKGSLLIGTLGS 322
gi 123480831 267 LVAGGNYGYKPDripgiydesvpMt------DPSrVPGAVAaAWSSGsttLATGSAAFvtgp--gwgpWDGALVMGGLKT 338
gi 119536933 259 LRKGGDYGWNPVpgy------deSVPMtdQsLPGrQRAA---VWRSGdptLATSGGGFvygk--rwgaLDGSFAVAALKA 327
gi 160339180 245 IVSGANYGWPDVig--------------dEtLEG-ATNPILhSGDDT---WAPSGSTFyygd--dmpmFDGKYFVAALKG 304
gi 118195710 273 IIPGGNYGWPDHe----------------CsGGG-YEDSIL-CFDPA---IEPGGLVVysge---qleFGGSLIMTSLRV 328
gi 160340370 246 ILAGKNYGWPEQe---------------cSgNES-FENAVL-CYDPS---IEPGGILYytgd---kfdFEFPFIMASMRA 302
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
2ISM_A       288 QALLRLVL-E-Gerg---------------rwrVLRVETAL------SGFG-RLREVQVGPDGALYVTTSnrDG---R 338
gi 123588226 348 KKLYAVNL-AnG---------------------EFTQSHIF------PEATgRLRDVFVTTEGNVAILTDgeDA---K 394
gi 123516805 345 RALIRVRF-DgDt-------------------kISRIERWFstdfkkGKYG-RLRDVVTGPDGAIYFTSSnrDG---R 398
gi 74517189  372 QTLLVTTLtPaGadlppgadaevydadwtddayTATTHSLLa-----NEIG-RIRHVEQGPDGGLYLVTSnrDGragD 443
gi 122980669 323 RHLQRVEF-ApDss------------------rVTRHEVYLr-----NTYG-RLREVIMGPDGHLYVTTSncDG---R 372
gi 123480831 339 KQLIFLRLaAdGq-------------------sVTAQTFGLq-----NQYG-RLRSVTPTADGSLLVTTD--NGstdQ 389
gi 119536933 328 ERVLFLQL-SaSgr-----------------lqRVRVPAALr------QHG-RIRTVVDGPGSVAYVTTDngNG---N 377
gi 160339180 305 QHIHVIEF-DeSy-------------------nVLFHGELFs-----GEFG-RIRDVANGPDG-LYFMTSnqDG---R 352
gi 118195710 329 GSLYGFDPtDgG---------------------LEDRQSIL------AGLG-RIRDVDEGPDGYLYALTSntDG---R 375
gi 160340370 303 SNVYQVDF-DeG---------------------LSSQKSIL------SGIG-RVRDVVQGPDGYLYVITSntDG---K 348
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