Conserved Protein Domain Family
Peptidase_S64

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pfam08192: Peptidase_S64 
Peptidase family S64
This family of fungal proteins is involved in the processing of membrane bound transcription factor Stp1. The processing causes the signalling domain of Stp1 to be passed to the nucleus where several permease genes are induced. The permeases are important for uptake of amino acids, and processing of tp1 only occurs in an amino acid-rich environment. This family is predicted to be distantly related to the trypsin family (MEROPS:S1) and to have a typical trypsin-like catalytic triad.
Statistics
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PSSM-Id: 311901
View PSSM: pfam08192
Aligned: 20 rows
Threshold Bit Score: 847.774
Threshold Setting Gi: 50552129
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74609558    3 KKLFGFNKKng-------------irGHSESDKEKNEGVGSRnnstDNKAESS---------------------IHDDRS 48
gi 74627370    4 KRFLSRSSNkttag-------qgddtSASIGSDLPIVPLPSN----QSGESHDsikelgpmf----rqqqnkqiADNDDS 68
gi 74603852    4 KNLLNRTTKseyke--------rdtpDAEERAVLDIKPVTSStmstSTEESQDsihqlrpmfs-splakaedetKSNSQK 74
gi 260946203   9 KK-------------------------ESAPASKPETPCASGaastTSVHSESdslkdl------------qpmfqhNSS 51
gi 255727777   4 KRFLSRSSNkkttttga-getppttaGTSSSFTSELVPTISN----HSGESHDsikdlrpm-----fnqmregqSSSANQ 73
gi 459369820   4 KRFLSRSSRkss-----------tdkDEEIPDNTIIQPIASN----QSGESHDslkdltpi------fnsrqasSTTTTS 62
gi 149238614   5 GRFSKSQGErdgeg-------enqdvSRKSLENKGLQPSRSN----HSGESQDslrelrpifg-gqnatttaaaAATAAA 72
gi 354546200   2 KRFLSRTNKsdssdsnqdtdaaagqdDTKSRTSSSLRPSKSN----ISHESYDsvtelrpmfg-eakqssssssSSSSSQ 76
gi 754406494   2 KRIFGIKKN---------------------DSNMSNESVDETrkskEVGDDASdalpveipidmsidnsgpslkGKEQES 60
gi 150864662   5 KRFLNRNRKse-------------tsDRESLTSRNLAPTTSN----STTESHDesvnalqpm---fdsshndvgEAVPSS 64
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74609558   49 TR-----------------------------------ISSSVQSSSIFS--KGRRTYNSGDSSLRSSTGKngnp------ 85
gi 74627370   69 YDmmhlnlnpti---------------snlnktvpsiKGSTIQ-DSLFS---SRQSYSTNQSSYKTGGTNtsggsssnsq 129
gi 74603852   75 FNfmhdtnlnlnps-----------ilntnlapsvmtKDSEYMVNSMYS--DSKKTYSTKQSSYLTQNSqkktga----- 136
gi 260946203  52 AKfandpdlnlnp--------------cisnsmsvgtSSASAGTRSVFS---SKYSSSTKQSSYMSSGSRakk------- 107
gi 255727777  74 YDmmhlnlnpti---------------snttkvasstKGSTIQ-ESVFS---SRQSYSTKQSSYQSDVSakr-------- 126
gi 459369820  63 NMmmnlnlnptisn------------atefskvaastKGSTIH-DSLFS--SRQSSYSTNPSSYASAGSGgg-------- 119
gi 149238614  73 TAtaigmgmgmgmydsslnlnpsilnaplesvlqtsqASALKGGNSLFS---SKQSFSTKQSSYQNSAPHsk-------- 141
gi 354546200  77 HRpseagffdtglnlnpsi--lgpsdtatvgasssrhSTVQREGNSLFS---SKQSFSTKQSSHQSANStkr-------- 143
gi 754406494  61 SEeddp---------------------------veslLPSSYNRSSLFS--RDQNTFQTLSTNPTSSSSGgggsqgqg-k 110
gi 150864662  65 FHfnndmslnlnpsi---------sntnskqatsvftKDSEYMDKSLFSrgQSRKTYSTKQSSYKSGTSNssg------- 128
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74609558   86 ---vneYRDLGTPLRIIDssrya-slatVNEEEQSttdqsldcpvv----------------------------ysnqns 133
gi 74627370  130 fgkrkhDLNTSQPLQTLK----------ILEENEHq-------------------------------------------- 155
gi 74603852  137 -ssaarNLEYGQPLQILN----------IAEESSEnp------------------------------------------- 162
gi 260946203 108 ----nrASEYGQALQILE----------IPEETRYdan------------------------------------------ 131
gi 255727777 127 ----klDFAPSQPLQILN----------ILEENEHq-------------------------------------------- 148
gi 459369820 120 ----ksYFSPSKPLQTLN----------VVKETDGddd------------------------------------------ 143
gi 149238614 142 ----ksFGDFGQALQTLN----------IVEGSTAske------------------------------------------ 165
gi 354546200 144 ----sfQYNYSQPLQILD-----------LEKTETgde------------------------------------------ 166
gi 754406494 111 qsnvikIDNIGKPLRVLStdrynelsrvGTSTSQHstnssipssfnrrrrsdndynlssgqviplpmnpgsnvnnqssss 190
gi 150864662 129 ---kkeAFHYSQPLQILN----------IPEEANE--------------------------------------------- 150
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74609558  134 nkeilTMSNESHYLVKAIKNLENNLLDLMDDVHQNVTNISRAVICATEYFKNFiqets---------------------- 191
gi 74627370  156 --------nLEELIRDNLKQLYQDLAYTMSQFYNSSASLSTTVINIIDCLKKFnvfve---------------------- 205
gi 74603852  163 --------dIKGTVVDKLHELYEDVLFIMNQYNNSSINLSTTVINTIDCFKKFvsfa----------------------- 211
gi 260946203 132 -------anAEEIIADRLHSLWQDISYISNQYVTSVDNLSSSVVNIMDRFKEFrksv----------------------- 181
gi 255727777 149 --------nLEDLICDNLKQLSQDLSYVVNQFNNSTINLSTAVINTIDCLKKFiafiek--------------------- 199
gi 459369820 144 ------eqtWEDRIRENLKQLYQDLAYIMNQYNNSTINLSTAVIDSIDCLKKFtqdn----------------------- 194
gi 149238614 166 -------kdEGYSVVDELRQLSQDLAYIMHQLNNSSVNLSTAVMNLIDCFKSFstsyravptisaatkekrtrtvgdaet 238
gi 354546200 167 -------rnYHDRVCDELKKLSQDLAYIVMQYNNATVNLSTTVVNCIDCFKEFnn------------------------- 214
gi 754406494 191 ggtggLNILTQEIVSKELSILNENLLGLIDQLNQNVINISKATISIVEFLDDFlp------------------------- 245
gi 150864662 151 -----VNRTPYETIADKLCTLYDDLAYIMNQYNNSLINLTTAVINSIDCFKRFvsfid---------------------- 203
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74609558  192 ---------------lpsltNGTVNYRVKMESCPSVRGITKIIFHFYDNLLNTEAYSNSRSILFRRYLSFLKKLEIQQDT 256
gi 74627370  206 ---------------katiaKPNEQYIFTSYNSSSLRKILKIYLELYDNLLTDQVYIKLKLLLVKNFNDFAMLLNSQEMN 270
gi 74603852  212 ----------------esfgSDSESWDITTFNNGDMRRIMKIYLHFYDNLLASDVYIKLKLLLVKNFNDFATTLNSRDKP 275
gi 260946203 182 ----------------knidALDGQWCFTSYNNDDVRKLLRTYLHYYDNLLKDDAYIRLKLLLCKAFNDFRLTLKSSSRV 245
gi 255727777 200 ---------------akyheFSNTEFCFTAYNSSSVRKILKIYLHMYDNLLRDDVYIKLKLLLVKNFNEFASVLNHTGLD 264
gi 459369820 195 ----------------vnedNGEGGFSFDTYNSSSLRKIFKIYLHFYDNLLNSQVYIKLKLLLVKNFNDFIMVLNPTELT 258
gi 149238614 239 eietetisknenknknenenENEFQTEVMAYNNLDLRKIIKIYLQYHDDLLQNEVYIKLKLLLMKHFNDFASKFDDEAKS 318
gi 354546200 215 ------------------niKEKQESDISTYNNLNLRMIVKYYLHFYDNLLKDDVYIKLKLLLVKHFNDFALHFSDNLND 276
gi 754406494 246 ------------------ftNVSNQFNITTENNEQLRNIIKIILQLYDNYLRFEVYINSKNLLIKSFIEFLSRLQFKFPF 307
gi 150864662 204 ----------------tinnPSSLDWNFTTFNNSNVRRIMKIYLNFYDNLLRDEVYIKLKLLLVKNFNDFTQTLNSRSSS 267
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74609558  257 TerdaQAMVLPSLKIFPIDDSC---NLPHKDRIYEIMEDIIKSdTK-LLSEDEGSFIAAVLRGVEKDASILSIVFGLPTI 332
gi 74627370  271 Q----ISEEMIKPKNYPIGSSKg-kSLPNEEILVRIMEKVSHS-NL-SMKEQNGSFIAPITRGISNNLNILCLYFGYPEP 343
gi 74603852  276 An--kPMQNMVKPQNYAIGIDPd-kSLPNEDLIEKIMKKIAST-SI-SVKEQNGSFIAPIARGISNDLNILCLYFGYPNP 350
gi 260946203 246 Av---APDSIQKPRNFAVGVNGg-qELPNQREISRIISKIANS-PM-GLKEQNGSFIAPIARGIDRDMNVLCLYFGYPSF 319
gi 255727777 265 SqfnaNPGEMIKPKNYAIGTNRs-sSLPNEEVLIKIMDRISQS-SL-STKEQNGAFIAPITRGISKDLNILCLYFGYPDP 341
gi 459369820 259 N-----NMEMIKPKNFAIGSNEnqySLPNEDVLMRIIDKISHNhNInSSKDQNGSFIAPITRGISSNLNILCLYFGYPDP 333
gi 149238614 319 S------TVLIKPRYYAVGSGDh-gPFPGEDSVATIMDRIAQV-NL-ASKDQNGSFIAPVLRGVTSKLRILCLYFGLPDP 389
gi 354546200 277 L------NVMVKPRNFSVGADSv-rDFPNEKVIVRIMDRIAQT-SI-SMQEQNGSFIAPIMRGVSTRLSILCLYFGYPDP 347
gi 754406494 308 N----LFETIPFMKNFAITDEI---ELPNKFKIQQIMETISQSsSN-IISDQEGSFIAPIMRGLTPKTSILAIMFGFPDP 379
gi 150864662 268 V----APATITKPQNFAVGNNKg-lSLPNEDVLERIIEKISST-AI-SMKEQNGSFIAPITRGLSKDLNILCLYFGYPDP 340
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74609558  333 RQEHQEMIKALYGLFPDVHFYCIQDYIKPAATTAIMP----------------------------ELKGTQQLNNINKEE 384
gi 74627370  344 TEYHHSLTQSLRELYDDVHVVLAKNQIELASATRVDA----------------------------ASTFNKPAAFNDGFP 395
gi 74603852  351 TDLHSKLIQSLHGLYDDIHVVVMKNQIELASIMAESA----------------------------SIPFPNYNASESVLP 402
gi 260946203 320 TEDNQRIISSITDLFDDVHVMVAKNQIELASSTSAPL----------------------------AGNV----------- 360
gi 255727777 342 KEYHYNLVQGLQGLYEEIHIILMKDQIELASSKEEAI----------------------------TIPPA---------- 383
gi 459369820 334 QEYHYNLIQGLRELYDDIHIILTKNQIELAASNTTTD----------------------------NQQHQQQHQ------ 379
gi 149238614 390 QENHQKVISGISELYDDIHVVIAKNRIELASASVETSiklnnvppvqkiqhhqhsqkgydqhlshSHKQQQHHHQQQQQQ 469
gi 354546200 348 QDMHYKLTQSIHDLYEDIHVMVMRNHIELASTSVSNP----------------------------PQLPTQHKPIVSNAL 399
gi 754406494 380 QQDHYEIINALFQSFPDVHFFLKKDYIKPCGIT--------------------------------PKPSS---------- 417
gi 150864662 341 TDYHYKLTQTLHELYDDIHVVVIKNQIELASSGAKAE----------------------------ASPITKLTSFESYHN 392
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74609558  385 q------------sYRFSPPYRTLENGNTPPISLSISTQNSLKMSGTLGGYVYPQV-DS-DSKLAQYAGATFAITCAHVV 450
gi 74627370  396 plqa-------qstQKFKLPFRVPTDIHHVPMSMSISIENATRTSGTMGGYIYPIIdLQkQPHLKSYANSKFAISCGHVC 468
gi 74603852  403 stqv------envvRKFKLPFRNPTDSSRPPISLSLSVENASRLSGTMGGYIYPQIdLEkQPHLESYTNSKFAISCGHVC 476
gi 260946203 361 --------------QKFKLPFRNPADPMRPPMSLSLSVETSSRISGTMGGFIYPKIdVSsQPQLTSYANSKFALSCGHVC 426
gi 255727777 384 --------------QKFKLPFRVPTEGEQIPMSMSLSIEKATRTSGTVGGYIHPIIdLEkQPHLKSYANSKFAVSCGHVC 449
gi 459369820 380 --------------QKFKLPFRIPTDNQQIPISMSISIENAVRTSGTMGGYIYPIIdLTkQPHLKSYANSKFAISCGHVC 445
gi 149238614 470 qqqg-------fpvQKFKLPFRVPVDPLQPPMSMSMSTENSLKTSGTVGGYIYPKIdIKkQPNLKSYAASKFALSCGHVC 542
gi 354546200 400 --------------HKFKLPFRIPTDPLEPPISMSISTENSNRVSGTLGGYIYPKIdLKkQPQLKSYASSKFAISCGHVC 465
gi 754406494 418 --------------SKFKPPFKTLSNKKKPEISLSISSENSIKTTGTLGGFIEPIFhSNtDKSLLKYKGSKFGITCAHVL 483
gi 150864662 393 pnnvgssaapisanQKFKLPFRIPTDAQRPPMSLSLSVENSSRTSGTVGGYIYPIIdIKkQPHLESYASSKFAITCGHVC 472
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74609558  451 LAESQD----YPEVAVPSRVLQKSYHKTLLEESSRYP---------QGSKEqRAFADEALQVER---------------- 501
gi 74627370  469 LD-SDNpe-nYPNVSSPSSVLISLYKQALTEQYHKSLnrnnstagvPSETR-VAFGAVLQQLEEmfplkqikksstrnnn 545
gi 74603852  477 LD-NNDedvnYPHVSAPLAVLISLYKKALWTQYQKFSqqgn--nvsTMEER-IAYGSVLKNLDKvfplkkvkv-----py 547
gi 260946203 427 LN-KSEdvveYPHVSSPSSVLIGLYKKALSAEYQKLDdieg--dnsVMDSK-LAYASVLKQLDEifplkevtvt----ds 498
gi 255727777 450 LD-SEDpe-nYPNVSSPSSVLISLYKDALTQQYHKSLhn------nAKDSK-AAFGAMLQQLESmfplk----------- 509
gi 459369820 446 LD-SMNpe-nYPNVASPSSVLISLYKQALTEQYHKCLky------gKDDSKvVAYRSILNQLEEmfplkkiks-----sq 512
gi 149238614 543 LD-PHSps-tYPNIAVPSAALIGMYKQALLAQYERVKg-------sMKDTE-VAYKAVLGELEEmfpsknvkv-----nm 607
gi 354546200 466 LD-PQDas-hYCNIASPSASLISLYKSALTAQYQRQGg-------qFNESH-IAYGTILNELEEmfplkkikv-----qe 530
gi 754406494 484 LNESQD----YPNVNVPSSVLVHAYMSALRDERDKYP---------ENCMEyVSYNEELKKSEN---------------- 534
gi 150864662 473 LDTTNTatteYPHVSAPSSVLISLYKQAVAQQYQKVAchad--eamFADSK-IAYGAVLKQLEEifplkrvkvt----dp 545
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74609558  502 -------SMKLQNQEKFGQVVWGERSIIN-----------------------QRLSDFAIIKVNPSMDCK-NFLGNNLAQ 550
gi 74627370  546 saykddyEVRNLPKYRFGQIIWGERTLIKlngdtngnssnnhqinemsgiveKKLSDLAIIKVNKKLKCEhNYLGDDVQF 625
gi 74603852  548 sskreghEIRNLPEHRFGQIIWGERTLINlkgsdk-----------asqdveNKLSDLAIIKVNKNLKCDqNFLGDDIAF 616
gi 260946203 499 ktkkkrtEVRNLPRTRFGQIIWGERTLIQakntkt-----------gkeisdKRLSDLAIIKVNKLLQCDqNYLGDDIAF 567
gi 255727777 510 --kisqdEVRNLPKVRFGQIIWGERTLLTigendein--------qvsgvveKKLSDLAIIKLNKNLKCEcNYLGDDVPF 579
gi 459369820 513 nekeqvvVMKNLPKHRFGQIIWGERTLLQinqstttpt-----kneisgvveKKLSDLAIIKVNKNLKCQyNYLGDDVLF 587
gi 149238614 608 dniqereLGRNLPRHKFGQIIWGERTLIEvlqtpna----------vsglteRKLSDLAIIKVNKHMKCSaNYLGDDVLF 677
gi 354546200 531 knspehyEMRNLPQVRFGQIIWGERTLINlsespne----------isglveRKLSDLAIIKVNKHLKCSyNYLGDDVQF 600
gi 754406494 535 ------------FSMDLGQVVWGERVLMPs---------------------sKKISDLSIIKCNSGLKCE-NILGDDLDY 580
gi 150864662 546 ktkqekyEVRNLPKNRFGQIIWGERTLINakkdtedkee----sanananaeKRLSDLAIIKVNKNLVCDqNFLGDDIQF 621
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74609558  551 V-PDPTLKFENVYVKkKI--MKIQP--------------------------------GTKVFKIGASTGYTTGVVNAVKL 595
gi 74627370  626 NeYDPSLMFDNLYVR-KV--INLKRyvpkvintaiedvd-----sdvsnnseiqtyfGIPVFKYGSTTKYTKGHLNGIKL 697
