Conserved Protein Domain Family
CASP_C

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pfam08172: CASP_C 
CASP C terminal
This domain is the C-terminal region of the CASP family of proteins. It is a Golgi membrane protein which is thought to have a role in vesicle transport.
Statistics
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PSSM-Id: 311893
View PSSM: pfam08172
Aligned: 92 rows
Threshold Bit Score: 148.133
Threshold Setting Gi: 552834730
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121936220 443 EALQEEL-------SSANMDLEKSRALNETLEADLEKVQQEASNAFDPS-GMSV---AGTYVSRYP-Q-----SsarrGR 505
gi 575478720 398 QNMQEKLaqytltkDSLEAQLTESKSLIVKLEADLLQLNPSCMASPQKY-TSMD---HGLESIMLD-N-----Ls--kTN 465
gi 301105399 456 QQAQGEL-------RDRDGKIREQATLIRNLEENVAALEKARRNRTAGV-IGGD---IGSEILLDA-M-----Ed--qFT 516
gi 397609589 284 egLSEKL-------SAAERSAADQERLIASLENDLQLAVSTPASASKKK-RSEA---ADHMPSTNP-P-----Dp--nTL 344
gi 695389045 457 QNVQGEL-------HDRDAKIREQATLIRNLEESVAALEKARRNRSTTGvIGGD---IGSEILMDA-M-----Ed--qFA 518
gi 514651903 418 DAFKEEH-------VEVSATIKEQGELISRLEDHLATVDPNTSATNSHS-NRTSqqhTPSLASRHV-G-----Dg--gDG 481
gi 350646029 431 tQVQSNE-------VEANQRIKEQTELIKLLESDLYRLQTNLDESLKLN-DSRN---RLEGHLLAE-V-----I------ 487
gi 219113141 510 ETLKKSM-------LDAEKTNNALEKLVASLERDLERAIATPSAATSRK-QSEH---VLVEENPAT-LehildPn--aAP 575
gi 299115281 414 arLQRAL-------DSATALASERLETINRLEDDLATAAGGGGGGAGTP-RGGE---GADALRELL-G-----Vg--eAE 474
gi 545500726 433 AELQVHV-------TEAMATAAEQRDLIARLEQDLSTIQSIQRPDAEGA-AEHG---LEKIPEP-IkE-----Atalfy- 494
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121936220 506 SS----------------PTSS------IisGFDnSPSNtlaslragepmggGSG--ILPMVTAQRDRFKKRNSELEAEL 561
gi 575478720 466 HP----------------VTGG------NipGTA------------------DAS--IVSILTSQRDRYKQRFEEVEQNM 503
gi 301105399 517 GT----------------SGSS------RghAVAtTDSStsiv-----atssDSK--MLEIVRGQRDRFRERMKELQAEK 567
gi 397609589 345 QSildp---------dapPIAT------SpsPLTpSIKSksase----reddDTS--IATIVMAQRDRLRARCDALESER 403
gi 695389045 519 GT----------------SGSSrgnataSatADSaSSNStt---------ssDSK--MLEIVRGQRDRFRERMKELQSEK 571
gi 514651903 482 MSeielsspssasssslrPVRT------PaaLVTpTDVNna---------naGNSgvLLGIVTSQRDRFRQRIVELESEV 546
gi 350646029 488 -----------------------------------GDQKps---------qyNQS--LLNIVQNQRDRFRTRAEELEQNE 521
gi 219113141 576 PL----------------PPPP------PpsARSqSESEsq---------qdDHS--VATIVMAQRDRLRARCEALEAER 622
gi 299115281 475 GGp----------------------------AGGgGGGGad---------agNHG--VLGIVQAQRDRFRRRIKKLEAER 515
gi 545500726 495 --------------gssaPASG------TlpEGQ------------------VDS--LLSIISSQRERFRARNQELEAEN 534
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121936220 562 QKSHQTVSSLRSEIGALQKDNLDLYEKTRYVNSY--------NR------T------P----YSANANTNPSTV------ 611
