Conserved Protein Domain Family
SEP

?
pfam08059: SEP 
Click on image for an interactive view with Cn3D
SEP domain
The SEP domain is named after Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47. In p47, the SEP domain has been shown to bind to and inhibit the cysteine protease cathepsin L. Most SEP domains are succeeded closely by a UBX domain.
Statistics
?
PSSM-Id: 311829
View PSSM: pfam08059
Aligned: 189 rows
Threshold Bit Score: 68.6236
Threshold Setting Gi: 569397397
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1SS6_A        16 LKLWKSGFSLDNGELRSYQ-DPSNAQFLESIRRG-EVPAELRrl---aHGGQVNLDMEDHRDEDFVKpkgAFKAFTGEGQ 90
gi 198431171 207 LKLWSNGFTVDDGPLRDFN-DPQNQEFLQSVKKG-QIPQELIrn---aKGGEVHVDMEDHREEDYKPqkkKLKPFSGQGQ 281
gi 796695145 203 LHLWADGVSIDDGPLLRFD-DPANEHIMQEINQG-RAPKALLdv---qPDQEVDLNLEPHKGENYVApkpKYKPFGGQGQ 277
gi 627811175 211 LHLWSDGVSIDDGPLFRFD-DPANQDMMTQINQG-RAPLSMLdv---qPDQEVDLSLAPHRGENYVQpkkQYKPFGGSGQ 285
gi 302506230 194 LHFWNDGFSVDDGDLYRSS-DPKNAQILEGIRQG-RAPLSIMnv---qVGQDVDVQVKQH-DSDYVRpkgKFKAFSGSGQ 267
gi 808357580  94 LHLWSDGLSIEDGPLMSRQ-DPRTIEFLESVGKG-EIPPSLVqq---yPGKEIDFKV-NRHHEEYVApk--mKPFGGSGv 165
gi 341892720  90 LHLWTDGLSIEDGPLMGRH-EPATVEFLEIVGRG-GIPPQLMqq---yDGRDIDFNI-DRRHEPYQQpk--mKPFGGNGv 161
gi 835892923 229 LHLWEDGFSINEDPLIKYErDVST--YLDEIAKG-KVPEDIRkrmgirPNEEVDVTVQQHAQQKWRQlpyVYRPWMDEGN 305
gi 303319701 196 LHFWNDGFSVDDGDLFRSD-DPRNSHILESIRRG-QAPLAIMnv---qPGQHVDVEVNQH-DSNYVKpkpkYKPFSGPGQ 269
gi 193697428 207 LKVWKEGFTINDGELHSID-RPENREFLLLVARGeEIPPLLLkeanvsSEDELHVSVEDHRYEEYVpskpKKKIFGGSGN 285
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap