Conserved Protein Domain Family
T4SS

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pfam07996: T4SS 
Type IV secretion system proteins
Members of this family are components of the type IV secretion system. They mediate intracellular transfer of macromolecules via a mechanism ancestrally related to that of bacterial conjugation machineries.
Statistics
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PSSM-Id: 311796
View PSSM: pfam07996
Aligned: 44 rows
Threshold Bit Score: 102.802
Threshold Setting Gi: 501411643
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81645527   22 GIPV-FDAVQ-------NVES-------INqwvqklqqWEDTVTHYKSELNA----YKQQL-------ATATGVrniQGF 75
gi 506354044  26 GILV-FDATS-------KMEN-------ARqwakeakqWMETVEHYKAQMNV----YKDQL-------ATSTGLrdiQGL 79
gi 499204398  38 GIPV-VDAAAagqrqmsMLQT-------VQqwakeakqWTDTVSHYKNELKA----YADQLa-------sQTGIrdvQAF 98
gi 501056612  27 GIPV-VDAAA-------NAQMttqnlkqIAewakeakrWVDTTTHYSAQLNA----YAKQL-------ATQSGVrdvTSF 87
gi 501337234  25 GIPV-VDATA-------IADR-------LKqdvktaaqWTKEAAQWTKELKA----YQDELl-------sKTGIrdvQGL 78
gi 501411643  23 GIPV-VDLAS-------IAKT-------VEegltraqeAAQQYEQLKRDYDQsvkyAEDQKkrlegftNFNFGFdtaSSY 87
gi 156534789  10 GIPIlVDADP-------MRETewlk---------eaqrWMETAKHYQSQIQA----YKDQL-------ATATGArdiADF 62
gi 556473674  22 GIPVaVDADP-------MRDVqwaq---------elkrWMETARHYQSQIQA----YKDQL-------ATATGVrdiADF 74
gi 505735123  22 GIPV-FDAVQ-------NTES-------MNqwiqklqqWQETVTHYRSELDA----YKQQL-------ATATGVrdvQAF 75
gi 503083722  22 GIPV-FDAVS-------NTES-------INqwmqklkqWQETVTHYKDELDA----YKQQL-------ATATGIrdiQGF 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81645527   76 LSDARs---LK----T-------DIDNLRKNGislddlltnhN---------GSY-------SSELQHLYSKYKSFSVCs 125
gi 506354044  80 LEQGKsl--------------qsEIKTLQNQGi--------sL---------NDLltsdnppRGALDSLYHKYKSFDVCg 128
gi 499204398  99 IGEAH----SLygeiNglkseftPVIDLVSGG----------K---------NAL-------SANAKSLFEKYNLFDRCk 148
gi 501056612  88 LEEAKdvydEA----KkvgttlgELKDFKNSG----------K---------DSI-------SSKVKKLMDKFFEYDYCk 137
gi 501337234  79 IQDAKei--------------agDLTDIYNEGt--------aFydnyienptGIL-------SEKAQALLDKYKVGEMCv 129
gi 501411643  88 MKQQ-----LN----DltdpkqyDVDSELDKFg----------------------------------------------- 111
gi 156534789  63 VNQAKs---LS----A-------DLERLRKPGqaln--dllmS---------GGS-------SGQFDELYEKYKIFNTCn 110
gi 556473674  75 VDQAKg---LK----A-------DLEKLRKPGqaln--dlllS---------GGS-------SGQFDALYEKYKIFDTCn 122
gi 505735123  76 LREAKs---LK----T-------DIDNLRQNGislddllsnqS---------GSY-------SSELNSLYNKYKSFDTC- 124
gi 503083722  76 LREAKs---LK----G-------DIDALRKNGislddlltnpD---------GSY-------SSALQGLYKKYQSFDSC- 124
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81645527  126 --tEQEGI-Ksqt-ltDSCQQMVLNQAMAIENTAEVENKITGTLSDISALSDRISNAQDSKESQDLANAIAAKSVQLNAL 201
gi 506354044 129 --dSTSSS-KlpasylNACKQETANKGYMIEQTAEVQKKINVALKDIGHLSHRIANAKDSKESQDLANAIQARSVQLNSL 205
gi 499204398 149 --nL-RQG-Ei-----TSCEANIVSTVESMSFLDSFESNVNSKLKTIDKLAKRMTKSQDVKESQDLKNAMDVQLAALQSQ 219
gi 501056612 138 divDVDKT-Tq-----NICYQKRSANIEDIVFYKERSDTIGMYSKNINKLAKKLQKSKDIKESSDLNNAIQAQVALMQAE 211
gi 501337234 130 --kQGFSGdLi-----KGCEARVLSDLASVAYGENLQENINKDNKKMKGLIDQVKSATDPKSTADAANAIALEQLKFEKM 202
gi 501411643 112 ------lN-Sn-----NLIKARLEGAAAKVKFFDSYNFELKDRAIKLEKLQGKYNEAITPQQKADLTNQLQTEQINMQYF 179
gi 156534789 111 ---TGQSG-Sy----aDVCKQEVINKAVQLEQTNDIQREVDNTLGEIDRLSNRIALSKDSKESQDLANSIQLKSVMLNTL 182
gi 556473674 123 ---TAQSG-Sy----aNVCKQQVINKAIQLEQTDEVQNQVSQTLGEINSLSNRVALAKDSKESQDLANSIQLKSVMLNTL 194
gi 505735123 125 ----NPSS-Aspr-ylDSCKQMILNQAVAIENTSEIENKITGTLGDISDLSDRIANAQDSKESQDLANAIAAKSVQLNAL 198
gi 503083722 125 ----NPSR-Sslr-yqDSCKQLLLNQALAIENTREVQDRITSTLNDIADLSDRITNAKDSKESQDLANAVAAKSVQLNAL 198
                        250       260
                 ....*....|....*....|..
gi 81645527  202 TSQWEMSVKQAEQRTTLLEQQR 223
gi 506354044 206 TSAWEMNIKAAEQRDKLLSAKR 227
gi 499204398 220 KVQLDLFNARQTEYRRLMNEQQ 241
gi 501056612 212 KIQIDLYAKQRENSKNIMEDRE 233
gi 501337234 203 KFQYEMYRDKQAQLSKykeemv 224
gi 501411643 180 MKQNELAEKQMEQQDKLRQEQl 201
gi 156534789 183 TNQWEMSVKAAEKREKVLQEQR 204
gi 556473674 195 TTQWEMSVKAAEKRENALEAER 216
gi 505735123 199 TSQWEMSVKQTEQRTVLLEQQK 220
gi 503083722 199 TSQWEMSVRQTEQRATLLEQQR 220
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