gi 575478720 504 REHIQTISDLRYEIANFKADNVKLYEKLRYAESY--------SN------T------R----FQGTNNRHSSAV------ 553
gi 301105399 568 NRVEELAQSYKNTVARLETDNMQLYHKIRYLQSY--------GGdksgraR------I----KPNFSALEDGSA------ 623
gi 397609589 404 DSFKLELQAQVAAAEGLKADNTKLYEKVRYLQSF--------GGgsraapS------T----SGIRSRGVAG-------- 457
gi 695389045 572 NRVEELAQSYKSTVARLETDNMQLYHKIRYLQSY--------GGdgksagSrvkpsfS----ALEDGSGGASDV------ 633
gi 514651903 547 GRERQQRQSMQNQVDQIRADNIKLYEKIRYLQSY--------NNntgtgsS------S----SSSRH--TSTTR------ 600
gi 350646029 522 INLRQQLVSLQREVESVRADNVKLYEKIRFLHSYgnpviqnrQNnlsnqhP------S----SPVTTSLSPSPF------ 585
gi 219113141 623 DSFKRELQGQVQASEHLKTDNTKLYEKVRYLQNY--------NKppssghG------T----AY---SRSISAG------ 675
gi 299115281 516 EDEQRETRAAQGVMENLQRDNLQLYEKVRFLQSY--------QRgatgadK------NnvlaAAGGVTPGIGDVeagggg 581
gi 545500726 535 RLAQHTIQALQSELDSLRADNIKLFEKIKFLQSY--------P----------------------GRSGGSDDT------ 578
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121936220 612 ---------------Niaa------------daSD----RYKASYESNLSPFAAFRGRESARAMKRMHLFERMVLRVTKF 660
gi 575478720 554 ---------------DitadrysnnqlldqdsvST----KYRGIYEESLDPFKRFHKQEEQRRFHSMNPAERAALSLTRL 614
gi 301105399 624 ---------------Gay-------------dvEA----RYRSMYEEKMNPFVQFNKMENQQRFTNLNPVDKILLTSAKL 671
gi 397609589 458 ---------------Ggd-------------ldLE----ALEQRYEANVDPFRQFSRAERQRKYNEMPPMEKVVFVVAKT 505
gi 695389045 634 ---------------Ea----------------------RYRGMYEEKMNPFVQFNKMENQQRFTNLNPVDKILLTSAKL 676
gi 514651903 601 ---------------Gnd-------------plLN----KYASEYEDKISPFHEFSSKERQRRIMNLNAGDRLTLTLGKA 648
gi 350646029 586 ---------------Qnh-------------esNDatiiKYSQVYEAQLNPFNQFSRYEKQRVYKKLQPYEKLMLHLGRF 637
gi 219113141 676 ---------------Drd-------------ldLE----ALEQRYEASVDPFRQFSKAERQRKLNEMSPMERTVFIVAKT 723
gi 299115281 582 ggggrgaaregeeggSrk-------------atEA----RYGQLYEARINPFTQFSQRERQRKYQELTVAEKITLNTTRM 644
gi 545500726 579 ---------------El----------------------RYSSQYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRL 621
                        330       340
                 ....*....|....*....|....*...
gi 121936220 661 VLQTRISRNMFAGYLIALHFIVFYMLFG 688
gi 575478720 615 LSTNKYSRWIFVIYSGALHLLVFFTLFQ 642
gi 301105399 672 LLGHRITRNMAFGYILLLHFLVFATLYS 699
gi 397609589 506 FLGSKEMRKALFFYVIGMHLLVFVTTYH 533
gi 695389045 677 LLAHRITRNMAFGYMLLLHFLVVATLYS 704
gi 514651903 649 VMGSKNARLIFLGYAIIVHLLIFVVLYK 676
gi 350646029 638 VSSDRRLRLGVFLYAIFLHLFIFIALYK 665
gi 219113141 724 FLATKEMRTALFFYVVAMHLLVFITTYH 751
gi 299115281 645 FLGNKFARNFVFFYVVLLHVVVFTTLNY 672
gi 545500726 622 VLSNKMARTIGFFYTLFLHCLVFLVLYK 649
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