1SS6


Conserved Protein Domain Family
SEP

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pfam08059: SEP 
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SEP domain
The SEP domain is named after Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47. In p47, the SEP domain has been shown to bind to and inhibit the cysteine protease cathepsin L. Most SEP domains are succeeded closely by a UBX domain.
Statistics
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PSSM-Id: 336912
View PSSM: pfam08059
Aligned: 189 rows
Threshold Bit Score: 69.4028
Threshold Setting Gi: 835892923
Created: 26-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1SS6_A         16 LKLWKSG-FSLDNGELRSYQDPSNAQFLE-------SIRRGEVPAELRRLA-HGGQVNLDMEDHrDEDFVK-Pk-Ga-Fk 83
gi 195996073  195 IQFWANG-FSVDDGPLRDPNDPANKQFLE-------EVSKGYVPSELMAMA-KGREVAVNLVDKrSEDYVK-Pkq--kLk 262
gi 566159270  243 VTLWRNG-FTVDDGPLRRFDDPANASFLE-------SIKRSECPKELEPLD-RGTQVHLDLM-RrEENYSE-Pek--pLv 309
gi 255568695  242 VTFWRNG-FTVNDGPLRRFDDPSNAAFLE-------SIKKSECPFELQPAD-GRSQVHLDLM-RrEENYYE-Pkk--rQt 308
gi 514801964  130 IHLWNNG-FSVDDGPLRAYDDPENADFIE-------SLKMSRCPQELEPAD-RTTPVHVNVM-KrLEDYRE-Pirp--rs 196
gi 302814965  117 ITFWRNG-FTVNDGGLRRLDDPANIPFLQvreieflSIHRGECPRELDSRN-PDIPVHVNLM-KrDADWTP-Ppp-aqQq 191
gi 290979001  229 ITFWADG-FTVDDGPLRLYDDPQNVQFME-------AINRGFAPRELA--E-PGVDIAVNLLNRkTDKWAE-Qpk--qFk 294
gi 1079404074 159 VTIWRNG-FTLDDHPLSTLDDPDNAIFLE-------VVESLESPRVLDSPE-TKQRFLVTLIRRqQEDFPD-Spk----- 223
gi 302844763  103 ITFYNNGvFTVDNGPPRYVDDPANARFIE-------SISKGECPEELETGK-HGAPVTVNLM-RkEEPYTEgDkaKq-Y- 171
gi 168047053  116 VQFWSNG-IAVNADPLRRLDDPSNSPSLE-------SINRSECPSELE-PSdRGIPVHVNLERRvIEDRKAtSkpKyvP- 185

                  ....*..
1SS6_A         84 aFTGEGQ 90
gi 195996073  263 aFTGQGH 269
gi 566159270  310 sFQGVGR 316
gi 255568695  309 sFQGVGR 315
gi 514801964  197 aFQGVGR 203
gi 302814965  192 yFFGAGR 198
gi 290979001  295 aFVGSGR 301
gi 1079404074 224 pFQGVGR 230
gi 302844763  172 -FTGTGR 177
gi 168047053  186 -FQGAGH 191
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