5LSK


Conserved Protein Domain Family
MIS13

?
pfam08202: MIS13 
Click on image for an interactive view with Cn3D
Mis12-Mtw1 protein family
Mis12-Mtw1 is a eukaryotic conserved kinetochore protein that is involved in chromosome segregation.
Statistics
?
PSSM-Id: 336953
View PSSM: pfam08202
Aligned: 10 rows
Threshold Bit Score: 230.858
Threshold Setting Gi: 74608578
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5LSK_D        12 LHLSPQEQSas-----yqDRRQSWRRAsmKETNRRKS-----------LHPIHQGI--TELSRSISVD-LAESKRLGCLL 72
gi 74602447  245 MNLEDSDTArtrn--qkaPNGKNKRRAsyHNRGKRVLsig-----ngfVGVPHEDVptSDYYKLLDTS-LPEPHRMKQLL 316
gi 74606276  193 NPLSQNRPIla------pEDSRAKRKSfmIQRGRRLSllnqe-nqlndIISPHKDVheSEFYRYMNNS-FAQDLKMKQLM 264
gi 74608578  115 IKVIDNEAAlks---slnERARNKRLSl-SQRGRRLSmlstg-vdrhvIVSPHKEVpeQEFYKHVGDLsFGKSLQLRQLF 189
gi 74626004   45 LPVSDTPIVkrnkelrkgKG----RRSslDQRGKRASsig-----tgfEALPHADVpsHEYYRHISKD-LSEPLRIKQLL 114
gi 28201793   78 LHLSPqeqs-----asyqDRRQSWRRAsmKETNRRKS-----------LHPIHQGI--TELSRSISVD-LAESKRLGCLL 138
gi 28201791   76 FHLSPqeqs-----irpqDRRQSWRRAsmKEVNRRKS-----------LAPFHPGI--TELCRSISVK-LAQSQRLGALL 136
gi 74634016  258 LPLKHTPVIqqqd-mrkvPAKTPERNH--DNRGRRISslg-----ngfEGEPHADVdaQNFYKHFEPG-LPEPHKARLLL 328
gi 85102960  233 LPLSDTPIInrnkemrkkGGASGSRRSslGMRGRRASslie----nghSAIPHREVdpSEFYKHIEAEgLSEPRRMRQLL 308
gi 765826336 219 QQLQQPHYI---------QRTRERKKSigSQRGRRLSmlasqanggstIISPHKDIpeEDFYTVVGNAsFGKNLQIRQLF 289
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5LSK_D        73 LSSFQFSIQKLE----------------------------------PFLRDTKGFSLESFRAKASSLSEELKHFADGLE- 117
gi 74602447  317 IWSFKKKLDQEEklsrsksks----------------ettedqtiiNIAKVIKEEVLRDLIEGQISISWYNRDDNEDET- 379
gi 74606276  265 NWCLIRALRKLEiknsqn-----------------------ksesrKITLTILKDFVRDIRKGSHDIDWDSEGPEAEPTv 321
gi 74608578  190 NWCCDRTYTRIQeadrkktqsqt------------leengsygdpkKITMNIIKSFVHDLKKGTLDIDWEAEEEEEEDDy 257
gi 74626004  115 LWASSKALEEQRkkyget----------------------eeaseaAIARSIVQEVLNELLANKVSVSWYQRP------- 165
gi 28201793  139 LSSFQFSIQKLE----------------------------------PFLRDTKGFSLESFRAKASSLSEELKHFADGLE- 183
gi 28201791  137 LSSFQFSVEKLE----------------------------------PFLKNTKDFSLECFRAKASSLSEELKHFTDRLG- 181
gi 74634016  329 TWSGKRAMMNHKtrmvresapqg-------------lsetdettarRIVRVIMEDIIRDMKDGKVNTSWYNRPEPDGDDh 395
gi 85102960  309 TWCGERALSEKPphgsh------------------------gssaiLGARAIQDQLLKDFGARSEFSDWFAREEAPKPPv 364
gi 765826336 290 NWCLMRSLHKLElkaknqeeegelehltkksklestkaetdyvdpkRLAMVIIKEFVDDLKKDHIAIDWEDEEKYEDEDe 369
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5LSK_D       118 ----------TDGTLQKcfe----------------------------------------------------------ds 129
gi 74602447  380 ----------NDNMLTNkev-----------------------------------------------------------t 390
gi 74606276  322 ---------eDESEISNlfkegntensilvdss---------------------------------lsnknkippiklak 359
gi 74608578  258 sg------ngNDTELNAlfddhndgntrhtsarqnltlyddefditlgiqptrpeleyrnnkknnrqstrkrkiqtphkk 331
gi 74626004  166 ----------PDAVIPNk-------------------------------------------------------------- 173
gi 28201793  184 ----------TDGTLQKcfe----------------------------------------------------------ds 195