gi 74603852  617 NeYDPALMFDNLYVR-KV--INLEReskelninevd-----------svasansnysGLSIFKYGSTTKFTRGNLNGIKL 682
gi 260946203 568 NeYDPALFFDNLYVR-KV--INLNRytkeidmdninevds--vdsvitesedsystnGLPVFKYGSTTKFTKGNLNGIKL 642
gi 255727777 580 NeYDPALMFDNLYVK-KV--LDLKRyapkvvhtdihdvds---disnydstinnnyyGLEAFKMGATTKYTRGCLNGIKI 653
gi 459369820 588 TeYDPGLIFDNLYIR-KV--LSLKRyipkpintniedidsnissssssssssdgtyyGIPVFKYGSTTKYTKGYMNGIKL 664
gi 149238614 678 NeYDPSLIFENLYVR-KV--LNLKRyepkpineavkdid-----sqvssfeetenlhGLEVFKYGSTTKYTRGNLNGIKL 749
gi 354546200 601 NeFDPALIMDNLYVR-KV--LNLKRfvpktihenvnevdss-vstsslsqdedqcynGIPVFKYGSTTKYTCGNLNGIKL 676
gi 754406494 581 --YNPSLKFKNLQIKkKIktIDFNK--------------------------------HSKIFKMGASTKYTQGEINGIKL 626
gi 150864662 622 NeFDPALMFDNLYVR-KV--INLTRyspkqldlnidevds---slssntaevaknysGLSVFKYGSTTKFTKGTLNGIKL 695
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74609558  596 IYWADGKLQSSEFIVSS--------PQPLFASGGDSGAWILTKLED------R-VGLGVLGMLHSYDGERKQFGLFTPIG 660
gi 74627370  698 VYWLDGAIHSSEFIVNSi------eANSSFASGGDSGSWILTKLDDied---nsKGLGVLGMLHSYDGEFKQFGLFTPMT 768
gi 74603852  683 VYWLDGAIHSSEFVINSv------eSNTAFAAGGDSGSWILTKLEDctsesnS-KGLGVLGMLHSYDGEHKQFGLFTPMC 755
gi 260946203 643 VYWLDGAIHSSEFVVNSd------dSTTYFAAGGDSGSWILTKLEDvqgsseR-KGLGVVGMLHSYDGEFRQFGLFTPMT 715
gi 255727777 654 VYWMDGQINSSEFVVSS---------DTTFASGGDSGSWLLTKLEDg-------SGLGVLGMLHSYDGQVKQFGLFTPMS 717
gi 459369820 665 VYWLDGAIHSSEFIVNSi------dNNSTFASGGDSGSWILTKLEDinnnggDqKGLGVLGMLHSYDGEFKQFGLFSPMT 738
gi 149238614 750 VYWLDGEMHSLEFIVNSs------dMTSVFASGGDSGSWIMSKLQDinp---neQGLGVLGMLHSYDGEFKQFGLFTPMC 820
gi 354546200 677 VYWLDGAMHSSEFIVNSi------eHNSAFAGGGDSGSWVLSKLQDlda---taNGLGVLGMLHSYDGEYKQFGLFTPMC 747
gi 754406494 627 VYWLDGSLQTSEFVVNSensnsnsnNSPIFANSGDSGSLILNNLYG------E-IGLGVIGMLHSFDGELKQFGLFTPVD 699
gi 150864662 696 VYWLDGAIHSSEFIVNSl------eNNSAFAAGGDSGSWILTKLEDieddsyS-KGLGVLGMLHSYDGEFKQFGLFTPIC 768
                        970
                 ....*....|....*.
gi 74609558  661 DILERLHTVTGIYWDI 676
gi 74627370  769 EILSRLEEVTNIKWGV 784
gi 74603852  756 EILERLETVTNIKWGV 771
gi 260946203 716 EILERLEDVTKIKWGV 731
gi 255727777 718 EILDRLETVTGIKWSV 733
gi 459369820 739 EILNRLEEVTNIKWGV 754
gi 149238614 821 EILSRLKEVTNIEWGI 836
gi 354546200 748 EILNRLEEVTNIKWGV 763
gi 754406494 700 DILDRLNQVTGIEWDf 715
gi 150864662 769 EILQRLEEVTSIRWGV 784
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