gi 28201791  182 ----------NDGTLQKcfve---------------------------------------------------------ds 194
gi 74634016  396 ----------SNSRFTK--------------------------------------------------------------- 402
gi 85102960  365 v------------------------------------------------------------------------------l 366
gi 765826336 370 ekildntenyDDTELRQlfqenddddddddevdyseiq----------------------rsrrkfserrkalpkepkkl 427
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5LSK_D       130 nGKASDFSLEASVAEMKEYITKFSLERQTWDQLLlHYQQ---------EAKEIL----SRgs-teAKITEVKVEPMTYlg 195
gi 74602447  391 lPNPLNITNEENIEIFTKKLKSLKQERSQWESSFnRSTSh-------iPNLKIDanqkEAdlqdyCQIRSETQDSSVDfn 463
gi 74606276  360 iPNEKNIQNKENAKILEEKIKTIKNEIEQWSKDLsDVKI---------PSYELPksqtSI-----VKLPDNLQLTATT-- 423
gi 74608578  332 lPNTKNVENEKNLIMLKQKIDILENDINEWANTL-DSHD---------PQKEWQli-------kdVKPDNTTPEQTIT-- 392
gi 74626004  174 -PHPQNLKNAQLVDELSAKLTQLHNEEAAWRAVAaNSVS---------SDKSILsfkkAVes-idSKQDLDKQDSPLPpd 242
gi 28201793  196 nGKASDFSLEASVAEMKEYITKFSLERQTWDQLLlHYQQ------------EAke-ilSRgs-teAKITEVKVEPMTYlg 261
gi 28201791  195 kEKAADFSLEASVAEVKEYITKFSLERQAWDRLLlQYQN------------EVPpeemPRgs-teTRITEVKVDPAAYlr 261
gi 74634016  403 -PNAQNIANAEKLALFKKRLAAQQAEIKEWAKLEaEAREr--------LDMAKGksqkLV-----AQLQKPFDSPPTLps 468
gi 85102960  367 qPNPRNLEHDAKIAELEAKIKRLKEEKKAWQALAkPLPDleplypdsdPAKAPLpepsLLda-eeAKILASLIEPDTAfs 445
gi 765826336 428 lPNSKNVENTKNLSILTSKVNAIKNEVKEWAVTL-DTSR---------PDLEWQeltsFSsq--pLEPLSDTEEPDLA-- 493
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5LSK_D       196 ssqnevlntkpdyqkilqnQSKVFDCMELVMDELQGSVKQLQ----AFMDESTQCFQ-KVSVQLGKRSMQQLDPSPARK- 269
gi 74602447  464 stvlnnslaekindnynnvNENIPHDVETSTDKLYDASYRLSqareLIAKLQTDKLNdKVSSLVQNYMTKHLREPLSPGt 543
gi 74606276  424 -------------------KESIHSDFQKRVDGLQETTRLLKsssiLLNETAGMKLQ-RLNGCIVKKRPEDKNS------ 477
gi 74608578  393 -------------------NANPVKELEDRLKAMSMNAHLLDstskTLLELSRIKLD-KLRRAYYDTAKNEKKQIE---- 448
gi 74626004  243 dap------------elpnISKLKPKFHTLLDMLAENIHTLHsltnAGPEVRSSYG-----RLAAQDFIAHRKSLLSFSk 305
gi 28201793  262 ssqnevlntkpdyqkilqnQSKVFDCMELVMDELQGSVKQLQa----FMDESTQCFQ-KVSVQLGKRSMQQLDPSPARK- 335
gi 28201791  262 ssqkevlstkpdyqrivqdQNQVFAYVELVMDELQGSVKQLQa----LMDESTQYLQ-KVSVQLKKRSMDQLDSSPARK- 335
gi 74634016  469 l---------------lsdVALSASTFSRQIDQVEDAVNKINscnvRASKFCDEQFQ-ALDNVLESRSRKRPRQSQDFRt 532
gi 85102960  446 sfrr----------rtrsrLQNVQSSLEFKIDHLADSVHKLDmrvsTAGREADQVL-----MLSAARLKEREE----REk 506
gi 765826336 494 -------------------IADVETKLETKVDELRYQSHILNshslALNEITNSKVN-KLNIETMRKISSETDDDHSQVi 553
                        410       420
                 ....*....|....*....|....*
5LSK_D       270 ----------------LLKLQLQNP 278
gi 74602447  544 sswpv-----pnrritTKELLRGIT 563
gi 74606276  478 ----------------TKKLLRGLS 486
gi 74608578  449 ----------------STRLLRGLA 457
gi 74626004  306 y-------------vdTMNLLRLLS 317
gi 28201793  336 ----------------LLKLQLQNP 344
gi 28201791  336 ----------------LLKLPLQSS 344
gi 74634016  533 ifnadrfrestldgeqTRDVLRTLS 557
gi 85102960  507 grvg-------trdlpTIEVLRSLG 524
gi 765826336 554 ---------------nPQQLLKGLS 563
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap